3(2H)-pyridazinone compounds derivatives and compositions for controlling and/or preventing insect pests intermediates for such compounds, and a process for their manufacture

ABSTRACT

A novel 3(2H)-pyridazinone derivative of the formula [I]: ##STR1## wherein, R represents an alkenyl group having 2 to 16 carbon atoms, an alkynyl group having 2 to 16 carbon atoms, an alkyl group having 3 to 8 carbon atoms substituted by an alkoxy group having 1 to 6 carbon atoms or G-Ra-; 
     A represents hydrogen atom, halogen atom, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, an alkylthio group having 1 to 4 carbon atoms, an alkylsulfinyl group having 1 to 4 carbon atoms or an alkylsulfonyl group having 1 to 4 carbon atoms; 
     R 1  represents hydrogen atom, halogen atom, an alkoxy group having 1 to 4 carbon atoms or hydroxyl group; 
     X represents oxygen or sulfur atom; 
     J represents ##STR2##  as well as insecticidal, acaricidal and nematicidal compositions and compositions for expelling ticks parasitic on animals, said compositions containing as an active ingredient at least one of the above derivatives.

BACKGROUND OF THE INVENTION

The present invention relates to novel 3(2H)-pyridazinone derivatives and insecticidal, acaricidal and nematicidal compositions and compositions for expelling ticks parasitic on animals containing as an active ingredient said derivatives.

The present invention concerns EP-A-0088384 which corresponds to U.S. Pat. No. 4,571,397, EP-A-0134439 which corresponds to U.S. Pat. No. 4,877,787, EP-A-0183212 which corresponds to U.S. Pat. No. 4,874,861, EP-A-0199281 which corresponds to U.S. Pat. No. 4,837,217, EP-A-0210647, EP-A-0193853 which corresponds to U.S. Pat. No. 4,783,462 and EP-A-0232825. The known compounds contained in these patent publications are represented by the following general formula [II]: ##STR3##

The characteristics of the compounds of these publications are, e.g., in the above formula [II]:

in case of EP-A-0088384, EP-A-0134439, EP-A-0183212, EP-A-0199281 and EP-A-0232825, Y' represents oxygen atom or sulfur atom, but R' represents an alkyl group;

in case of EP-A-0210647, R' represents an aryl group; and

in case of EP-A-0193853, Y' represents nitrogen or oxygen atom, but R' represents hydrogen atom or an alkyl group.

However, the compounds of the present invention are novel compounds which are not covered by these European patent publications.

On the other hand, DT-OS-3328770 discloses the compounds of the following formula: ##STR4##

In the DT-OS-3328770, the above-described compound A is disclosed merely as an intermediate and the objective compounds derived from said compound A are described to have fungicidal activity for agriculture. However, said compound A is different from the present invention in chemical structure and use in comparison with the compound [I] of the present invention given below.

SUMMARY OF THE INVENTION

An object of the present invention is to provide novel 3(2H)-pyridazinone derivatives which have insecticidal, acaricidal and nematicidal activities.

Another object of the present invention is to provide a process for preparing such 3(2H)-pyridazinone derivatives.

Still another object of the present invention is to provide insecticidal, acaricidal and nematicidal compositions and compositions for expelling ticks parasitic on animals, said compositions containing at least one of such 3(2H)-pyridazinone derivatives as an active ingredient.

Still another object of the present invention is to provide a method for controlling and/or preventing insect pests by using the above-mentioned derivatives or compositions.

Other objects of the present invention will become apparent from the description given below.

DETAILED DESCRIPTION OF THE INVENTION

The present invention relates to novel 3(2H)-pyridazinone derivatives of the formula [I]: ##STR5## wherein,

R represents an alkenyl group having 2 to 16 carbon atoms, an alkynyl group having 2 to 16 carbon atoms, an alkyl group having 3 to 8 carbon atoms substituted by an alkoxy group having 1 to 6 carbon atoms or G-Ra- in which G represents hydrogen atom, RbO-, RbS-, ##STR6##

RbSO₂ -, ##STR7## RbCO₂ -, ##STR8##

RbNHCO₂ -, RbNH-, (Rb)₂ N- or a cyano group in which Rb represents an alkyl group having 1 to 4 carbon atoms, and Ra represents a halogenated alkylene group having 3 to 16 carbon atoms, a halogenated alkenylene group having 2 to 16 carbon atoms, a halogenated alkynylene group having 2 to 16 carbon atoms, a halogenated cycloalkylene group having 3 to 8 carbon atoms, a halogenated cycloalkylene having 5 to 8 carbon atoms, a halogenated oxacycloalkylene group having 5 to 8 carbon atoms, a halogenated thiacycloalkylene group having 5 to 8 carbon atoms, an alkylene group having 1 to 4 carbon atoms substituted by a cycloalkyl group having 3 to 8 carbon atoms and halogen atom, an alkylene group having 1 to 4 carbon atoms substituted by an oxirane group and halogen atom, an alkylene group having 1 to 4 carbon atoms substituted by a phenyl group which may be substituted and halogen atom or an alkylene group having 1 to 4 carbon atoms substituted by heterocyclic group which may be substituted and halogen atom;

A represents hydrogen atom, halogen atom, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, an alkylthio group having 1 to 4 carbon atoms, an alkylsulfinyl group having 1 to 4 carbon atoms or an alkylsulfonyl group having 1 to 4 carbon atoms;

R¹ represents hydrogen atom, halogen atom, an alkoxy group having 1 to 4 carbon atoms or hydroxyl group;

X represents oxygen or sulfur atom;

J represents ##STR9## in which R², Rc, Rd, Re and Rf independently represent hydrogen atom or an alkyl group having 1 to 4 carbon atoms, X¹ represents ##STR10## (Rg represents an alkyl group having 1 to 4 carbon atoms) and Hal represents halogen atom, Q represents a substituted phenyl group, a naphthyl group which may be substituted or a heterocyclic group which may be substituted, and Q¹ represents a phenyl group which may be substituted, a naphthyl group which may be substituted or a heterocyclic group which may be substituted; a process for producing said derivatives and insecticidal, acaricidal or nematicidal compositions and compositions for expelling ticks parasitic on animals containing as an active ingredient at least one of said derivatives.

After the intensive researches, the present inventors have found that the compounds represented by the general formula [I] have excellent insecticidal, acaricidal and nematicidal activities.

For example, the known compounds of the formula [II] have strong insecticidal, acaricidal, nematicidal and fungicidal activities and have wide insecticidal spectrum and are excellent in prompt-effectiveness. On the other hand, the compounds of the present invention are slow in effectiveness because they have action to inhibit metamorphosis of insect pests. Moreover, the compounds of the present invention are effective, with very low drug-concentration, on various kinds of insect pests; e.g., agricultural insect pests such as green rice leafhopper (Nephotettix cincticeps), brown rice planthopper (Nilaparvata lugens), green peach aphid (Myzus persicae), diamondback moth (Plutella xylostella); sanitary insect pests such as house mosquito (Culex pipiens palens), house fly (Musca domestica), German cockroach (Blattella germanica), ant (Formicidae); stored product insect pests such as maize weevil (Sitophilus oryzae), red flour beetle (Tribolium castaneum), almond moth (Cadra cautella); house insect pests such as termites and veterinary insect pests such as ticks, mites, acarids, lice and the like. In other words, the compounds of the present invention can effectively control and prevent Dictyoptera, Isoptera, Hemiptera, Lepidoptera, Coleoptera, Hymenoptera, Diptera, ticks and lice.

The above-mentioned effects are described in detail in the biological examples later described.

In the substituent "J" in the above-mentioned formula [I], when Q represents an aryl group, J represents a substituted phenyl group or a substituted or unsubstituted napthyl group, and when Q¹ represents an aryl group, J represents a phenyl group which may be substituted or naphthyl group which may be substituted.

As the kinds of substituents are exemplified halogen atom, an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, an alkyloxy group, an alkenyloxy group, an alkynyloxy group, a methylenedioxy group, a halogenomethylenedioxy group, an alkylthio group, an alkenylthio group, an alkylsulfinyl group, an alkysulfonyl group, a cycloalkyloxy group, a haloalkyl group, a haloalkyloxy group, a haloalkylthio group, an alkylamino group, an alkylcarbonylamino group, nitro group, cyano group, hydroxyl group, an alkylcarbonyl group, an alkoxycarbonyl group, carboxyl group, aryl group, an aryloxy group, an arylthio group, an arylamino group, an arylcarbonyl group, an arylmethyleneoxy group, an aryloxymethyl group, an arylmethylenecarbonyl group, substituted or unsubstituted pyridyloxy group, hydroxyalkyl group, an alkylcarbonyloxy alkyl group, an alkoxyalkyl group, an alkylthioalkyl group, an alkylcarbonylalkyl group, an alkoxycarbonylalkyl group, cyanoalkyl group, haloalkylcarbonyl group.

In the substituent "J" of the general formula (I), when Q or Q¹ is hetero ring group, the following are raised as hetero ring; e.g., thiophene, furan, pyrrole, imidazole, thiazole, oxazole, pyrazole, pyridine, pyridazine, pyrimidine, pyrazine, benzoxazole, benzothiazole, benzothiophene, dibenzothiophene, benzofuran, benzimidazole, indole, indazole, quinoline, isoquinoline, quinoxaline. In case that the hetero ring groups have substituents, the following is raised as the kinds of their substituent: e.g., halogen atom, an alkyl group, an alkoxy group, an alkylthio group, an alkylsulfonyl group, haloalkyl group, haloalkoxy group, nitro group, cyano group, an alkylcarbonyl group, phenyl group, substituted aryl group.

The compounds of the present invention may be produced by many producing methods. These methods are, for example, as follows: ##STR11##

In the above schemes (1), (2) and (3), R, A, R¹, X, X¹, Rc, Rd, Re, Rf, Q¹ and J each have the same meanings as defined above and Z¹ represents halogen atom or azole group; Z² represents halogen atom, alkylsulfonate group and arylsulfonate group; Z³ represents halogen atom, R³ represents compounds having double bond and R⁴ represents substituents having reactive functional group.

In the reaction shown in the schemes (1), (2) and (3), as the solvent may be used lower alcohols such as methanol and ethanol; ketones such as acetone and methylethylketone; hydrocarbons such as benzene and toluene; ethers such as isopropyl ether, tetrahydrofuran and 1,4-dioxane; amides such as N,N-dimethylformamides and hexamethyl phosphoric triamide; halogenated hydrocarbons such as dichloromethane and dichloroethane. If necessary, these solvents may be used as a mixture or mixture with water.

As the base may be used inorganic bases such as sodium hydride, sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, sodium hydrogencarbonate and organic bases such as sodium methoxide, sodium ethoxide, triethylamine, pyridine, etc. If necessary, a tetraammonium salt such as triethylbenzylammonium chloride or the like can be added to reaction system as a catalyst. The reaction temperature ranges from -20° C. to the boiling point of the solvent used in the reaction system, and is preferably in the range of -5° C. to the boiling point of the solvent used therein. Molar ratio of the starting materials can be optionally selected for reaction. However, it is advantageous to use the materials in an equimolar ratio or near such ratio.

More specifically, in the Process 1-a of the scheme (1), the compound of the present invention of the formula [I] can be produced by reacting Z¹ of the compound of the formula [III] with alcohols or thiols of the formula [IV] in a suitable solvent in the presence of the base. Z¹ is preferable to be halogen atom, especially, chlorine or bromine atom, and azoles, especially, 1-imidazole. As the solvent, it is preferble to use N,N-dimethylformamide, methanol, ethanol, toluene and a mixture solvent of toluene-water. As the base, it is preferable to use inorganic base, especially, sodium carbonate, potassium carbonate, sodium hydroxide and potassium hydroxide. The reaction temperature is preferably in the range of from 20° C. to 50° C.

In this reaction, there may be a case that compounds are by-produced in which alcohols or thiols of the formula [IV] is substituted at the 4-position of pyridazinone ring. In that case, the by-products are required to be removed to purify the objective compounds of the present invention; thus the necessary separation and purification procedure being conducted by using conventional purification method such as re-crystallization, column chromatography and the like.

In the Process 1-b, the present compounds can be produced by reacting pyridazinone derivatives of the formula [V] with alkyl halides or alkylsulfonates of the formula [VI] in a suitable solvent in the presence of the base. Z² is preferable to be chlorine or bromine atom. As the solvent, it is preferable to use N,N-dimethylformamide, methanol, ethanol, acetonitrile, toluene and a mixture solvent of toluene-water. As the base, it is preferable to use inorganic base, especially, sodium carbonate, potassium carbonate, sodium hydroxide and potassium hydroxide. The reaction temperature is preferably in the range of from 20° C. to 120° C., with proviso that when XH of the pyridazinone derivatives of the formula [V] is OH, it is preferable in the range from 20° C. to 120° C. and that when XH is SH, it is preferable to be in the range from 20° C. to 50° C.

In the Process 2-a of the scheme (2), the present compounds can be produced by alkylating the 2-position of pyridazinone derivatives of the formula [VII] with R-Z² of the formula [VIII]. In the above procedure, the present compounds may be readily produced by adding inorganic or organic bases to the reaction system to raise the reactivity of the pyridazinone derivatives of the formula [VII].

In the Process 2-b of the scheme (2), the present compound of the formula [I] can be produced by adding N-halogenopyridazinones of the formula [IX] to olefin of the formula [X]. ##STR12##

The Process 2-b is an appropriate process for producing the present compounds of the formula [I] by referring the related technology disclosed in G.B.P. 999,448.

Z¹ is preferable to be halogen atom, especially, chlorine, bromine or iodine atom. In this process, the present compounds of the formula [I] can be produced by reacting pyridazinone derivatives of the formula [IX] with equimolar or excess amount of (ten-time mols) of olefin of the formula [X] at the temperature of range from -5° C. to 120° C. The reaction may be well proceeded even by diluting the reaction system with a suitable solvent. As the solvent, it is preferable to use hydrocarbons, halogenated hydrocarbons, ketones, ethers, lower alcohols; more preferably, benzene, toluene, hexane, heptane, methylene chloride, chloroform, carbon tetrachloride, methyl ethyl ketone, methyl isobutyl ketone, isopropyl ether, 1,4-dioxane, methanol, ethanol. When olefin of the formula [X] having low boiling point is used, the good results can be obtained by using pressure reactor such as an autoclave.

N-Halogenopyridazinone derivative as a raw material can be synthesized according to the method disclosed by German Patent No. 1122069 or a somewhat improved method thereof. The Process 2-c of the scheme (2) is a method to produce the present compound of the formula [I] by chemically modifying the functional groups in the N-substituent (R⁴) of the pyridazinone derivatives of the formula [XI] to be converted into an intended N-substituent (R).

More specifically, the following methods are exemplified: a method in which halogen atom contained in R⁴ is substituted with neucleophic reagents (R'O⁻, R'S⁻, CN⁻, R'COO⁻, etc.); a method in which oxirane group contained in R⁴ is ring-opened by the above-mentioned neucleophilic reagents or electrophillic reagents (alkyl halide Lewis acid reagent); a method in which double or triple bonds contained in R⁴ are added with halogen molecules; a method in which the above-mentioned neucleophilic reagent is added in Michael type adding method to the double bond adjacent to the electron-withdrawing group contained in R⁴ ; a method in which halogen atom contained in R⁴ is converted into hydrogen halide in the presence of base and the hydrogen halide is splitted off from R⁴ to form double bond; a method in which alcohol group contained in R⁴ is oxidized into aldehyde group, ketone group or carboxyl group; a method in which the double bond contained in R⁴ is converted into oxirane group by oxidizing agent; a method in which aldehyde group, ketone group, carboxyl group or carboxylate contained in R⁴ is reduced into alcohol; a method in which halogen atom contained in R⁴ is dehalogenated; a method in which alcohol group contained in R⁴ is converted into the corresponding halide by using halogenating reagent; a method in which alcohol group and halogen atom contained in R⁴ are intramolecularly cyclized in the presence of the base to convert into oxacycloalkyl group; and a method in which thiol group and halogen atom contained in R⁴ are intramolecularly cyclized in the presence of the base to convert into thiacycloalkyl group.

The Process 3-a of the scheme (3) produces compounds of the formula [XIII] by reacting the compound of the formula [III] with compound of the formula [XII] in a suitable solvent in the presence of the base. Further, the produced compound in the above is reacted with heterocyclic halides or acid halides of the formula [XIV] in a suitable solvent in the presence of the base to produce the present compounds.

The compounds encompassed by the present invention are illustrated in detail by the compounds listed in Tables 1, 2 and 3. However, it should be understood that the compounds in Tables 1, 2 and 3 are merely illustrated and not to restrict the present invention.

In the Tables, Me represents methyl, Et represents ethyl, Pr represents propyl, Bu represents butyl, Pen represents pentyl, Hex represents hexyl, Ph represents unsubstituted phenyl, t represents tertiary, s represents secondary, i represents iso, and c represents cyclo.

Incidentally, a compound of the present invention which contains asymmetric carbon atom(s) includes optically active (+) compound and (-) compound.

Furthermore, compounds among the present invention in which geometric isomer exists therein include cis compound and trans compound.

                                      TABLE 1                                      __________________________________________________________________________     In Compounds of the formula:                                                    ##STR13##                                                                     R                            A     X  R.sup.1                                                                             R.sup.2                                                                             Y                              __________________________________________________________________________     Cl.sub.2 CHC(Me).sub.2       Cl    O  H    H    4-Cl                           Cl.sub.2 CHC(Me).sub.2       Cl    O  H    H    2,4-Cl.sub.2                   Cl.sub.2 CHC(Me).sub.2       Cl    O  H    H    4-I                            Cl.sub.2 CHC(Me).sub.2       I     O  H    H    4-Cl                           Cl.sub.2 CHC(Me).sub.2       I     O  H    H    4-I                            Cl.sub.2 CHC(Me).sub.2       Cl    O  H    H    4-Br                           Cl.sub.2 CHC(Me).sub.2       Cl    O  H    Me   4-Cl                           Cl.sub.2 CHC(Me).sub.2       Cl    O  Cl   H    4-Cl                           Cl.sub.2 CHC(Me).sub.2       Cl    O  H    H    2,4,6-Cl.sub.3                 Cl.sub.2 CHC(Me).sub.2       Cl    S  H    H    4-Cl                           Cl.sub.2 CHC(Me).sub.2       Cl    S  H    H    4-Bu-t                         Cl.sub.2 CHC(Me).sub.2       Cl    S  H    H    4-I                            BrClCHC(Me).sub. 2           Cl    O  H    H    4-Cl                           BrClCHC(Me).sub.2            Cl    O  H    H    4-I                            BrClCHC(Me).sub.2            Br    O  H    H    4-Cl                           BrClCHC(Me).sub.2            I     O  H    H    4-Cl                           BrClCHC(Me).sub.2            Cl    O  H    H    4-Br                           BrClCHC(Me).sub.2            Cl    O  H    H    2,4-F.sub.2                    BrClCHC(Me).sub.2            Cl    S  H    H    4-Cl                           BrClCHC(Me).sub.2            Cl    S  H    H    4-Bu-t                         Br.sub.2 CHC(Me).sub.2       Cl    O  H    H    4-Cl                           Br.sub.2 CHC(Me).sub.2       Cl    O  H    H    4-I                            Br.sub.2 CHC(Me).sub.2       Br    O  H    H    4-I                            Br.sub.2 CHC(Me).sub.2       I     O  H    H    4-I                            Br.sub.2 CHC(Me).sub.2       Cl    O  H    H    4-Br                           Br.sub.2 CHC(Me).sub.2       OMe   O  H    H    4-Cl                           Br.sub.2 CHC(Me).sub.2       SMe   O  H    H    4-Cl                           Br.sub.2 CHC(Me).sub.2       Cl    O  H    H    3-CF.sub.3                     Br.sub.2 CHC(Me).sub.2       Cl    O  H    H    4-Ph                           Br.sub.2 CHC(Me).sub.2       Cl    O  H    H    4-OCH.sub.2 CF.sub.3           Br.sub.2 CHC(Me).sub.2       Cl    S  H    H    4-Cl                           Br.sub.2 CHC(Me).sub.2       Cl    S  H    H    4-Bu-t                         Br.sub.2 CHC(Me).sub.2       Cl    S  H    H    4-Et                           BrClCHCH(Me)                 Cl    O  H    H    4-Cl                           BrClCHCH(Me)                 Cl    O  H    H    4-I                            Br.sub.2 CHCH(Me)            Cl    O  H    H    4-Cl                           Br.sub.2 CHCH(Me)            Cl    O  H    H    4-I                            Cl.sub.2 CHCH(CH.sub.2 Cl)   Cl    O  H    H    4-Cl                           Cl.sub.2 CHCH(CH.sub.2 Cl)   Cl    O  H    H    4-I                            Cl.sub.2 CHCH(CH.sub.2 Cl)   Br    O  H    H    4-Cl                           Cl.sub.2 CHCH(CH.sub.2 Cl)   I     O  H    H    4-Cl                           BrClCHCH(CH.sub.2 Cl)        Cl    O  H    H    4-Cl                           BrClCHCH(CH.sub.2 Cl)        Cl    O  H    H    4-I                            BrClCHCH(CH.sub.2 Br)        Cl    O  H    H    4-Cl                           Br.sub.2 CHCH(CH.sub.2 Br)   Cl    O  H    H    4-Cl                           Br.sub.2 CHCH(CH.sub.2 Br)   Cl    O  H    H    4-I                            Cl.sub.2 CHCCl(CH.sub.2 Cl)  Cl    O  H    H    4-Cl                           Cl.sub.2 CHCCl(CH.sub.2 Cl)  Cl    O  H    H    4-I                            Cl.sub.2 CHCCl(CH.sub.2 Cl)  I     O  H    H    4-Cl                           BrClCHCCl(CH.sub.2 Cl)       Cl    O  H    H    4-Cl                           BrClCHCCl(CH.sub.2 Cl)       Cl    O  H    H    4-I                            ClCH.sub.2 CCl(Me)           Cl    O  H    H    4-Cl                           ClCH.sub.2 CCl(Me)           Cl    O  H    H    4-I                            ClCH.sub.2 CCl(Me)           I     O  H    H    4-Cl                           BrCH.sub.2 CBr(Me)           Cl    O  H    H    4-Cl                           BrCH.sub.2 CBr(Me)           Cl    O  H    H    4-I                            BrCH.sub.2 CBr(Me)           Br    O  H    H    4-Cl                           BrCH.sub.2 CBr(Me)           I     O  H    H    4-Cl                           Cl.sub.3 CCH(Me)             Cl    O  H    H    4-Cl                           Cl.sub. 3 CCH(Me)            Cl    O  H    H    4-I                            BrCl.sub.2 CCH(Me)           Cl    O  H    H    4-Cl                           MeCHClCHBr                   Cl    O  H    H    4-Cl                           MeCHClCHBr                   Cl    O  H    H    4-I                            MeCHBrCHBr                   Cl    O  H    H    4-Cl                           MeCHBrCHBr                   Cl    O  H    H    4-I                            MeCCl.sub.2 CH.sub.2         Cl    O  H    H    4-Cl                           MeCCl.sub.2 CH.sub.2         Cl    O  H    H    4-I                            MeCCl.sub.2 CH.sub.2         Br    O  H    H    4-Cl                           MeCCl.sub.2 CH.sub.2         I     O  H    H    4-Cl                           MeCCl.sub.2 CH.sub.2         Cl    O  H    H    4-Br                           MeCCl.sub.2 CH.sub.2         H     O  H    H    4-Cl                           MeCCl.sub.2 CH.sub.2         H     O  H    H    4-I                            MeCCl.sub.2 CH.sub.2         I     O  H    H    4-I                            MeCCl.sub.2 CH.sub.2         Cl    O  H    H    2,4-Cl.sub.2                   MeCCl.sub.2 CH.sub.2         F     O  H    H    4-I                            MeCCl.sub.2 CH.sub.2         SMe   O  H    H    4-Cl                           MeCCl.sub.2 CH.sub.2         I     O  H    Me   4-Cl                           MeCCl.sub.2 CH.sub.2         Cl    O  H    H    4-OMe                          MeCCl.sub.2 CH.sub.2         Cl    O  H    H    4-C.sub.6 H.sub.4 Cl-4'        MeCCl.sub.2 CH.sub.2         Cl    O  H    H    4-CN                           MeCCl.sub.2 CH.sub.2         Cl    O  H    H    3,5-Cl.sub.2                   MeCCl.sub.2 CH.sub.2         Cl    S  H    H    4-Cl                           MeCCl.sub. 2 CH.sub.2        Cl    S  H    H    4-Bu-t                         MeCCl.sub.2 CH.sub.2         Cl    S  H    H    4-Hex                          MeCCl.sub.2 CH.sub.2         Cl    S  H    H    4-OC(Me).sub.2 CH.sub.2                                                        OPr                            MeCCl.sub.2 CH.sub.2         Cl    S  H    H    4-CH.sub.2 Ph                  MeCCl.sub.2 CH.sub.2         Cl    S  H    H    4-CH.sub.2 SMe                 MeCBrClCH.sub.2              Cl    O  H    H    4-Cl                           MeCBrClCH.sub.2              Cl    O  H    H    4-I                            MeCBrClCH.sub.2              Br    O  H    H    4-Cl                           MeCBrClCH.sub.2              I     O  H    H    4-Cl                           MeCBrClCH.sub.2              Cl    O  H    H    4-Br                           MeCBrClCH.sub.2              Cl    O  H    H    4-Pr                           MeCBrClCH.sub.2              I     O  H    H    4-I                            MeCBrClCH.sub.2              Cl    O  H    H    2,4-Cl.sub.2                   MeCBrClCH.sub.2              Me    O  H    H    4-Br                           MeCBrClCH.sub.2              SMe   O  H    H    2-F,4-Cl                       MeCBrClCH.sub.2              Cl    O  OH   H    4-Cl                           MeCBrClCH.sub.2              Cl    O  H    H    4-Pr                           MeCBrClCH.sub.2              Cl    O  H    H    2-Cl, 4-F                      MeCBrClCH.sub.2              Cl    S  H    H    4-Cl                           MeCBrClCH.sub.2              Cl    S  H    H    4-Bu-t                         MeCBrClCH.sub.2              Cl    S  H    H    4-(Q4)                         MeCBrClCH.sub.2              Cl    S  H    H    3,4-Cl.sub.2                   MeCBr.sub.2 CH.sub.2         Cl    O  H    H    4-Cl                           MeCBr.sub.2 CH.sub.2         Cl    O  H    H    4-I                            MeCBr.sub.2 CH.sub.2         Br    O  H    H    4-Cl                           MeCBr.sub.2 CH.sub.2         I     O  H    H    4-Cl                           MeCBr.sub.2 CH.sub.2         Cl    O  H    H    4-Br                           MeCBr.sub.2 CH.sub.2         Cl    O  H    H    2,4-Cl.sub.2                   MeCBr.sub.2 CH.sub.2         Et    O  H    H    4-Cl                           MeCBr.sub.2 CH.sub.2         SEt   O  H    H    4-Cl                           MeCBr.sub.2 CH.sub.2         Cl    O  H    H    4-Pen                          MeCBr.sub.2 CH.sub.2         Cl    O  H    H    4-OPr-i                        MeCBr.sub.2 CH.sub.2         Cl    O  H    H    2-Cl, 4-CF.sub.3               MeCBr.sub.2 CH.sub.2         Cl    S  H    H    4-Bu-t                         MeCBr.sub.2 CH.sub.2         Cl    S  H    H    4-Cl                           MeCBr.sub.2 CH.sub.2         Cl    S  H    H    4-CH.sub.2 OPr                 MeC(Br).sub.2 CH.sub.2       Cl    S  H    H    4-OPr                          ClCH.sub.2 CHClCHCl          Cl    O  H    H    4-Cl                           ClCH.sub.2 CHClCHCl          Cl    O  H    H    4-I                            ClCH.sub.2 CHClCHCl          Br    O  H    H    4-Cl                           ClCH.sub.2 CHClCHCl          I     O  H    H    4-Cl                           BrCH.sub.2 CHClCHBr          Cl    O  H    H    4-Cl                           BrCH.sub.2 CHClCHBr          Cl    O  H    H    4-I                            BrCH.sub.2 CHClCHBr          I     O  H    H    4-Cl                           ClCH.sub.2 CHBrCHCl          Cl    O  H    H    4-Cl                           ClCH.sub.2 CHBrCHCl          Cl    O  H    H    4-I                            BrCH.sub.2 CHBrCHBr          Cl    O  H    H    4-Cl                           BrCH.sub.2 CHBrCHBr          Cl    O  H    H    4-I                            BrCH.sub.2 CHBrCHBr          Br    O  H    H    4-Cl                           BrCH.sub.2 CHBrCHBr          I     O  H    H    4-Cl                           ClCH.sub.2 CCl.sub.2 CH.sub.2                                                                               Cl    O  H    H    4-Cl                           ClCH.sub.2 CCl.sub.2 CH.sub.2                                                                               Cl    O  H    H    4-I                            ClCH.sub.2 CCl.sub.2 CH.sub.2                                                                               Br    O  H    H    4-Cl                           ClCH.sub.2 CCl.sub.2 CH.sub.2                                                                               I     O  H    H    4-Cl                           ClCH.sub.2 CCl.sub.2 CH.sub.2                                                                               Cl    O  H    H    4-Br                           ClCH.sub.2 CCl.sub.2 CH.sub.2                                                                               H     O  H    H    4-Cl                           ClCH.sub.2 CCl.sub.2 CH.sub.2                                                                               H     O  H    H    4-I                            ClCH.sub.2 CCl.sub.2 CH.sub.2                                                                               I     O  H    H    4-I                            ClCH.sub.2 CCl.sub.2 CH.sub.2                                                                               Cl    O  H    H    2,4-Cl.sub.2                   ClCH.sub.2 CCl.sub.2 CH.sub.2                                                                               Pr    O  H    H    4-Cl                           ClCH.sub.2 CCl.sub.2 CH.sub.2                                                                               SEt   O  H    H    4-I                            ClCH.sub.2 CCl.sub.2 CH.sub.2                                                                               Br    O  Cl   H    4-Cl                           ClCH.sub.2 CCl.sub.2 CH.sub.2                                                                               Cl    O  H    H    2,3,4,5, 6-F.sub.5             ClCH.sub.2 CCl.sub.2 CH.sub.2                                                                               Cl    O  H    H    2,6-Cl.sub.2, 4-F              ClCH.sub.2 CCl.sub.2 CH.sub.2                                                                               Cl    S  H    H    4-Cl                           ClCH.sub.2 CCl.sub.2 CH.sub.2                                                                               Cl    S  H    H    4-Bu-t                         ClCH.sub.2 CCl.sub.2 CH.sub.2                                                                               Cl    S  H    H    4-O(CH.sub.2).sub.3 OMe        ClCH.sub.2 CCl.sub.2 CH.sub.2                                                                               Cl    S  H    H    4-Et                           ClCH.sub.2 CCl.sub.2 CH.sub.2                                                                               Cl    S  H    H    4-CH.sub.2 OEt                 ClCH.sub.2 CBrClCH.sub.2     Cl    O  H    H    4-Cl                           ClCH.sub.2 CBrClCH.sub.2     Cl    O  H    H    4-I                            ClCH.sub.2 CBrClCH.sub.2     Br    O  H    H    4-Cl                           ClCH.sub.2 CBrClCH.sub.2     I     O  H    H    4-Cl                           ClCH.sub.2 CBrClCH.sub.2     Cl    O  H    H    4-Br                           ClCH.sub.2 CBrClCH.sub.2     Cl    O  H    H    2,4-Cl.sub.2                   ClCH.sub.2 CBrClCH.sub.2     Pr-i  O  H    H    4-Cl                           ClCH.sub.2 CBrClCH.sub.2     SPr   O  H    H    4-Cl                           ClCH.sub.2 CBrClCH.sub.2     Br    O  OMe  H    4-Cl                           ClCH.sub.2 CBrClCH.sub.2     Cl    O  H    H    4-Bu-t                         ClCH.sub.2 CBrClCH.sub.2     Cl    O  H    H    2-OMe, 4-Cl                    ClCH.sub.2 CBrClCH.sub.2     Cl    S  H    H    4-Cl                           ClCH.sub.2 CBrClCH.sub.2     Cl    S  H    H    4-Bu-t                         ClCH.sub.2 CBrClCH.sub.2     Cl    S  H    H    4-C.sub.8 H.sub.17             ClCH.sub.2 CBrClCH.sub.2     Cl    S  H    H    4-OCH.sub.2 C.sub.6                                                            H.sub.4 Cl-4'                  ClCH.sub.2 CBrClCH.sub.2     Cl    S  H    H    4-OCH.sub.2 CHCHMe             BrCH.sub.2 CBrClCH.sub.2     Cl    O  H    H    4-Cl                           BrCH.sub.2 CBrClCH.sub.2     Cl    O  H    H    4-I                            BrCH.sub.2 CBrClCH.sub.2     Br    O  H    H    4-Cl                           BrCH.sub.2 CBrClCH.sub.2     I     O  H    H    4-Cl                           BrCH.sub.2 CBrClCH.sub.2     Cl    O  H    H    4-Br                           BrCH.sub.2 CBrClCH.sub.2     Bu    O  H    H    4-Cl                           BrCH.sub.2 CBrClCH.sub.2     SOMe  O  H    H    4-Cl                           BrCH.sub.2 CBrClCH.sub.2     Cl    O  H    H    4-OBu-s                        BrCH.sub.2 CBrClCH.sub.2     Cl    S  H    H    4-Cl                           BrCH.sub.2 CBrClCH.sub.2     Cl    S  H    H    4-CH.sub.2 OMe                 BrCH.sub.2 CBrClCH.sub.2     Cl    S  H    H    4-CH.sub.2 -Q1                 BrCH.sub.2 CBrClCH.sub.2     Cl    S  H    H    4-OPh                          BrCH.sub.2 CBr.sub.2 CH.sub.2                                                                               Cl    O  H    H    4-Cl                           BrCH.sub.2 CBr.sub.2 CH.sub.2                                                                               Cl    O  H    H    4-I                            BrCH.sub.2 CBr.sub.2 CH.sub.2                                                                               Br    O  H    H    4-Cl                           BrCH.sub.2 CBr.sub.2 CH.sub.2                                                                               I     O  H    H    4-Cl                           BrCH.sub.2 CBr.sub.2 CH.sub.2                                                                               Cl    O  H    H    4-Br                           BrCH.sub.2 CBr.sub.2 CH.sub.2                                                                               OMe   O  H    H    4-Br                           BrCH.sub.2 CBr.sub.2 CH.sub.2                                                                               SO.sub.2 Et                                                                          O  H    H    4-Cl                           BrCH.sub.2 CBr.sub.2 CH.sub.2                                                                               Cl    O  H    H    2,4,5-Cl.sub. 3                BrCH.sub.2 CBr.sub.2 CH.sub.2                                                                               Cl    S  H    H    4-Cl                           BrCH.sub.2 CBr.sub.2 CH.sub.2                                                                               Cl    S  H    H    4-Bu-t                         BrCH.sub.2 CBr.sub.2 CH.sub.2                                                                               Cl    S  H    H    4-C.sub.6 H.sub.4 Cl4'         BrCH.sub.2 CBr.sub.2 CH.sub.2                                                                               Cl    S  H    H    4-CH(C.sub.6 H.sub.3                                                           F.sub.2 -2,4)                  BrCH.sub.2 CBr.sub.2 CH.sub.2                                                                               Cl    S  H    H    4-NMe.sub.2                    MeCHBrCCl.sub.2              Cl    O  H    H    4-Cl                           MeCHBrCCl.sub.2              Cl    O  H    H    4-I                            MeCHBrCCl.sub.2              Cl    O  H    H    4-Cl                           MeCHBrCCl.sub.2              Cl    O  H    H    4-I                            ClCH.sub.2 CHClCH.sub.2      Cl    O  H    H    4-Cl                           ClCH.sub.2 CHClCH.sub.2      Cl    O  H    H    2,4-Cl.sub.2                   ClCH.sub.2 CHClCH.sub.2      Cl    O  H    H    4-I                            ClCH.sub.2 CHClCH.sub.2      Br    O  H    H    4-Cl                           ClCH.sub.2 CHClCH.sub.2      Br    O  H    H    4-I                            ClCH.sub.2 CHClCH.sub.2      I     O  H    H    4-Cl                           ClCH.sub.2 CHClCH.sub.2      I     O  H    H    4-I                            ClCH.sub.2 CHClCH.sub.2      Cl    S  H    H    4-Cl                           ClCH.sub.2 CHClCH.sub.2      Cl    S  H    H    4-Bu-t                         ClCH.sub.2 CHClCH.sub.2      Cl    S  H    H    4-CO-Q1                        ClCH.sub.2 CHClCH.sub.2      Cl    S  H    H    4-CH.sub.2(C.sub. 6                                                            H.sub.3 Cl.sub.2 -2,4)         ClCH.sub.2 CHClCH.sub.2      Cl    S  H    H    4-OCH.sub.2 CH.sub.2                                                           NMe.sub.2                      ClCH.sub.2 CHClCH.sub.2      Cl    S  H    H    4-O(CH.sub.2).sub.3 OMe        ClCH.sub.2 CHClCH.sub.2      Cl    S  H    H    4-I                            ClCH.sub.2 CHClCH.sub.2      Cl    O  H    H    4-Cl                           ClCH.sub.2 CHClCH.sub.2      Cl    O  H    H    4-I                            ClCH.sub.2 CHClCH.sub.2      Br    O  H    H    4-Cl                           ClCH.sub.2 CHClCH.sub.2      I     O  H    H    4-Cl                           ClCH.sub.2 CHClCH.sub.2      Cl    S  H    H    4-Cl                           ClCH.sub.2 CHClCH.sub.2      Cl    S  H    H    4-Bu-t                         ClCH.sub.2 CHClCH.sub.2      Cl    S  H    H    4-CH.sub.2 CHCH.sub.2          ClCH.sub.2 CHClCH.sub.2      Cl    S  H    H    4-SPh                          BrCH.sub.2 CHClCH.sub.2      Cl    O  H    H    4-Cl                           BrCH.sub.2 CHClCH.sub.2      Cl    O  H    H    2,4-Cl.sub.2                   BrCH.sub.2 CHClCH.sub.2      Cl    O  H    H    4-I                            BrCH.sub.2 CHClCH.sub.2      Br    O  H    H    4-Cl                           BrCH.sub.2 CHClCH.sub.2      I     O  H    H    4-Cl                           BrCH.sub.2 CHClCH.sub.2      Cl    S  H    H    4-Cl                           BrCH.sub.2 CHClCH.sub.2      Cl    S  H    H    4-Bu-t                         BrCH.sub.2 CHClCH.sub.2      Cl    S  H    H    4-OCH.sub.2 CH.sub.2 SEt       BrCH.sub.2 CHClCH.sub.2      Cl    S  H    H    4-SO.sub.2 Pr                  BrCH.sub.2 CHClCH.sub.2      Cl    S  H    H    4-C.sub.6 H.sub.4 F-4'         BrCH.sub.2 CHClCH.sub.2      Cl    O  H    H    4-Cl                           BrCH.sub.2 CHClCH.sub.2      Cl    O  H    H    2,4-Cl.sub.2                   BrCH.sub.2 CHClCH.sub.2      Cl    O  H    H    4-I                            BrCH.sub.2 CHClCH.sub.2      Br    O  H    H    4-Cl                           BrCH.sub.2 CHClCH.sub.2      I     O  H    H    4-Cl                           BrCH.sub.2 CHClCH.sub.2      H     O  H    H    4-Cl                           BrCH.sub.2 CHClCH.sub.2      H     O  H    H    4-I                            BrCH.sub.2 CHClCH.sub.2      Cl    S  H    H    4-Cl                           BrCH.sub.2 CHClCH.sub.2      Cl    S  H    H    4-Bu-t                         BrCH.sub.2 CHClCH.sub.2      Cl    S  H    H    4-CH.sub.2 Ph                  ICH.sub.2 CHClCH.sub.2       Cl    O  H    H    4-Cl                           ICH.sub.2 CHClCH.sub.2       Cl    O  H    H    4-I                            ICH.sub.2 CHClCH.sub.2       Br    O  H    H    4-Cl                           ICH.sub.2 CHClCH.sub.2       I     O  H    H    4-Cl                           ICH.sub.2 CHClCH.sub.2       I     O  H    H    4-I                            ICH.sub.2 CHClCH.sub.2       Cl    S  H    H    4-Cl                           ICH.sub.2 CHClCH.sub.2       Cl    S  H    H    4-Bu-t                         ICH.sub.2 CHClCH.sub.2       Cl    S  H    H    4-OEt                          ICH.sub.2 CHClCH.sub.2       Cl    S  H    H    3,4-Cl.sub.2                   ICH.sub.2 CHClCH.sub.2       Cl    O  H    H    4-Cl                           ICH.sub.2 CHClCH.sub.2       Cl    O  H    H    2,4-Cl.sub.2                   ICH.sub.2 CHClCH.sub.2       Cl    O  H    H    4-I                            ICH.sub.2 CHClCH.sub.2       Br    O  H    H    4-Cl                           ICH.sub.2 CHClCH.sub.2       I     O  H    H    4-Cl                           ICH.sub.2 CHClCH.sub.2       Cl    S  H    H    4-Cl                           ICH.sub.2 CHClCH.sub.2       Cl    S  H    H    4-Bu-t                         MeCHClCCl(Me)                Cl    O  H    H    4-Cl                           MeCHClCCl(Me)                Cl    O  H    H    4-I                            MeCHClCCl(Me)                Cl    O  H    H    4-Cl                           MeCHClCCl(Me)                Cl    O  H    H    4-I                            MeCHClCCl(Me)                Cl    O  H    H    4-Cl                           MeCHClCCl(Me)                Cl    O  H    H    4-I                            MeCHClCCl(Me)                Cl    O  H    H    4-Cl                           MeCHClCCl(Me)                Cl    O  H    H    4-I                            MeCCl.sub.2 CH(Me)           Cl    O  H    H    4-Cl                           MeCCl.sub.2 CH(Me)           Cl    O  H    H    4-I                            MeCBrClCH(Me)                Cl    O  H    H    4-Cl                           MeCBrClCH(Me)                Cl    O  H    H    4-I                            MeCBr.sub.2 CH(Me)           Cl    O  H    H    4-Cl                           MeCBr.sub.2 CH(Me)           Cl    O  H    H    4-I                            Me.sub.2 CClCHCl             Cl    O  H    H    4-Cl                           Me.sub.2 CClCHCl             Cl    O  H    H    2,4-Cl.sub.2                   Me.sub.2 CClCHCl             Cl    O  H    H    4-I                            Me.sub.2 CClCHCl             Br    O  H    H    4-Cl                           Me.sub.2 CClCHCl             Br    O  H    H    4-I                            Me.sub.2 CClCHCl             I     O  H    H    4-Cl                           Me.sub.2 CClCHCl             I     O  H    H    4-I                            Me.sub.2 CClCHCl             Cl    S  H    H    4-Cl                           Me.sub.2 CClCHCl             Cl    S  H    H    4-Bu-t                         Me.sub.2 CClCHCl             Cl    S  H    H    4-O(CH.sub.2).sub.3 OMe        Me.sub.2 CClCHCl             Cl    S  H    H    4-Et                           Me.sub.2 CClCHCl             Cl    S  H    H    4-OCF.sub.3                    Me.sub.2 CClCHCl             Cl    O  H    H    4-Cl                           Me.sub.2 CClCHCl             Cl    O  H    H    4-I                            Me.sub.2 CClCHCl             Br    O  H    H    4-Cl                           Me.sub.2 CClCHCl             I     O  H    H    4-Cl                           Me.sub.2 CClCHCl             Cl    S  H    H    4-Cl                           Me.sub.2 CClCHCl             Cl    S  H    H    4-Bu-t                         Me.sub.2 CClCHCl             Cl    S  H    H    4-OCH.sub.2 C.sub.6                                                            H.sub.4 Cl-4'                  Me.sub.2 CClCHCl             Cl    S  H    H    4-SOEt                         Me.sub.2 CClCHCl             Cl    S  H    H    4-OCH.sub.2 CHCHMe             Me.sub.2 CBrCHCl             Cl    O  H    H    4-Cl                           Me.sub.2 CBrCHCl             Cl    O  H    H    2,4-Cl.sub.2                   Me.sub.2 CBrCHCl             Cl    O  H    H    4-I                            Me.sub.2 CBrCHCl             Br    O  H    H    4-Cl                           Me.sub.2 CBrCHCl             I     O  H    H    4-Cl                           Me.sub.2 CBrCHCl             Cl    S  H    H    4-Cl                           Me.sub.2 CBrCHCl             Cl    S  H    H    4-Bu-t                         Me.sub.2 CBrCHCl             Cl    S  H    H    4-OPh                          Me.sub.2 CBrCHCl             Cl    S  H    H    4-(Q1)                         Me.sub.2 CBrCHCl             Cl    S  H    H    4-SBu                          Me.sub.2 CBrCHBr             Cl    O  H    H    4-Cl                           Me.sub.2 CBrCHBr             Cl    O  H    H    2,4-Cl.sub.2                   Me.sub.2 CBrCHBr             Br    O  H    H    4-Cl                           Me.sub.2 CBrCHBr             I     O  H    H    4-Cl                           Me.sub.2 CBrCHBr             H     O  H    H    4-Cl                           Me.sub.2 CBrCHBr             H     O  H    H    4-I                            Me.sub.2 CBrCHBr             Cl    S  H    H    4-Cl                           Me.sub.2 CBrCHBr             Cl    S  H    H    4-Bu-t                         (ClCH.sub.2).sub.2 CClCH.sub.2                                                                              Cl    O  H    H    4-Cl                           (ClCH.sub.2).sub.2 CClCH.sub.2                                                                              Cl    O  H    H    4-I                            (ClCH.sub.2).sub.2 CClCH.sub.2                                                                              Br    O  H    H    4-Cl                           (ClCH.sub.2).sub.2 CClCH.sub.2                                                                              I     O  H    H    4-Cl                           (ClCH.sub.2).sub.2 CClCH.sub.2                                                                              Cl    O  H    H    4-Br                           (ClCH.sub.2).sub.2 CClCH.sub.2                                                                              Cl    O  H    H    2-F, 4-Cl                      (ClCH.sub.2).sub.2 CClCH.sub.2                                                                              OBu   O  H    H    4-Cl                           (ClCH.sub.2).sub.2 CClCH.sub.2                                                                              Cl    O  H    Me   4-I                            (ClCH.sub.2).sub.2 CClCH.sub.2                                                                              Cl    O  H    H    2,5-Me.sub.2                   (ClCH.sub.2).sub.2 CClCH.sub.2                                                                              Cl    O  H    H    4-OCHF.sub.2                   (ClCH.sub.2).sub.2 CClCH.sub.2                                                                              Cl    O  H    H    2,4,6-Cl.sub.3                 (ClCH.sub.2).sub.2 CClCH.sub.2                                                                              Cl    S  H    H    4-Cl                           (ClCH.sub.2).sub.2 CClCH.sub.2                                                                              Cl    S  H    H    4-Bu-t                         (ClCH.sub.2).sub.2 CClCH.sub.2                                                                              Cl    S  H    H    4-SO.sub.2 Et                  (ClCH.sub.2).sub.2 CClCH.sub.2                                                                              Cl    S  H    H    4-SMe                          (ClCH.sub.2).sub.2 CClCH.sub.2                                                                              Cl    S  H    H    4-I                            (ClCH.sub.2).sub.2 CClCH.sub.2                                                                              Cl    S  H    H    4-O(CH.sub.2).sub.3 OMe        (ClCH.sub.2).sub.2 CBrCH.sub.2                                                                              Cl    O  H    H    4-Cl                           (ClCH.sub.2).sub.2 CBrCH.sub.2                                                                              Cl    O  H    H    4-I                            (ClCH.sub.2).sub.2 CBrCH.sub.2                                                                              Br    O  H    H    4-Cl                           (ClCH.sub.2).sub.2 CBrCH.sub.2                                                                              I     O  H    H    4-Cl                           (ClCH.sub.2).sub.2 CBrCH.sub.2                                                                              Cl    O  H    H    4-Br                           (ClCH.sub.2).sub.2 CBrCH.sub.2                                                                              Cl    O  H    Et   4-Cl                           (ClCH.sub.2).sub.2 CBrCH.sub.2                                                                              Cl    O  H    H    4-Bu-s                         (ClCH.sub.2).sub.2 CBrCH.sub.2                                                                              Cl    O  H    H    2,4-F.sub.2                    (ClCH.sub.2).sub.2 CBrCH.sub.2                                                                              Cl    S  H    H    4-Cl                           (ClCH.sub.2).sub.2 CBrCH.sub.2                                                                              Cl    S  H    H    4-Bu-t                         (ClCH.sub.2).sub.2 CBrCH.sub.2                                                                              Cl    S  H    H    4-SPh                          ClCH.sub.2 CBr(CH.sub.2 Br)CH.sub.2                                                                         Cl    O  H    H    4-Cl                           ClCH.sub.2 CBr(CH.sub.2 Br)CH.sub.2                                                                         Cl    O  H    H    4-I                            ClCH.sub.2 CBr(CH.sub.2 Br)CH.sub.2                                                                         Br    O  H    Me   4-Cl                           ClCH.sub.2 CBr(CH.sub.2 Br)CH.sub.2                                                                         Cl    O  H    H    3-CF.sub.3                     ClCH.sub.2 CBr(CH.sub.2 Br)CH.sub.2                                                                         Cl    O  H    H    4-OCH.sub.2 CF.sub.3           ClCH.sub.2 CBr(CH.sub.2 Br)CH.sub.2                                                                         Cl    S  H    H    4-Cl                           ClCH.sub.2 CBr(CH.sub.2 Br)CH.sub.2                                                                         Cl    S  H    H    4-Bu-t                         ClCH.sub.2 CBr(CH.sub.2 Br)CH.sub.2                                                                         Cl    S  H    H    4-CH.sub.2 C.sub.6                                                             H.sub.4 Cl-4'                  ClCH.sub.2 CCl(Me)CH.sub.2   Cl    O  H    H    4-Cl                           ClCH.sub.2 CCl(Me)CH.sub.2   Cl    O  H    H    4-Br                           ClCH.sub.2 CCl(Me)CH.sub.2   Cl    O  H    H    2,4-Cl.sub.2                   ClCH.sub.2 CCl(Me)CH.sub.2   Cl    O  H    H    4-I                            ClCH.sub.2 CCl(Me)CH.sub.2   Br    O  H    H    4-Cl                           ClCH.sub.2 CCl(Me)CH.sub.2   Br    O  H    H    2,4-Cl.sub.2                   ClCH.sub.2 CCl(Me)CH.sub.2   I     O  H    H    4-Cl                           ClCH.sub.2 CCl(Me)CH.sub.2   I     O  H    H    4-I                            ClCH.sub.2 CCl(Me)CH.sub.2   F     O  H    H    4-Cl                           ClCH.sub.2 CCl(Me)CH.sub.2   Me    O  H    H    4-Cl                           ClCH.sub.2 CCl(Me)CH.sub.2   OMe   O  H    H    4-Cl                           ClCH.sub.2 CCl(Me)CH.sub.2   OMe   O  H    H    4-I                            ClCH.sub.2 CCl(Me)CH.sub.2   SMe   O  H    H    4-Cl                           ClCH.sub.2 CCl(Me)CH.sub.2   SO.sub.2 Me                                                                          O  H    H    4-Cl                           ClCH.sub.2 CCl(Me)CH.sub.2   Cl    O  H    Me   4-Cl                           ClCH.sub.2 CCl(Me)CH.sub.2   Cl    O  Cl   H    4-Cl                           ClCH.sub.2 CCl(Me)CH.sub.2   F     O  H    H    4-I                            ClCH.sub.2 CCl(Me)CH.sub.2   SMe   O  H    H    2,4-Cl.sub.2                   ClCH.sub.2 CCl(Me)CH.sub.2   I     O  H    Me   4-Cl                           ClCH.sub.2 CCl(Me)CH.sub.2   Cl    O  H    H    4-OMe                          ClCH.sub.2 CCl(Me)CH.sub.2   Cl    O  H    H    4-C.sub.6 H.sub.4 Cl-4'        ClCH.sub.2 CCl(Me)CH.sub.2   Cl    O  H    H    4-CN                           ClCH.sub.2 CCl(Me)CH.sub.2   Cl    O  H    H    3,5-Cl.sub.2                   ClCH.sub.2 CCl(Me)CH.sub.2   Cl    S  H    H    4-Cl                           ClCH.sub.2 CCl(Me)CH.sub.2   Cl    S  H    H    4-Bu-t                         ClCH.sub.2 CCl(Me)CH.sub.2   Cl    S  H    H    4-Hex                          ClCH.sub.2 CCl(Me)CH.sub.2   Cl    S  H    H    4-O-(Q4)                       ClCH.sub.2 CCl(Me)CH.sub.2   Cl    S  H    H    4-OC(Me).sub.2 CH.sub.2                                                        OPr                            ClCH.sub.2 CCl(Me)CH.sub.2   Cl    S  H    H    4-COC.sub.6 H.sub.4                                                            CF.sub.3 -4'                   ClCH.sub.2 CCl(Me)CH.sub.2   Cl    S  H    H    4-COEt                         ClCH.sub.2 CCl(Me)CH.sub.2   Cl    O  H    H    4-Cl                           ClCH.sub.2 CCl(Me)CH.sub.2   Cl    O  H    H    4-Br                           ClCH.sub.2 CCl(Me)CH.sub.2   Cl    O  H    H    2,4-Cl.sub.2                   ClCH.sub.2 CCl(Me)CH.sub.2   Cl    O  H    H    4-I                            ClCH.sub.2 CBr(Me)CH.sub.2   Br    O  H    H    4-Cl                           ClCH.sub.2 CCl(Me)CH.sub.2   Br    O  H    H    4-I                            ClCH.sub.2 CCl(Me)CH.sub.2   I     O  H    H    4-Cl                           ClCH.sub.2 CCl(Me)CH.sub.2   I     O  H    H    4-I                            ClCH.sub.2 CCl(Me)CH.sub.2   F     O  H    H    4-Cl                           ClCH.sub.2 CCl(Me)CH.sub.2   Me    O  H    H    4-Cl                           ClCH.sub.2 CCl(Me)CH.sub.2   OMe   O  H    H    4-Cl                           ClCH.sub.2 CCl(Me)CH.sub.2   OMe   O  H    H    4-I                            ClCH.sub.2 CCl(Me)CH.sub.2   SMe   O  H    H    4-Cl                           ClCH.sub.2 CCl(Me)CH.sub.2   SO.sub.2 Me                                                                          O  H    H    4-Cl                           ClCH.sub.2 CBr(Me)CH.sub.2   Cl    O  H    Me   4-Cl                           ClCH.sub.2 CCl(Me)CH.sub.2   Cl    O  Cl   H    4-Cl                           ClCH.sub.2 CCl(Me)CH.sub.2   Pr    O  H    H    4-Cl                           ClCH.sub.2 CCl(Me)CH.sub.2   SBu   O  H    H    2-F, 4-Cl                      ClCH.sub.2 CCl(Me)CH.sub.2   Cl    O  OH   H    4-Cl                           ClCH.sub.2 CCl(Me)CH.sub.2   Cl    O  H    H    2-Cl, 4-F                      ClCH.sub.2 CCl(Me)CH.sub.2   Cl    S  H    H    4-Cl                           ClCH.sub.2 CCl(Me)CH.sub.2   Cl    S  H    H    4-Bu-t                         ClCH.sub.2 CCl(Me)CH.sub.2   Cl    S  H    H    4-COC.sub.6 H.sub.4 F-4'       ClCH.sub.2 CCl(Me)CH.sub.2   Cl    S  H    H    3,4-Cl.sub.2                   ClCH.sub.2 CHClCH(CH.sub.2 Cl)                                                                              Cl    O  H    H    4-Cl                           ClCH.sub.2 CHClCH(CH.sub.2 Cl)                                                                              Cl    O  H    H    4-I                            ClCH.sub.2 CHClCH(CH.sub.2 Cl)                                                                              Br    O  H    H    4-Cl                           ClCH.sub.2 CHClCH(CH.sub.2 Cl)                                                                              I     O  H    H    4-Cl                           ClCH.sub.2 CHClCH(CH.sub.2 Cl)                                                                              Cl    O  H    H    4-Cl                           ClCH.sub.2 CHClCH(CH.sub.2 Cl)                                                                              Cl    O  H    H    4-I                            BrCH.sub.2 CHClCH(CH.sub.2 Br)                                                                              Cl    O  H    H    4-Cl                           BrCH.sub.2 CHClCH(CH.sub.2 Br)                                                                              Cl    O  H    H    4-I                            BrCH.sub.2 CHClCH(CH.sub.2 Br)                                                                              Cl    O  H    H    4-Cl                           BrCH.sub.2 CHClCH(CH.sub.2 Br)                                                                              Cl    O  H    H    4-I                            BrCH.sub.2 CHClCH(CH.sub.2 Br)                                                                              Br    O  H    H    4-Cl                           BrCH.sub.2 CHClCH(CH.sub.2 Br)                                                                              I     O  H    H    4-Cl                           MeCCl.sub.2 CH(CH.sub.2 Cl)  Cl    O  H    H    4-Cl                           MeCCl.sub.2 CH(CH.sub.2 Cl)  Cl    O  H    H    4-I                            MeCCl.sub.2 CH(CH.sub.2 Cl)  Br    O  H    H    4-Cl                           MeCCl.sub.2 CH(CH.sub.2 Cl)  I     O  H    H    4-Cl                           MeCCl.sub.2 CH(CH.sub.2 Cl)  Cl    O  H    H    4-Cl                           MeCCl.sub.2 CH(CH.sub.2 Cl)  Cl    O  H    H    4-I                            MeCCl.sub.2 CH(CH.sub.2 Cl)  I     O  H    H    4-Cl                           ClCH.sub.2 CHClCHCl          Cl    O  H    H    4-Cl                           ClCH.sub.2 CHClCHCl          Cl    O  H    H    4-I                            ClCH.sub.2 CHBrCHCl          Cl    O  H    H    4-Cl                           ClCH.sub.2 CHBrCHCl          Cl    O  H    H    4-I                            (Me).sub.2 CClCH(CH.sub.2 Br)                                                                               Cl    O  H    H    4-Cl                           (Me).sub.2 CClCH(CH.sub.2 Br)                                                                               Cl    O  H    H    4-I                            (Me).sub.2 CClCH(CH.sub.2 Br)                                                                               Br    O  H    H    4-Cl                           (Me).sub.2 CClCH(CH.sub.2 Br)                                                                               I     O  H    H    4-Cl                           (Me).sub.2 CBrCH(CH.sub.2 Br)                                                                               Cl    O  H    H    4-Cl                           (Me).sub.2 CBrCH(CH.sub.2 Br)                                                                               Cl    O  H    H    4-I                            (Me).sub.2 CBrCH(CH.sub.2 Br)                                                                               Br    O  H    H    4-Cl                           (Me).sub.2 CBrCH(CH.sub.2 Br)                                                                               I     O  H    H    4-Cl                           (Me).sub.2 CClCH(C.sub.2 H.sub.4 Br)                                                                        Cl    O  H    H    4-Cl                           (Me).sub.2 CClCH(C.sub.2 H.sub.4 Br)                                                                        Cl    O  H    H    4-I                            (Me).sub.2 CBrCH(C.sub.2 H.sub.4 Br)                                                                        Cl    O  H    H    4-Cl                           (Me).sub.2 CBrCH(C.sub.2 H.sub.5 Br)                                                                        Cl    O  H    H    4-I                            ClCH.sub.2 CHClC(Me).sub.2   Cl    O  H    H    4-Cl                           ClCH.sub.2 CHClC(Me).sub.2   Cl    O  H    H    4-I                            ClCH.sub.2 CHClC(Me).sub.2   Br    O  H    H    4-Cl                           ClCH.sub.2 CHClC(Me).sub.2   I     O  H    H    4-Cl                           ClCH.sub.2 CHBrC(Me).sub.2   Cl    O  H    H    4-Cl                           ClCH.sub.2 CHBrC(Me).sub.2   Cl    O  H    H    4-I                            BrCH.sub.2 CHClC(Me).sub.2   Cl    O  H    H    4-Cl                           BrCH.sub.2 CHClC(Me).sub.2   Cl    O  H    H    4-I                            BrCH.sub.2 CHClC(Me).sub.2   I     O  H    H    4-Cl                           BrCH.sub.2 CHClC(Me).sub.2   Cl    O  H    H    4-Cl                           BrCH.sub.2 CHClC(Me).sub.2   Cl    O  H    H    4-I                            BrCH.sub.2 CHClC(Me).sub.2   I     O  H    H    4-Cl                           ClCH.sub.2 CHClCH(Me)        Cl    O  H    H    4-Cl                           ClCH.sub.2 CHClCH(Me)        Cl    O  H    H    4-I                            ClCH.sub.2 CHClCH(Me)        Br    O  H    H    4-Cl                           ClCH.sub.2 CHClCH(Me)        I     O  H    H    4-Cl                           ClCH.sub.2 CHBrCH(Me)        Cl    O  H    H    4-Cl                           ClCH.sub.2 CHBrCH(Me)        Cl    O  H    H    4-I                            MeCHClCH(CH.sub.2 Cl)        Cl    O  H    H    4-CI                           MeCHClCH(CH.sub.2 Cl)        Cl    O  H    H    4-I                            MeCHClCH(CH.sub.2 Cl)        Br    O  H    H    4-Cl                           MeCHClCH(CH.sub.2 Cl)        I     O  H    H    4-Cl                           MeCHBrCH(CH.sub.2 Cl)        Cl    O  H    H    4-Cl                           MeCHBrCH(CH.sub.2 Cl)        Cl    O  H    H    4-I                            ClCH.sub.2 CCl.sub.2 CHCl    Cl    O  H    H    4-Cl                           ClCH.sub.2 CCl.sub.2 CHCl    Cl    O  H    H    4-I                            ClCH.sub.2 CCl.sub.2 CHCl    Br    O  H    H    4-Cl                           ClCH.sub.2 CCl.sub.2 CHCl    I     O  H    H    4-Cl                           ClCH.sub.2 CBrClCHCl         Cl    O  H    H    4-Cl                           ClCH.sub.2 CBrClCHCl         Cl    O  H    H    4-I                            ClCH.sub.2 CHClCCl(Me)       Cl    O  H    H    4-Cl                           ClCH.sub.2 CHClCCl(Me)       Cl    O  H    H    4-I                            ClCH.sub.2 CHClCCl(Me)       Br    O  H    H    4-Cl                           ClCH.sub.2 CHClCCl(Me)       I     O  H    H    4-Cl                           ClCH.sub.2 CHBrCCl(Me)       Cl    O  H    H    4-Cl                           ClCH.sub.2 CHBrCCl(Me)       Cl    O  H    H    4-I                            Cl.sub.2 CHCHClCH.sub.2      Cl    O  H    H    4-Cl                           Cl.sub.2 CHCHClCH.sub.2      Cl    O  H    H    4-I                            Cl.sub.2 CHCHClCH.sub.2      Br    O  H    H    4-Cl                           Cl.sub.2 CHCHClCH.sub.2      I     O  H    H    4-Cl                           BrClCHCHBrCH.sub.2           Cl    O  H    H    4-Cl                           BrClCHCHBrCH.sub.2           Cl    O  H    H    4-I                            BrClCHCHBrCH.sub.2           Br    O  H    H    4-Cl                           BrClCHCHBrCH.sub.2           I     O  H    H    4-Cl                           Cl.sub.2 CHCCl.sub.2 CH.sub.2                                                                               Cl    O  H    H    4-Cl                           Cl.sub.2 CHCCl.sub.2 CH.sub.2                                                                               Cl    O  H    H    4-Br                           Cl.sub.2 CHCCl.sub.2 CH.sub.2                                                                               Cl    O  H    H    4-I                            Cl.sub.2 CHCCl.sub.2 CH.sub.2                                                                               Br    O  H    H    4-Cl                           Cl.sub.2 CHCCl.sub.2 CH.sub.2                                                                               Br    O  H    H    4-I                            Cl.sub.2 CHCCl.sub.2 CH.sub. 2                                                                              I     O  H    H    4-Cl                           Cl.sub.2 CHCCl.sub.2 CH.sub.2                                                                               I     O  H    H    4-I                            Cl.sub.2 CHCCl.sub.2 CH.sub.2                                                                               Et    O  H    H    4-Cl                           Cl.sub.2 CHCCl.sub.2 CH.sub.2                                                                               SEt   O  H    H    4-Cl                           Cl.sub.2 CHCCl.sub.2 CH.sub.2                                                                               Cl    O  OMe  H    4-Cl                           Cl.sub.2 CHCCl.sub.2 CH.sub.2                                                                               Cl    O  H    H    4-Pen                          Cl.sub.2 CHCCl.sub.2 CH.sub.2                                                                               Cl    O  H    H    4-Bu-i                         Cl.sub.2 CHCCl.sub.2 CH.sub.2                                                                               Cl    O  H    H    4-OPr-i                        Cl.sub.2 CHCCl.sub.2 CH.sub.2                                                                               Cl    O  H    H    2-Cl, 4-CF.sub.3               Cl.sub.2 CHCCl.sub.2 CH.sub.2                                                                               Cl    S  H    H    4-Bu-t                         Cl.sub.2 CHCCl.sub.2 CH.sub.2                                                                               Cl    S  H    H    4-Cl                           Cl.sub.2 CHCCl.sub.2 CH.sub.2                                                                               Cl    S  H    H    4-OCH.sub.2 C(Me)CH.sub.2                                                      9                              Cl.sub.2 CHCCl.sub.2 CH.sub.2                                                                               Cl    S  H    H    4-OPr                          ClBrCHCClBrCH.sub.2          Cl    O  H    H    4-Cl                           ClBrCHCClBrCH.sub.2          Cl    O  H    H    4-I                            ClBrCHCClBrCH.sub.2          Br    O  H    H    4-Cl                           ClBrCHCClBrCH.sub.2          H     O  H    H    4-Cl                           ClBrCHCClBrCH.sub.2          H     O  H    H    4-I                            ClBrCHCClBrCH.sub.2          Bu    O  H    H    4-Cl                           ClBrCHCClBrCH.sub.2          SEt   O  H    H    4-I                            ClBrCHCClBrCH.sub.2          Cl    O  H    H    3-Cl                           ClBrCHCClBrCH.sub.2          Cl    S  H    H    4-Cl                           ClBrCHCClBrCH.sub.2          Cl    S  H    H    4-Bu-t                         ClCH.sub.2 CH.sub.2 CHClCH.sub.2                                                                            Cl    O  H    H    4-Cl                           ClCH.sub.2 CH.sub.2 CHClCH.sub.2                                                                            Cl    O  H    H    4-I                            ClCH.sub.2 CH.sub.2 CHClCH.sub.2                                                                            Br    O  H    H    4-Cl                           ClCH.sub.2 CH.sub.2 CHClCH.sub.2                                                                            I     O  H    H    4-Cl                           ClCH.sub.2 CH.sub.2 CHClCH.sub.2                                                                            Cl    O  H    H    4-Cl                           ClCH.sub.2 CH.sub.2 CHClCH.sub.2                                                                            Cl    O  H    H    4-I                            BrCH.sub.2 CH.sub.2 CHClCH.sub.2                                                                            Cl    O  H    H    4-Cl                           BrCH.sub.2 CH.sub.2 CHClCH.sub.2                                                                            Cl    O  H    H    4-I                            BrCH.sub.2 CH.sub.2 CHClCH.sub.2                                                                            Cl    O  H    H    4-Cl                           BrCH.sub.2 CH.sub.2 CHClCH.sub.2                                                                            Cl    O  H    H    4-I                            BrCH.sub.2 CH.sub.2 CHClCH.sub.2                                                                            Br    O  H    H    4-Cl                           BrCH.sub.2 CH.sub.2 CHClCH.sub.2                                                                            I     O  H    H    4-Cl                           MeCHClCHClCH.sub.2           Cl    O  H    H    4-Cl                           MeCHClCHClCH.sub.2           Cl    O  H    H    2,4-Cl.sub.2                   MeCHClCHClCH.sub.2           Cl    O  H    H    4-I                            MeCHClCHClCH.sub.2           Br    O  H    H    4-Cl                           MeCHClCHClCH.sub.2           Br    O  H    H    4-I                            MeCHClCHClCH.sub.2           I     O  H    H    4-Cl                           MeCHClCHClCH.sub.2           I     O  H    H    4-I                            MeCHClCHBrCH.sub.2           Cl    O  H    H    4-Cl                           MeCHClCHBrCH.sub.2           Cl    O  H    H    2,4-Cl.sub.2                   MeCHClCHBrCH.sub.2           Cl    O  H    H    4-I                            MeCHClCHBrCH.sub.2           Br    O  H    H    4-Cl                           MeCHClCHBrCH.sub.2           Br    O  H    H    4-I                            MeCHClCHBrCH.sub.2           I     O  H    H    4-Cl                           MeCHClCHBrCH.sub.2           I     O  H    H    4-I                            MeCHBrCHClCH.sub.2           Cl    O  H    H    4-Cl                           MeCHBrCHClCH.sub.2           Cl    O  H    H    2,4-Cl.sub.2                   MeCHBrCHClCH.sub.2           Cl    O  H    H    4-I                            MeCHBrCHClCH.sub.2           Br    O  H    H    4-Cl                           MeCHBrCHClCH.sub.2           I     O  H    H    4-Cl                           MeCHBrCHBrCH.sub.2           Cl    O  H    H    4-Cl                           MeCHBrCHBrCH.sub.2           Cl    O  H    H    4-I                            MeCHBrCHBrCH.sub.2           Br    O  H    H    4-Cl                           MeCHBrCHBrCH.sub.2           I     O  H    H    4-Cl                           ClCH.sub.2 CHClCHClCH.sub.2  Cl    O  H    H    4-Cl                           ClCH.sub.2 CHClCHClCH.sub.2  Cl    O  H    H    4-I                            ClCH.sub.2 CHClCHClCH.sub.2  Br    O  H    H    4-Cl                           ClCH.sub.2 CHClCHClCH.sub.2  I     O  H    H    4-Cl                           ClCH.sub.2 CHClCHBrCH.sub.2  Cl    O  H    H    4-Cl                           ClCH.sub.2 CHClCHBrCH.sub.2  Cl    O  H    H    4-I                            ClCH.sub.2 CHBrCHBrCH.sub.2  Cl    O  H    H    4-Cl                           ClCH.sub.2 CHBrCHBrCH.sub.2  Cl    O  H    H    4-I                            BrCH.sub.2 CH.sub.2 CHClC(Me).sub.2                                                                         Cl    O  H    H    4-Cl                           BrCH.sub.2 CH.sub.2 CHClC(Me).sub.2                                                                         Cl    O  H    H    4-I                            BrCH.sub.2 CH.sub.2 CHClC(Me).sub.2                                                                         Cl    O  H    H    4-Cl                           BrCH.sub.2 CH.sub.2 CHClC(Me).sub.2                                                                         Cl    O  H    H    4-I                            Me.sub.2 CClCHClCH.sub.2     Cl    O  H    H    4-Cl                           Me.sub.2 CClCHClCH.sub.2     Cl    O  H    H    4-I                            Me.sub.2 CClCHClCH.sub.2     Br    O  H    H    4-Cl                           Me.sub.2 CClCHClCH.sub.2     I     O  H    H    4-Cl                           Me.sub.2 CClCHBrCH.sub.2     Cl    O  H    H    4-Cl                           Me.sub.2 CClCHBrCH.sub.2     Cl    O  H    H    4-I                            Me.sub.2 CBrCHClCH.sub.2     Cl    O  H    H    4-Cl                           Me.sub.2 CBrCHClCH.sub.2     Cl    O  H    H    4-I                            Me.sub.2 CBrCHClCH.sub.2     I     O  H    H    4-Cl                           Me.sub.2 CBrCHBrCH.sub.2     Cl    O  H    H    4-Cl                           Me.sub.2 CBrCHBrCH.sub.2     Cl    O  H    H    4-I                            Me.sub.2 CBrCHBrCH.sub.2     Br    O  H    H    4-Cl                           Me.sub.2 CBrCHBrCH.sub.2     I     O  H    H    4-Cl                           ClCH.sub.2 CHClCH.sub.2 CH.sub.2                                                                            Cl    O  H    H    4-Cl                           ClCH.sub.2 CHClCH.sub.2 CH.sub.2                                                                            Cl    O  H    H    4-I                            ClCH.sub.2 CHClCH.sub.2 CH.sub.2                                                                            Br    O  H    H    4-Cl                           ClCH.sub.2 CHClCH.sub.2 CH.sub.2                                                                            I     O  H    H    4-Cl                           BrCH.sub.2 CHBrCH.sub.2 CH.sub.2                                                                            Cl    O  H    H    4-Cl                           BrCH.sub.2 CHBrCH.sub.2 CH.sub.2                                                                            Cl    O  H    H    4-I                            BrCH.sub.2 CHBrCH.sub.2 CH.sub.2                                                                            Br    O  H    H    4-Cl                           BrCH.sub.2 CHBrCH.sub.2 CH.sub.2                                                                            I     O  H    H    4-Cl                           MeCCl.sub.2 CHClCH.sub.2     Cl    O  H    H    4-Cl                           MeCCl.sub.2 CHClCH.sub.2     Cl    O  H    H    4-I                            MeCCl.sub.2 CHClCH.sub.2     Br    O  H    H    4-Cl                           MeCCl.sub.2 CHClCH.sub.2     I     O  H    H    4-Cl                           MeCClBrCHBrCH.sub.2          Cl    O  H    H    4-Cl                           MeCClBrCHBrCH.sub.2          Cl    O  H    H    4-I                            Br(CH.sub.2).sub.3 CHClCH.sub.2                                                                             Cl    O  H    H    4-Cl                           Br(CH.sub.2).sub.3 CHClCH.sub.2                                                                             Cl    O  H    H    4-I                            Br(CH.sub.2).sub.3 CHBrCH.sub.2                                                                             Cl    O  H    H    4-Cl                           Br(CH.sub.2).sub.3 CHBrCH.sub.2                                                                             Cl    O  H    H    4-I                            PrCCl(CH.sub.2 Cl)CH.sub.2   Cl    O  H    H    4-Cl                           PrCCl(CH.sub.2 Cl)CH.sub.2   Cl    O  H    H    4-I                            PrCCl(CH.sub.2 Cl)CH.sub.2   I     O  H    H    4-I                            PrCCl(CH.sub.2 Cl)CH.sub.2   Cl    O  H    H    4-Cl                           PrCCl(CH.sub.2 Cl)CH.sub.2   Cl    O  H    H    4-I                            Br(CH.sub.2).sub.4 CHClCH.sub.2                                                                             Cl    O  H    H    4-Cl                           Br(CH.sub.2).sub.4 CHClCH.sub.2                                                                             Cl    O  H    H    4-I                            Br(CH.sub.2).sub.4 CHBrCH.sub.2                                                                             Cl    O  H    H    4-Cl                           Br(CH.sub.2).sub.4 CHBrCH.sub.2                                                                             Cl    O  H    H    4-I                            Br(CH.sub.2).sub.6 CHClCH.sub.2                                                                             Cl    O  H    H    4-Cl                           Br(CH.sub.2).sub.6 CHClCH.sub.2                                                                             Cl    O  H    H    4-I                            Br(CH.sub.2).sub.6 CHBrCH.sub.2                                                                             Cl    O  H    H    4-Cl                           Br(CH.sub.2).sub.6 CHBrCH.sub.2                                                                             Cl    O  H    H    4-I                            ClCH.sub.2 CH(Me)            Cl    O  H    H    4-Cl                           ClCH.sub.2 CH(Me)            Cl    O  H    H    4-I                            ClCH.sub.2 C(Me).sub.2       Cl    O  H    H    4-Cl                           ClCH.sub.2 C(Me)             Cl    O  H    H    4-I                            Cl(CH.sub.2).sub.3           Cl    O  H    H    4-Cl                           Cl(CH.sub.2).sub.3           Cl    O  H    H    4-I                            Cl(CH.sub.2).sub.3           Cl    O  H    H    2,4-Cl.sub.2                   Cl(CH.sub.2).sub.3           Br    O  H    H    4-Cl                           Cl(CH.sub.2).sub.3           I     O  H    H    4-Cl                           Cl(CH.sub.2).sub.3           Cl    S  H    H    4-Cl                           Cl(CH.sub.2).sub.3           Cl    S  H    H    4-Bu-t                         Br(CH.sub.2).sub.3           Cl    O  H    H    4-Cl                           Br(CH.sub.2).sub.3           Cl    O  H    H    4-I                            Br(CH.sub.2).sub.3           Cl    O  H    H    2,4-Cl.sub.2                   Br(CH.sub.2).sub.3           Br    O  H    H    4-Cl                           Br(CH.sub.2).sub.3           I     O  H    H    4-Cl                           Br(CH.sub.2).sub.3           Cl    S  H    H    4-Cl                           Br(CH.sub.2).sub.3           Cl    S  H    H    4-Bu-t                         I(CH.sub.2).sub.3            Cl    O  H    H    4-Cl                           I(CH.sub.2).sub.3            Cl    O  H    H    4-I                            I(CH.sub.2).sub.3            Cl    O  H    H    2,4-Cl.sub.2                   I(CH.sub.2).sub.3            Br    O  H    H    4-Cl                           I(CH.sub.2).sub.3            I     O  H    H    4-Cl                           I(CH.sub.2).sub.3            Cl    S  H    H    4-Cl                           I(CH.sub.2).sub.3            Cl    S  H    H    4-Bu-t                         MeCHClCH.sub.2               Cl    O  H    H    4-Cl                           MeCHClCH.sub.2               Cl    O  H    H    4-I                            MeCHBrCH.sub.2               Cl    O  H    H    4-Cl                           MeCHBrCH.sub.2               Cl    O  H    H    4-I                            Me.sub.2 CClC(Me).sub.2      Cl    O  H    H    4-Cl                           Me.sub.2 CClC(Me).sub.2      Cl    O  H    H    4-I                            Me.sub.2 CBrC(Me).sub.2      Cl    O  H    H    4-Cl                           Me.sub.2 CBrC(Me).sub.2      Cl    O  H    H    4-I                            MeCHClCH(Et)                 Cl    O  H    H    4-Cl                           MeCHClCH(Et)                 Cl    O  H    H    4-I                            MeCHBrCH(Et)                 Cl    O  H    H    4-Cl                           MeCHBrCH(Et)                 Cl    O  H    H    4-I                            MeCHClCH(Pr)                 Cl    O  H    H    4-Cl                           MeCHClCH(Pr)                 Cl    O  H    H    4-I                            MeCHBrCH(Pr)                 Cl    O  H    H    4-Cl                           MeCHBrCH(Pr)                 Cl    O  H    H    4-I                            MeCHClCH(Pr-i)               Cl    O  H    H    4-Cl                           MeCHClCH(Pr-i)               Cl    O  H    H    4-I                            MeCHBrCH(Pr-i)               Cl    O  H    H    4-Cl                           MeCHBrCH(Pr-i)               Cl    O  H    H    4-I                            MeCHClCH(Bu)                 Cl    O  H    H    4-Cl                           MeCHClCH(Bu)                 Cl    O  H    H    4-I                            MeCHBrCH(Bu)                 Cl    O  H    H    4-Cl                           MeCHBrCH(Bu)                 Cl    O  H    H    4-I                            MeCHClCH(Pen)                Cl    O  H    H    4-Cl                           MeCHClCH(Pen)                Cl    O  H    H    4-I                            MeCHBrCH(Pen)                Cl    O  H    H    4-Cl                           MeCHBrCH(Pen)                Cl    O  H    H    4-I                            Me.sub.2 CClCH.sub.2         Cl    O  H    H    4-Cl                           Me.sub.2 CClCH.sub.2         Cl    O  H    H    4-Br                           Me.sub.2 CClCH.sub.2         Br    O  H    H    4-Cl                           Me.sub.2 CClCH.sub.2         Br    O  H    H    4-I                            Me.sub.2 CClCH.sub.2         I     O  H    H    4-Cl                           Me.sub.2 CClCH.sub.2         I     O  H    H    4-I                            Me.sub.2 CClCH.sub.2         Cl    O  H    H    2,4-Cl.sub.2                   Me.sub.2 CClCH.sub.2         Pr-i  O  H    H    4-Cl                           Me.sub.2 CClCH.sub.2         SPr   O  H    H    4-Cl                           Me.sub.2 CClCH.sub.2         Br    O  OMe  H    4-Cl                           Me.sub.2 CClCH.sub.2         Cl    O  H    H    4-Bu-t                         Me.sub.2 CClCH.sub.2         Cl    O  H    H    3-OBu                          Me.sub.2 CClCH.sub.2         Cl    O  H    H    4-F                            Me.sub.2 CClCH.sub.2         Cl    S  H    H    4-Cl                           Me.sub.2 CClCH.sub.2         Cl    S  H    H    4-Bu-t                         Me.sub.2 CClCH.sub.2         Cl    S  H    H    4-CF.sub.3                     Me.sub.2 CClCH.sub.2         Cl    S  H    H    4-CH(OH)Et                     Me.sub.2 CClCH.sub.2         Cl    S  H    H    4-OCH.sub.2 CHCHMe             Me.sub.2 CBrCH.sub.2         Cl    O  H    H    4-Cl                           Me.sub.2 CBrCH.sub.2         Cl    O  H    H    4-Br                           Me.sub.2 CBrCH.sub.2         Br    O  H    H    4-Cl                           Me.sub.2 CBrCH.sub.2         I     O  H    H    4-Cl                           Me.sub.2 CBrCH.sub.2         H     O  H    H    4-Cl                           Me.sub.2 CBrCH.sub.2         H     O  H    H    4-I                            Me.sub.2 CBrCH.sub.2         Cl    O  H    H    2,4-Cl.sub.2                   Me.sub.2 CBrCH.sub.2         Bu    O  H    H    4-Cl                           Me.sub.2 CBrCH.sub.2         SOEt  O  H    H    4-Cl                           Me.sub.2 CBrCH.sub.2         I     O  Cl   H    4-Cl                           Me.sub.2 CBrCH.sub.2         Cl    O  H    H    4-OBu-s                        Me.sub.2 CBrCH.sub.2         Cl    S  H    H    4-Cl                           Me.sub.2 CBrCH.sub.2         Cl    S  H    H    4-Bu-t                         Me.sub.2 CBrCH.sub.2         Cl    S  H    H    4-Ph                           Me.sub.2 CBrCH.sub.2         Cl    S  H    H    4-OPh                          Me.sub.2 CBrCH.sub.2         Cl    S  H    H    4-CH(OMe)Et                    MeCHClCH(Me)                 Cl    O  H    H    4-Cl                           MeCHClCH(Me)                 Cl    O  H    H    4-I                            MeCHBrCH(Me)                 Cl    O  H    h    4-Cl                           MeCHBrCH(Me)                 Cl    O  H    h    4-I                            MeCHClC(Me).sub.2            Cl    O  H    H    4-Cl                           MeCHClC(Me).sub.2            Cl    O  H    H    4-I                            MeCHBrC(Me).sub.2            Cl    O  H    H    4-Cl                           MeCHBrC(Me).sub.2            Cl    O  H    H    4-I                            Me.sub.2 CClCH(Me)           Cl    O  H    H    4-Cl                           Me.sub.2 CClCH(Me)           Cl    O  H    H    4-I                            Me.sub.2 CBrCH(Me)           Cl    O  H    H    4-Cl                           Me.sub.2 CBrCH(Me)           Cl    O  H    H    4-I                            Me.sub.2 CClCH(Bu-t)         Cl    O  H    H    4-Cl                           Me.sub.2 CClCH(Bu-t)         Cl    O  H    H    4-I                            Me.sub.2 CBrCH(Bu-t)         Cl    O  H    H    4-Cl                           Me.sub.2 CBrCH(Bu-t)         Cl    O  H    H    4-I                            MeCHClC(Me)(Et)              Cl    O  H    H    4-Cl                           MeCHClC(Me)(Et)              Cl    O  H    H    4-I                            MeCHBrC(Me)(Et)              Cl    O  H    H    4-Cl                           MeCHBrC(Me)(Et)              Cl    O  H    H    4-I                            Cl(CH.sub.2).sub.4           Cl    O  H    H    4-Cl                           Cl(CH.sub.2).sub.4           Cl    O  H    H    2,4-Cl.sub.2                   Cl(CH.sub.2).sub.4           Cl    O  H    H    4-I                            Cl(CH.sub.2).sub.4           Br    O  H    H    4-Cl                           Cl(CH.sub.2).sub.4           I     O  H    H    4-Cl                           Cl(CH.sub.2).sub.4           Cl    S  H    H    4-Cl                           Cl(CH.sub.2).sub.4           Cl    S  H    H    4-Bu-t                         Br(CH.sub.2).sub.4           Cl    O  H    H    4-Cl                           Br(CH.sub.2).sub.4           Cl    O  H    H    2,4-Cl.sub.2                   Br(CH.sub.2).sub.4           Cl    O  H    H    4-I                            Br(CH.sub.2).sub.4           Br    O  H    H    4-Cl                           Br(CH.sub.2).sub.4           I     O  H    H    4-Cl                           Br(CH.sub.2).sub.4           Cl    S  H    H    4-Cl                           Br(CH.sub.2).sub.4           Cl    S  H    H    4-Bu-t                         I(CH.sub.2).sub.4            Cl    O  H    H    4-Cl                           I(CH.sub.2).sub.4            Cl    O  H    H    2,4-Cl.sub.2                   I(CH.sub.2).sub.4            Cl    O  H    H    4-I                            I(CH.sub.2).sub.4            Br    O  H    H    4-Cl                           I(CH.sub.2).sub.4            I     O  H    H    4-Cl                           I(CH.sub.2).sub.4            Cl    S  H    H    4-Cl                           I(CH.sub.2).sub.4            Cl    S  H    H    4-Bu-t                         MeCHClCH.sub.2 CH.sub.2      Cl    O  H    H    4-Cl                           MeCHClCH.sub.2 CH.sub.2      Cl    O  H    H    4-I                            Cl(CH.sub.2).sub.5           Cl    O  H    H    4-Cl                           Cl(CH.sub.2).sub.5           Cl    O  H    H    4-I                            Br(CH.sub.2).sub.5           Cl    O  H    H    4-Cl                           Br(CH.sub.2).sub.5           Cl    O  H    H    4-I                            I(CH.sub.2).sub.5            Cl    O  H    H    4-Cl                           I(CH.sub.2).sub.5            Cl    O  H    H    4-I                            MeCHBrCH.sub.2 CH.sub.2 CH.sub.2                                                                            Cl    O  H    H    4-Cl                           MeCHBrCH.sub.2 CH.sub.2 CH.sub.2                                                                            Cl    O  H    H    4-I                            Cl(CH.sub.2).sub.6           Cl    O  H    H    4-Cl                           Cl(CH.sub.2).sub.6           Cl    O  H    H    4-I                            I(CH.sub.2).sub.6            Cl    O  H    H    4-Cl                           I(CH.sub.2).sub.6            Cl    O  H    H    4-I                            Br(CH.sub.2).sub.8           Cl    O  H    H    4-Cl                           Br(CH.sub.2).sub.8           Cl    O  H    H    4-I                            I(CH.sub.2).sub.8            Cl    O  H    H    4-Cl                           I(CH.sub.2).sub.8            Cl    O  H    H    4-I                            EtCHClCH.sub.2               Cl    O  H    H    4-Cl                           EtCHClCH.sub.2               Cl    O  H    H    4-I                            EtCHBrCH.sub.2               Cl    O  H    H    4-Cl                           EtCHBrCH.sub.2               Cl    O  H    H    4-I                            i-PrCCl(Et)CH.sub.2          Cl    O  H    H    4-Cl                           i-PrCCl(Et)CH.sub.2          Cl    O  H    H    4-Br                           i-PrCCl(Et)CH.sub.2          Cl    O  H    H    4-I                            i-PrCCl(Et)CH.sub.2          Br    O  H    H    4-Cl                           i-PrCCl(Et)CH.sub.2          Br    O  H    H    4-I                            i-PrCCl(Et)CH.sub.2          I     O  H    H    4-Cl                           i-PrCCl(Et)CH.sub.2          I     O  H    H    4-I                            i-PrCCl(Et)CH.sub.2          Cl    O  H    H    2,4-Cl.sub.2                   i-PrCCl(Et)CH.sub.2          OMe   O  H    H    4-Br                           i-PrCCl(Et)CH.sub.2          SO.sub.2 Pr                                                                          O  H    H    4-Cl                           i-PrCCl(Et)CH.sub.2          Cl    O  H    H    4-OPr                          i-PrCCl(Et)CH.sub.2          Cl    O  H    H    4-CF.sub.3                     i-PrCCl(Et)CH.sub.2          Cl    O  H    H    2,4,5-Cl.sub. 3                i-PrCCl(Et)CH.sub.2          Cl    S  H    H    4-Cl                           i-PrCCl(Et)CH.sub.2          Cl    S  H    H    4-Bu-t                         i-PrCCl(Et)CH.sub.2          Cl    S  H    H    4-C.sub.6 H.sub.4 Cl-'         i-PrCCl(Et)CH.sub.2          Cl    S  H    H    4-OC.sub.6 H.sub.4 F-4'        i-PrCCl(Et)CH.sub.2          Cl    S  H    H    4-SiMe.sub.3                   i-PrCBr(Et)CH.sub.2          Cl    O  H    H    4-Cl                           i-PrCBr(Et)CH.sub.2          Cl    O  H    H    4-Br                           i-PrCBr(Et)CH.sub.2          Cl    O  H    H    4-I                            i-PrCBr(Et)CH.sub.2          Br    O  H    H    4-Cl                           i-PrCBr(Et)CH.sub.2          I     O  H    H    4-Cl                           i-PrCBr(Et)CH.sub.2          H     O  H    H    4-Cl                           i-PrCBr(Et)CH.sub.2          H     O  H    H    4-I                            i-PrCBr(Et)CH.sub.2          Cl    O  H    H    2,4-Cl.sub.2                   i-PrCBr(Et)CH.sub.2          Cl    O  H    H    2-F, 4-Cl                      i-PrCBr(Et)CH.sub.2          OEt   O  H    H    4-Cl                           i-PrCBr(Et)CH.sub.2          Cl    O  H    Me   4-I                            i-PrCBr(Et)CH.sub.2          Cl    O  H    H    4-Me                           i-PrCBr(Et)CH.sub.2          Cl    O  H    H    2,5-Me.sub.2                   i-PrCBr(Et)CH.sub.2          Cl    O  H    H    4-OCHF.sub.2                   i-PrCBr(Et)CH.sub.2          Cl    O  H    H    2,4,5-Cl.sub.3                 i-PrCBr(Et)CH.sub.2          Cl    S  H    H    4-Cl                           i-PrCBr(Et)CH.sub.2          Cl    S  H    H    4-Bu-t                         i-PrCBr(Et)CH.sub.2          Cl    S  H    H    3-Me                           i-PrCBr(Et)CH.sub.2          Cl    S  H    H    4-CHCHMe                       i-PrCBr(Et)CH.sub.2          Cl    S  H    H    4-C(Me).sub.2 CH.sub.2                                                         CN                             i-PrCBr(Et)CH.sub.2          Cl    S  H    H    4-O(CH.sub.2).sub.3 OMe        EtCCl(Me)CH.sub.2            Cl    O  H    H    4-Cl                           EtCCl(Me)CH.sub.2            Cl    O  H    H    4-Br                           EtCCl(Me)CH.sub.2            Cl    O  H    H    4-I                            EtCCl(Me)CH.sub.2            Cl    O  H    H    2,4-Cl.sub.2                   EtCCl(Me)CH.sub.2            Br    O  H    H    4-Cl                           EtCCl(Me)CH.sub.2            Br    O  H    H    4-I                            EtCCl(Me)CH.sub.2            I     O  H    H    4-Cl                           EtCCl(Me)CH.sub.2            I     O  H    H    4-I                            EtCCl(Me)CH.sub.2            F     O  H    H    4-Cl                           EtCCl(Me)CH.sub.2            Me    O  H    H    4-Cl                           EtCCl(Me)CH.sub.2            OMe   O  H    H    4-Cl                           EtCCl(Me)CH.sub.2            OMe   O  H    H    4-I                            EtCCl(Me)CH.sub.2            SMe   O  H    H    4-Cl                           EtCCl(Me)CH.sub.2            SMe   O  H    H    4-I                            EtCCl(Me)CH.sub.2            SO.sub.2 Me                                                                          O  H    H    4-Cl                           EtCCl(Me)CH.sub.2            Cl    O  H    Me   4-Cl                           EtCCl(Me)CH.sub.2            Cl    O  Cl   H    4-Cl                           EtCCl(Me)CH.sub.2            Cl    O  H    H    2,Cl, 4-Br                     EtCCl(Me)CH.sub.2            OBu   O  H    H    4-Cl                           EtCCl(Me)CH.sub.2            Cl    O  H    Et   4-Cl                           EtCCl(Me)CH.sub.2            Cl    O  H    H    4-Bu-s                         EtCCl(Me)CH.sub.2            Cl    O  H    H    3,4-Cl.sub.2                   EtCCl(Me)CH.sub.2            Cl    O  H    H    4-OCF.sub.3                    EtCCl(Me)CH.sub.2            Cl    O  H    H    2,4-F.sub.2                    EtCCl(Me)CH.sub.2            Cl    S  H    H    4-Cl                           EtCCl(Me)CH.sub.2            Cl    S  H    H    4-Bu-t                         EtCCl(Me)CH.sub.2            Cl    S  H    H    4-Me                           EtCCl(Me)CH.sub.2            Cl    S  H    H    4-OPr                          EtCCl(Me)CH.sub.2            Cl    S  H    H    4-CH.sub.2(C.sub.6                                                             H.sub.3 Cl.sub.2 -2,4)         EtCCl(Me)CH.sub.2            Cl    S  H    H    4-COC.sub.6 H.sub.4                                                            Cl-4'                          EtCCl(Me)CH.sub.2            Cl    S  H    H    4-OCH(Me)CH.sub.2 OEt          EtCBr(Me)CH.sub.2            Cl    O  H    H    4-Cl                           EtCBr(Me)CH.sub.2            Cl    O  H    H    4-Br                           EtCBr(Me)CH.sub.2            Cl    O  H    H    4-I                            EtCBr(Me)CH.sub.2            Cl    O  H    H    2,4-Cl.sub.2                   EtCBr(Me)CH.sub.2            Br    O  H    H    4-Cl                           EtCBr(Me)CH.sub.2            Br    O  H    H    4-I                            EtCBr(Me)CH.sub.2            I     O  H    H    4-Cl                           EtCBr(Me)CH.sub.2            I     O  H    H    4-I                            EtCBr(Me)CH.sub.2            F     O  H    H    4-Cl                           EtCBr(Me)CH.sub.2            Me    O  H    H    4-Cl                           EtCBr(Me)CH.sub.2            OMe   O  H    H    4-Cl                           EtCBr(Me)CH.sub.2            SMe   O  H    H    4-Cl                           EtCBr(Me)CH.sub.2            Cl    O  H    Me   4-Cl                           EtCBr(Me)CH.sub.2            Br    O  H    Me   4-Cl                           EtCBr(Me)CH.sub.2            Cl    O  H    H    3-CF.sub.3                     EtCBr(Me)CH.sub.2            Cl    O  H    H    4-Ph                           EtCBr(Me)CH.sub.2            Cl    O  H    H    4-OCH.sub.2 CF.sub.3           EtCBr(Me)CH.sub.2            Cl    O  H    H    2,6-Cl.sub.2                   EtCBr(Me)CH.sub.2            Cl    S  H    H    4-Cl                           EtCBr(Me)CH.sub.2            Cl    S  H    H    4-Bu-t                         EtCBr(Me)CH.sub.2            Cl    S  H    H    4-OC.sub. 10 H.sub.21          EtCBr(Me)CH.sub.2            Cl    S  H    H    4-C.sub.6 H.sub.4 F-4'         EtCBr(Me)CH.sub.2            Cl    S  H    H    4-CH.sub.2(C.sub.6                                                             H.sub.3 Cl.sub.2 -3,5)         Et.sub.2 CClCH.sub.2         Cl    O  H    H    4-Cl                           Et.sub.2 CClCH.sub.2         Cl    O  H    H    4-Br                           Et.sub.2 CClCH.sub.2         Cl    O  H    H    4-I                            Et.sub.2 CClCH.sub.2         Cl    O  H    H    2,4-Cl.sub.2                   Et.sub.2 CClCH.sub.2         Br    O  H    H    4-Cl                           Et.sub.2 CClCH.sub.2         Br    O  H    H    4-I                            Et.sub.2 CClCH.sub.2         I     O  H    H    4-Cl                           Et.sub.2 CClCH.sub.2         I     O  H    H    4-I                            Et.sub.2 CClCH.sub.2         F     O  H    H    4-Cl                           Et.sub.2 CClCH.sub.2         Me    O  H    H    4-Cl                           Et.sub.2 CClCH.sub.2         OMe   O  H    H    4-Cl                           Et.sub.2 CClCH.sub.2         OMe   O  H    H    4-I                            Et.sub.2 CClCH.sub.2         SMe   O  H    H    4-Cl                           Et.sub.2 CClCH.sub.2         Cl    O  H    H    4-OC.sub.10 H.sub.21           Et.sub.2 CClCH.sub.2         SO.sub.2 Me                                                                          O  H    H    4-Cl                           Et.sub.2 CClCH.sub.2         Cl    O  H    Me   4-Cl                           Et.sub.2 CClCH.sub.2         Cl    O  Cl   H    4-Cl                           Et.sub.2 CClCH.sub.2         F     O  H    H    4-I                            Et.sub.2 CClCH.sub.2         SMe   O  H    H    2,4-Cl.sub.2                   Et.sub.2 CClCH.sub.2         I     O  H    Me   4-Cl                           Et.sub.2 CClCH.sub.2         Cl    O  H    H    4-C.sub.6 H.sub.4 Cl-4'        Et.sub.2 CClCH.sub.2         Cl    O  H    H    4-CN                           Et.sub.2 CClCH.sub.2         Cl    O  H    H    4-OCH.sub.2 CH.sub.2NHCOOE                                                     t                              Et.sub.2 CClCH.sub.2         Cl    S  H    H    4-Cl                           Et.sub.2 CClCH.sub.2         Cl    S  H    H    4-Bu-t                         Et.sub.2 CClCH.sub.2         Cl    S  H    H    4-Hex                          Et.sub.2 CClCH.sub.2         Cl    S  H    H    4-OC(Me).sub.2 CH.sub.2                                                        OPr                            Et.sub.2 CClCH.sub.2         Cl    S  H    H    4-OCH.sub.2 CHCH.sub.2         Et.sub.2 CClCH.sub.2         Cl    S  H    H    4-CH.sub.2 CH.sub.2 Ph         Et.sub.2 CBrCH.sub.2         Cl    O  H    H    4-Cl                           Et.sub.2 CBrCH.sub.2         Cl    O  H    H    4-Br                           Et.sub.2 CBrCH.sub.2         Cl    O  H    H    4-I                            Et.sub.2 CBrCH.sub.2         Cl    O  H    H    2,4-Cl.sub.2                   Et.sub.2 CBrCH.sub.2         Br    O  H    H    4-Cl                           Et.sub.2 CBrCH.sub.2         I     O  H    H    4-Cl                           Et.sub.2 CBrCH.sub.2         H     O  H    H    4-Cl                           Et.sub.2 CBrCH.sub.2         H     O  H    H    4-I                            Et.sub.2 CBrCH.sub.2         F     O  H    H    4-Cl                           Et.sub.2 CBrCH.sub.2         Me    O  H    H    4-Cl                           Et.sub.2 CBrCH.sub.2         OMe   O  H    H    4-Cl                           Et.sub.2 CBrCH.sub.2         SMe   O  H    H    4-Cl                           Et.sub.2 CBrCH.sub.2         Me    O  H    H    4-Br                           Et.sub.2 CBrCH.sub.2         Cl    O  OH   H    4-Cl                           Et.sub.2 CBrCH.sub.2         Cl    O  H    H    4-Pr                           Et.sub.2 CBrCH.sub.2         Cl    O  H    H    2-Cl, 4-F                      Et.sub.2 CBrCH.sub.2         Cl    S  H    H    4-Cl                           Et.sub.2 CBrCH.sub.2         Cl    S  H    H    4-Bu-t                         Et.sub.2 CBrCH.sub.2         Cl    S  H    H    4-(Q4)                         Et.sub.2 CBrCH.sub.2         Cl    S  H    H    4-OCH.sub.2 CH.sub.2NHCOOE                                                     t                              t-BuCHBrCH.sub.2             Cl    O  H    H    4-Cl                           t-BuCHBrCH.sub.2             Cl    O  H    H    4-I                            t-BuCHBrCH.sub.2             Br    O  H    H    4-Cl                           t-BuCHBrCH.sub.2             I     O  H    H    4-Cl                           t-BuCHBrCH.sub.2             Cl    O  H    H    4-Cl                           t-BuCHBrCH.sub.2             Cl    O  H    H    4-I                            EtCHClCH(Me)                 Cl    O  H    H    4-Cl                           EtCHClCH(Me)                 Cl    O  H    H    4-I                            EtCHBrCH(Me)                 Cl    O  H    H    4-Cl                           EtCHBrCH(Me)                 Cl    O  H    H    4-I                            EtCHClCH(Et)                 Cl    O  H    H    4-Cl                           EtCHClCH(Et)                 Cl    O  H    H    4-I                            EtCHBrCH(Me)                 Cl    O  H    H    4-Cl                           EtCHBrCH(Et)                 Cl    O  H    H    4-I                            EtCHClCH(Pr)                 Cl    O  H    H    4-Cl                           EtCHClCH(Pr)                 Cl    O  H    H    4-I                            EtCHBrCH(Pr)                 Cl    O  H    H    4-Cl                           EtCHBrCH(Pr)                 Cl    O  H    H    4-I                            i-PrCHClCH.sub.2             Cl    O  H    H    4-Cl                           i-PrCHClCH.sub.2             Cl    O  H    H    4-I                            i-PrCHBrCH.sub.2             Cl    O  H    H    4-Cl                           i-PrCHBrCH.sub.2             Cl    O  H    H    4-I                            EtCHClC(Me).sub.2            Cl    O  H    H    4-Cl                           EtCHClC(Me).sub.2            Cl    O  H    H    4-I                            EtCHBrC(Me).sub.2            Cl    O  H    H    4-Cl                           EtCHBrC(Me).sub.2            Cl    O  H    H    4-I                            EtCCl(Me)CH(Me)              Cl    O  H    H    4-Cl                           EtCCl(Me)CH(Me)              Cl    O  H    H    4-I                            EtCBr(Me)CH(Me)              Cl    O  H    H    4-Cl                           EtCBr(Me)CH(Me)              Cl    O  H    H    4-I                            i-PrCHClCH(Me)               Cl    O  H    H    4-Cl                           i-PrCHClCH(Me)               Cl    O  H    H    4-I                            i-PrCHBrCH(Me)               Cl    O  H    H    4-Cl                           i-PrCHBrCH(Me)               Cl    O  H    H    4-I                            t-BuCCl(Me)CH.sub.2          Cl    O  H    H    4-Cl                           t-BuCCl(Me)CH.sub.2          Cl    O  H    H    4-Br                           t-BuCCl(Me)CH.sub.2          Cl    O  H    H    4-I                            t-BuCCl(Me)CH.sub.2          Br    O  H    H    4-Cl                           t-BuCCl(Me)CH.sub.2          Br    O  H    H    4-I                            t-BuCCl(Me)CH.sub.2          I     O  H    H    4-Cl                           t-BuCCl(Me)CH.sub.2          I     O  H    H    4-I                            t-BuCCl(Me)CH.sub.2          Cl    O  H    H    2,4-Cl.sub.2                   t-BuCCl(Me)CH.sub.2          F     O  H    H    4-Cl                           t-BuCCl(Me)CH.sub.2          Me    O  H    H    4-Cl                           t-BuCCl(Me)CH.sub.2          OMe   O  H    H    4-Cl                           t-BuCCl(Me)CH.sub.2          OMe   O  H    H    4-I                            t-BuCCl(Me)CH.sub.2          SMe   O  H    H    4-Cl                           t-BuCCl(Me)CH.sub.2          Me    O  H    H    4-I                            t-BuCCl(Me)CH.sub.2          Cl    O  H    H    2-F, 4-Cl                      t-BuCCl(Me)CH.sub.2          OEt   O  H    H    4-Cl                           t-BuCCl(Me)CH.sub.2          Cl    O  H    Me   4-I                            t-BuCCl(Me)CH.sub.2          Cl    O  H    H    4-Me                           t-BuCCl(Me)CH.sub.2          Cl    O  H    H    2,5-Me.sub.2                   t-BuCCl(Me)CH.sub.2          Cl    O  H    H    4-OCHF.sub.2                   t-BuCCl(Me)CH.sub.2          Cl    S  H    H    4-Cl                           t-BuCCl(Me)CH.sub.2          Cl    S  H    H    4-Bu-t                         t-BuCCl(Me)CH.sub.2          Cl    S  H    H    3-Me                           t-BuCCl(Me)CH.sub.2          Cl    S  H    H    4-SMe                          t-BuCCl(Me)CH.sub.2          Cl    S  H    H    4-I                            t-BuCCl(Me)CH.sub.2          Cl    S  H    H    4-SPr                          t-BuCBr(Me)CH.sub.2          Cl    O  H    H    4-Cl                           t-BuCBr(Me)CH.sub.2          Cl    O  H    H    4-Br                           t-BuCBr(Me)CH.sub.2          Cl    O  H    H    4-I                            t-BuCBr(Me)CH.sub.2          Br    O  H    H    4-Cl                           t-BuCBr(Me)CH.sub.2          Br    O  H    H    4-I                            t-BuCBr(Me)CH.sub.2          I     O  H    H    4-Cl                           t-BuCBr(Me)CH.sub.2          I     O  H    H    4-I                            Br(CH.sub.2).sub.6 CHClCH.sub.2                                                                             Cl    O  H    H    4-Cl                           Br(CH.sub.2).sub.6 CHClCH.sub.2                                                                             Cl    O  H    H    4-I                            Br(CH.sub.2).sub.6 CHBrCH.sub.2                                                                             Cl    O  H    H    4-Cl                           Br(CH.sub.2).sub.6 CHBrCH.sub.2                                                                             Cl    O  H    H    4-I                            ClCH.sub.2 CH(Me)            Cl    O  H    H    4-Cl                           ClCH.sub.2 CH(Me)            Cl    O  H    H    4-I                            ClCH.sub.2 C(Me).sub.2       Cl    O  H    H    4-Cl                           ClCH.sub.2 C(Me)             Cl    O  H    H    4-I                            Cl(CH.sub.2).sub.3           Cl    O  H    H    4-Cl                           Cl(CH.sub.2).sub.3           Cl    O  H    H    4-I                            Cl(CH.sub.2).sub.3           Cl    O  H    H    2,4-Cl.sub.2                   Cl(CH.sub.2).sub.3           Br    O  H    H    4-Cl                           Cl(CH.sub.2).sub.3           I     O  H    H    4-Cl                           Cl(CH.sub.2).sub.3           Cl    S  H    H    4-Cl                           Cl(CH.sub.2).sub.3           Cl    S  H    H    4-Bu-t                         Br(CH.sub.2).sub.3           Cl    O  H    H    4-Cl                           Br(CH.sub.2).sub.3           Cl    O  H    H    4-I                            Br(CH.sub.2).sub.3           Cl    O  H    H    2,4-Cl.sub.2                   Br(CH.sub.2).sub.3           Br    O  H    H    4-Cl                           Br(CH.sub.2).sub.3           I     O  H    H    4-Cl                           Br(CH.sub.2).sub.3           Cl    S  H    H    4-Cl                           Br(CH.sub.2).sub.3           Cl    S  H    H    4-Bu-t                         I(CH.sub.2).sub.3            Cl    O  H    H    4-Cl                           I(CH.sub.2).sub.3            Cl    O  H    H    4-I                            I(CH.sub.2).sub.3            Cl    O  H    H    2,4-Cl.sub.2                   I(CH.sub.2).sub.3            Br    O  H    H    4-Cl                           I(CH.sub.2).sub.3            I     O  H    H    4-Cl                           I(CH.sub.2).sub.3            Cl    S  H    H    4-Cl                           I(CH.sub.2).sub.3            Cl    S  H    H    4-Bu-t                         MeCHClCH.sub.2               Cl    O  H    H    4-Cl                           MeCHClCH.sub.2               Cl    O  H    H    4-I                            MeCHBrCH.sub.2               Cl    O  H    H    4-Cl                           MeCHBrCH.sub.2               Cl    O  H    H    4-I                            Me.sub.2 CClC(Me).sub.2      Cl    O  H    H    4-Cl                           Me.sub.2 CClC(Me).sub.2      Cl    O  H    H    4-I                            Me.sub.2 CBrC(Me).sub.2      Cl    O  H    H    4-Cl                           Me.sub.2 CBrC(Me).sub.2      Cl    O  H    H    4-I                            MeCHClCH(Et)                 Cl    O  H    H    4-Cl                           MeCHClCH(Et)                 Cl    O  H    H    4-I                            MeCHBrCH(Et)                 Cl    O  H    H    4-Cl                           MeCHBrCH(Et)                 Cl    O  H    H    4-I                            MeCHClCH(Pr)                 Cl    O  H    H    4-Cl                           MeCHClCH(Pr)                 Cl    O  H    H    4-I                            MeCHBrCH(Pr)                 Cl    O  H    H    4-Cl                           MeCHBrCH(Pr)                 Cl    O  H    H    4-I                            MeCHClCH(Pr-i)               Cl    O  H    H    4-Cl                           MeCHClCH(Pr-i)               Cl    O  H    H    4-I                            MeCHBrCH(Pr-i)               Cl    O  H    H    4-Cl                           MeCHBrCH(Pr-i)               Cl    O  H    H    4-I                            MeCHClCH(Bu)                 Cl    O  H    H    4-Cl                           MeCHClCH(Bu)                 Cl    O  H    H    4-I                            MeCHBrCH(Bu)                 Cl    O  H    H    4-Cl                           MeCHBrCH(Bu)                 Cl    O  H    H    4-I                            MeCHClCH(Pen)                Cl    O  H    H    4-Cl                           MeCHClCH(Pen)                Cl    O  H    H    4-I                            MeCHBrCH(Pen)                Cl    O  H    H    4-Cl                           MeCHBrCH(Pen)                Cl    O  H    H    4-I                            Me.sub.2 CClCH.sub.2         Cl    O  H    H    4-Cl                           Me.sub.2 CClCH.sub.2         Cl    O  H    H    4-Br                           Me.sub.2 CClCH.sub.2         Br    O  H    H    4-Cl                           Me.sub.2 CClCH.sub.2         Br    O  H    H    4-I                            Me.sub.2 CClCH.sub.2         I     O  H    H    4-Cl                           Me.sub.2 CClCH.sub.2         I     O  H    H    4-I                            Me.sub.2 CClCH.sub.2         Cl    O  H    H    2,4-Cl.sub.2                   Me.sub.2 CClCH.sub.2         Pr-i  O  H    H    4-Cl                           Me.sub.2 CClCH.sub.2         SPr   O  H    H    4-Cl                           Me.sub.2 CClCH.sub.2         Br    O  OMe  H    4-Cl                           Me.sub.2 CClCH.sub.2         Cl    O  H    H    4-Bu-t                         Me.sub.2 CClCH.sub.2         Cl    O  H    H    3-OBu                          Me.sub.2 CClCH.sub.2         Cl    O  H    H    4-F                            Me.sub.2 CClCH.sub.2         Cl    S  H    H    4-Cl                           Me.sub.2 CClCH.sub.2         Cl    S  H    H    4-Bu-t                         Me.sub.2 CClCH.sub.2         Cl    S  H    H    4-CF.sub.3                     Me.sub.2 CClCH.sub.2         Cl    S  H    H    4-CH(OH)Et                     Me.sub.2 CClCH.sub.2         Cl    S  H    H    4-OCH.sub.2 CHCHMe             Me.sub.2 CBrCH.sub.2         Cl    O  H    H    4-Cl                           Me.sub.2 CBrCH.sub.2         Cl    O  H    H    4-Br                           Me.sub.2 CBrCH.sub.2         Br    O  H    H    4-Cl                           Me.sub.2 CBrCH.sub.2         I     O  H    H    4-Cl                           Me.sub.2 CBrCH.sub.2         H     O  H    H    4-Cl                           Me.sub.2 CBrCH.sub.2         H     O  H    H    4-I                            Me.sub.2 CBrCH.sub.2         Cl    O  H    H    2,4-Cl.sub.2                   Me.sub.2 CBrCH.sub.2         Bu    O  H    H    4-Cl                           Me.sub.2 CBrCH.sub.2         SOEt  O  H    H    4-Cl                           Me.sub.2 CBrCH.sub.2         I     O  Cl   H    4-Cl                           Me.sub.2 CBrCH.sub.2         Cl    O  H    H    4-OBu-s                        Me.sub.2 CBrCH.sub.2         Cl    S  H    H    4-Cl                           Me.sub.2 CBrCH.sub.2         Cl    S  H    H    4-Bu-t                         Me.sub.2 CBrCH.sub.2         Cl    S  H    H    4-Ph                           Me.sub.2 CBrCH.sub.2         Cl    S  H    H    4-OPh                          Me.sub.2 CBrCH.sub.2         Cl    S  H    H    4-CH(OMe)Et                    MeCHClCH(Me)                 Cl    O  H    H    4-Cl                           MeCHClCH(Me)                 Cl    O  H    H    4-I                            MeCHBrCH(Me)                 Cl    O  H    h    4-Cl                           MeCHBrCH(Me)                 Cl    O  H    h    4-I                            MeCHClC(Me).sub.2            Cl    O  H    H    4-Cl                           MeCHClC(Me).sub.2            Cl    O  H    H    4-I                            MeCHBrC(Me).sub.2            Cl    O  H    H    4-Cl                           MeCHBrC(Me).sub.2            Cl    O  H    H    4-I                            Me.sub.2 CClCH(Me)           Cl    O  H    H    4-Cl                           Me.sub.2 CClCH(Me)           Cl    O  H    H    4-I                            Me.sub.2 CBrCH(Me)           Cl    O  H    H    4-Cl                           Me.sub. 2 CBrCH(Me)          Cl    O  H    H    4-I                            Me.sub.2 CClCH(Bu-t)         Cl    O  H    H    4-Cl                           Me.sub.2 CClCH(Bu-t)         Cl    O  H    H    4-I                            Me.sub.2 CBrCH(Bu-t)         Cl    O  H    H    4-Cl                           Me.sub.2 CBrCH(Bu-t)         Cl    O  H    H    4-I                            MeCHClC(Me)(Et)              Cl    O  H    H    4-Cl                           MeCHClC(Me)(Et)              Cl    O  H    H    4-I                            MeCHBrC(Me)(Et)              Cl    O  H    H    4-Cl                           MeCHBrC(Me)(Et)              Cl    O  H    H    4-I                            Cl(CH.sub.2).sub.4           Cl    O  H    H    4-Cl                           Cl(CH.sub.2).sub.4           Cl    O  H    H    2,4-Cl.sub.2                   Cl(CH.sub.2).sub.4           Cl    O  H    H    4-I                            Cl(CH.sub.2).sub.4           Br    O  H    H    4-Cl                           Cl(CH.sub.2).sub.4           I     O  H    H    4-Cl                           Cl(CH.sub.2).sub.4           Cl    S  H    H    4-Cl                           Cl(CH.sub.2).sub.4           Cl    S  H    H    4-Bu-t                         Br(CH.sub.2).sub.4           Cl    O  H    H    4-Cl                           Br(CH.sub.2).sub.4           Cl    O  H    H    2,4-Cl.sub.2                   Br(CH.sub.2).sub.4           Cl    O  H    H    4-I                            Br(CH.sub.2).sub.4           Br    O  H    H    4-Cl                           Br(CH.sub.2).sub.4           I     O  H    H    4-Cl                           Br(CH.sub.2).sub.4           Cl    S  H    H    4-Cl                           Br(CH.sub.2).sub.4           Cl    S  H    H    4-Bu-t                         I(CH.sub.2).sub.4            Cl    O  H    H    4-Cl                           I(CH.sub.2).sub.4            Cl    O  H    H    2,4-Cl.sub.2                   I(CH.sub.2).sub.4            Cl    O  H    H    4-I                            I(CH.sub.2).sub.4            Br    O  H    H    4-Cl                           I(CH.sub.2).sub.4            I     O  H    H    4-Cl                           I(CH.sub.2).sub.4            Cl    S  H    H    4-Cl                           I(CH.sub.2).sub.4            Cl    S  H    H    4-Bu-t                         MeCHClCH.sub.2 CH.sub.2      Cl    O  H    H    4-Cl                           MeCHClCH.sub.2 CH.sub.2      Cl    O  H    H    4-I                            Cl(CH.sub.2).sub.5           Cl    O  H    H    4-Cl                           Cl(CH.sub.2).sub.5           Cl    O  H    H    4-I                            Br(CH.sub.2).sub.5           Cl    O  H    H    4-Cl                           Br(CH.sub.2).sub.5           Cl    O  H    H    4-I                            I(CH.sub.2).sub.5            Cl    O  H    H    4-Cl                           I(CH.sub.2).sub.5            Cl    O  H    H    4-I                            MeCHBrCH.sub.2 CH.sub.2 CH.sub.2                                                                            Cl    O  H    H    4-Cl                           MeCHBrCH.sub.2 CH.sub.2 CH.sub.2                                                                            Cl    O  H    H    4-I                            Cl(CH.sub.2).sub.6           Cl    O  H    H    4-Cl                           Cl(CH.sub.2).sub.6           Cl    O  H    H    4-I                            I(CH.sub.2).sub.6            Cl    O  H    H    4-Cl                           I(CH.sub.2).sub.6            Cl    O  H    H    4-I                            Br(CH.sub.2).sub.8           Cl    O  H    H    4-Cl                           Br(CH.sub.2).sub.8           Cl    O  H    H    4-I                            I(CH.sub.2).sub.8            Cl    O  H    H    4-Cl                           I(CH.sub.2).sub.8            Cl    O  H    H    4-I                            EtCHClCH.sub.2               Cl    O  H    H    4-Cl                           EtCHClCH.sub.2               Cl    O  H    H    4-I                            EtCHBrCH.sub.2               Cl    O  H    H    4-Cl                           EtCHBrCH.sub.2               Cl    O  H    H    4-I                            i-PrCCl(Et)CH.sub.2          Cl    O  H    H    4-Cl                           i-PrCCl(Et)CH.sub.2          Cl    O  H    H    4-Br                           i-PrCCl(Et)CH.sub.2          Cl    O  H    H    4-I                            i-PrCCl(Et)CH.sub.2          Br    O  H    H    4-Cl                           i-PrCCl(Et)CH.sub.2          Br    O  H    H    4-I                            i-PrCCl(Et)CH.sub.2          I     O  H    H    4-Cl                           i-PrCCl(Et)CH.sub.2          I     O  H    H    4-I                            i-PrCCl(Et)CH.sub.2          Cl    O  H    H    2,4-Cl.sub.2                   i-PrCCl(Et)CH.sub.2          OMe   O  H    H    4-Br                           i-PrCCl(Et)CH.sub.2          SO.sub.2 Pr                                                                          O  H    H    4-Cl                           i-PrCCl(Et)CH.sub.2          Cl    O  H    H    4-OPr                          i-PrCCl(Et)CH.sub.2          Cl    O  H    H    4-CF.sub.3                     i-PrCCl(Et)CH.sub.2          Cl    O  H    H    2,4,5-Cl.sub.3                 i-PrCCl(Et)CH.sub.2          Cl    S  H    H    4-Cl                           i-PrCCl(Et)CH.sub.2          Cl    S  H    H    4-Bu-t                         i-PrCCl(Et)CH.sub.2          Cl    S  H    H    4-C.sub.6 H.sub.4 Cl-'         i-PrCCl(Et)CH.sub.2          Cl    S  H    H    4-OC.sub.6 H.sub.4 F-4'        i-PrCCl(Et)CH.sub.2          Cl    S  H    H    4-SiMe.sub.3                   i-PrCBr(Et)CH.sub.2          Cl    O  H    H    4-Cl                           i-PrCBr(Et)CH.sub.2          Cl    O  H    H    4-Br                           i-PrCBr(Et)CH.sub.2          Cl    O  H    H    4-I                            i-PrCBr(Et)CH.sub.2          Br    O  H    H    4-Cl                           i-PrCBr(Et)CH.sub.2          I     O  H    H    4-Cl                           i-PrCBr(Et)CH.sub.2          H     O  H    H    4-Cl                           i-PrCBr(Et)CH.sub.2          H     O  H    H    4-I                            i-PrCBr(Et)CH.sub.2          Cl    O  H    H    2,4-Cl.sub.2                   i-PrCBr(Et)CH.sub.2          Cl    O  H    H    2-F, 4-Cl                      i-PrCBr(Et)CH.sub.2          OEt   O  H    H    4-Cl                           i-PrCBr(Et)CH.sub.2          Cl    O  H    Me   4-I                            i-PrCBr(Et)CH.sub.2          Cl    O  H    H    4-Me                           i-PrCBr(Et)CH.sub.2          Cl    O  H    H    2,5-Me.sub.2                   i-PrCBr(Et)CH.sub.2          Cl    O  H    H    4-OCHF.sub.2                   i-PrCBr(Et)CH.sub.2          Cl    O  H    H    2,4,5-Cl.sub.3                 i-PrCBr(Et)CH.sub.2          Cl    S  H    H    4-Cl                           i-PrCBr(Et)CH.sub.2          Cl    S  H    H    4-Bu-t                         i-PrCBr(Et)CH.sub.2          Cl    S  H    H    3-Me                           i-PrCBr(Et)CH.sub.2          Cl    S  H    H    4-CHCHMe                       i-PrCBr(Et)CH.sub.2          Cl    S  H    H    4-C(Me).sub.2 CH.sub.2                                                         CN                             i-PrCBr(Et)CH.sub.2          Cl    S  H    H    4-O(CH.sub.2).sub.3 OMe        EtCCl(Me)CH.sub.2            Cl    O  H    H    4-Cl                           EtCCl(Me)CH.sub.2            Cl    O  H    H    4-Br                           EtCCl(Me)CH.sub.2            Cl    O  H    H    4-I                            EtCCl(Me)CH.sub.2            Cl    O  H    H    2,4-Cl.sub.2                   EtCCl(Me)CH.sub.2            Br    O  H    H    4-Cl                           EtCCl(Me)CH.sub.2            Br    O  H    H    4-I                            EtCCl(Me)CH.sub.2            I     O  H    H    4-Cl                           EtCCl(Me)CH.sub.2            I     O  H    H    4-I                            EtCCl(Me)CH.sub.2            F     O  H    H    4-Cl                           EtCCl(Me)CH.sub.2            Me    O  H    H    4-Cl                           EtCCl(Me)CH.sub.2            OMe   O  H    H    4-Cl                           EtCCl(Me)CH.sub.2            OMe   O  H    H    4-I                            EtCCl(Me)CH.sub.2            SMe   O  H    H    4-Cl                           EtCCl(Me)CH.sub.2            SMe   O  H    H    4-I                            EtCCl(Me)CH.sub.2            SO.sub.2 Me                                                                          O  H    H    4-Cl                           EtCCl(Me)CH.sub.2            Cl    O  H    Me   4-Cl                           EtCCl(Me)CH.sub.2            Cl    O  Cl   H    4-Cl                           EtCCl(Me)CH.sub.2            Cl    O  H    H    2,Cl, 4-Br                     EtCCl(Me)CH.sub.2            OBu   O  H    H    4-Cl                           EtCCl(Me)CH.sub.2            Cl    O  H    Et   4-Cl                           EtCCl(Me)CH.sub.2            Cl    O  H    H    4-Bu-s                         EtCCl(Me)CH.sub.2            Cl    O  H    H    3,4-Cl.sub.2                   EtCCl(Me)CH.sub.2            Cl    O  H    H    4-OCF.sub.3                    EtCCl(Me)CH.sub.2            Cl    O  H    H    2,4-F.sub.2                    EtCCl(Me)CH.sub.2            Cl    S  H    H    4-Cl                           EtCCl(Me)CH.sub.2            Cl    S  H    H    4-Bu-t                         EtCCl(Me)CH.sub.2            Cl    S  H    H    4-Me                           EtCCl(Me)CH.sub.2            Cl    S  H    H    4-OPr                          EtCCl(Me)CH.sub.2            Cl    S  H    H    4-CH.sub.2(C.sub.6                                                             H.sub.3 Cl.sub.2 -2,4)         EtCCl(Me)CH.sub.2            Cl    S  H    H    4-COC.sub.6 H.sub.4                                                            Cl-4'                          EtCCl(Me)CH.sub.2            Cl    S  H    H    4-OCH(Me)CH.sub.2 OEt          EtCBr(Me)CH.sub.2            Cl    O  H    H    4-Cl                           EtCBr(Me)CH.sub.2            Cl    O  H    H    4-Br                           EtCBr(Me)CH.sub.2            Cl    O  H    H    4-I                            EtCBr(Me)CH.sub.2            Cl    O  H    H    2,4-Cl.sub.2                   EtCBr(Me)CH.sub.2            Br    O  H    H    4-Cl                           EtCBr(Me)CH.sub.2            Br    O  H    H    4-I                            EtCBr(Me)CH.sub.2            I     O  H    H    4-Cl                           EtCBr(Me)CH.sub.2            I     O  H    H    4-I                            EtCBr(Me)CH.sub.2            F     O  H    H    4-Cl                           EtCBr(Me)CH.sub.2            Me    O  H    H    4-Cl                           EtCBr(Me)CH.sub.2            OMe   O  H    H    4-Cl                           EtCBr(Me)CH.sub.2            SMe   O  H    H    4-Cl                           EtCBr(Me)CH.sub.2            Cl    O  H    Me   4-Cl                           EtCBr(Me)CH.sub.2            Br    O  H    Me   4-Cl                           EtCBr(Me)CH.sub.2            Cl    O  H    H    3-CF.sub.3                     EtCBr(Me)CH.sub.2            Cl    O  H    H    4-Ph                           EtCBr(Me)CH.sub.2            Cl    O  H    H    4-OCH.sub.2 CF.sub.3           EtCBr(Me)CH.sub.2            Cl    O  H    H    2,6-Cl.sub.2                   EtCBr(Me)CH.sub.2            Cl    S  H    H    4-Cl                           EtCBr(Me)CH.sub.2            Cl    S  H    H    4-Bu-t                         EtCBr(Me)CH.sub.2            Cl    S  H    H    4-OC.sub.10 H.sub.21           EtCBr(Me)CH.sub.2            Cl    S  H    H    4-C.sub.6 H.sub.4 F-4'         EtCBr(Me)CH.sub.2            Cl    S  H    H    4-CH.sub.2(C.sub.6                                                             H.sub.3 Cl.sub.2 -3,5)         Et.sub.2 CClCH.sub.2         Cl    O  H    H    4-Cl                           Et.sub.2 CClCH.sub.2         Cl    O  H    H    4-Br                           Et.sub.2 CClCH.sub.2         Cl    O  H    H    4-I                            Et.sub.2 CClCH.sub.2         Cl    O  H    H    2,4-Cl.sub.2                   Et.sub.2 CClCH.sub.2         Br    O  H    H    4-Cl                           Et.sub.2 CClCH.sub.2         Br    O  H    H    4-I                            Et.sub.2 CClCH.sub.2         I     O  H    H    4-Cl                           Et.sub.2 CClCH.sub.2         I     O  H    H    4-I                            Et.sub.2 CClCH.sub.2         F     O  H    H    4-Cl                           Et.sub.2 CClCH.sub.2         Me    O  H    H    4-Cl                           Et.sub.2 CClCH.sub.2         OMe   O  H    H    4-Cl                           Et.sub.2 CClCH.sub.2         OMe   O  H    H    4-I                            Et.sub.2 CClCH.sub.2         SMe   O  H    H    4-Cl                           Et.sub.2 CClCH.sub.2         Cl    O  H    H    4-OC.sub.10 H.sub.21           Et.sub.2 CClCH.sub.2         SO.sub.2 Me                                                                          O  H    H    4-Cl                           Et.sub.2 CClCH.sub.2         Cl    O  H    Me   4-Cl                           Et.sub.2 CClCH.sub.2         Cl    O  Cl   H    4-Cl                           Et.sub.2 CClCH.sub.2         F     O  H    H    4-I                            Et.sub.2 CClCH.sub.2         SMe   O  H    H    2,4-Cl.sub.2                   Et.sub.2 CClCH.sub.2         I     O  H    Me   4-Cl                           Et.sub.2 CClCH.sub.2         Cl    O  H    H    4-C.sub.6 H.sub.4 Cl-4'        Et.sub.2 CClCH.sub.2         Cl    O  H    H    4-CN                           Et.sub.2 CClCH.sub.2         Cl    O  H    H    4-OCH.sub.2 CH.sub.2NHCOOE                                                     t                              Et.sub.2 CClCH.sub. 2        Cl    S  H    H    4-Cl                           Et.sub.2 CClCH.sub.2         Cl    S  H    H    4-Bu-t                         Et.sub.2 CClCH.sub.2         Cl    S  H    H    4-Hex                          Et.sub.2 CClCH.sub.2         Cl    S  H    H    4-OC(Me).sub.2 CH.sub.2                                                        OPr                            Et.sub.2 CClCH.sub.2         Cl    S  H    H    4-OCH.sub.2 CHCH.sub.2         Et.sub.2 CClCH.sub.2         Cl    S  H    H    4-CH.sub.2 CH.sub.2 Ph         Et.sub.2 CBrCH.sub.2         Cl    O  H    H    4-Cl                           Et.sub.2 CBrCH.sub.2         Cl    O  H    H    4-Br                           Et.sub.2 CBrCH.sub.2         Cl    O  H    H    4-I                            Et.sub.2 CBrCH.sub.2         Cl    O  H    H    2,4-Cl.sub.2                   Et.sub.2 CBrCH.sub.2         Br    O  H    H    4-Cl                           Et.sub.2 CBrCH.sub.2         I     O  H    H    4-Cl                           Et.sub.2 CBrCH.sub.2         H     O  H    H    4-Cl                           Et.sub.2 CBrCH.sub.2         H     O  H    H    4-I                            Et.sub.2 CBrCH.sub.2         F     O  H    H    4-Cl                           Et.sub.2 CBrCH.sub.2         Me    O  H    H    4-Cl                           Et.sub.2 CBrCH.sub.2         OMe   O  H    H    4-Cl                           Et.sub.2 CBrCH.sub.2         SMe   O  H    H    4-Cl                           Et.sub.2 CBrCH.sub.2         Me    O  H    H    4-Br                           Et.sub.2 CBrCH.sub.2         Cl    O  OH   H    4-Cl                           Et.sub.2 CBrCH.sub.2         Cl    O  H    H    4-Pr                           Et.sub. 2 CBrCH.sub.2        Cl    O  H    H    2-Cl, 4-F                      Et.sub.2 CBrCH.sub.2         Cl    S  H    H    4-Cl                           Et.sub.2 CBrCH.sub.2         Cl    S  H    H    4-Bu-t                         Et.sub.2 CBrCH.sub.2         Cl    S  H    H    4-(Q4)                         Et.sub.2 CBrCH.sub.2         Cl    S  H    H    4-OCH.sub.2 CH.sub.2NHCOOE                                                     t                              t-BuCHBrCH.sub.2             Cl    O  H    H    4-Cl                           t-BuCHBrCH.sub.2             Cl    O  H    H    4-I                            t-BuCHBrCH.sub.2             Br    O  H    H    4-Cl                           t-BuCHBrCH.sub.2             I     O  H    H    4-Cl                           t-BuCHBrCH.sub.2             Cl    O  H    H    4-Cl                           t-BuCHBrCH.sub.2             Cl    O  H    H    4-I                            EtCHClCH(Me)                 Cl    O  H    H    4-Cl                           EtCHClCH(Me)                 Cl    O  H    H    4-I                            EtCHBrCH(Me)                 Cl    O  H    H    4-Cl                           EtCHBrCH(Me)                 Cl    O  H    H    4-I                            EtCHClCH(Et)                 Cl    O  H    H    4-Cl                           EtCHClCH(Et)                 Cl    O  H    H    4-I                            EtCHBrCH(Me)                 Cl    O  H    H    4-Cl                           EtCHBrCH(Et)                 Cl    O  H    H    4-I                            EtCHClCH(Pr)                 Cl    O  H    H    4-Cl                           EtCHClCH(Pr)                 Cl    O  H    H    4-I                            EtCHBrCH(Pr)                 Cl    O  H    H    4-Cl                           EtCHBrCH(Pr)                 Cl    O  H    H    4-I                            i-PrCHClCH.sub.2             Cl    O  H    H    4-Cl                           i-PrCHClCH.sub.2             Cl    O  H    H    4-I                            i-PrCHBrCH.sub.2             Cl    O  H    H    4-Cl                           i-PrCHBrCH.sub.2             Cl    O  H    H    4-I                            EtCHClC(Me).sub.2            Cl    O  H    H    4-Cl                           EtCHClC(Me).sub.2            Cl    O  H    H    4-I                            EtCHBrC(Me).sub.2            Cl    O  H    H    4-Cl                           EtCHBrC(Me).sub.2            Cl    O  H    H    4-I                            EtCCl(Me)CH(Me)              Cl    O  H    H    4-Cl                           EtCCl(Me)CH(Me)              Cl    O  H    H    4-I                            EtCBr(Me)CH(Me)              Cl    O  H    H    4-Cl                           EtCBr(Me)CH(Me)              Cl    O  H    H    4-I                            i-PrCHClCH(Me)               Cl    O  H    H    4-Cl                           i-PrCHClCH(Me)               Cl    O  H    H    4-I                            i-PrCHBrCH(Me)               Cl    O  H    H    4-Cl                           i-PrCHBrCH(Me)               Cl    O  H    H    4-I                            t-BuCCl(Me)CH.sub.2          Cl    O  H    H    4-Cl                           t-BuCCl(Me)CH.sub.2          Cl    O  H    H    4-Br                           t-BuCCl(Me)CH.sub.2          Cl    O  H    H    4-I                            t-BuCCl(Me)CH.sub.2          Br    O  H    H    4-Cl                           t-BuCCl(Me)CH.sub.2          Br    O  H    H    4-I                            t-BuCCl(Me)CH.sub.2          I     O  H    H    4-Cl                           t-BuCCl(Me)CH.sub.2          I     O  H    H    4-I                            t-BuCCl(Me)CH.sub.2          Cl    O  H    H    2,4-Cl.sub.2                   t-BuCCl(Me)CH.sub.2          F     O  H    H    4-Cl                           t-BuCCl(Me)CH.sub.2          Me    O  H    H    4-Cl                           t-BuCCl(Me)CH.sub.2          OMe   O  H    H    4-Cl                           t-BuCCl(Me)CH.sub.2          OMe   O  H    H    4-I                            t-BuCCl(Me)CH.sub.2          SMe   O  H    H    4-Cl                           t-BuCCl(Me)CH.sub.2          Me    O  H    H    4-I                            t-BuCCl(Me)CH.sub.2          Cl    O  H    H    2-F, 4-Cl                      t-BuCCl(Me)CH.sub.2          OEt   O  H    H    4-Cl                           t-BuCCl(Me)CH.sub.2          Cl    O  H    Me   4-I                            t-BuCCl(Me)CH.sub.2          Cl    O  H    H    4-Me                           t-BuCCl(Me)CH.sub.2          Cl    O  H    H    2,5-Me.sub.2                   t-BuCCl(Me)CH.sub.2          Cl    O  H    H    4-OCHF.sub.2                   t-BuCCl(Me)CH.sub.2          Cl    S  H    H    4-Cl                           t-BuCCl(Me)CH.sub.2          Cl    S  H    H    4-Bu-t                         t-BuCCl(Me)CH.sub.2          Cl    S  H    H    3-Me                           t-BuCCl(Me)CH.sub.2          Cl    S  H    H    4-SMe                          t-BuCCl(Me)CH.sub.2          Cl    S  H    H    4-I                            t-BuCCl(Me)CH.sub.2          Cl    S  H    H    4-SPr                          t-BuCBr(Me)CH.sub.2          Cl    O  H    H    4-Cl                           t-BuCBr(Me)CH.sub.2          Cl    O  H    H    4-Br                           t-BuCBr(Me)CH.sub.2          Cl    O  H    H    4-I                            t-BuCBr(Me)CH.sub.2          Br    O  H    H    4-Cl                           t-BuCBr(Me)CH.sub.2          Br    O  H    H    4-I                            t-BuCBr(Me)CH.sub.2          I     O  H    H    4-Cl                           t-BuCBr(Me)CH.sub.2          I     O  H    H    4-I                            Br(CH.sub.2).sub.6 CHClCH.sub.2                                                                             Cl    O  H    H    4-Cl                           Br(CH.sub.2).sub.6 CHClCH.sub.2                                                                             Cl    O  H    H    4-I                            Br(CH.sub.2).sub.6 CHBrCH.sub.2                                                                             Cl    O  H    H    4-Cl                           Br(CH.sub.2).sub.6 CHBrCH.sub.2                                                                             Cl    O  H    H    4-I                            ClCH.sub.2 CH(Me)            Cl    O  H    H    4-Cl                           ClCH.sub.2 CH(Me)            Cl    O  H    H    4-I                            ClCH.sub.2 C(Me).sub.2       Cl    O  H    H    4-Cl                           ClCH.sub.2 C(Me)             Cl    O  H    H    4-I                            Cl(CH.sub.2).sub.3           Cl    O  H    H    4-Cl                           Cl(CH.sub.2).sub.3           Cl    O  H    H    4-I                            Cl(CH.sub.2).sub. 3          Cl    O  H    H    2,4-Cl.sub.2                   Cl(CH.sub.2).sub.3           Br    O  H    H    4-Cl                           Cl(CH.sub.2).sub.3           I     O  H    H    4-Cl                           Cl(CH.sub.2).sub.3           Cl    S  H    H    4-Cl                           Cl(CH.sub.2).sub.3           Cl    S  H    H    4-Bu-t                         Br(CH.sub.2).sub.3           Cl    O  H    H    4-Cl                           Br(CH.sub.2).sub.3           Cl    O  H    H    4-I                            Br(CH.sub.2).sub.3           Cl    O  H    H    2,4-Cl.sub.2                   Br(CH.sub.2).sub.3           Br    O  H    H    4-Cl                           Br(CH.sub.2).sub.3           I     O  H    H    4-Cl                           Br(CH.sub.2).sub.3           Cl    S  H    H    4-Cl                           Br(CH.sub.2).sub.3           Cl    S  H    H    4-Bu-t                         I(CH.sub.2).sub.3            Cl    O  H    H    4-Cl                           I(CH.sub.2).sub.3            Cl    O  H    H    4-I                            I(CH.sub.2).sub.3            Cl    O  H    H    2,4-Cl.sub.2                   I(CH.sub.2).sub.3            Br    O  H    H    4-Cl                           I(CH.sub.2).sub.3            I     O  H    H    4-Cl                           I(CH.sub.2).sub.3            Cl    S  H    H    4-Cl                           I(CH.sub.2).sub.3            Cl    S  H    H    4-Bu-t                         MeCHClCH.sub.2               Cl    O  H    H    4-Cl                           MeCHClCH.sub.2               Cl    O  H    H    4-I                            MeCHBrCH.sub.2               Cl    O  H    H    4-Cl                           MeCHBrCH.sub.2               Cl    O  H    H    4-I                            Me.sub. 2 CClC(Me).sub.2     Cl    O  H    H    4-Cl                           Me.sub.2 CClC(Me).sub.2      Cl    O  H    H    4-I                            Me.sub.2 CBrC(Me).sub.2      Cl    O  H    H    4-Cl                           Me.sub.2 CBrC(Me).sub.2      Cl    O  H    H    4-I                            MeCHClCH(Et)                 Cl    O  H    H    4-Cl                           MeCHClCH(Et)                 Cl    O  H    H    4-I                            MeCHBrCH(Et)                 Cl    O  H    H    4-Cl                           MeCHBrCH(Et)                 Cl    O  H    H    4-I                            MeCHClCH(Pr)                 Cl    O  H    H    4-Cl                           MeCHClCH(Pr)                 Cl    O  H    H    4-I                            MeCHBrCH(Pr)                 Cl    O  H    H    4-Cl                           MeCHBrCH(Pr)                 Cl    O  H    H    4-I                            MeCHClCH(Pr-i)               Cl    O  H    H    4-Cl                           MeCHClCH(Pr-i)               Cl    O  H    H    4-I                            MeCHBrCH(Pr-i)               Cl    O  H    H    4-Cl                           MeCHBrCH(Pr-i)               Cl    O  H    H    4-I                            MeCHClCH(Bu)                 Cl    O  H    H    4-Cl                           MeCHClCH(Bu)                 Cl    O  H    H    4-I                            MeCHBrCH(Bu)                 Cl    O  H    H    4-Cl                           MeCHBrCH(Bu)                 Cl    O  H    H    4-I                            MeCHClCH(Pen)                Cl    O  H    H    4-Cl                           MeCHClCH(Pen)                Cl    O  H    H    4-I                            MeCHBrCH(Pen)                Cl    O  H    H    4-Cl                           MeCHBrCH(Pen)                Cl    O  H    H    4-I                            Me.sub.2 CClCH.sub.2         Cl    O  H    H    4-Cl                           Me.sub.2 CClCH.sub.2         Cl    O  H    H    4-Br                           Me.sub.2 CClCH.sub.2         Br    O  H    H    4-Cl                           Me.sub.2 CClCH.sub.2         Br    O  H    H    4-I                            Me.sub.2 CClCH.sub.2         I     O  H    H    4-Cl                           Me.sub.2 CClCH.sub.2         I     O  H    H    4-I                            Me.sub.2 CClCH.sub.2         Cl    O  H    H    2,4-Cl.sub.2                   Me.sub.2 CClCH.sub.2         Pr-i  O  H    H    4-Cl                           Me.sub.2 CClCH.sub.2         SPr   O  H    H    4-Cl                           Me.sub.2 CClCH.sub.2         Br    O  OMe  H    4-Cl                           Me.sub.2 CClCH.sub.2         Cl    O  H    H    4-Bu-t                         Me.sub.2 CClCH.sub.2         Cl    O  H    H    3-OBu                          Me.sub.2 CClCH.sub.2         Cl    O  H    H    4-F                            Me.sub.2 CClCH.sub.2         Cl    S  H    H    4-Cl                           Me.sub.2 CClCH.sub.2         Cl    S  H    H    4-Bu-t                         Me.sub.2 CClCH.sub.2         Cl    S  H    H    4-CF.sub.3                     Me.sub.2 CClCH.sub.2         Cl    S  H    H    4-CH(OH)Et                     Me.sub.2 CClCH.sub.2         Cl    S  H    H    4-OCH.sub.2 CHCHMe             Me.sub.2 CBrCH.sub.2         Cl    O  H    H    4-Cl                           Me.sub.2 CBrCH.sub.2         Cl    O  H    H    4-Br                           Me.sub.2 CBrCH.sub.2         Br    O  H    H    4-Cl                           Me.sub.2 CBrCH.sub.2         I     O  H    H    4-Cl                           Me.sub.2 CBrCH.sub.2         H     O  H    H    4-Cl                           Me.sub.2 CBrCH.sub.2         H     O  H    H    4-I                            Me.sub.2 CBrCH.sub.2         Cl    O  H    H    2,4-Cl.sub.2                   Me.sub.2 CBrCH.sub.2         Bu    O  H    H    4-Cl                           Me.sub.2 CBrCH.sub.2         SOEt  O  H    H    4-Cl                           Me.sub.2 CBrCH.sub.2         I     O  Cl   H    4-Cl                           Me.sub.2 CBrCH.sub.2         Cl    O  H    H    4-OBu-s                        Me.sub.2 CBrCH.sub.2         Cl    S  H    H    4-Cl                           Me.sub.2 CBrCH.sub.2         Cl    S  H    H    4-Bu-t                         Me.sub.2 CBrCH.sub.2         Cl    S  H    H    4-Ph                           Me.sub.2 CBrCH.sub.2         Cl    S  H    H    4-OPh                          Me.sub.2 CBrCH.sub.2         Cl    S  H    H    4-CH(OMe)Et                    MeCHClCH(Me)                 Cl    O  H    H    4-Cl                           MeCHClCH(Me)                 Cl    O  H    H    4-I                            MeCHBrCH(Me)                 Cl    O  H    h    4-Cl                           MeCHBrCH(Me)                 Cl    O  H    h    4-I                            MeCHClC(Me).sub.2            Cl    O  H    H    4-Cl                           MeCHClC(Me).sub.2            Cl    O  H    H    4-I                            MeCHBrC(Me).sub.2            Cl    O  H    H    4-Cl                           MeCHBrC(Me).sub.2            Cl    O  H    H    4-I                            Me.sub.2 CClCH(Me)           Cl    O  H    H    4-Cl                           Me.sub.2 CClCH(Me)           Cl    O  H    H    4-I                            Me.sub.2 CBrCH(Me)           Cl    O  H    H    4-Cl                           Me.sub.2 CBrCH(Me)           Cl    O  H    H    4-I                            Me.sub.2 CClCH(Bu-t)         Cl    O  H    H    4-Cl                           Me.sub.2 CClCH(Bu-t)         Cl    O  H    H    4-I                            Me.sub.2 CBrCH(Bu-t)         Cl    O  H    H    4-Cl                           Me.sub.2 CBrCH(Bu-t)         Cl    O  H    H    4-I                            MeCHClC(Me)(Et)              Cl    O  H    H    4-Cl                           MeCHClC(Me)(Et)              Cl    O  H    H    4-I                            MeCHBrC(Me)(Et)              Cl    O  H    H    4-Cl                           MeCHBrC(Me)(Et)              Cl    O  H    H    4-I                            Cl(CH.sub.2).sub.4           Cl    O  H    H    4-Cl                           Cl(CH.sub.2).sub.4           Cl    O  H    H    2,4-Cl.sub.2                   Cl(CH.sub.2).sub.4           Cl    O  H    H    4-I                            Cl(CH.sub.2).sub.4           Br    O  H    H    4-Cl                           Cl(CH.sub.2).sub.4           I     O  H    H    4-Cl                           Cl(CH.sub.2).sub.4           Cl    S  H    H    4-Cl                           Cl(CH.sub.2).sub.4           Cl    S  H    H    4-Bu-t                         Br(CH.sub.2).sub.4           Cl    O  H    H    4-Cl                           Br(CH.sub.2).sub.4           Cl    O  H    H    2,4-Cl.sub.2                   Br(CH.sub.2).sub.4           Cl    O  H    H    4-I                            Br(CH.sub.2).sub.4           Br    O  H    H    4-Cl                           Br(CH.sub.2).sub.4           I     O  H    H    4-Cl                           Br(CH.sub.2).sub.4           Cl    S  H    H    4-Cl                           Br(CH.sub.2).sub.4           Cl    S  H    H    4-Bu-t                         I(CH.sub.2).sub.4            Cl    O  H    H    4-Cl                           I(CH.sub.2).sub.4            Cl    O  H    H    2,4-Cl.sub.2                   I(CH.sub.2).sub.4            Cl    O  H    H    4-I                            I(CH.sub.2).sub.4            Br    O  H    H    4-Cl                           I(CH.sub.2).sub.4            I     O  H    H    4-Cl                           I(CH.sub.2).sub.4            Cl    S  H    H    4-Cl                           I(CH.sub.2).sub.4            Cl    S  H    H    4-Bu-t                         MeCHClCH.sub. 2 CH.sub.2     Cl    O  H    H    4-Cl                           MeCHClCH.sub.2 CH.sub.2      Cl    O  H    H    4-I                            Cl(CH.sub.2).sub.5           Cl    O  H    H    4-Cl                           Cl(CH.sub.2).sub.5           Cl    O  H    H    4-I                            Br(CH.sub.2).sub.5           Cl    O  H    H    4-Cl                           Br(CH.sub.2).sub.5           Cl    O  H    H    4-I                            I(CH.sub.2).sub.5            Cl    O  H    H    4-Cl                           I(CH.sub.2).sub.5            Cl    O  H    H    4-I                            MeCHBrCH.sub.2 CH.sub.2 CH.sub.2                                                                            Cl    O  H    H    4-Cl                           MeCHBrCH.sub.2 CH.sub.2 CH.sub.2                                                                            Cl    O  H    H    4-I                            Cl(CH.sub.2).sub.6           Cl    O  H    H    4-Cl                           Cl(CH.sub.2).sub.6           Cl    O  H    H    4-I                            I(CH.sub.2).sub.6            Cl    O  H    H    4-Cl                           I(CH.sub.2).sub.6            Cl    O  H    H    4-I                            Br(CH.sub.2).sub.8           Cl    O  H    H    4-Cl                           Br(CH.sub.2).sub.8           Cl    O  H    H    4-I                            I(CH.sub.2).sub.8            Cl    O  H    H    4-Cl                           I(CH.sub.2).sub.8            Cl    O  H    H    4-I                            EtCHClCH.sub.2               Cl    O  H    H    4-Cl                           EtCHClCH.sub.2               Cl    O  H    H    4-I                            EtCHBrCH.sub.2               Cl    O  H    H    4-Cl                           EtCHBrCH.sub.2               Cl    O  H    H    4-I                            i-PrCCl(Et)CH.sub.2          Cl    O  H    H    4-Cl                           i-PrCCl(Et)CH.sub.2          Cl    O  H    H    4-Br                           i-PrCCl(Et)CH.sub.2          Cl    O  H    H    4-I                            i-PrCCl(Et)CH.sub.2          Br    O  H    H    4-Cl                           i-PrCCl(Et)CH.sub.2          Br    O  H    H    4-I                            i-PrCCl(Et)CH.sub.2          I     O  H    H    4-Cl                           i-PrCCl(Et)CH.sub.2          I     O  H    H    4-I                            i-PrCCl(Et)CH.sub.2          Cl    O  H    H    2,4-Cl.sub.2                   i-PrCCl(Et)CH.sub.2          OMe   O  H    H    4-Br                           i-PrCCl(Et)CH.sub.2          SO.sub.2 Pr                                                                          O  H    H    4-Cl                           i-PrCCl(Et)CH.sub.2          Cl    O  H    H    4-OPr                          i-PrCCl(Et)CH.sub.2          Cl    O  H    H    4-CF.sub.3                     i-PrCCl(Et)CH.sub.2          Cl    O  H    H    2,4,5-Cl.sub.3                 i-PrCCl(Et)CH.sub.2          Cl    S  H    H    4-Cl                           i-PrCCl(Et)CH.sub.2          Cl    S  H    H    4-Bu-t                         i-PrCCl(Et)CH.sub.2          Cl    S  H    H    4-C.sub.6 H.sub.4 Cl-'         i-PrCCl(Et)CH.sub.2          Cl    S  H    H    4-OC.sub.6 H.sub.4 F-4'        i-PrCCl(Et)CH.sub.2          Cl    S  H    H    4-SiMe.sub.3                   i-PrCBr(Et)CH.sub.2          Cl    O  H    H    4-Cl                           i-PrCBr(Et)CH.sub.2          Cl    O  H    H    4-Br                           i-PrCBr(Et)CH.sub.2          Cl    O  H    H    4-I                            i-PrCBr(Et)CH.sub.2          Br    O  H    H    4-Cl                           i-PrCBr(Et)CH.sub.2          I     O  H    H    4-Cl                           i-PrCBr(Et)CH.sub.2          H     O  H    H    4-Cl                           i-PrCBr(Et)CH.sub.2          H     O  H    H    4-I                            i-PrCBr(Et)CH.sub.2          Cl    O  H    H    2,4-Cl.sub.2                   i-PrCBr(Et)CH.sub.2          Cl    O  H    H    2-F, 4-Cl                      i-PrCBr(Et)CH.sub.2          OEt   O  H    H    4-Cl                           i-PrCBr(Et)CH.sub.2          Cl    O  H    Me   4-I                            i-PrCBr(Et)CH.sub.2          Cl    O  H    H    4-Me                           i-PrCBr(Et)CH.sub.2          Cl    O  H    H    2,5-Me.sub.2                   i-PrCBr(Et)CH.sub.2          Cl    O  H    H    4-OCHF.sub.2                   i-PrCBr(Et)CH.sub.2          Cl    O  H    H    2,4,5-Cl.sub.3                 i-PrCBr(Et)CH.sub.2          Cl    S  H    H    4-Cl                           i-PrCBr(Et)CH.sub.2          Cl    S  H    H    4-Bu-t                         i-PrCBr(Et)CH.sub.2          Cl    S  H    H    3-Me                           i-PrCBr(Et)CH.sub.2          Cl    S  H    H    4-CHCHMe                       i-PrCBr(Et)CH.sub.2          Cl    S  H    H    4-C(Me).sub.2 CH.sub.2                                                         CN                             i-PrCBr(Et)CH.sub.2          Cl    S  H    H    4-O(CH.sub.2).sub.3 OMe        EtCCl(Me)CH.sub.2            Cl    O  H    H    4-Cl                           EtCCl(Me)CH.sub.2            Cl    O  H    H    4-Br                           EtCCl(Me)CH.sub.2            Cl    O  H    H    4-I                            EtCCl(Me)CH.sub.2            Cl    O  H    H    2,4-Cl.sub.2                   EtCCl(Me)CH.sub.2            Br    O  H    H    4-Cl                           EtCCl(Me)CH.sub.2            Br    O  H    H    4-I                            EtCCl(Me)CH.sub.2            I     O  H    H    4-Cl                           EtCCl(Me)CH.sub.2            I     O  H    H    4-I                            EtCCl(Me)CH.sub.2            F     O  H    H    4-Cl                           EtCCl(Me)CH.sub.2            Me    O  H    H    4-Cl                           EtCCl(Me)CH.sub.2            OMe   O  H    H    4-Cl                           EtCCl(Me)CH.sub.2            OMe   O  H    H    4-I                            EtCCl(Me)CH.sub.2            SMe   O  H    H    4-Cl                           EtCCl(Me)CH.sub.2            SMe   O  H    H    4-I                            EtCCl(Me)CH.sub.2            SO.sub.2 Me                                                                          O  H    H    4-Cl                           EtCCl(Me)CH.sub.2            Cl    O  H    Me   4-Cl                           EtCCl(Me)CH.sub.2            Cl    O  Cl   H    4-Cl                           EtCCl(Me)CH.sub.2            Cl    O  H    H    2,Cl, 4-Br                     EtCCl(Me)CH.sub.2            OBu   O  H    H    4-Cl                           EtCCl(Me)CH.sub.2            Cl    O  H    Et   4-Cl                           EtCCl(Me)CH.sub.2            Cl    O  H    H    4-Bu-s                         EtCCl(Me)CH.sub.2            Cl    O  H    H    3,4-Cl.sub.2                   EtCCl(Me)CH.sub.2            Cl    O  H    H    4-OCF.sub.3                    EtCCl(Me)CH.sub.2            Cl    O  H    H    2,4-F.sub.2                    EtCCl(Me)CH.sub.2            Cl    S  H    H    4-Cl                           EtCCl(Me)CH.sub.2            Cl    S  H    H    4-Bu-t                         EtCCl(Me)CH.sub.2            Cl    S  H    H    4-Me                           EtCCl(Me)CH.sub.2            Cl    S  H    H    4-OPr                          EtCCl(Me)CH.sub.2            Cl    S  H    H    4-CH.sub.2(C.sub.6                                                             H.sub.3 Cl.sub.2 -2,4)         EtCCl(Me)CH.sub.2            Cl    S  H    H    4-COC.sub.6 H.sub.4                                                            Cl-4'                          EtCCl(Me)CH.sub.2            Cl    S  H    H    4-OCH(Me)CH.sub.2 OEt          EtCBr(Me)CH.sub.2            Cl    O  H    H    4-Cl                           EtCBr(Me)CH.sub.2            Cl    O  H    H    4-Br                           EtCBr(Me)CH.sub.2            Cl    O  H    H    4-I                            EtCBr(Me)CH.sub.2            Cl    O  H    H    2,4-Cl.sub.2                   EtCBr(Me)CH.sub.2            Br    O  H    H    4-Cl                           EtCBr(Me)CH.sub.2            Br    O  H    H    4-I                            EtCBr(Me)CH.sub.2            I     O  H    H    4-Cl                           EtCBr(Me)CH.sub.2            I     O  H    H    4-I                            EtCBr(Me)CH.sub.2            F     O  H    H    4-Cl                           EtCBr(Me)CH.sub. 2           Me    O  H    H    4-Cl                           EtCBr(Me)CH.sub.2            OMe   O  H    H    4-Cl                           EtCBr(Me)CH.sub.2            SMe   O  H    H    4-Cl                           EtCBr(Me)CH.sub.2            Cl    O  H    Me   4-Cl                           EtCBr(Me)CH.sub.2            Br    O  H    Me   4-Cl                           EtCBr(Me)CH.sub.2            Cl    O  H    H    3-CF.sub.3                     EtCBr(Me)CH.sub.2            Cl    O  H    H    4-Ph                           EtCBr(Me)CH.sub.2            Cl    O  H    H    4-OCH.sub.2 CF.sub.3           EtCBr(Me)CH.sub.2            Cl    O  H    H    2,6-Cl.sub.2                   EtCBr(Me)CH.sub.2            Cl    S  H    H    4-Cl                           EtCBr(Me)CH.sub.2            Cl    S  H    H    4-Bu-t                         EtCBr(Me)CH.sub.2            Cl    S  H    H    4-OC.sub.10 H.sub.21           EtCBr(Me)CH.sub.2            Cl    S  H    H    4-C.sub.6 H.sub.4 F-4'         EtCBr(Me)CH.sub.2            Cl    S  H    H    4-CH.sub.2(C.sub.6                                                             H.sub.3 Cl.sub.2 -3,5)         Et.sub.2 CClCH.sub.2         Cl    O  H    H    4-Cl                           Et.sub.2 CClCH.sub.2         Cl    O  H    H    4-Br                           Et.sub.2 CClCH.sub.2         Cl    O  H    H    4-I                            Et.sub.2 CClCH.sub.2         Cl    O  H    H    2,4-Cl.sub.2                   Et.sub.2 CClCH.sub.2         Br    O  H    H    4-Cl                           Et.sub.2 CClCH.sub.2         Br    O  H    H    4-I                            Et.sub.2 CClCH.sub.2         I     O  H    H    4-Cl                           Et.sub.2 CClCH.sub.2         I     O  H    H    4-I                            Et.sub.2 CClCH.sub.2         F     O  H    H    4-Cl                           Et.sub.2 CClCH.sub.2         Me    O  H    H    4-Cl                           Et.sub.2 CClCH.sub.2         OMe   O  H    H    4-Cl                           Et.sub.2 CClCH.sub.2         OMe   O  H    H    4-I                            Et.sub.2 CClCH.sub.2         SMe   O  H    H    4-Cl                           Et.sub.2 CClCH.sub.2         Cl    O  H    H    4-OC.sub.10 H.sub.21           Et.sub.2 CClCH.sub.2         SO.sub.2 Me                                                                          O  H    H    4-Cl                           Et.sub.2 CClCH.sub.2         Cl    O  H    Me   4-Cl                           Et.sub.2 CClCH.sub.2         Cl    O  Cl   H    4-Cl                           Et.sub.2 CClCH.sub.2         F     O  H    H    4-I                            Et.sub.2 CClCH.sub.2         SMe   O  H    H    2,4-Cl.sub.2                   Et.sub.2 CClCH.sub.2         I     O  H    Me   4-Cl                           Et.sub.2 CClCH.sub.2         Cl    O  H    H    4-C.sub.6 H.sub.4 Cl-4'        Et.sub.2 CClCH.sub.2         Cl    O  H    H    4-CN                           Et.sub.2 CClCH.sub.2         Cl    O  H    H    4-OCH.sub.2 CH.sub.2NHCOOE                                                     t                              Et.sub.2 CClCH.sub.2         Cl    S  H    H    4-Cl                           Et.sub.2 CClCH.sub.2         Cl    S  H    H    4-Bu-t                         Et.sub.2 CClCH.sub.2         Cl    S  H    H    4-Hex                          Et.sub.2 CClCH.sub.2         Cl    S  H    H    4-OC(Me).sub.2 CH.sub.2                                                        OPr                            Et.sub.2 CClCH.sub.2         Cl    S  H    H    4-OCH.sub.2 CHCH.sub.2         Et.sub.2 CClCH.sub.2         Cl    S  H    H    4-CH.sub.2 CH.sub.2 Ph         Et.sub.2 CBrCH.sub.2         Cl    O  H    H    4-Cl                           Et.sub.2 CBrCH.sub.2         Cl    O  H    H    4-Br                           Et.sub.2 CBrCH.sub.2         Cl    O  H    H    4-I                            Et.sub.2 CBrCH.sub.2         Cl    O  H    H    2,4-Cl.sub.2                   Et.sub.2 CBrCH.sub.2         Br    O  H    H    4-Cl                           Et.sub.2 CBrCH.sub.2         I     O  H    H    4-Cl                           Et.sub.2 CBrCH.sub.2         H     O  H    H    4-Cl                           Et.sub.2 CBrCH.sub.2         H     O  H    H    4-I                            Et.sub.2 CBrCH.sub.2         F     O  H    H    4-Cl                           Et.sub.2 CBrCH.sub.2         Me    O  H    H    4-Cl                           Et.sub.2 CBrCH.sub.2         OMe   O  H    H    4-Cl                           Et.sub.2 CBrCH.sub.2         SMe   O  H    H    4-Cl                           Et.sub.2 CBrCH.sub.2         Me    O  H    H    4-Br                           Et.sub.2 CBrCH.sub.2         Cl    O  OH   H    4-Cl                           Et.sub.2 CBrCH.sub.2         Cl    O  H    H    4-Pr                           Et.sub.2 CBrCH.sub.2         Cl    O  H    H    2-Cl, 4-F                      Et.sub.2 CBrCH.sub.2         Cl    S  H    H    4-Cl                           Et.sub.2 CBrCH.sub.2         Cl    S  H    H    4-Bu-t                         Et.sub.2 CBrCH.sub.2         Cl    S  H    H    4-(Q4)                         Et.sub.2 CBrCH.sub.2         Cl    S  H    H    4-OCH.sub.2 CH.sub.2NHCOOE                                                     t                              t-BuCHBrCH.sub.2             Cl    O  H    H    4-Cl                           t-BuCHBrCH.sub.2             Cl    O  H    H    4-I                            t-BuCHBrCH.sub.2             Br    O  H    H    4-Cl                           t-BuCHBrCH.sub.2             I     O  H    H    4-Cl                           t-BuCHBrCH.sub.2             Cl    O  H    H    4-Cl                           t-BuCHBrCH.sub.2             Cl    O  H    H    4-I                            EtCHClCH(Me)                 Cl    O  H    H    4-Cl                           EtCHClCH(Me)                 Cl    O  H    H    4-I                            EtCHBrCH(Me)                 Cl    O  H    H    4-Cl                           EtCHBrCH(Me)                 Cl    O  H    H    4-I                            EtCHClCH(Et)                 Cl    O  H    H    4-Cl                           EtCHClCH(Et)                 Cl    O  H    H    4-I                            EtCHBrCH(Me)                 Cl    O  H    H    4-Cl                           EtCHBrCH(Et)                 Cl    O  H    H    4-I                            EtCHClCH(Pr)                 Cl    O  H    H    4-Cl                           EtCHClCH(Pr)                 Cl    O  H    H    4-I                            EtCHBrCH(Pr)                 Cl    O  H    H    4-Cl                           EtCHBrCH(Pr)                 Cl    O  H    H    4-I                            i-PrCHClCH.sub.2             Cl    O  H    H    4-Cl                           i-PrCHClCH.sub.2             Cl    O  H    H    4-I                            i-PrCHBrCH.sub.2             Cl    O  H    H    4-Cl                           i-PrCHBrCH.sub.2             Cl    O  H    H    4-I                            EtCHClC(Me).sub.2            Cl    O  H    H    4-Cl                           EtCHClC(Me).sub.2            Cl    O  H    H    4-I                            EtCHBrC(Me).sub.2            Cl    O  H    H    4-Cl                           EtCHBrC(Me).sub.2            Cl    O  H    H    4-I                            EtCCl(Me)CH(Me)              Cl    O  H    H    4-Cl                           EtCCl(Me)CH(Me)              Cl    O  H    H    4-I                            EtCBr(Me)CH(Me)              Cl    O  H    H    4-Cl                           EtCBr(Me)CH(Me)              Cl    O  H    H    4-I                            i-PrCHClCH(Me)               Cl    O  H    H    4-Cl                           i-PrCHClCH(Me)               Cl    O  H    H    4-I                            i-PrCHBrCH(Me)               Cl    O  H    H    4-Cl                           i-PrCHBrCH(Me)               Cl    O  H    H    4-I                            t-BuCCl(Me)CH.sub.2          Cl    O  H    H    4-Cl                           t-BuCCl(Me)CH.sub.2          Cl    O  H    H    4-Br                           t-BuCCl(Me)CH.sub.2          Cl    O  H    H    4-I                            t-BuCCl(Me)CH.sub.2          Br    O  H    H    4-Cl                           t-BuCCl(Me)CH.sub.2          Br    O  H    H    4-I                            t-BuCCl(Me)CH.sub.2          I     O  H    H    4-Cl                           t-BuCCl(Me)CH.sub.2          I     O  H    H    4-I                            t-BuCCl(Me)CH.sub.2          Cl    O  H    H    2,4-Cl.sub.2                   t-BuCCl(Me)CH.sub.2          F     O  H    H    4-Cl                           t-BuCCl(Me)CH.sub.2          Me    O  H    H    4-Cl                           t-BuCCl(Me)CH.sub.2          OMe   O  H    H    4-Cl                           t-BuCCl(Me)CH.sub.2          OMe   O  H    H    4-I                            t-BuCCl(Me)CH.sub.2          SMe   O  H    H    4-Cl                           t-BuCCl(Me)CH.sub.2          Me    O  H    H    4-I                            t-BuCCl(Me)CH.sub.2          Cl    O  H    H    2-F, 4-Cl                      t-BuCCl(Me)CH.sub.2          OEt   O  H    H    4-Cl                           t-BuCCl(Me)CH.sub.2          Cl    O  H    Me   4-I                            t-BuCCl(Me)CH.sub.2          Cl    O  H    H    4-Me                           t-BuCCl(Me)CH.sub.2          Cl    O  H    H    2,5-Me.sub.2                   t-BuCCl(Me)CH.sub.2          Cl    O  H    H    4-OCHF.sub.2                   t-BuCCl(Me)CH.sub.2          Cl    S  H    H    4-Cl                           t-BuCCl(Me)CH.sub.2          Cl    S  H    H    4-Bu-t                         t-BuCCl(Me)CH.sub.2          Cl    S  H    H    3-Me                           t-BuCCl(Me)CH.sub.2          Cl    S  H    H    4-SMe                          t-BuCCl(Me)CH.sub.2          Cl    S  H    H    4-I                            t-BuCCl(Me)CH.sub.2          Cl    S  H    H    4-SPr                          t-BuCBr(Me)CH.sub.2          Cl    O  H    H    4-Cl                           t-BuCBr(Me)CH.sub.2          Cl    O  H    H    4-Br                           t-BuCBr(Me)CH.sub.2          Cl    O  H    H    4-I                            t-BuCBr(Me)CH.sub.2          Br    O  H    H    4-Cl                           t-BuCBr(Me)CH.sub.2          Br    O  H    H    4-I                            t-BuCBr(Me)CH.sub.2          I     O  H    H    4-Cl                           t-BuCBr(Me)CH.sub.2          I     O  H    H    4-I                            t-BuCBr(Me)CH.sub.2          Cl    O  H    H    2,4-Cl.sub.2                   t-BuCCl(Me)CH.sub.2          F     O  H    H    4-Cl                           t-BuCBr(Me)CH.sub.2          Me    O  H    H    4-Cl                           t-BuCBr(Me)CH.sub.2          OMe   O  H    H    4-Cl                           t-BuCBr(Me)CH.sub.2          OMe   O  H    H    4-I                            t-BuCBr(Me)CH.sub.2          SMe   O  H    H    4-Cl                           t-BuCBr(Me)CH.sub.2          SMe   O  H    H    4-I                            t-BuCBr(Me)CH.sub.2          Cl    O  H    H    2,4-F.sub.2                    t-BuCBr(Me)CH.sub.2          OBu   O  H    H    4-Cl                           t-BuCBr(Me)CH.sub.2          Cl    O  H    Et   4-Cl                           t-BuCBr(Me)CH.sub.2          Cl    O  H    H    4-Bu-s                         t-BuCBr(Me)CH.sub.2          Cl    O  H    H    3,4-Cl.sub.2                   t-BuCBr(Me)CH.sub.2          Cl    O  H    H    4-OCF.sub.3                    t-BuCBr(Me)CH.sub.2          Cl    S  H    H    4-Cl                           t-BuCBr(Me)CH.sub.2          Cl    S  H    H    4-Bu-t                         t-BuCBr(Me)CH.sub.2          Cl    S  H    H    4-Me                           t-BuCBr(Me)CH.sub.2          Cl    S  H    H    4-COC.sub.7 H.sub.15           t-BuCBr(Me)CH.sub.2          Cl    S  H    H    4-SPh                          t-BuCHClC(Me).sub.2          Cl    O  H    H    4-Cl                           t-BuCHClC(Me).sub.2          Cl    O  H    H    4-I                            t-BuCHBrC(Me).sub.2          Cl    O  H    H    4-Cl                           t-BuCHBrC(Me).sub.2          Cl    O  H    H    4-I                            PrCHClCH.sub.2               Cl    O  H    H    4-Cl                           PrCHClCH.sub.2               Cl    O  H    H    4-I                            PrCHBrCH.sub.2               Cl    O  H    H    4-Cl                           PrCHBrCH.sub.2               Cl    O  H    H    4-I                            PrCHClCH(Me)                 Cl    O  H    H    4-Cl                           PrCHClCH(Me)                 Cl    O  H    H    4-I                            PrCHBrCH(Me)                 Cl    O  H    H    4-Cl                           PrCHBrCH(Me)                 Cl    O  H    H    4-I                            PrCHClCH(Et)                 Cl    O  H    H    4-Cl                           PrCHClCH(Et)                 Cl    O  H    H    4-I                            PrCHBrCH(Et)                 Cl    O  H    H    4-Cl                           PrCHBrCH(Et)                 Cl    O  H    H    4-I                            PrCHClCH(Pr)                 Cl    O  H    H    4-Cl                           PrCHClCH(Pr)                 Cl    O  H    H    4-I                            PrCHBrCH(Pr)                 Cl    O  H    H    4-Cl                           PrCHBrCH(Pr)                 Cl    O  H    H    4-I                            PrCCl(Me)CH.sub.2            Cl    O  H    H    4-Cl                           PrCCl(Me)CH.sub.2            Cl    O  H    H    4-Br                           PrCCl(Me)CH.sub.2            Cl    O  H    H    4-I                            PrCCl(Me)CH.sub.2            Cl    O  H    H    2,4-Cl.sub.2                   PrCCl(Me)CH.sub.2            Br    O  H    H    4-Cl                           PrCCl(Me)CH.sub.2            Br    O  H    H    4-I                            PrCCl(Me)CH.sub.2            I     O  H    H    4-Cl                           PrCCl(Me)CH.sub.2            I     O  H    H    4-I                            PrCCl(Me)CH.sub.2            F     O  H    H    4-Cl                           PrCCl(Me)CH.sub.2            Me    O  H    H    4-Cl                           PrCCl(Me)CH.sub.2            OMe   O  H    H    4-Cl                           PrCCl(Me)CH.sub.2            OMe   O  H    H    4-I                            PrCCl(Me)CH.sub.2            SMe   O  H    H    4-Cl                           PrCCl(Me)CH.sub. 2           SMe   O  H    H    4-I                            PrCCl(Me)CH.sub.2            Cl    O  H    H    2-F, 4-Cl                      PrCCl(Me)CH.sub.2            Cl    O  H    H    4-F                            PrCCl(Me)CH.sub.2            Cl    O  H    H    4-Br                           PrCCl(Me)CH.sub.2            Cl    O  H    H    4-CF.sub.3                     PrCCl(Me)CH.sub.2            Cl    O  H    H    4-Me                           PrCCl(Me)CH.sub.2            Cl    O  H    H    4-Ph                           PrCCl(Me)CH.sub.2            Cl    O  H    H    4-O(C.sub.6 H.sub.3 Cl-2,                                                      CF.sub.3 -4)                   PrCCl(Me)CH.sub.2            Cl    O  H    H    4-COC.sub.6 H.sub.4                                                            Cl-4'                          PrCCl(Me)CH.sub.2            Cl    O  H    H    4-OCH.sub.2 C.sub.6                                                            H.sub.4 Cl-4'                  PrCCl(Me)CH.sub.2            Cl    O  H    H    4-SMe                          PrCCl(Me)CH.sub.2            Cl    S  H    H    4-Cl                           PrCCl(Me)CH.sub.2            Cl    S  H    H    4-Bu-t                         PrCCl(Me)CH.sub.2            Cl    S  H    H    4-F                            PrCCl(Me)CH.sub.2            Cl    S  H    H    4-OCH.sub.2 C(Me)CH.sub.2      PrCCl(Me)CH.sub.2            Cl    S  H    H    4-CH.sub.2 -Q4                 PrCCl(Me)CH.sub.2            Cl    S  H    H    4-C(Me).sub.2 Et               PrCCl(Me)CH.sub.2            Cl    S  H    H    4-CF.sub.3                     BuCBr(Me)CH.sub.2            Cl    O  H    H    4-Cl                           BuCBr(Me)CH.sub.2            Cl    O  H    H    4-Br                           BuCBr(Me)CH.sub.2            Cl    O  H    H    4-I                            BuCBr(Me)CH.sub.2            Cl    O  H    H    2,4-Cl.sub.2                   BuCBr(Me)CH.sub.2            Br    O  H    H    4-Cl                           BuCBr(Me)CH.sub.2            Br    O  H    H    4-I                            BuCBr(Me)CH.sub.2            I     O  H    H    4-Cl                           BuCBr(Me)CH.sub.2            I     O  H    H    4-I                            BuCBr(Me)CH.sub.2            F     O  H    H    4-Cl                           BuCBr(Me)CH.sub.2            Me    O  H    H    4-Cl                           BuCBr(Me)CH.sub.2            OMe   O  H    H    4-Cl                           BuCBr(Me)CH.sub.2            OMe   O  H    H    4-I                            BuCBr(Me)CH.sub.2            SMe   O  H    H    4-Cl                           BuCBr(Me)CH.sub.2            SMe   O  H    H    4-I                            BuCBr(Me)CH.sub.2            SO.sub.2 Me                                                                          O  H    H    4-Cl                           BuCBr(Me)CH.sub.2            Cl    O  H    Me   4-Cl                           BuCBr(Me)CH.sub.2            Cl    O  Cl   H    4-Cl                           BuCBr(Me)CH.sub.2            Pr    O  H    H    4-Cl                           BuCBr(Me)CH.sub.2            SEt   O  H    H    4-I                            BuCBr(Me)CH.sub.2            Br    O  Cl   H    4-Cl                           BuCBr(Me)CH.sub.2            Cl    O  H    H    3-Cl                           BuCBr(Me)CH.sub.2            Cl    O  H    H    2,3,4,5,6-F.sub.5              BuCBr(Me)CH.sub.2            Cl    O  H    H    4-OHex                         BuCBr(Me)CH.sub.2            Cl    O  H    H    2,6-Cl.sub.2, 4-F              BuCBr(Me)CH.sub.2            Cl    S  H    H    4-Cl                           BuCBr(Me)CH.sub.2            Cl    S  H    H    4-Bu-t                         BuCBr(Me)CH.sub.2            Cl    S  H    H    4-O(CH.sub.2).sub.3 OMe        BuCBr(Me)CH.sub.2            Cl    S  H    H    4-OCH.sub.2 C.sub.6                                                            H.sub.4 CF.sub.3 -4'           BuCBr(Me)CH.sub.2            Cl    S  H    H    4-Et                           BuCBr(Me)CH.sub.2            Cl    S  H    H    4-C(Me).sub.2 CH.sub.2                                                         OH                             BuCBr(Me)CH.sub.2            Cl    S  H    H    4-COC.sub.9 H.sub.19           BuCBr(Me)CH.sub. 2           Bu    O  H    H    4-Cl                           BuCBr(Me)CH.sub.2            Cl    O  H    H    4-OBu-s                        BuCBr(Me)CH.sub.2            Cl    O  H    H    2-Me, 4-Cl                     BuCBr(Me)CH.sub.2            Cl    S  H    H    4-Cl                           BuCBr(Me)CH.sub.2            Cl    S  H    H    4-Bu-t                         BuCBr(Me)CH.sub.2            Cl    S  H    H    4-Ph                           BuCBr(Me)CH.sub.2            Cl    S  H    H    4-C(Me).sub.2 CH.sub.2                                                         OCOMe                          BuCBr(Me)CH.sub.2            Cl    S  H    H    4-SBu                          PrCH(Me)CHClCH.sub.2         Cl    O  H    H    4-Cl                           PrCH(Me)CHClCH.sub.2         Cl    O  H    H    4-I                            PrCH(Me)CHBrCH.sub.2         Cl    O  H    H    4-Cl                           PrCH(Me)CHBrCH.sub.2         Cl    O  H    H    4-I                            BuCHClCH.sub.2               Cl    O  H    H    4-Cl                           BuCHClCH.sub.2               Cl    O  H    H    4-I                            BuCHClCH.sub.2               Br    O  H    h    4-Cl                           BuCHClCH.sub.2               I     O  H    h    4-Cl                           BuCHBrCH.sub.2               Cl    O  H    H    4-Cl                           BuCHBrCH.sub.2               Cl    O  H    H    4-I                            BuCHBrCH.sub.2               Br    O  H    H    4-Cl                           BuCHBrCH.sub.2               I     O  H    H    4-Cl                           PenCHClCH.sub.2              Cl    O  H    H    4-Cl                           PenCHClCH.sub.2              Cl    O  H    H    4-I                            PenCHBrCH.sub.2              Cl    O  H    H    4-Cl                           PenCHBrCH.sub.2              Cl    O  H    H    4-I                            PenCHClCH(Me)                Cl    O  H    H    4-Cl                           PenCHClCH(Me)                Cl    O  H    H    4-I                            PenCHBrCH(Me)                Cl    O  H    H    4-Cl                           PenCHBrCH(Me)                Cl    O  H    H    4-I                            PenCCl(Me)CH.sub.2           Cl    O  H    H    4-Cl                           PenCCl(Me)CH.sub.2           Cl    O  H    H    4-I                            PenCCl(Me)CH.sub.2           I     O  H    H    4-Cl                           PenCBr(Me)CH.sub.2           Cl    O  H    H    4-Cl                           PenCBr(Me)CH.sub.2           Cl    O  H    H    4-I                            PenCBr(Me)CH.sub.2           I     O  H    H    4-I                            HexCHClCH.sub.2              Cl    O  H    H    4-Cl                           HexCHClCH.sub.2              Cl    O  H    H    4-I                            BuCCl(Me)CH.sub.2            Br    O  H    H    4-I                            BuCCl(Me)CH.sub.2            I     O  H    H    4-Cl                           BuCCl(Me)CH.sub.2            I     O  H    H    4-I                            BuCCl(Me)CH.sub.2            F     O  H    H    4-Cl                           BuCCl(Me)CH.sub.2            Me    O  H    H    4-Cl                           BuCCl(Me)CH.sub.2            OMe   O  H    H    4-Cl                           BuCCl(Me)CH.sub.2            OMe   O  H    H    4-I                            BuCCl(Me)CH.sub.2            SMe   O  H    H    4-Cl                           BuCCl(Me)CH.sub.2            SMe   O  H    H    4-I                            BuCCl(Me)CH.sub.2            SO.sub.2 Me                                                                          O  H    H    4-Cl                           BuCCl(Me)CH.sub.2            Cl    O  H    Me   4-Cl                           BuCCl(Me)CH.sub.2            Cl    O  Cl   H    4-Cl                           BuCCl(Me)CH.sub.2            Pr-i  O  H    H    4-Cl                           BuCCl(Me)CH.sub.2            SPr   O  H    H    4-Cl                           BuCCl(Me)CH.sub.2            Br    O  OMe  H    4-Cl                           BuCCl(Me)CH.sub.2            Cl    O  H    H    4-Bu                           BuCCl(Me)CH.sub.2            Cl    O  H    H    4-F                            BuCCl(Me)CH.sub.2            Cl    O  H    H    2-OMe, 4-Cl                    BuCCl(Me)CH.sub.2            Cl    S  H    H    4-Cl                           BuCCl(Me)CH.sub.2            Cl    S  H    H    4-Bu-t                         BuCCl(Me)CH.sub.2            Cl    S  H    H    4-CF.sub.3                     BuCCl(Me)CH.sub.2            Cl    S  H    H    4-OCH.sub.2 C.sub.6                                                            H.sub.4 Cl-'                   BuCCl(Me)CH.sub.2            Cl    S  H    H    4-C(Me).sub.2 CH.sub.2                                                         OMe                            BuCCl(Me)CH.sub.2            Cl    S  H    H    4-OCH.sub.2 CHCHMe             BuCBr(Me)CH.sub.2            Cl    O  H    H    4-Cl                           BuCBr(Me)CH.sub.2            Cl    O  H    H    4-Br                           BuCBr(Me)CH.sub.2            Cl    O  H    H    4-I                            BuCBr(Me)CH.sub.2            Cl    O  H    H    2,4-Cl.sub.2                   BuCBr(Me)CH.sub.2            Br    O  H    H    4-Cl                           BuCBr(Me)CH.sub.2            Br    O  H    H    4-I                            BuCBr(Me)CH.sub.2            I     O  H    H    4-Cl                           BuCBr(Me)CH.sub.2            I     O  H    H    4-I                            BuCBr(Me)CH.sub.2            F     O  H    H    4-Cl                           BuCBr(Me)CH.sub.2            Me    O  H    H    4-Cl                           BuCBr(Me)CH.sub.2            OMe   O  H    H    4-Cl                           BuCBr(Me)CH.sub.2            SMe   O  H    H    4-Cl                           i-PrCBr(Me)CH.sub.2          Me    O  H    H    4-Cl                           i-PrCBr(Me)CH.sub.2          OMe   O  H    H    4-Cl                           i-PrCBr(Me)CH.sub.2          OMe   O  H    H    4-I                            i-PrCBr(Me)CH.sub.2          SMe   O  H    H    4-Cl                           i-PrCBr(Me)CH.sub.2          SMe   O  H    H    4-I                            i-PrCBr(Me)CH.sub.2          SO.sub.2 Me                                                                          O  H    H    4-Cl                           i-PrCBr(Me)CH.sub.2          F     O  H    H    4-I                            i-PrCBr(Me)CH.sub.2          SMe   O  H    H    2,4-Cl.sub.2                   i-PrCBr(Me)CH.sub.2          Cl    O  H    H    4-OMe                          i-PrCBr(Me)CH.sub.2          Cl    O  H    H    4-C.sub.6 H.sub.4 Cl-4'        i-PrCBr(Me)CH.sub.2          Cl    O  H    H    4-CN                           i-PrCBr(Me)CH.sub.2          Cl    S  H    H    4-Cl                           i-PrCBr(Me)CH.sub.2          Cl    S  H    H    4-Bu-t                         i-PrCBr(Me)CH.sub.2          Cl    S  H    H    4-CH.sub.2 Ph                  i-PrCBr(Me)CH.sub.2          Cl    S  H    H    4-C(Me).sub.2 CN               i-BuCHClCH.sub.2             Cl    O  H    H    4-Cl                           i-BuCHClCH.sub.2             Cl    O  H    H    4-I                            i-BuCHBrCH.sub.2             Cl    O  H    H    4-Cl                           i-BuCHBrCH.sub.2             Cl    O  H    H    4-I                            s-BuCHClCH.sub.2             Cl    O  H    H    4-Cl                           s-BuCHClCH.sub.2             Cl    O  H    H    4-I                            s-BuCHBrCH.sub.2             Cl    O  H    H    4-Cl                           s-BuCHBrCH.sub.2             Cl    O  H    H    4-I                            t-BuCH.sub.2 CCl(Me)CH.sub.2 Cl    O  H    H    4-Cl                           t-BuCH.sub.2 CCl(Me)CH.sub.2 Cl    O  H    H    4-I                            t-BuCH.sub.2 CBr(Me)CH.sub.2 Cl    O  H    H    4-Cl                           t-BuCH.sub.2 CBr(Me)CH.sub.2 Cl    O  H    H    4-I                            BuCHClCH(Me)                 Cl    O  H    H    4-Cl                           BuCHClCH(Me)                 Cl    O  H    H    4-I                            BuCHBrCH(Me)                 Cl    O  H    H    4-Cl                           BuCHBrCH(Me)                 Cl    O  H    H    4-I                            BuCCl(Me)CH.sub.2            Cl    O  H    H    4-Cl                           BuCCl(Me)CH.sub.2            Cl    O  H    H    4-Br                           BuCCl(Me)CH.sub.2            Cl    O  H    H    4-I                            BuCCl(Me)CH.sub.2            Cl    O  H    H    2,4-Cl.sub.2                   BuCCl(Me)CH.sub.2            Br    O  H    H    4-Cl                           i-PrCCl(Me)CH.sub.2          Cl    O  H    H    4-Cl                           i-PrCCl(Me)CH.sub. 2         Cl    O  H    H    4-Br                           i-PrCCl(Me)CH.sub.2          Cl    O  H    H    4-I                            i-PrCCl(Me)CH.sub.2          Cl    O  H    H    2,4-Cl.sub.2                   i-PrCCl(Me)CH.sub.2          Br    O  H    H    4-Cl                           i-PrCCl(Me)CH.sub.2          Br    O  H    H    4-I                            i-PrCCl(Me)CH.sub.2          I     O  H    H    4-Cl                           i-PrCCl(Me)CH.sub.2          I     O  H    H    4-I                            i-PrCCl(Me)CH.sub.2          F     O  H    H    4-Cl                           i-PrCCl(Me)CH.sub.2          Me    O  H    H    4-Cl                           i-PrCCl(Me)CH.sub.2          OMe   O  H    H    4-Cl                           i-PrCCl(Me)CH.sub.2          OMe   O  H    H    4-I                            i-PrCCl(Me)CH.sub.2          SMe   O  H    H    4-Cl                           i-PrCCl(Me)CH.sub.2          SMe   O  H    H    4-I                            i-PrCCl(Me)CH.sub.2          SO.sub.2 Me                                                                          O  H    H    4-Cl                           i-PrCCl(Me)CH.sub.2          Cl    O  H    Me   4-Cl                           i-PrCCl(Me)CH.sub.2          Cl    O  Cl   H    4-Cl                           i-PrCCl(Me)CH.sub.2          Cl    O  H    H    2-Cl, 4-I                      i-PrCCl(Me)CH.sub.2          Cl    O  H    H    4-Ph                           i-PrCCl(Me)CH.sub.2          Cl    O  H    H    4-OCH.sub.2 CF.sub.3           i-PrCCl(Me)CH.sub.2          Cl    O  H    H    2,6-Cl.sub.2                   i-PrCCl(Me)CH.sub.2          Cl    S  H    H    4-Cl                           i-PrCCl(Me)CH.sub.2          Cl    S  H    H    4-Bu-t                         i-PrCCl(Me)CH.sub.2          Cl    S  H    H    4-Et                           i-PrCCl(Me)CH.sub.2          Cl    S  H    H    4-COOEt                        i-PrCCl(Me)CH.sub.2          Cl    S  H    H    4-C.sub.6 H.sub.4 F-4'         i-PrCCl(Me)CH.sub.2          Cl    S  H    H    4-COPh                         i-PrCBr(Me)CH.sub.2          Cl    O  H    H    4-Cl                           i-PrCBr(Me)CH.sub.2          Cl    O  H    H    4-Br                           i-PrCBr(Me)CH.sub.2          Cl    O  H    H    4-I                            i-PrCBr(Me)CH.sub.2          Cl    O  H    H    2,4-Cl.sub.2                   i-PrCBr(Me)CH.sub.2          Br    O  H    H    4-Cl                           i-PrCBr(Me)CH.sub.2          Br    O  H    H    4-I                            i-PrCBr(Me)CH.sub.2          I     O  H    H    4-Cl                           i-PrCBr(Me)CH.sub.2          I     O  H    H    4-I                            i-PrCBr(Me)CH.sub.2          F     O  H    H    4-Cl                           HexCHBrCH.sub.2              Cl    O  H    H    4-Cl                           HexCHBrCH.sub.2              Cl    O  H    H    4-I                            i-BuCCl(Me)CH.sub.2          Cl    O  H    H    4-Cl                           i-BuCCl(Me)CH.sub.2          Cl    O  H    H    4-Br                           i-BuCCl(Me)CH.sub.2          Cl    O  H    H    4-I                            i-BuCCl(Me)CH.sub.2          Cl    O  H    H    2,4-Cl.sub.2                   i-BuCCl(Me)CH.sub.2          Br    O  H    H    4-Cl                           i-BuCCl(Me)CH.sub.2          I     O  H    H    4-Cl                           i-BuCCl(Me)CH.sub.2          I     O  H    H    4-I                            i-BuCCl(Me)CH.sub.2          Me    O  H    H    4-Cl                           i-BuCCl(Me)CH.sub.2          OMe   O  H    H    4-Cl                           i-BuCCl(Me)CH.sub.2          Sme   O  H    H    4-Cl                           i-BuCCl(Me)CH.sub.2          F     O  H    H    4-Cl                           i-BuCCl(Me)CH.sub.2          Cl    O  H    H    2-F,4-Cl                       i-BuCCl(Me)CH.sub.2          Cl    O  H    H    4-OCH.sub.2 CH(Me)O-Q17        i-BuCCl(Me)CH.sub.2          Cl    S  H    H    4-Cl                           i-BuCCl(Me)CH.sub.2          Cl    S  H    H    4-Bu-t                         i-BuCCl(Me)CH.sub.2          Cl    S  H    H    4-(Q4)                         i-BuCCl(Me)CH.sub.2          Cl    S  H    H    4-OC(Me).sub.2 CH.sub.2                                                        OMe                            i-BuCBr(Me)CH.sub. 2         C1    O  H    H    4-Cl                           i-BuCBr(Me)CH.sub.2          Cl    O  H    H    4-Br                           i-BuCBr(Me)CH.sub.2          Cl    O  H    H    4-I                            i-BuCBr(Me)CH.sub.2          Cl    O  H    H    2,4-Cl.sub.2                   i-BuCBr(Me)CH.sub.2          Br    O  H    H    4-Cl                           i-BuCBr(Me)CH.sub.2          I     O  H    H    4-Cl                           i-BuCBr(Me)CH.sub.2          Cl    S  H    H    4-Cl                           i-BuCBr(Me)CH.sub.2          Cl    S  H    H    4-O(CH.sub.2).sub.3 CCCl       C.sub.8 H.sub.17 CHClCH.sub.2                                                                               Cl    O  H    H    4-Cl                           Me.sub.2 C(OMe)(CH.sub.2).sub.3 C(Me)CHCHCl                                                                 Cl    O  H    H    4-Cl                           Me.sub.2 C(OMe)(CH.sub.2).sub.3 CCl(Me)CHClCH.sub.2                                                         Cl    O  H    H    4-Cl                           C.sub.14 H.sub.29 CHClCH.sub.2                                                                              Cl    O  H    H    4-Cl                           Me.sub.2 CCHCH.sub.2 CH.sub.2 CCl(Me)CHClCH.sub.2                                                           Cl    O  H    H    4-Cl                           EtCHC(Me)CH.sub.2 CH.sub.2 CHClC(Me).sub.2                                                                  Cl    O  H    H    4-Cl                           HCC(CH.sub.2).sub.10 CHClCH.sub.2                                                                           Cl    O  H    H    4-Cl                           s-BuCCl(Me)CH.sub.2          Cl    O  H    H    4-Cl                           s-BuCCl(Me)CH.sub.2          Cl    O  H    H    4-Br                           s-BuCCl(Me)CH.sub.2          Cl    O  H    H    4-I                            s-BuCCl(Me)CH.sub.2          Cl    O  H    H    2,4-Cl.sub.2                   s-BuCCl(Me)CH.sub.2          Br    O  H    H    4-Cl                           s-BuCCl(Me)CH.sub.2          I     O  H    H    4-Cl                           s-BuCCl(Me)CH.sub.2          I     O  H    H    4-I                            s-BuCCl(Me)CH.sub.2          Me    O  H    H    4-Cl                           s-BuCCl(Me)CH.sub.2          OMe   O  H    H    4-Cl                           s-BuCCl(Me)CH.sub.2          SMe   O  H    H    4-Cl                           s-BuCCl(Me)CH.sub.2          F     O  H    H    4-Cl                           s-BuCCl(Me)CH.sub.2          Cl    O  H    H    2-F, 4-Cl                      s-BuCCl(Me)CH.sub.2          Cl    O  H    H    4-O(CH.sub.2).sub.3 CCCl       s-BuCCl(Me)CH.sub.2          Cl    S  H    H    4-Cl                           s-BuCCl(Me)CH.sub.2          Cl    S  H    H    4-Bu-t                         s-BuCCl(Me)CH.sub.2          Cl    S  H    H    4-Et                           s-BuCCl(Me)CH.sub.2          Cl    S  H    H    4-OCH.sub.2 CH(Me)O-Q17        s-BuCBr(Me)CH.sub.2          Cl    O  H    H    4-Cl                           s-BuCBr(Me)CH.sub.2          Cl    O  H    H    4-Br                           s-BuCBr(Me)CH.sub.2          Cl    O  H    H    4-I                            s-BuCBr(Me)CH.sub.2          Cl    O  H    H    2,4-Cl.sub.2                   s-BuCBr(Me)CH.sub.2          Br    O  H    H    4-Cl                           s-BuCBr(Me)CH.sub.2          I     O  H    H    4-Cl                           s-BuCBr(Me)CH.sub.2          Cl    O  H    H    4-Bu-t                         s-BuCBr(Me)CH.sub.2          Cl    S  H    H    4-Cl                           s-BuCBr(Me)CH.sub.2          Cl    S  H    H    4-Bu-t                         MeCHCH(CH.sub.2).sub.7 CHClCH.sub.2                                                                         Cl    O  H    H    4-Cl                           (3,3-Me.sub.2 -Q21)CH.sub.2 CH.sub.2 C(Me)CHCH.sub.2 CCl(Me)CH.sub.2                                        Cl    O  H    H    4-Cl                           Me.sub.2 C(OMe)(CH.sub.2).sub. 3 CH(Me)CH.sub.2 CHCHCCl(Me)CH.sub.2                                         Cl    O  H    H    4-Cl                           CH.sub.2CH(CH.sub.2).sub.12 CHClCH.sub.2                                                                    Cl    O  H    H    4-Cl                           MeCC(CH.sub.2).sub.3 CHClCH.sub.2                                                                           Cl    O  H    H    4-Cl                           s-BuCBr(Me)CH.sub.2          Cl    S  H    H    4-OC(Me).sub.2 CH.sub.2                                                        OEt                            ClCHCH                       Cl    O  H    H    4-Cl                           ClCHCH                       Cl    O  H    H    4-I                            BrCHCH                       Cl    O  H    H    4-Cl                           BrCHCH                       Cl    O  H    H    4-I                            CH.sub.2C(Cl)                Cl    O  H    H    4-Cl                           CH.sub.2C(Cl)                Cl    O  H    H    4-I                            CH.sub.2C(Br)                Cl    O  H    H    4-Cl                           CH.sub.2C(Br)                Cl    O  H    H    4-I                            CH.sub.2C(CH.sub.2 Cl)       Cl    O  H    H    4-Cl                           CH.sub.2C(CH.sub.2 Cl)       Cl    O  H    H    4-I                            CH.sub.2C(CH.sub.2 Br)       Cl    O  H    H    4-Cl                           Me.sub.2 CC(CH.sub.2 Cl)     Cl    O  H    H    4-Cl                           Me.sub.2 CC(CH.sub.2 Cl)     Cl    O  H    H    4-I                            CH.sub.2C(Cl)CH.sub.2        Cl    O  H    H    4-Cl                           CH.sub.2C(Cl)CH.sub.2        Cl    O  H    H    4-I                            CH.sub.2C(Br)CH.sub.2        Cl    O  H    H    4-Cl                           Me.sub.2 CC(Cl)CH.sub.2      Cl    O  H    H    4-Cl                           Me.sub.2 CC(Cl)CH.sub.2      Cl    O  H    H    4-I                            Me.sub.2 CC(Br)CH.sub.2      Cl    O  H    H    4-Cl                           Me.sub.2 CC(Br)CH.sub.2      Cl    O  H    H    4-I                            CH.sub.2CHCH(Me)CHClCH.sub.2 Cl    O  H    H    4-Cl                           CH.sub.2CHCH(Me)CHClCH.sub.2 Cl    O  H    H    4-I                            CH.sub.2CHCH(Me)CHBrCH.sub.2 Cl    O  H    H    4-Cl                           CH.sub.2CHCH(Me)CHBrCH.sub.2 Cl    O  H    H    4-I                            CH.sub.2CHCH.sub.2 CCl(Me)CH.sub.2                                                                          Cl    O  H    H    4-Cl                           CH.sub.2CHCH.sub.2 CCl(Me)CH.sub.2                                                                          Cl    O  H    H    4-I                            CH.sub.2CHCH.sub.2 CBr(Me)CH.sub.2                                                                          Cl    O  H    H    4-Cl                           CH.sub.2CHCH.sub.2 CBr(Me)CH.sub.2                                                                          Cl    O  H    H    4-I                            CH.sub.2C(Me)CH.sub.2 CHClCH.sub.2                                                                          Cl    O  H    H    4-Cl                           CH.sub.2C(Me)CH.sub.2 CHClCH.sub.2                                                                          Cl    O  H    H    4-I                            CH.sub.2C(Me)CH.sub.2 CHBrCH.sub.2                                                                          Cl    O  H    H    4-Cl                           CH.sub.2C(Me)CH.sub.2 CH.sub.2 CCl(Me)CH.sub.2                                                              Cl    O  H    H    4-Cl                           CH.sub.2C(Me)CH.sub.2 CH.sub.2 CCl(Me)CH.sub.2                                                              Cl    O  H    H    4-I                            CH.sub.2C(Me)CH.sub.2 CH.sub.2 CBr(Me)CH.sub.2                                                              Cl    O  H    H    4-Cl                           CH.sub.2CHCH.sub.2 CH.sub.2 CHClCH.sub.2                                                                    Cl    O  H    H    4-Cl                           CH.sub.2CHCH.sub.2 CH.sub.2 CHClCH.sub.2                                                                    Cl    O  H    H    4-I                            CH.sub.2CHCH.sub.2 CH.sub.2 CHBrCH.sub.2                                                                    Cl    O  H    H    4-Cl                           CH.sub.2CHCH.sub.2 CH.sub.2 CCl(Me)CH.sub.2                                                                 Cl    O  H    H    4-Cl                           CH.sub.2CHCH.sub.2 CH.sub.2 CCl(Me)CH.sub.2                                                                 Cl    O  H    H    4-I                            CH.sub.2CHCH.sub.2 CH.sub.2 CBr(Me)CH.sub.2                                                                 Cl    O  H    H    4-Cl                           CH.sub.2C(Me)CH.sub.2 CH.sub.2 CHClCH.sub.2                                                                 Cl    O  H    H    4-Cl                           CH.sub.2C(Me)CH.sub.2 CH.sub.2 CHClCH.sub.2                                                                 Cl    O  H    H    4-I                            CH.sub.2C(Me)CH.sub.2 CH.sub.2 CHBrCH.sub.2                                                                 Cl    O  H    H    4-Cl                           CH.sub.2CHCH(Me)CH.sub.2 CHClCH.sub.2                                                                       Cl    O  H    H    4-Cl                           CH.sub.2CHCH(Me)CH.sub.2 CHClCH.sub.2                                                                       Cl    O  H    H    4-I                            CH.sub.2CHCH.sub.2 CH(Me)CHClCH.sub.2                                                                       Cl    O  H    H    4-Cl                           CH.sub.2CHCH.sub.2 CH(Me)CHClCH.sub.2                                                                       Cl    O  H    H    4-I                            CH.sub.2CHCH.sub.2 CH(Me)CHBrCH.sub.2                                                                       Cl    O  H    H    4-Cl                           CH.sub.2CHCH.sub.2 CH(Me)CHBrCH.sub.2                                                                       Cl    O  H    H    4-I                            MeCHCHCH.sub.2 CHClCH.sub.2  Cl    O  H    H    4-Cl                           MeCHCHCH.sub.2 CHClCH.sub.2  Cl    O  H    H    4-I                            MeCHCHCH.sub.2 CHBrCH.sub. 2 Cl    O  H    H    4-Cl                           MeCHCHCH.sub.2 CHBrCH.sub.2  Cl    O  H    H    4-I                            CH.sub.2CH(CH.sub.2).sub.3 CHClCH.sub.2                                                                     Cl    O  H    H    4-Cl                           CH.sub.2CH(CH.sub.2).sub.3 CHClCH.sub.2                                                                     Cl    O  H    H    4-I                            CH.sub.2CH(CH.sub.2).sub.3 CHBrCH.sub.2                                                                     Cl    O  H    H    4-Cl                           CH.sub.2CH(CH.sub.2).sub.3 CHBrCH.sub.2                                                                     Cl    O  H    H    4-I                            CH.sub.2Ch(CH.sub.2).sub.4 CHClCH.sub.2                                                                     Cl    O  H    H    4-Cl                           CH.sub.2CH(CH.sub.2).sub.2 CHClCH.sub.2                                                                     Cl    O  H    H    4-I                            CH.sub.2CH(CH.sub.2).sub.4 CHClCH.sub.2                                                                     Br    O  H    H    4-Cl                           CH.sub.2CH(CH.sub.2).sub.4 CHClCH.sub.2                                                                     I     O  H    H    4-I                            Ch.sub.2CH(CH.sub.2).sub.4 CHBrCH.sub.2                                                                     Cl    O  H    H    4-Cl                           CH.sub.2CH(CH.sub.2).sub.4 CHBrCH.sub.2                                                                     Cl    O  H    H    4-I                            CH.sub.2C(Cl)CH.sub.2        Cl    O  H    H    4-Cl                           CH.sub.2C(Cl)CH.sub.2        Cl    O  H    H    4-I                            CH.sub.2C(Cl)CH.sub.2        Br    O  H    H    4-Cl                           CH.sub.2C(Cl)CH.sub.2        I     O  H    H    4-i                            Ch.sub.2C(CH.sub.2 Cl)CH.sub.2                                                                              Cl    O  H    H    4-Cl                           CH.sub.2C(CH.sub.2 Cl)CH.sub.2                                                                              Cl    O  H    H    4-I                            CH.sub.2C(CH.sub.2 Cl)CH.sub.2                                                                              Br    O  H    H    4-Cl                           Ch.sub.2C(CH.sub.2 Cl)CH.sub.2                                                                              I     O  H    H    4-I                            ClCHCHCH.sub.2               Cl    O  H    H    4-Cl                           ClCHCHCH.sub.2               Cl    O  H    H    4-I                            ClCHCHCH.sub.2               Br    O  H    H    4-Cl                           ClCHCHCH.sub.2               I     O  H    H    4-Cl                           BrCHCHCH.sub.2               Cl    O  H    H    4-Cl                           BrCHCHCH.sub.2               Cl    O  H    H    4-I                            ClCHC(Cl)CH.sub.2            Cl    O  H    H    4-Cl                           ClCHC(Cl)CH.sub.2            Cl    O  H    H    4-I                            ClCHC(C1)CH.sub.2            Br    O  H    H    4-Cl                           ClCHC(Cl)CH.sub.2            I     O  H    H    4-Cl                           BrCHC(Br)CH.sub.2            Cl    O  H    H    4-Cl                           BrCHC(Br)CH.sub.2            Cl    O  H    H    4-I                            ClCH.sub.2 CHCHCH.sub.2      Cl    O  H    H    4-Cl                           ClCH.sub.2 CHCHCH.sub.2      Cl    O  H    H    4-I                            ClCH.sub.2 CHCHCH.sub.2      Br    O  H    H    4-Cl                           ClCH.sub.2 CHCHCH.sub.2      I     O  H    H    4-Cl                           BrCN.sub.2 CNCHCH.sub.2      Cl    O  H    H    4-Cl                           BrCN.sub.2 CHCHCH.sub.2      Cl    O  H    H    4-I                            BrCH.sub.2 CHCHCH.sub.2      Br    O  H    H    4-Cl                           BrCH.sub.2 CHCHCH.sub.2      I     O  H    H    4-Cl                           MeC(Cl)CHCH.sub.2            Cl    O  H    H    4-Cl                           MeC(Cl)CHCH.sub.2            Cl    O  H    H    4-I                            MeC(Cl)CHCH.sub.2            Br    O  H    H    4-Cl                           MeC(Cl)CHCH.sub.2            I     O  H    H    4-Cl                           CH.sub.2CHCHClCH.sub.2       Cl    0  H    H    4-Cl                           CH.sub.2CHCHClCH.sub.2       Cl    O  H    H    4-I                            CH.sub.2CHCHClCH.sub.2       Br    O  H    H    4-Cl                           CH.sub.2CHCHClCH.sub.2       I     O  H    H    4-Cl                           ClCH.sub.2 CCCH.sub.2        Cl    O  H    H    4-Cl                           ClCH.sub.2 CCCH.sub.2        Cl    O  H    H    4-I                            ClCC                         Cl    O  H    H    4-Cl                           ClCC                         Cl    O  H    H    4-I                            BrCC                         Cl    O  H    H    4-I                            ClcCCH.sub.2                 Cl    0  H    H    methyl                         ClCCCH.sub.2                 Cl    O  H    H    4-I                            BrC CCH.sub.2                Cl    O  H    H    4-Cl                           BrCCCH.sub.2                 Cl    O  H    H    4-I                            ClCH.sub.2 CC                Cl    O  H    H    4-Cl                           ClCH.sub.2 CC                C1    0  H    H    4-Cl                           BrCH.sub.2 CC                Cl    O  H    H    4-Cl                           BrCH.sub.2 CC                Cl    O  H    H    4-I                            Q1-2,2-F.sub.2               Cl    O  H    H    4-Cl                           Q1-2,2-F.sub.2               Cl    O  H    H    4-I                            (Q1-2,2-Cl.sub.2)            CH.sub.5                                                                             Cl H    H    4-Cl                           (Q1-2,2-Cl.sub.2)CH.sub.3    Cl    O  H    H    4-I                            (Q1-2,2-Br.sub.2)CH.sub.2    Cl    O  O    H    H                              (Q1-2,2-Br.sub.2)CH.sub.2    Cl    O  H    H    4-I                            (Q1-2,2-F.sub.2)CH.sub.2     Cl    O  H    H    4-Cl                           (Q1-2,2-F.sub.2)CH.sub.2     C     O  H    H    4-I                            (Q1-2,2-F.sub.2 -3-Me)CH.sub.2                                                                              Cl    O  H    H    4-Cl                           (Q1-2,2-F.sub.2 -3-Me)CH.sub.2                                                                              Cl    O  H    H    4-I                            (Q1-2,2-Cl.sub.2 -3-Me)CH.sub.2                                                                             Cl    O  H    H    4-Cl                           (Q1-2,2-Cl.sub.2 -3-Me)CH.sub.2                                                                             Cl    O  H    H    4-I                            (Q1-2,2-F.sub.2 3,3-Me.sub.2)CH.sub.2                                                                       Cl    O  H    H    4-Cl                           (Q1-2,2-F.sub.2 3,3-Me.sub.2)CH.sub.2                                                                       Cl    O  H    H    4-I                            (Q1-2,2-Cl.sub.2 3,3-Me.sub.2)CH.sub.2                                                                      Cl    O  H    H    4-Cl                           (Q1-2,2-Cl.sub.2 3,3-Me.sub.2)CH.sub.2                                                                      Cl    O  H    H    4-I                            (Q1-2,2-Br.sub.2 3,3-Me.sub.2)CH.sub.2                                                                      Cl    O  H    H    4-Cl                           (Q1-2,2-Br.sub.2 3,3-Me.sub.2)CH.sub.2                                                                      Cl    O  H    H    4-I                            (Q1-2-Cl-3,3-Me.sub.2)CH.sub.2                                                                              Cl    O  H    H    4-Cl                           (Q1-2-Cl-3,3-Me.sub.2)CH.sub.2                                                                              Cl    O  H    H    4-I                            (Q1-2-cl-3-Me)CH.sub.2       Cl    O  H    H    4-Cl                           (Q1-2-Cl-3-Me)CH.sub.2       Cl    O  H    H    4-I                            (Q1-2,2-Cl.sub.2 -1-Me)CH(Me)                                                                               Cl    O  H    H    4-Cl                           (Q1-2,2-Cl.sub.2 -1-Me)CH(Me)                                                                               Cl    O  H    H    4-I                            (Q1-2,2-F.sub.2 -1-Me)CH.sub.2                                                                              Cl    O  H    H    4-Cl                           (Q1-2,2-F.sub.2 -1-Me)CH.sub.2                                                                              Cl    O  H    H    4-I                            (Q1-2,2-F.sub.2 -l-Cl)CH.sub.2                                                                              Cl    O  H    H    4-Cl                           (Q1-2,2-F.sub.2 -1-Cl)CH.sub.2                                                                              Cl    O  H    H    4-I                            (Q1-2,2-Cl.sub.2 l-Me)CH.sub.2 CH.sub.2                                                                     Cl    O  H    H    4-Cl                           (Q1-2,2-Cl.sub.2 -1-Mel) CH.sub.2 CH.sub.3                                                                  Cl    O  H    H    4-I                            (Q1-2,2-Cl.sub.2 3,3-Me.sub.2)CH.sub.2 CH.sub.2                                                             Cl    O  H    H    4-Cl                           (Q1-2,2-Cl.sub.2 3,3-Me.sub.2)CH.sub.2 Ch.sub.2                                                             Cl    O  H    H    4-I                            (Q1-2-Cl)CH.sub.2 CH.sub.2   Cl    O  H    H    4-Cl                           (Q1-2-Cl)CH.sub.2 Ch.sub.2   Cl    O  H    H    4-I                            (Q1-2,2-F.sub.2)CH.sub.2 Ch.sub.2                                                                           Cl    O  H    H    4-Cl                           (Q1-2,2-F.sub.2)CH.sub.2 CH.sub.2                                                                           Cl    O  H    H    4-I                            (Q1-2,2-F.sub.2)CH.sub.2 Ch.sub.2 CH.sub.2                                                                  Cl    O  H    H    4-Cl                           (Q1-2,2-F.sub.2)CH.sub.2 Ch.sub.2 CH.sub.2                                                                  Cl    O  H    H    4-I                            (Q1-1-Cl)CH.sub.2            Cl    O  H    H    4-Cl                           (Q1-1-Cl)CH.sub.2            Cl    O  H    H    4-I                            (Q1-1-Cl)CH.sub.2            Br    O  H    H    4-Cl                           (Q1-1-Cl)CH.sub.2            I     O  H    H    4-Cl                           (Q1-1-Br)CH.sub.2            Cl    O  H    H    4-Cl                           (Q1-1-Br)CH.sub.2            Cl    O  H    H    4-I                            (Q1-1-Br)CH.sub.2            Br    O  H    H    4-Cl                           (Q1-1-Br)CH.sub.2            I     O  H    H    4-Cl                           (Q2-1-Cl)CH.sub.2            Cl    O  H    H    4-Cl                           (Q2-1-Cl)CH.sub.2            Cl    O  H    H    4-I                            (Q2-1-Cl)CH.sub.2            Br    O  H    H    4-Cl                           (Q2-1-Cl)CH.sub.2            I     O  H    H    4-Cl                           (Q2-1-Br)CH.sub.2            Cl    O  H    H    4-Cl                           (Q2-1-Br)CH.sub.2            Cl    O  H    H    4-I                            (Q2-1-Br)CH.sub.2            Br    O  H    H    4-Cl                           (Q2-1-Br)CH.sub.2            I     O  H    H    4-Cl                           (Q3-1-Cl)CH.sub.2            Cl    O  H    H    4-Cl                           (Q3-1-Cl)CH.sub.2            Cl    O  H    H    4-I                            (Q3-1-Cl)CH.sub.2            Br    O  H    H    4-Cl                           (Q3-1-Cl)CH.sub.2            I     O  H    H    4-Cl                           (Q3-1-Br)CH.sub.2            Cl    O  H    H    4-Cl                           (Q3-1-Br)CH.sub.2            Cl    O  H    H    4-I                            (Q3-1-Br)CH.sub.2            Br    O  H    H    4-Cl                           (Q3-1-Br)CH.sub.2            I     O  H    H    4-Cl                           Q3-2-Cl                      Cl    O  H    H    4-Cl                           Q3-2-Cl                      Cl    O  H    H    2,4-Cl.sub.2                   Q3-2-Cl                      Cl    O  H    H    4-I                            Q3-2-Cl                      Br    O  H    H    4-Cl                           Q3-2-Cl                      I     O  H    H    4-Cl                           Q3-2-cl                      Cl    S  H    H    4-Cl                           Q3-2-Cl                      Cl    S  H    H    4-Bu-t                         Q3-2-Br                      Cl    O  H    H    4-Cl                           Q3-2-Br                      Cl    O  H    H    2,4-Cl.sub.2                   Q3-2-Br                      Cl    O  H    H    4-I                            Q3-2-Br                      Br    O  H    H    4-Cl                           Q3-2-Br                      I     O  H    H    4-Cl                           Q3-2-Br                      Cl    S  H    H    4-Cl                           Q3-2-Br                      Cl    S  H    H    4-Bu-t                         Q3-CH(Cl)CH.sub.2            Cl    O  H    H    4-Cl                           Q3-CH(Cl)CH.sub.2            Cl    O  H    H    4-I                            Q3-CH(Br)CH.sub.2            Cl    O  H    H    4-Cl                           Q3-CH(Br)CH.sub.2            Cl    O  H    H    4-I                            Q3-1,2,3,3,4,4,5,5-F.sub.8   Cl    O  H    H    4-Cl                           Q3-1,2,3,3,4,4,5,5-F.sub.8   Cl    O  H    H    4-I                            Q3-1,2,3,3,4,4,5-F.sub.7     Cl    O  H    H    4-Cl                           Q3-1,2,3,3,4,4,5-F.sub.7     Cl    O  H    H    4-I                            Q4-CHClCH.sub.2              Cl    O  H    H    4-Cl                           Q4-CHClCH.sub.2              Cl    O  H    H    4-I                            Q4-CHBrCH.sub.2              Cl    O  H    H    4-Cl                           Q4-CHBrCH.sub.2              Cl    O  H    H    4-I                            (Q4-1-Cl)CH.sub.2            Cl    O  H    H    4-Cl                           (Q4-1-Cl)CH.sub.2            Cl    O  H    H    4-I                            (Q4-1-Cl)CH.sub.2            Br    O  H    H    4-Cl                           (Q4-1-Cl)CH.sub.2            I     O  H    H    4-Cl                           (Q4-1-Br)CH.sub.2            Cl    O  H    H    4-Cl                           (Q4-1-Br)CH.sub.2            Cl    O  H    H    4-I                            (Q4-1-Br)CH.sub.2            Br    O  H    H    4-Cl                           (Q4-1-Br)CH.sub.2            I     O  H    H    4-Cl                           Q4-1,2-Cl.sub.2              Cl    O  H    H    4-Cl                           Q4-1,2-Cl.sub.2              Cl    O  H    H    4-I                            Q4-1,2-C.sub.2               Br    O  H    H    4-Cl                           Q4-1,2-Cl.sub.2              I     O  H    H    4-Cl                           Q4-1,2-Br.sub.2              Cl    O  H    H    4-Cl                           Q4-1,2-Br.sub.2              Cl    O  H    H    4-I                            Q4-1,2-Br.sub.2              Br    O  H    H    4-Cl                           Q4-1,2-Br.sub.2              I     O  H    H    4-Cl                           Q4-2-Cl-2-Me                 Cl    O  H    H    4-Cl                           Q4-2-Cl-2-Me                 Cl    O  H    H    4-I                            Q4-2-Cl-2-Me                 Br    O  H    H    4-Cl                           Q4-2-Cl-2-Me                 I     O  H    H    4-Cl                           Q4-2-Br-2-Me                 Cl    O  H    H    4-Cl                           Q4-2-Br-2-Me                 Cl    O  H    H    4-I                            Q4-2-Br-2-Me                 Br    O  H    H    4-Cl                           Q4-2-Br-2-Me                 I     O  H    H    4-Cl                           Q4-2-Cl-1-Me                 Cl    O  H    H    4-Cl                           Q4-2-Cl-1-Me                 Cl    O  H    H    4-I                            Q4-2-Cl-1-Me                 Br    O  H    H    4-Cl                           Q4-2-Cl-1-Me                 I     O  H    H    4-Cl                           Q4-2-Br-1-Me                 Cl    O  H    H    4-Cl                           Q4-2-Br-1-Me                 Cl    O  H    H    4-I                            Q4-2-Br-1-Me                 Br    O  H    H    4-Cl                           Q4-2-Br-1-Me                 I     O  H    H    4-Cl                           Q4-2,2-Cl.sub.2              Cl    O  H    H    4-Cl                           Q4-2,2-Cl.sub.2              Cl    O  H    H    4-I                            Q4-2,2-Cl.sub.2              Br    O  H    H    4-Cl                           Q4-2,2-Cl.sub.2              I     O  H    H    4-Cl                           Q4-2-Cl-2-Br                 Cl    O  H    H    4-Cl                           Q4-2-Cl-2-Br                 Cl    O  H    H    4-I                            Q4-2-Cl-2-Br                 Br    O  H    H    4-Cl                           Q4-2-Cl-2-Br                 I     O  H    H    4-Cl                           Q4-2-Cl-4-Me                 Cl    O  H    H    4-Cl                           Q4-2-Cl-4-Me                 Cl    O  H    H    4-I                            Q4-2-Cl-4-Me                 Br    O  H    H    4-Cl                           Q4-2-Cl-4-Me                 I     O  H    H    4-Cl                           Q4-2-Br-4-Me                 Cl    O  H    H    4-Cl                           Q4-2-Br-4-Me                 Cl    O  H    H    4-I                            Q4-2-Br-4-Me                 Br    O  H    H    4-Cl                           Q4-2-Br-4-Me                 I     O  H    H    4-Cl                           Q4-2-Cl-5-Me                 Cl    O  H    H    4-Cl                           Q4-2-Cl-5-Me                 Cl    O  H    H    4-I                            Q4-2-Cl-5-Me                 Br    O  H    H    4-Cl                           Q4-2-Cl-5-Me                 I     O  H    H    4-Cl                           Q4-2-Br-5-Me                 Cl    O  H    H    4-Cl                           Q4-2-Br-5-Me                 Cl    O  H    H    4-I                            Q4-2-Br-5-Me                 Br    O  H    H    4-Cl                           Q4-2-Br-5-Me                 I     O  H    H    4-Cl                           Q4-2-Cl                      Cl    O  H    H    4-Cl                           Q4-2-Cl                      Cl    O  H    H    4-Br                           Q4-2-Cl                      Cl    O  H    H    2,4-Cl.sub.2                   Q4-2-Cl                      Br    O  H    H    4-Cl                           Q4-2-Cl                      Br    O  H    H    4-I                            Q4-2-Cl                      I     O  H    H    4-Cl                           Q4-2-Cl                      F     O  H    H    4-Cl                           Q4-2-Cl                      Me    O  H    H    4-Cl                           Q4-2-Cl                      OMe   O  H    H    4-Cl                           Q4-2-Cl                      OMe   O  H    H    4-I                            Q4-2-Cl                      SMe   O  H    H    4-Cl                           Q4-2-Cl                      SMe   O  H    H    4-I                            Q4-2-Cl                      SO.sub.2 Me                                                                          O  H    H    4-Cl                           Q4-2-Cl                      Cl    O  H    Me   4-Cl                           Q4-2-Cl                      Cl    O  Cl   H    4-Cl                           Q4-2-Cl                      OMe   O  H    H    4-Br                           Q4-2-Cl                      SO.sub.2 Et                                                                          O  H    H    4-Cl                           Q4-2-Cl                      Cl    O  H    H    2-Me                           Q4-2-Cl                      Cl    O  H    H    4-OPr                          Q4-2-Cl                      Cl    O  H    H    4-CF.sub.3                     Q4-2-Cl                      Cl    O  H    H    2,4,5-Cl.sub.3                 Q4-2-Cl                      Cl    S  H    H    4-Cl                           Q4-2-Cl                      Cl    S  H    H    4-Bu-t                         Q4-2-Cl                      Cl    S  H    H    4-C.sub.6 H.sub.4 Cl-4'        Q4-2-Cl                      Cl    S  H    H    4-OC.sub.6 H.sub.4 F-4'        Q4-2-Cl                      Cl    S  H    H    4-(Q4)                         Q4-2-Cl                      Cl    S  H    H    4-SiMe.sub.3                   Q4-2-Br                      Cl    O  H    H    4-Cl                           Q4-2-Br                      Cl    O  H    H    4-Br                           Q4-2-Br                      Cl    O  H    H    2,4-Cl.sub.2                   Q4-2-Br                      Br    O  H    H    4-Cl                           Q4-2-Br                      Br    O  H    H    4-I                            Q4-2-Br                      I     O  H    H    4-Cl                           Q4-2-Br                      F     O  H    H    4-Cl                           Q4-2-Br                      Me    O  H    H    4-Cl                           Q4-2-Br                      OEt   O  H    H    4-Cl                           Q4-2-Br                      SEt   O  H    H    4-Cl                           Q4-2-Br                      SO.sub.2 Me                                                                          O  H    H    4-Cl                           Q4-2-Br                      Cl    O  H    Et   4-Cl                           Q4-2-Br                      Cl    O  Cl   H    4-Cl                           Q4-2-Br                      Cl    O  H    H    2-F,4-cl                       Q4-2-Br                      OPr   O  H    H    4-Cl                           Q4-2-Br                      Cl    O  H    Bu   4-I                            Q4-2-Br                      Cl    O  H    H    4-Me                           Q4-2-Br                      Cl    O  H    H    4-OCHF.sub.2                   Q4-2-Br                      Cl    S  H    H    4-Cl                           Q4-2-Br                      Cl    S  H    H    4-Bu-t                         Q4-2-Br                      Cl    S  H    H    4-OC(Me).sub.2 CH.sub.2                                                        OPr                            Q4-2-Br                      Cl    S  H    H    4-SMe                          Q4-2-Br                      Cl    S  H    H    4-I                            Q4-F.sub.11                  Cl    O  H    H    4-Cl                           Q4-F.sub.11                  Cl    O  H    H    4-I                            (Q4-F.sub.11)CH.sub.2        C1    O  H    H    4-Cl                           (Q4-F.sub.11)CH.sub.2        cl    O  H    H    4-I                            (Q4-1,2,2,3,4,4,5,5,6,6-F.sub.10 -3-CFp.sub.3)CH.sub.2                                                      Cl    O  H    H    4-Cl                           (Q4-1,2,2,3,3,4,5,5,6,6-F.sub.10 -4-CF.sub.3 O)CH.sub.2                                                     Cl    O  H    H    4-Cl                           Q5-2-Cl                      C1    O  H    H    4-Cl                           Q5-2-Cl                      Cl    O  H    H    2,4-Cl.sub.2                   Q5-2-Cl                      Cl    O  H    H    4-I                            Q5-2-Cl                      Br    O  H    H    4-Cl                           Q5-2-Cl                      I     O  H    H    4-Cl                           Q5-2-Cl                      Cl    S  H    H    4-Cl                           Q5-2-Cl                      Cl    S  H    H    4-Bu-t                         Q5-2-Cl                      Cl    O  H    H    4-Cl                           Q5-2-Cl                      Cl    O  H    H    2,4-Cl.sub.2                   Q5-2-Cl                      Cl    O  H    H    4-I                            Q5-2-Cl                      Br    O  H    H    4-Cl                           Q5-2-Cl                      I     O  H    H    4-Cl                           Q5-2-Cl                      Cl    S  H    H    4-Cl                           Q5-2-Cl                      Cl    S  H    H    4-Bu-t                         FCH.sub.2 C(Me).sub.2        Cl    O  H    H    4-Cl                           FCH.sub.2 C(Me).sub.2        Cl    O  H    H    4-I                            Me.sub.2 CF                  Cl    O  H    H    4-Cl                           Me.sub.2 CF                  Cl    O  H    H    4-I                            (CF.sub.3).sub.2 CH          Cl    O  H    H    4-Cl                           (CF.sub.3).sub.2 CH          Cl    O  H    H    4-I                            (CF.sub.3).sub.2 CF          Cl    O  H    H    4-Cl                           (CF.sub.3).sub.2 CF          Cl    O  H    H    4-I                            CHF.sub.2 C(CF.sub.3)F       Cl    O  H    H    4-Cl                           CHF.sub.2 C(CF.sub.3)F       Cl    O  H    H    4-I                            (CHF.sub.2).sub.2 C(Me)      Cl    O  H    H    4-Cl                           (CHF.sub.2).sub.2 C(Me)      Cl    O  H    H    4-I                            MeCH(F)CH.sub.2              Cl    O  H    H    4-Cl                           MeCH(F)CH.sub.2              Cl    O  H    H    4-I                            CF.sub.3 CH.sub.2 CH.sub.2   Cl    O  H    H    4-Cl                           CF.sub.3 CH.sub.2 CH.sub.2   Cl    O  H    H    4-I                            CHF.sub.2 CF.sub.2 CH.sub.2  Cl    O  H    H    4-Cl                           CHF.sub.2 CF.sub.2 CH.sub.2  Cl    O  H    H    4-I                            CF.sub.3 CCl.sub.2 CH.sub.2  Cl    O  H    H    4-Cl                           CF.sub.3 CCl.sub.2 CH.sub.2  Cl    O  H    H    4-I                            CF.sub.3 CHFCF.sub.2         Cl    O  H    H    4-Cl                           CF.sub.3 CHFCF.sub.2         Cl    O  H    H    4-I                            CF.sub.3 CHFCF(CF.sub.3)     Cl    O  H    H    4-Cl                           CF.sub.3 CHFCF(CF.sub.3)     Cl    O  H    H    4-I                            CF.sub.3 CHCH                Cl    O  H    H    4-Cl                           CF.sub.3 CHCH                Cl    O  H    H    4-I                            CF.sub.3 CFCF                Cl    O  H    H    4-Cl                           CF.sub.3 CFCF                Cl    O  H    H    4-I                            CF.sub.3 CCl.sub.2 CCl(CF.sub.3)                                                                            Cl    O  H    H    4-Cl                           CF.sub.3 CCl.sub.2 CCl(CF.sub.3)                                                                            Cl    O  H    H    4-I                            CF.sub.3 CBrClCCl(CF.sub.3)  Cl    O  H    H    4-Cl                           CF.sub.3 CF.sub.2 CF.sub.2   Cl    O  H    H    4-Cl                           CF.sub.3 CF.sub.2 CF.sub.2   Cl    O  H    H    4-I                            CF.sub.3 CHFCF.sub.2         Cl    O  H    H    4-Cl                           CF.sub.3 CHFCF.sub.2         Cl    O  H    H    4-I                            (CF.sub.3).sub.2 CFCH.sub.2  Cl    O  H    H    4-Cl                           (CF.sub.3).sub.2 CFCHFCF.sub.2                                                                              Cl    O  H    H    4-Cl                           (CF.sub.3).sub.2 CFCHFCF.sub.2                                                                              Cl    O  H    H    4-I                            CF.sub.2CFCH.sub.2 CH.sub.2  Cl    O  H    H    4-Cl                           CF.sub.2CFCH.sub.2 CH.sub.2  Cl    O  H    H    4-I                            C.sub.3 F.sub.7 CHClCH.sub.2 Cl    O  H    H    4-Cl                           C.sub.3 F.sub.7 CHClCH.sub.2 Cl    O  H    H    4-I                            C.sub.3 F.sub.7 CHBrCH.sub.2 Cl    O  H    H    4-Cl                           C.sub.3 F.sub.7 CHBrCH.sub.2 Cl    O  H    H    4-I                            H(CF.sub.2).sub.4 CH.sub.2   Cl    O  H    H    4-Cl                           H(CF.sub.2).sub.4 CH.sub.2   Cl    O  H    H    4-I                            H(CF.sub.2).sub.6 CH.sub.2   Cl    O  H    H    4-Cl                           H(CF.sub.2).sub.6 CH.sub.2   Cl    O  H    H    4-I                            F(CF.sub.2).sub.3 CF(CF.sub.3)CH.sub.2                                                                      Cl    O  H    H    4-Cl                           F(CF.sub.2).sub.3 CF(CF.sub.3)CH.sub.2                                                                      Cl    O  H    H    4-I                            F(CF.sub.2).sub.5 CHFCF.sub.2                                                                               Cl    O  H    H    4-Cl                           F(CF.sub.2).sub.5 CHFCF.sub.2                                                                               Cl    O  H    H    4-I                            F(CF.sub.2).sub.8            Cl    O  H    H    4-Cl                           F(CF.sub.2).sub.8            Cl    O  H    H    4-I                            CF.sub.3 CFClCF.sub.2        Cl    O  H    H    4-Cl                           CF.sub.3 CFClCF.sub.2        Cl    O  H    H    4-I                            CF.sub. 3 CFBrCF.sub.2       Cl    O  H    H    4-Cl                           CF.sub.3 CF(OMe)CF.sub.2     Cl    O  H    H    4-Cl                           CF.sub.3 CF(OMe)CF.sub.2     Cl    O  H    H    4-I                            Q6-3-Cl                      Cl    O  H    H    4-Cl                           Q6-3-Cl                      Cl    O  H    H    4-I                            Q6-3-Br                      Cl    O  H    H    4-Cl                           Q6-3-Br                      Cl    O  H    H    4-I                            (Q1-2,2-Me.sub.2 -3-COOEt)CHClC(Me).sub.2                                                                   Cl    O  H    H    4-Cl                           (Q1-2,2-Me.sub.2 -3-COOEt)CHClC(Me).sub.2                                                                   Cl    O  H    H    4-I                            (Q1-2,2-Me.sub.2 -3-COOEt)CHBrC(Me).sub.2                                                                   Cl    O  H    H    4-Cl                           (Q1-2,2-Me-.sub.2 -3-COOEt)CH(CCl(Me).sub.2)                                                                Cl    O  H    H    4-Cl                           (Q1-2,2-Me.sub.2 -3-COOEt)CH(CCl(Me).sub.2)                                                                 Cl    O  H    H    4-I                            Q3-1-Me-2-Cl                 Cl    O  H    H    4-Cl                           Q3-1-Me-2-Cl                 Cl    O  H    H    4-I                            Q3-1-Me-2-Br                 Cl    O  H    H    4-I                            Q3-2-Me-1-Cl                 Cl    O  H    H    4-Cl                           Q3-2-Me-1-Cl                 Cl    O  H    H    4-I                            Q3-2-Me-1-Br                 Cl    O  H    H    4-Cl                           Q4-1-Ph-2-Cl                 Cl    O  H    H    4-Cl                           Q4-1-Ph-2-Cl                 Cl    O  H    H    4-I                            Q4-1-Ph-2-Br                 Cl    O  H    H    4-Cl                           Q4-2-Ph-1-Cl                 Cl    O  H    H    4-Cl                           Q4-2-Ph-1-Cl                 Cl    O  H    H    4-I                            Q4-2-Cl-3-CHMe(OMe)          Cl    O  H    H    4-Cl                           Q4-2-Cl-3-CHMe(OMe)          Cl    O  H    H    4-I                            Q4-2-Cl-6-CHMe(OMe)          Cl    O  H    H    4-Cl                           Q4-2-Cl-6-CHMe(OMe)          Cl    O  H    H    4-I                            Q4-2-Cl-3-CHMe(OCOMe)        Cl    O  H    H    4-Cl                           Q4-2-Cl-4-COMe               Cl    O  H    H    4-Cl                           Q4-2-Cl-4-COMe               Cl    O  H    H    4-I                            Q4-2-Cl-5-COMe               Cl    O  H    H    4-I                            Q7-2-Cl                      Cl    O  H    H    4-Cl                           Q7-2-Cl                      Cl    O  H    H    4-I                            Q7-2-Br                      Cl    O  H    H    4-Cl                           Q7-2-Br                      Cl    O  H    H    4-I                            Q8-1-Cl                      Cl    O  H    H    4-Cl                           Q8-1-Cl                      Cl    O  H    H    4-I                            Q8-1-Br                      Cl    O  H    H    4-I                            Q8-3-Cl                      Cl    O  H    H    4-Cl                           Q8-3-Cl                      Cl    O  H    H    4-I                            Q8-3-Br                      Cl    O  H    H    4-Cl                           Q7-1-Me-2-Cl                 Cl    O  H    H    4-Cl                           Q7-1-Me-2-Cl                 Cl    O  H    H    4-I                            Q7-1-Me-2-Cl                 I     O  H    H    4-Cl                           Q8-1-Me-1-Cl                 Cl    O  H    H    4-Cl                           Q8-1-Me-1-Cl                 Cl    O  H    H    4-I                            Q8-1-Me-1-Cl                 I     O  H    H    4-Cl                           Q10-4-Cl-4-OMe               Cl    O  H    H    4-I                            Q11-3-Cl-4-OMe               Cl    O  H    H    4-Cl                           Q9-3-Cl-6-COOMe              Cl    O  H    H    4-Cl                           Q10-2-Cl-6-COOMe             Cl    O  H    H    4-Cl                           Q9-3-Cl-6-CH.sub.2 OMe       Cl    O  H    H    4-Cl                           Q10-2-Cl-6-CH.sub.2 OEt      Cl    O  H    H    4-Cl                           Q9-3-Cl                      Cl    O  H    H    4-Cl                           Q9-3-Cl                      Cl    O  H    H    4-I                            Q9-3-Cl                      Br    O  H    H    4-Cl                           Q9-3-Cl                      I     O  H    H    4-Cl                           Q9-3-Cl                      Cl    S  H    H    4-Cl                           Q9-3-Cl                      Cl    S  H    H    4-Bu-t                         Q9-3-Br                      Cl    O  H    H    4-Cl                           Q9-3-Br                      Cl    O  H    H    4-I                            Q9-3-Br                      Br    O  H    H    4-Cl                           Q9-3-Br                      I     O  H    H    4-Cl                           Q9-3-Br                      Cl    S  H    H    4-Cl                           Q9-3-Br                      Cl    S  H    H    4-Bu-t                         Q10-2-Cl                     Cl    O  H    H    4-Cl                           Q10-2-Cl                     Cl    O  H    H    4-I                            Q10-2-Cl                     Br    O  H    H    4-Cl                           Q10-2-Cl                     I     O  H    H    4-Cl                           Q10-2-Cl                     Cl    S  H    H    4-Cl                           Q10-2-Cl                     Cl    S  H    H    4-Bu-t                         Q10-2-Br                     Cl    O  H    H    4-Cl                           Q10-2-Br                     Cl    O  H    H    4-I                            Q10-2-Br                     Br    O  H    H    4-Cl                           Q10-2-Br                     I     O  H    H    4-Cl                           Q10-2-Br                     Cl    S  H    H    4-Cl                           Q10-2-Br                     Cl    S  H    H    4-Bu-t                         Q9-3-Cl-6-OEt                Cl    O  H    H    4-I                            Q10-2-Cl-6-OEt               Cl    O  H    H    4-Cl                           Q10-2-Cl-6-OEt               Cl    O  H    H    4-I                            Q9-3-Cl-6-OMe                Cl    O  H    H    4-Cl                           Q10-2-Cl-6-OMe               Cl    O  H    H    4-Cl                           Q10-2-Cl-6-OMe               Cl    O  H    H    4-I                            Q12-2-Cl-1-Me                Cl    O  H    H    4-Cl                           Q12-2-Cl-1-Me                Cl    O  H    H    4-I                            Q13-1-Cl-1-Me                Cl    O  H    H    4-Cl                           Q13-1-Cl-1-Me                I     O  H    H    4-I                            Q12-2-Cl                     Cl    O  H    H    4-Cl                           Q12-2-Cl                     Cl    O  H    H    4-I                            Q12-2-Cl                     Br    O  H    H    4-Cl                           Q12-2-Cl                     I     O  H    H    4-Cl                           Q12-2-Cl                     Cl    S  H    H    4-Cl                           Q12-2-Cl                     Cl    S  H    H    4-Bu-t                         Q12-2-Br                     Cl    O  H    H    4-Cl                           Q12-2-Br                     Cl    O  H    H    4-I                            Q13-1-Cl                     Cl    O  H    H    4-Cl                           Q13-1-Cl                     Cl    O  H    H    4-I                            Q13-1-Cl                     Br    O  H    H    4-Cl                           Q13-1-Cl                     I     O  H    H    4-Cl                           Q13-1-Cl                     Cl    S  H    H    4-Cl                           Q13-1-Cl                     Cl    S  H    H    4-Bu-t                         Q13-1-Br                     Cl    O  H    H    4-Cl                           Q13-1-Br                     Cl    O  H    H    4-I                            Q14-1-Cl                     Cl    O  H    H    4-Cl                           Q14-1-Cl                     Cl    O  H    H    4-I                            Q14-1-Br                     Cl    O  H    H    4-Cl                           Q14-1-Br                     Cl    O  H    H    4-I                            Q15-1-Cl                     Cl    O  H    H    4-Cl                           Q15-1-Cl                     Cl    O  H    H    4-I                            Q15-1-Cl                     Br    O  H    H    4-Cl                           Q15-1-Cl                     I     O  H    H    4-Cl                           Q15-1-Cl                     Cl    S  H    H    4-Cl                           Q15-1-Cl                     Cl    S  H    H    4-Bu-t                         Q15-1-Br                     Cl    O  H    H    4-Cl                           Q15-1-Br                     Cl    O  H    H    4-I                            Q15-4-Cl                     Cl    O  H    H    4-Cl                           Q15-4-Cl                     Cl    O  H    H    4-I                            Q16-3-Cl                     Cl    O  H    H    4-Cl                           Q16-3-Cl                     Cl    O  H    H    4-I                            Q15-4-Cl-4-Me                Cl    O  H    H    4-Cl                           Q15-4-Cl-4-Me                Cl    O  H    H    4-I                            Q16-3-Cl-4-Me                Cl    O  H    H    4-Cl                           Q16-3-Cl-4-Me                Cl    O  H    H    4-I                            Q14-2-Cl-4-CHCl.sub.2        Cl    O  H    H    4-Cl                           Q14-2-Cl-4-CHCl.sub.2        Cl    O  H    H    4-I                            Q15-1-Cl-4-CHCl.sub.2        Cl    O  H    H    4-I                            ClCH.sub.2 CHPh              Cl    O  H    H    4-Cl                           ClCH.sub.2 CHPh              Cl    O  H    H    4-I                            ClCH.sub.2 CHPh              Br    O  H    H    4-Cl                           ClCH.sub.2 CHPh              I     O  H    H    4-Cl                           PhCHClCH.sub.2               Cl    O  H    H    4-Cl                           PhCHClCH.sub.2               Cl    O  H    H    4-I                            BrCH.sub.2 CHPh              Cl    O  H    H    4-Cl                           PhCHBrCH.sub.2               Cl    O  H    H    4-Cl                           ClCH.sub.2 C(Me)Ph           Cl    O  H    H    4-Cl                           ClCH.sub.2 C(Me)Ph           Cl    O  H    H    4-I                            ClCH.sub.2 C(Me)Ph           Br    O  H    H    4-Cl                           ClCH.sub.2 C(Me)Ph           I     O  H    H    4-Cl                           PhCCl(Me)CH.sub.2            Cl    O  H    H    4-Cl                           PhCCl(Me)CH.sub.2            Cl    O  H    H    4-I                            PhCBr(Me)CH.sub.2            Cl    O  H    H    4-Cl                           PhCBr(Me)CH.sub.2            Cl    O  H    H    4-I                            MeCHClC(Me)Ph                Cl    O  H    H    4-Cl                           MeCHClC(Me)Ph                Cl    O  H    H    4-I                            MeCHClc(Et)Ph                Cl    O  H    H    4-I                            MeCHClCHPh                   Cl    O  H    H    4-Cl                           MeCHClCHPh                   Cl    O  H    H    4-I                            ClCH.sub.2 CH(Q-17)          Cl    O  H    H    4-Cl                           ClCH.sub.2 CH(Q-17)          Cl    O  H    H    4-I                            BrCH.sub.2 CH(Q-17)          Cl    O  H    H    4-I                            ClCH.sub.2 CH(Q-18)          Cl    O  H    H    4-Cl                           ClCH.sub.2 CH(Q-18)          Cl    O  H    H    4-I                            ClCH.sub.2 CH(Q-18)          Cl    O  H    H    4-Cl                           ClCH.sub.2 CH(Q-18)          Cl    O  H    H    4-I                            ClCH.sub.2 CH(Q-18)          Br    O  H    H    4-Cl                           ClCH.sub.2 CH(Q-18)          I     O  H    H    4-Cl                           ClCH.sub.2 CH(Q-18)          Cl    S  H    H    4-Cl                           ClCH.sub.2 CH(Q-18)          Cl    S  H    H    4-Bu-t                         BrCH.sub.2 CH(Q-18)          Cl    O  H    H    4-Cl                           BrCH.sub.2 CH(Q-18)          Cl    O  H    H    4-I                            Q19-5-Cl                     Cl    O  H    H    4-Cl                           Q19-5-Cl                     Cl    O  H    H    4-I                            Q19-5-Cl                     Cl    O  H    H    4-Cl                           Q19-5-Cl                     Cl    O  H    H    4-I                            Q19-5-Cl                     Br    O  H    H    4-Cl                           Q19-5-Cl                     I     O  H    H    4-Cl                           Q19-5-Cl                     Cl    S  H    H    4-Cl                           Q19-5-Cl                     Cl    S  H    H    4-Bu-t                         Q19-5-Br                     Cl    O  H    H    4-Cl                           Q19-5-Br                     Cl    O  H    H    4-I                            Q20-5-Cl                     Cl    O  H    H    4-Cl                           Q20-5-Cl                     Cl    O  H    H    4-I                            Q20-5-Cl                     Cl    O  H    H    4-Cl                           Q20-5-Cl                     Cl    O  H    H    4-I                            Q20-5-Cl                     Br    O  H    H    4-Cl                           Q20-5-Cl                     I     O  H    H    4-Cl                           Q20-5-Cl                     Cl    S  H    H    4-Cl                           Q20-5-Cl                     Cl    S  H    H    4-Bu-t                         Q20-5-Br                     Cl    O  H    H    4-Cl                           Q20-5-Br                     Cl    O  H    H    4-I                            EtOCH.sub.2 CHClCH.sub.2     Cl    O  H    H    4-Cl                           EtOCH.sub.2 CHClCH.sub.2     Cl    O  H    H    4-I                            EtOCH.sub.2 CHClCH.sub.2     Cl    O  H    H    4-Cl                           EtOCH.sub.2 CHClCH.sub.2     Cl    O  H    H    4-I                            EtOCH.sub. 2 CHClCH.sub.2    Br    O  H    H    4-Cl                           EtOCH.sub.2 CHClCH.sub.2     I     O  H    H    4-Cl                           EtOCH.sub.2 CHClCH.sub.2     Cl    S  H    H    4-Cl                           EtOCH.sub.2 CHClCH.sub.2     Cl    S  H    H    4-Bu-t                         EtOCH.sub.2 CHBrCH.sub.2     Cl    O  H    H    4-Cl                           EtOCH.sub.2 CHBrCH.sub.2     Cl    O  H    H    4-I                            PrOCH.sub.2 CHClCH.sub.2     Cl    O  H    H    4-Cl                           PrOCH.sub.2 CHClCH.sub.2     Cl    O  H    H    4-I                            MeCCl(OMe)CH.sub.2           Cl    O  H    H    4-Cl                           MeCCl(OMe)CH.sub.2           Cl    O  H    H    4-I                            PrCCl(OMe)CH.sub.2           Cl    O  H    H    4-Cl                           PrCCl(OMe)CH.sub.2           Cl    O  H    H    4-I                            MeCCl(COOMe)CH.sub.2         Cl    O  H    H    4-Cl                           MeCCl(COOMe)CH.sub.2         Cl    O  H    H    4-I                            MeCCl(COOMe)CH.sub.2         Cl    O  H    H    4-Cl                           MeCCl(COOMe)CH.sub.2         Cl    O  H    H    4-Cl                           MeCCl(COOMe)CH.sub.2         Br    O  H    H    4-Cl                           MeCCl(COOMe)CH.sub.2         I     O  H    H    4-Cl                           MeCCl(COOMe)CH.sub.2         Cl    S  H    H    4-Cl                           MeCCl(COOMe)CH.sub.2         Cl    S  H    H    4-Bu-t                         MeCBr(COOMe)CH.sub.2         Cl    O  H    H    4-Cl                           MeCBr(COOMe)CH.sub.2         Cl    O  H    H    4-I                            MeCCl(COOEt)CH.sub.2         Cl    O  H    H    4-Cl                           MeCCl(COOEt)CH.sub.2         Cl    O  H    H    4-I                            MeCCl(COOEt)CH.sub.2         Cl    O  H    H    4-Cl                           MeCCl(COOEt)CH.sub.2         Cl    O  H    H    4-I                            MeCCl(COOEt)CH.sub.2         Br    O  H    H    4-Cl                           MeCCl(COOEt)CH.sub.2         I     O  H    H    4-Cl                           MeCCl(COOEt)CH.sub.2         Cl    S  H    H    4-Cl                           MeCCl(COOEt)CH.sub.2         Cl    S  H    H    4-Bu-t                         MeCBr(COOEt)CH.sub.2         Cl    O  H    H    4-Cl                           MeCBr(COOEt)CH.sub.2         Cl    O  H    H    4-I                            MeC(COOCH.sub.2 CH.sub.2 OEt)(Cl)CH.sub.2                                                                   Cl    O  H    H    4-Cl                           MeSCH.sub.2 CHClCH.sub.2     Cl    O  H    H    4-Cl                           MeSCH.sub.2 CHClCH.sub.2     Cl    O  H    H    4-I                            MeSCH.sub.2 CHClCH.sub.2     Cl    O  H    H    4-I                            MeCCl(SMe)CH.sub.2           Cl    O  H    H    4-Cl                           MeCCl(SMe)CH.sub.2           Cl    O  H    H    4-I                            PrCCl(SMe)CH.sub.2           Cl    O  H    H    4-Cl                           PrCCl(SMe)CH.sub.2           Cl    O  H    H    4-I                            PrCCl(CH.sub.2 OMe)CH.sub.2  Cl    O  H    H    4-I                            PrCCl(CH.sub.2 OMe)CH.sub.2  Cl    O  H    H    4-Cl                           PrCCl(CH.sub.2 OMe)CH.sub.2  Cl    O  H    H    4-I                            PrCCl(CH.sub.2 OMe)CH.sub.2  Cl    O  H    H    4-Cl                           MeCCl(CH.sub.2 CH.sub.2 OMe)CH.sub.2                                                                        Cl    O  H    H    4-Cl                           PrCCl(CH.sub.2 CH.sub.2 OMe)CH.sub.2                                                                        Cl    O  H    H    4-Cl                           PrCCl(CH.sub.2 CN)CH.sub.2   Cl    O  H    H    4-Cl                           PrCCl(CH.sub.2 CN)CH.sub.2   Cl    O  H    H    4-I                            PrCCl(CH.sub.2 COOMe)CH.sub.2                                                                               Cl    O  H    H    4-I                            PrCCl(CH.sub.2 COOMe)CH.sub.2                                                                               Cl    O  H    H    4-Cl                           NCCH.sub. 2 CHClCH.sub.2     Cl    O  H    H    4-Cl                           NCCH.sub.2 CHClCH.sub.2      Cl    O  H    H    4-I                            NCCH.sub.2 CHClCH.sub.2      Cl    O  H    H    4-Cl                           NCCH.sub.2 CHClCH.sub.2      Cl    O  H    H    4-I                            NCCH.sub.2 CHClCH.sub.2      Br    O  H         4-Cl                           NCCH.sub.2 CHClCH.sub.2      I     O  H    H    4-Cl                           NCCH.sub.2 CHClCH.sub.2      Cl    S  H    H    4-Cl                           NCCH.sub.2 CHClCH.sub.2      Cl    S  H    H    4-Bu-t                         NCCH.sub.2 CHBrCH.sub.2      Cl    O  H    H    4-Cl                           NCCH.sub.2 CHBrCH.sub.2      Cl    O  H    H    4-I                            NCCH.sub.2 CCl(Me)CH.sub.2   Cl    O  H    H    4-Cl                           NCCH.sub.2 CCl(Me)CH.sub.2   Cl    O  H    H    4-I                            NCCH.sub.2 CCl(Me)CH.sub.2   Cl    O  H    H    4-Cl                           NCCH.sub.2 CCl(Me)CH.sub.2   Cl    O  H    H    4-I                            NCCH.sub.2 CCl(Me)CH.sub.2   Br    O  H    H    4-Cl                           NCCH.sub.2 CCl(Me)CH.sub.2   I     O  H    H    4-Cl                           NCCH.sub.2 CCl(Me)CH.sub.2   Cl    S  H    H    4-Cl                           NCCH.sub.2 CCl(Me)CH.sub.2   Cl    S  H    H    4-Bu-t                         NCCH.sub.2 Br(Me)CH.sub.2    Cl    O  H    H    4-Cl                           NCCH.sub.2 Br(Me)CH.sub.2    Cl    O  H    H    4-I                            PrCOOCCl(Me)CH.sub.2         Cl    O  H    H    4-Cl                           PrCOOCCl(Me)CH.sub.2         Cl    O  H    H    4-I                            MeCOOCH.sub.2 CHClCH.sub.2   Cl    O  H    H    4-Cl                           MeCOOCH.sub.2 CHClCH.sub.2   Cl    O  H    H    4-I                            MeCOOCH.sub.2 CHBrCH.sub.2   Cl    O  H    H    4-Cl                           EtCOOCH.sub.2 CHClCH.sub.2   Cl    O  H    H    4-Cl                           PrCOOCH.sub.2 CHClCH.sub.2   Cl    O  H    H    4-I                            MeCOOCH.sub.2 CCl(Me)CH.sub.2                                                                               Cl    O  H    H    4-Cl                           MeCOOCH.sub.2 CCl(Me)CH.sub.2                                                                               Cl    O  H    H    4-I                            MeCOOCH.sub.2 CCl(Me)CH.sub.2                                                                               I     O  H    H    4-Cl                           MeCOOCH.sub.2 CBr(Me)CH.sub.2                                                                               Cl    O  H    H    4-Cl                           EtCOOCH.sub.2 CCl(Me)CH.sub.2                                                                               Cl    O  H    H    4-Cl                           EtCOOCH.sub.2 CCl(Me)CH.sub.2                                                                               Cl    O  H    H    4-I                            MeCH(OMe)CH.sub.2 CHClCH.sub.2                                                                              Cl    O  H    H    4-I                            MeCH(OCOMe)CH.sub.2 CHClCH.sub.2                                                                            Cl    O  H    H    4-Cl                           PrCH(OMe)CH.sub.2 CHClCH.sub.2                                                                              Cl    O  H    H    4-Cl                           MeCH(OMe)CH.sub.2 CCl(Me)CH.sub.2                                                                           Cl    O  H    H    4-Cl                           MeCH(OMe)CH.sub.2 CCl(Me)CH.sub.2                                                                           Cl    O  H    H    4-I                            MeCH(OMe)CH.sub.2 CCl(Me)CH.sub.2                                                                           I     O  H    H    4-Cl                           MeCH(OMe)CH.sub.2 CBr(Me)CH.sub.2                                                                           Cl    O  H    H    4-Cl                           MeCH(OCOMe)CH.sub.2 CCl(Me)CH.sub.2                                                                         Cl    O  H    H    4-Cl                           EtCH(OMe)CH.sub.2 CCl(Me)CH.sub.2                                                                           Cl    O  H    H    4-Cl                           EtCH(OMe)CH.sub.2 CCl(Me)CH.sub.2                                                                           Cl    O  H    H    4-I                            EtCH(OCOMe)CH.sub.2 CCl(Me)CH.sub.2                                                                         Cl    O  H    H    4-Cl                           MeCH(OMe)CH(Me)CHClCH.sub.2  Cl    O  H    H    4-Cl                           EtCF(Me)CH(CN)               Cl    O  H    H    4-Cl                           EtCF(Me)CH(CN)               Cl    O  H    H    4-I                            CF.sub.3 C(CN)(Me)           Cl    O  H    H    4-Cl                           CF.sub.3 C(CN)(Me)           Cl    O  H    H    4-I                            MeOCH.sub.2 CCl(Me)CH.sub.2  Cl    O  H    H    4-Cl                           MeOCH.sub.2 CCl(Me)CH.sub.2  Cl    O  H    H    4-I                            MeOCH.sub.2 CCl(Me)CH.sub.2  Br    O  H    H    4-Cl                           MeOCH.sub.2 CCl(Me)CH.sub.2  I     O  H    H    4-Cl                           MeOCH.sub.2 CCl(Me)CH.sub.2  Cl    S  H    H    4-Cl                           MeOCH.sub.2 CCl(Me)CH.sub.2  Cl    S  H    H    4-Bu-t                         MeOCH.sub.2 CBr(Me)CH.sub.2  Cl    O  H    H    4-Cl                           MeOCH.sub.2 CBr(Me)CH.sub.2  Cl    O  H    H    4-I                            EtOCH.sub.2 CCl(Me)CH.sub.2  Cl    O  H    H    4-Cl                           EtOCH.sub.2 CCl(Me)CH.sub.2  Cl    O  H    H    4-I                            EtOCH.sub.2 CCl(Me)CH.sub.2  Br    O  H    H    4-Cl                           EtOCH.sub.2 CCl(Me)CH.sub.2  I     O  H    H    4-Cl                           EtOCH.sub.2 CCl(Me)CH.sub.2  Cl    S  H    H    4-Cl                           EtOCH.sub.2 CCl(Me)CH.sub.2  Cl    S  H    H    4-Bu-t                         EtOCH.sub.2 CBr(Me)CH.sub.2  Cl    O  H    H    4-Cl                           EtOCH.sub.2 CBr(Me)CH.sub.2  Cl    O  H    H    4-I                            PrOCH.sub.2 CCl(Me)CH.sub.2  Cl    O  H    H    4-Cl                           PrOCH.sub.2 CCl(Me)CH.sub.2  Cl    O  H    H    4-I                            MeSCH.sub.2 CCl(Me)CH.sub.2  Cl    O  H    H    4-Cl                           MeSCH.sub.2 CCl(Me)CH.sub. 2 Cl    O  H    H    4-I                            MeSCH.sub.2 CCl(Me)CH.sub.2  Br    O  H    H    4-Cl                           MeSCH.sub.2 CCl(Me)CH.sub.2  I     O  H    H    4-Cl                           MeSCH.sub.2 CCl(Me)CH.sub.2  Cl    S  H    H    4-Cl                           MeSCH.sub.2 CCl(Me)CH.sub.2  Cl    S  H    H    4-Bu-t                         MeSCH.sub.2 CBr(Me)CH.sub.2  Cl    O  H    H    4-Cl                           MeSCH.sub.2 CBr(Me)CH.sub.2  Cl    O  H    H    4-I                            EtSCH.sub.2 CCl(Me)CH.sub.2  Cl    O  H    H    4-Cl                           EtSCH.sub.2 CCl(Me)CH.sub.2  Cl    O  H    H    4-I                            EtSCH.sub.2 CCl(Me)CH.sub.2  Br    O  H    H    4-Cl                           EtSCH.sub.2 CCl(Me)CH.sub.2  I     O  H    H    4-Cl                           EtSCH.sub.2 CCl(Me)CH.sub.2  Cl    S  H    H    4-Cl                           EtSCH.sub.2 CCl(Me)CH.sub.2  Cl    S  H    H    4-Bu-t                         EtSCH.sub.2 CBr(Me)CH.sub.2  Cl    O  H    H    4-Cl                           EtSCH.sub.2 CBr(Me)CH.sub.2  Cl    O  H    H    4-I                            PrSCH.sub.2 CCl(Me)CH.sub.2  Cl    O  H    H    4-Cl                           PrSCH.sub.2 CCl(Me)CH.sub.2  Cl    O  H    H    4-I                            MeCCl(CN)CH.sub.2            Cl    O  H    H    4-Cl                           MeCCl(CN)CH.sub.2            Cl    O  H    H    4-I                            MeCCl(CN)CH.sub.2            Br    O  H    H    4-Cl                           MeCCl(CN)CH.sub.2            I     O  H    H    4-Cl                           MeCCl(CN)CH.sub.2            Cl    S  H    H    4-Cl                           MeCCl(CN)CH.sub.2            Cl    S  H    H    4-Bu-t                         MeCBr(CN)CH.sub.2            Cl    O  H    H    4-Cl                           MeCBr(CN)CH.sub. 2           Cl    O  H    H    4-I                            MeSO.sub.2 CCl(Me)CH.sub.2   Cl    O  H    H    4-Cl                           MeSO.sub.2 CCl(Me)CH.sub.2   Cl    O  H    H    4-I                            MeSO.sub.2 CBr(Me)CH.sub.2   Cl    O  H    H    4-Cl                           MeSO.sub.2 CCl(Pr)CH.sub.2   Cl    O  H    H    4-Cl                           BuSO.sub.2 CCl(Me)CH.sub.2   Cl    O  H    H    4-Cl                           Me.sub.2 NCCl(Me)CH.sub.2    Cl    O  H    H    4-Cl                           Me.sub.2 NCCl(Me)CH.sub.2    Cl    O  H    H    4-I                            Me.sub.2 NCCl(Et)CH.sub.2    Cl    O  H    H    4-Cl                           MeNHCCl(Pr)CH.sub.2          Cl    O  H    H    4-Cl                           EtOCONHCH.sub.2 CCl(Me)CH.sub.2                                                                             Cl    O  H    H    4-Cl                           MeOCONHCH.sub.2 CHClCH.sub.2 Cl    O  H    H    4-Cl                           MeNHCOOCHClCH.sub.2          Cl    O  H    H    4-Cl                           EtCHNOCH.sub.2 CCl(Me)CH.sub.2                                                                              Cl    O  H    H    4-Cl                           EtCHNOCH.sub.2 CHClCH.sub.2  Cl    O  H    H    4-Cl                           MeCHNOCH.sub.2 CHBrCH.sub.2  Cl    O  H         4-Cl                           EtONCHCH.sub.2 CCl(Me)CH.sub.2                                                                              Cl    O  H    H    4-Cl                           EtONCHCHClCH.sub.2           Cl    O  H    H    4-Cl                           MeONCHCHBrCH.sub.2           Cl    O  H    H    4-Cl                           Me.sub.2 CClCH.sub.2         Cl    O  H    H    4-I                            Me.sub.2 CClCH.sub.2         Cl    O  H    H    4-OEt                          Me.sub.2 CClCH.sub.2         Cl    O  H    H    4-OPr-i                        Me.sub.2 CClCH.sub.2         Cl    O  H    H    4-OCF.sub.3                    Me.sub.2 CClCH.sub.2         Cl    O  H    H    4-OCHF.sub.2                   Me.sub.2 CClCH.sub.2         Cl    O  H    H    4-OCH.sub.2 CF.sub.3           Me.sub.2 CClCH.sub.2         Cl    O  H    H    4-Et                           Me.sub.2 CClCH.sub.2         Cl    O  H    H    4-Pr-i                         Me.sub.2 CClCH.sub.2         Me    O  H    H    4-I                            Me.sub.2 CClCH.sub.2         Br    O  H    H    4-Cl                           Me.sub.2 CClCH.sub.2         Br    O  H    H    4-I                            Me.sub.2 CClCH.sub.2         Cl    O  H    H    4-CF.sub.3                     Me.sub.2 CClCH.sub.2         OMe   O  H    H    4-I                            Me.sub.2 CBrCH.sub.2         Cl    O  H    H    4-I                            Me.sub.2 CBrCH.sub.2         Cl    O  H    H    4-CF.sub.3                     Me.sub.2 CBrCH.sub.2         Cl    O  H    H    4-Et                           Me.sub.2 CBrCH.sub.2         Cl    O  H    H    4-OEt                          Me.sub.2 CBrCH.sub.2         Cl    O  H    H    4-OPr-i                        Me.sub.2 CBrCH.sub.2         Cl    O  H    H    4-OCF.sub.3                    Me.sub.2 CBrCH.sub.2         Br    O  H    H    4-I                            Me.sub.2 CBrCH.sub.2         Br    O  H    H    4-CF.sub.3                     Me.sub.2 CBrCH.sub.2         Br    O  H    H    4-Et                           PrCCl(Me)CH.sub.2            Cl    O  H    H    4-OEt                          PrCCl(Me)CH.sub.2            Cl    O  H    H    4-OPr-i                        PrCCl(Me)CH.sub.2            Cl    O  H    H    4-OPr                          PrCCl(Me)CH.sub.2            Cl    O  H    H    4-OCF.sub.3                    PrCCl(Me)CH.sub.2            Cl    O  H    H    4-CF.sub.3                     PrCCl(Me)CH.sub.2            Cl    O  H    H    4-Et                           PrCCl(Me)CH.sub.2            Cl    O  H    H    4-Pr-i                         PrCCl(Me)CH.sub.2            Br    O  H    H    4-Br                           PrCCl(Me)CH.sub.2            Br    O  H    H    4-CF.sub.3                     PrCCl(Me)CH.sub.2            Br    O  H    H    4-Et                           PrCCl(Me)CH.sub.2            Br    O  H    H    4-OEt                          PrCBr(Me)CH.sub.2            Cl    O  H    H    4-Br                           MeCCl(CN)CH.sub.2            Cl    O  H    H    4-Et                           MeCCl(CN)CH.sub.2            Cl    O  H    H    4-Pr-i                         Me.sub.2 CClCH.sub.2         Cl    O  H    H    4-I                            Me.sub.2 CClCH.sub.2         Cl    O  H    H    4-OEt                          Me.sub.2 CClCH.sub.2         Cl    O  H    H    4-OPr-i                        Me.sub.2 CClCH.sub.2         Cl    O  H    H    4-OCF.sub.3                    Me.sub.2 CClCH.sub.2         Cl    O  H    H    4-OCHF.sub.2                   Me.sub.2 CClCH.sub.2         Cl    O  H    H    4-OCH.sub.2 CF.sub.3           Me.sub.2 CClCH.sub.2         Cl    O  H    H    4-Et                           Me.sub.2 CClCH.sub.2         Cl    O  H    H    4-Pr-i                         Me.sub.2 CClCH.sub.2         Me    O  H    H    4-I                            Me.sub.2 CClCH.sub.2         Br    O  H    H    4-Cl                           Me.sub.2 CClCH.sub.2         Br    O  H    H    4-I                            Me.sub.2 CClCH.sub.2         Cl    O  H    H    4-CF.sub.3                     Me.sub.2 CClCH.sub.2         OMe   O  H    H    4-I                            Me.sub.2 CBrCH.sub. 2        Cl    O  H    H    4-I                            Me.sub.2 CBrCH.sub.2         Cl    O  H    H    4-CF.sub.3                     Me.sub.2 CBrCH.sub.2         Cl    O  H    H    4-Et                           Me.sub.2 CBrCH.sub.2         Cl    O  H    H    4-OEt                          Me.sub.2 CBrCH.sub.2         Cl    O  H    H    4-OPr-i                        Me.sub.2 CBrCH.sub.2         Cl    O  H    H    4-OCF.sub.3                    Me.sub.2 CBrCH.sub.2         Br    O  H    H    4-I                            Me.sub.2 CBrCH.sub.2         Br    O  H    H    4-CF.sub.3                     Me.sub.2 CBrCH.sub.2         Br    O  H    H    4-Et                           PrCCl(Me)CH.sub.2            Cl    O  H    H    4-OEt                          PrCCl(Me)CH.sub.2            Cl    O  H    H    4-OPr-i                        PrCCl(Me)CH.sub.2            Cl    O  H    H    4-OPr                          PrCCl(Me)CH.sub.2            Cl    O  H    H    4-OCF.sub.3                    PrCCl(Me)CH.sub.2            Cl    O  H    H    4-CF.sub.3                     PrCCl(Me)CH.sub.2            Cl    O  H    H    4-Et                           PrCCl(Me)CH.sub.2            Cl    O  H    H    4-Pr-i                         PrCCl(Me)CH.sub.2            Br    O  H    H    4-Br                           PrCCl(Me)CH.sub.2            Br    O  H    H    4-CF.sub.3                     PrCCl(Me)CH.sub.2            Br    O  H    H    4-Et                           PrCCl(Me)CH.sub.2            Br    O  H    H    4-OEt                          PrCBr(Me)CH.sub.2            Cl    O  H    H    4-Br                           PrCBr(Me)CH.sub.2            Cl    O  H    H    4-Et                           PrCBr(Me)CH.sub.2            Cl    O  H    H    4-Pr-i                         PrCBr(Me)CH.sub.2            Cl    O  H    H    4-OEt                          PrCBr(Me)CH.sub.2            Cl    O  H    H    4-CF.sub.3                     PrCBr(Me)CH.sub.2            Cl    O  H    H    4-OCF.sub.3                    PrCBr(Me)CH.sub.2            Cl    O  H    H    4-Pr                           PrCBr(Me)CH.sub.2            Br    O  H    H    4-Br                           PrCBr(Me)CH.sub.2            Br    O  H    H    4-CF.sub.3                     PrCBr(Me)CH.sub.2            Br    O  H    H    4-OCF.sub.3                    PrCBr(Me)CH.sub.2            Br    O  H    H    4-Et                           PrCBr(Me)CH.sub.2            Br    O  H    H    4-Pr-i                         PrCBr(Me)CH.sub.2            Br    O  H    H    4-OEt                          PrCBr(Me)CH.sub.2            Br    O  H    H    4-OPr-i                        Cl.sub.2 CCH                 Cl    O  H    H    4-Cl                           Cl.sub.2 CCH                 Cl    O  H    H    4-Br                           Cl.sub.2 CCH                 Cl    O  H    H    4-I                            Cl.sub.2 CCH                 Cl    O  H    H    4-CF.sub.3                     Cl.sub.2 CCH                 Cl    O  H    H    4-Et                           Cl.sub.2 CCH                 Cl    O  H    H    4-OEt                          Cl.sub.2 CCH                 Cl    O  H    H    4-OPr-i                        Cl.sub.2 CCH                 Cl    O  H    H    4-Pr-i                         Cl.sub.2 CCH                 Br    O  H    H    4-I                            Cl.sub.2 CCH                 Br    O  H    H    4-Br                           Cl.sub.2 CCH                 Br    O  H    H    4-Et                           Cl.sub.2 CCH                 Br    O  H    H    4-CF.sub.3                     Cl.sub.2 CCH                 Br    O  H    H    4-OEt                          Br.sub.2 CCH                 Cl    O  H    H    4-I                            Br.sub.2 CCH                 Cl    O  H    H    4-OEt                          Br.sub.2 CCH                 Cl    O  H    H    4-Et                           Br.sub.2 CCH                 Br    O  H    H    4-I                            Br.sub.2 CCH                 Br    O  H    H    4-Br                           Br.sub.2 CCH                 Br    O  H    H    4-OEt                          MeCClCH                      Cl    O  H    H    4-Cl                           MeCClCH                      Cl    O  H    H    4-Br                           MeCClCH                      Cl    O  H    H    4-I                            MeCClCH                      Cl    O  H    H    4-CF.sub.3                     MeCClCH                      Cl    O  H    H    4-OCF.sub.3                    MeCClCH                      Cl    O  H    H    4-OCHF.sub.2                   MeCClCH                      Cl    O  H    H    4-Et                           MeCClCH                      Cl    O  H    H    4-Pr                           MeCClCH                      Cl    O  H    H    4-Pr-i                         MeCClCH                      Cl    O  H    H    4-OEt                          MeCClCH                      Cl    O  H    H    4-OPr-i                        MeCClCH                      Br    O  H    H    4-I                            MeCClCH                      Br    O  H    H    4-Et                           MeCClCH                      Br    O  H    H    4-CF.sub.3                     MeCClCH                      Br    O  H    H    4-Cl                           MeCBrCH                      Cl    O  H    H    4-I                            MeCBrCH                      Cl    O  H    H    4-Et                           MeCBrCH                      Cl    O  H    H    4-CF.sub.3                     MeCBrCH                      Br    O  H    H    4-Br                           MeCBrCH                      Br    O  H    H    4-I                            MeCBrCH                      Br    O  H    H    4-Et                           EtCClCH                      Cl    O  H    H    4-CF.sub.3                     EtCClCH                      Cl    O  H    H    4-Br                           EtCClCH                      Cl    O  H    H    4-I                            EtCClCH                      Cl    O  H    H    4-Et                           EtCClCH                      Br    O  H    H    4-I                            PrCClCH                      Cl    O  H    H    4-I                            PrCClCH                      Cl    O  H    H    4-CF.sub.3                     PrCClCH                      Cl    O  H    H    4-Et                           PrCClCH                      Cl    O  H    H    4-Br                           PrCClCH                      Cl    O  H    H    4-Cl                           PrCClCH                      Cl    O  H    H    4-OCF.sub.3                    PrCClCH                      Br    O  H    H    4-I                            Me.sub.2 CCH                 Cl    O  H    H    4-Cl                           Me.sub.2 CCH                 Cl    O  H    H    4-Br                           Me.sub.2 CCH                 Cl    O  H    H    4-I                            Me.sub.2 CCH                 Cl    O  H    H    4-Et                           Me.sub.2 CCH                 Cl    O  H    H    4-CF.sub.3                     Me.sub.2 CCH                 Cl    O  H    H    4-OEt                          Me.sub.2 CCH                 Br    O  H    H    4-I                            Me.sub.2 CCH                 Br    O  H    H    4-Et                           MeC(Et)CH                    Cl    O  H    H    4-Cl                           MeC(Et)CH                    Cl    O  H    H    4-I                            MeC(Et)CH                    Cl    O  H    H    4-CF.sub.3                     MeC(Et)CH                    Cl    O  H    H    4-Et                           MeC(Et)CH                    Cl    O  H    H    4-OEt                          MeC(Et)CH                    Cl    O  H    H    4-OCF.sub.3                    MeC(Et)CH                    Cl    O  H    H    4-Br                           MeC(Et) CH                   Br    O  H    H    4-I                            MeC(Et)CH                    Br    O  H    H    4-Et                           MeC(Pr)CH                    Cl    O  H    H    4-Cl                           MeC(Pr)CH                    Cl    O  H    H    4-Br                           MeC(Pr)CH                    Cl    O  H    H    4-I                            MeC(Pr)CH                    Cl    O  H    H    4-CF.sub.3                     MeC(Pr)CH                    Cl    O  H    H    4-Et                           MeC(Pr)CH                    Cl    O  H    H    4-OEt                          MeC(Pr)CH                    Cl    O  H    H    4-Pr-i                         MeC(Pr)CH                    Br    O  H    H    4-I                            MeC(Pr)CH                    Br    O  H    H    4-OPr-i                        MeC(Pr-i)CH                  Cl    O  H    H    4-I                            MeC(Pr-i)CH                  Cl    O  H    H    4-Et                           MeC(Pr-i)CH                  Cl    O  H    H    4-CF.sub.3                     MeC(Pr-i)CH                  Cl    O  H    H    4-OPr-i                        MeC(Pr-i)CH                  Cl    O  H    H    4-OEt                          MeC(Pr-i)CH                  Cl    O  H    H    4-OCF.sub.3                    MeC(Pr-i)CH                  Br    O  H    H    4-I                            MeC(Bu)CH                    Cl    O  H    H    4-I                            MeC(Bu)CH                    Cl    O  H    H    4-CF.sub.3                     MeC(Bu)CH                    Cl    O  H    H    4-Et                           MeC(Bu)CH                    Cl    O  H    H    4-OEt                          MeC(Bu)CH                    Cl    O  H    H    4-OCF.sub.3                    MeC(Bu)CH                    Cl    O  H    H    4-Pr-i                         MeC(Bu)CH                    Br    O  H    H    4-OPr-i                        MeC(Pen)CH                   Cl    O  H    H    4-Br                           MeC(Pen)CH                   Cl    O  H    H    4-I                            MeC(Pen)CH                   Cl    O  H    H    4-OEt                          MeC(Pen)CH                   Cl    O  H    H    4-Et                           MeC(Hex)CH                   Cl    O  H    H    4-I                            MeC(Hex)CH                   Cl    O  H    H    4-Br                           MeC(Hex)CH                   Cl    O  H    H    4-OPr-i                        EtC(Et)CH                    Cl    O  H    H    4-Br                           EtC(Pr)CH                    Cl    O  H    H    4-I                            CF.sub.3 CClCH               Cl    O  H    H    4-Cl                           CF.sub.3 CClCH               Cl    O  H    H    4-Br                           CF.sub.3 CClCH               Cl    O  H    H    4-I                            CF.sub.3 CClCH               Cl    O  H    H    4-Et                           CF.sub.3 CClCH               Cl    O  H    H    4-CF.sub.3                     CF.sub.3 CClCH               Cl    O  H    H    4-OPr-i                        CF.sub.3 CClCH               Br    O  H    H    4-I                            CF.sub.3 CClCH               Br    O  H    H    4-Et                           CF.sub.3 CBrCH               Cl    O  H    H    4-I                            CF.sub.3 CBrCH               Cl    O  H    H    4-Cl                           CF.sub.3 CBrCH               Cl    O  H    H    4-Et                           CF.sub.3 CBrCH               Cl    O  H    H    4-CF.sub.3                     CF.sub.3 CBrCH               Cl    O  H    H    4-OPr-i                        CF.sub.3 CBrCH               Br    O  H    H    4-I                            CF.sub.3 CBrCH               Br    O  H    H    4-Br                           CH.sub.2CH                   Cl    O  H    H    4-Cl                           CH.sub.2CH                   Cl    O  H    H    4-I                            CH.sub.2CH                   Br    S  H    H    4-CF.sub.3                     CH.sub.2CH                   Br    O  H    H    3,4-Cl.sub.2                   CH.sub.2CHCH.sub.2           Cl    O  H    H    4-I                            CH.sub.2CHCH.sub.2           Cl    O  H    H    4-Cl                           CH.sub.2CHCH.sub.2           Br    O  H    H    4-Br                           CH.sub.2CHCH.sub.2           CH.sub.3                                                                             O  H    H    4-Cl                           MeCHCHCH.sub.2               Cl    O  H    H    4-CF.sub.3                     MeCHCHCH.sub.2               Cl    S  H    H    4-I                            MeCHCHCH.sub.2               Br    O  H    H    4-I                            CH.sub.2C(Me)CH.sub.2        Cl    O  H    H    4-Cl                           CH.sub.2C(Me)CH.sub.2        Cl    O  H    H    4-Br                           CH.sub.2C(Me)CH.sub.2        Cl    O  H    H    4-I                            CH.sub.2C(Me)CH.sub.2        Cl    O  H    H    4-Et                           CH.sub.2C(Me)CH.sub.2        Cl    O  H    H    4-Pr-i                         CH.sub.2C(Me)CH.sub.2        Cl    O  H    H    4-CF.sub.3                     CH.sub.2C(Me)CH.sub.2        Cl    O  H    H    4-OEt                          CH.sub.2C(Me)CH.sub.2        Br    O  H    H    4-OCF.sub.3                    CH.sub.2C(Me)CH.sub.2        Br    O  H    H    4-OPr-i                        CH.sub.2C(Me)CH.sub.2        OMe   O  H    H    4-Cl                           CH.sub.2C(Et)CH.sub.2        Cl    O  H    H    4-Cl                           CH.sub.2C(Et)CH.sub.2        Cl    O  H    H    4-I                            CH.sub.2C(Et)CH.sub.2        Cl    O  H    H    4-Br                           CH.sub.2C(Et)CH.sub.2        Cl    O  H    H    4-Et                           CH.sub.2C(Et)CH.sub.2        Cl    O  H    H    4-Pr                           CH.sub.2C(Et)CH.sub.2        Br    O  H    H    4-CF.sub.3                     CH.sub.2C(Et)CH.sub.2        Br    O  H    H    4-Et                           CH.sub.2C(Pr)CH.sub.2        Cl    O  H    H    4-I                            CH.sub.2C(Pr)CH.sub.2        Cl    O  H    H    4-Et                           CH.sub.2C(Pr)CH.sub.2        Cl    O  H    H    4-CF.sub.3                     CH.sub.2C(Pr)CH.sub.2        Cl    O  H    H    4-OCF.sub.3                    CH.sub.2C(Pr)CH.sub.2        Br    O  H    H    4-I                            CH.sub.2C(Bu)CH.sub.2        Cl    O  H    H    4-I                            CH.sub.2C(Bu)CH.sub.2        Cl    O  H    H    4-Cl                           CH.sub.2C(Bu)CH.sub.2        Cl    O  H    H    4-I                            CH.sub.2C(Bu)CH.sub.2        Cl    O  H    H    4-CF.sub.3                     CH.sub.2C(Bu)CH.sub.2        Br    O  H    H    4-Et                           MeCHC(Me)CH.sub.2            Cl    O  H    H    4-I                            MeCHC(Me)CH.sub.2            Cl    O  H    H    4-Et                           MeCHC(Me)CH.sub.2            Cl    O  H    H    4-CF.sub.3                     MeCHC(Me)CH.sub.2            Cl    O  H    H    4-OCF.sub.3                    MeCHC(Me)CH.sub.2            Br    O  H    H    4-I                            MeCHC(Me)CH.sub.2            Br    O  H    H    4-Et                           EtCHC(Me)CH.sub.2            Cl    O  H    H    4-I                            EtCHC(Me)CH.sub.2            Cl    O  H    H    4-Br                           EtCHC(Me)CH.sub.2            Cl    O  H    H    4-Cl                           EtCHC(Me)CH.sub. 2           Cl    O  H    H    4-Et                           EtCHC(Me)CH.sub.2            Cl    O  H    H    4-CF.sub.3                     EtCHC(Me)CH.sub.2            Br    O  H    H    4-CF.sub.3                     PrCHC(Me)CH.sub.2            Cl    O  H    H    4-Cl                           PrCHC(Me)CH.sub.2            Cl    O  H    H    4-I                            PrCHC(Me)CH.sub.2            Br    O  H    H    4-Et                           PrCHC(Me)CH.sub.2            Br    O  H    H    4-CF.sub.3                     PrCHC(Me)CH.sub.2            Br    O  H    H    4-Cl                           MeCHC(Et)CH.sub.2            Cl    O  H    H    4-Br                           MeCHC(Et)CH.sub.2            Cl    O  H    H    4-I                            MeCHC(Et)CH.sub.2            Cl    O  H    H    4-Et                           MeCHC(Et)CH.sub.2            Cl    O  H    H    4-CF.sub.3                     MeCC(Me)CH.sub.2             Cl    O  H    H    4-Cl                           MeCC(Me)CH.sub.2             Cl    O  H    H    4-I                            MeCC(Me)CH.sub.2             Cl    O  H    H    4-Et                           MeCC(Me)CH.sub.2             Br    O  H    H    4-OEt                          MeCC(Et)CH.sub.2             Cl    O  H    H    4-CF.sub.3                     MeCC(Et)CH.sub.2             Cl    O  H    H    4-I                            MeCC(Et)CH.sub.2             Br    O  H    H    4-Br                           BuCHC(Me)CH.sub.2            Cl    O  H    H    4-I                            BuCHC(Me)CH.sub.2            Cl    O  H    H    4-CF.sub.3                     PenCHC(Me)CH.sub.2           Cl    O  H    H    4-Et                           PenCHC(Me)CH.sub.2           Cl    O  H    H    4-I                            HexCHC(Me)CH.sub.2           Cl    O  H    H    4-I                            HexCHC(Me)CH.sub.2           Cl    O  H    H    4-CF.sub.3                     CH.sub.2CHC(Me).sub.2 CH.sub.2                                                                              Cl    O  H    H    4-Cl                           CH.sub.2CHC(Me).sub.2 CH.sub.2                                                                              Cl    O  H    H    4-I                            CH.sub.2CHC(Me).sub.2 CH.sub.2                                                                              Cl    O  H    H    4-Et                           CH.sub.2CHC(Me).sub.2 CH.sub.2                                                                              Cl    O  H    H    4-CF.sub.3                     MeCHCHC(Me).sub.2 CH.sub.2   Cl    O  H    H    4-I                            MeCHCHC(Me).sub.2 CH.sub.2   Cl    O  H    H    4-Br                           MeCHCHC(Me).sub.2 CH.sub.2   Cl    O  H    H    4-Et                           MeCHCHC(Me).sub.2 CH.sub.2   Br    O  H    H    4-Et                           HCCCH.sub.2                  Cl    O  H    H    4-Cl                           HCCCH.sub.2                  Br    O  H    H    4-I                            HCCCH.sub.2                  Me    S  H    H    4-CF.sub.3                     CH.sub.3 CCCH.sub.2          Cl    O  H    H    4-Cl                           CH.sub.3 CCCH.sub.2          Br    S  H    H    4-Br                           HCCC(Me).sub.2 CH.sub.2      Cl    O  H    H    4-Cl                           HC CC(Me).sub.2 CH.sub.2     Cl    O  H    H    4-I                            HCCC(Me).sub.2 CH.sub.2      Cl    O  H    H    4-Et                           HCCC(Me).sub.2 CH.sub.2      Cl    O  H    H    4-CF.sub.3                     HCCC(Me).sub.2 CH.sub.2      Br    O  H    H    4-Cl                           MeCCC(Me).sub.2 CH.sub.2     Cl    O  H    H    4-I                            MeCCC(Me).sub.2 CH.sub.2     Cl    O  H    H    4-Et                           MeCCC(Me).sub.2 CH.sub.2     Cl    O  H    H    4-CF.sub.3                     MeCCC(Me).sub.2 CH.sub.2     Br    O  H    H    4-OCF.sub.3                    CH.sub.2CHCH.sub.2 C(Me).sub.2 CH.sub.2                                                                     Cl    O  H    H    4-I                            CH.sub.2CHCH.sub.2 C(Me).sub.2 CH.sub.2                                                                     Cl    O  H    H    4-Et                           MeCHCHCH.sub.2 C(Me).sub.2 CH.sub.2                                                                         Cl    O  H    H    4-CF.sub.3                     HC CCH.sub.2 C(Me).sub.2 CH.sub.2                                                                           Cl    O  H    H    4-I                            HCCCH.sub.2 C(Me).sub.2 CH.sub.2                                                                            Cl    O  H    H    4-Et                           MeCCCH.sub.2 C(Me).sub.2 CH.sub.2                                                                           Cl    O  H    H    4-Cl                           MeCCCH.sub.2 C(Me).sub.2 CH.sub.2                                                                           Cl    O  H    H    4-I                            Me.sub.2 C(OMe)CH.sub.2      Cl    O  H    H    4-Cl                           Me.sub.2 C(OMe)CH.sub.2      Cl    O  H    H    4-Br                           Me.sub.2 C(OMe)CH.sub.2      Cl    O  H    H    4-I                            Me.sub.2 C(OMe)CH.sub.2      Cl    O  H    H    4-CF.sub.3                     Me.sub.2 C(OMe)CH.sub.2      Cl    O  H    H    4-Et                           Me.sub.2 C(OMe)CH.sub.2      Cl    O  H    H    4-OEt                          Me.sub.2 C(OMe)CH.sub.2      Br    O  H    H    4-I                            Me.sub.2 C(OEt)CH.sub.2      Cl    O  H    H    4-I                            Me.sub.2 C(OEt)CH.sub.2      Cl    O  H    H    4-Et                           Me.sub.2 C(OEt)CH.sub.2      Cl    O  H    H    4-CF.sub.3                     Me.sub.2 C(OEt)CH.sub.2      Cl    O  H    H    4-OPr-i                        Me.sub.2 C(OEt)CH.sub.2      Br    O  H    H    4-I                            Me.sub.2 C(OEt)CH.sub.2      Br    O  H    H    4-Cl                           Me.sub.2 C(OPr)CH.sub.2      Cl    O  H    H    4-Cl                           Me.sub.2 C(OPr)CH.sub.2      Cl    O  H    H    4-Me                           Me.sub.2 C(OPr)CH.sub.2      Cl    O  H    H    4-Et                           Me.sub.2 C(OPr)CH.sub.2      Cl    O  H    H    4-CF.sub.3                     Me.sub.2 C(OPr)CH.sub.2      Cl    O  H    H    4-OCF.sub.3                    Me.sub.2 C(OPr)CH.sub.2      Br    O  H    H    4-I                            Me.sub.2 C(OBu)CH.sub.2      Cl    O  H    H    4-Cl                           Me.sub.2 C(OBu)CH.sub.2      Cl    O  H    H    4-Cl                           Me.sub.2 C(OBu)CH.sub.2      Br    O  H    H    4-I                            Me.sub.2 C(OPen)CH.sub.2     Cl    O  H    H    4-CF.sub.3                     Me.sub.2 C(OPen)CH.sub.2     Cl    O  H    H    4-OCF.sub.3                    Me.sub.2 C(OHex)CH.sub.2     Cl    O  H    H    4-Cl                           Me.sub.2 C(OHex)CH.sub.2     Br    O  H    H    4-Br                           MeC(Et)(OMe)CH.sub.2         Cl    O  H    H    4-Cl                           MeC(Et)(OMe)CH.sub.2         Cl    O  H    H    4-I                            MeC(Pr)(OMe)CH.sub.2         Cl    O  H    H    4-Cl                           MeC(Pr)(OMe)CH.sub.2         Cl    O  H    H    4-I                            MeC(Pr)(OMe)CH.sub.2         Cl    O  H    H    4-Et                           MeC(Bu)(OMe)CH.sub.2         Cl    O  H    H    4-Et                           MeC(Bu)(OMe)CH.sub.2         Br    O  H    H    4-I                            MeC(Et)(OEt)CH.sub.2         Cl    O  H    H    4-Cl                           MeC(Et)(OEt)CH.sub.2         Cl    O  H    H    4-I                            MeC(Et)(OEt)CH.sub.2         Cl    O  H    H    4-CF.sub.3                     MeOCH.sub.2 C(Me).sub.2 CH.sub.2                                                                            Cl    O  H    H    4-I                            MeOCH.sub. 2 C(Me).sub.2 CH.sub.2                                                                           Cl    O  H    H    4-Cl                           MeOCH.sub.2 C(Me).sub.2 CH.sub.2                                                                            Cl    O  H    H    4-Et                           MeOCH.sub.2 C(Me).sub.2 CH.sub.2                                                                            Cl    O  H    H    4-CF.sub.3                     MeOCH.sub.2 C(Me).sub.2 CH.sub.2                                                                            Br    O  H    H    4-I                            EtOCH.sub.2 C(Me).sub.2 CH.sub.2                                                                            Cl    O  H    H    4-I                            EtOCH.sub.2 C(Me).sub.2 CH.sub.2                                                                            Cl    O  H    H    4-Et                           EtOCH.sub.2 C(Me).sub.2 CH.sub.2                                                                            Cl    O  H    H    4-CF.sub.3                     EtOCH.sub.2 C(Me).sub.2 CH.sub.2                                                                            Cl    O  H    H    4-OCF.sub.3                    EtOCH.sub.2 C(Me).sub.2 CH.sub.2                                                                            Br    O  H    H    4-I                            PrOCH.sub.2 C(Me).sub.2 CH.sub.2                                                                            Cl    O  H    H    4-I                            PrOCH.sub.2 C(Me).sub.2 CH.sub.2                                                                            Cl    O  H    H    4-Et                           PrOCH.sub.2 C(Me).sub.2 CH.sub.2                                                                            Cl    O  H    H    4-OCF.sub.3                    PrOCH.sub.2 C(Me).sub.2 CH.sub.2                                                                            Cl    O  H    H    4-OEt                          MeOCH.sub.2 CH.sub.2 C(Me).sub.2 CH.sub.2                                                                   Cl    O  H    H    4-I                            MeOCH.sub.2 CH.sub.2 C(Me).sub.2 CH.sub.2                                                                   Cl    O  H    H    4-Et                           MeOCH.sub.2 CH.sub.2 C(Me).sub.2 CH.sub.2                                                                   Cl    O  H    H    4-Cl                           MeOCH.sub.2 CH.sub.2 C(Me).sub.2 CH.sub.2                                                                   Br    O  H    H    4-Br                           EtOCH.sub.2 CH.sub.2 C(Me).sub.2 CH.sub.2                                                                   Cl    O  H    H    4-I                            EtOCH.sub.2 CH.sub.2 C(Me).sub.2 CH.sub.2                                                                   Cl    O  H    H    4-Et                           EtOCH.sub.2 CH.sub.2 C(Me).sub.2 CH.sub.2                                                                   Cl    O  H    H    4-CF.sub.3                     EtOCH.sub.2 CH.sub.2 C(Me).sub.2 CH.sub.2                                                                   Cl    O  H    H    4-OEt                          MeO(CH.sub.2).sub.3 C(Me).sub.2 CH.sub.2                                                                    Cl    O  H    H    4-CF.sub.3                     MeO(CH.sub.2).sub.3 C(Me).sub.2 CH.sub.2                                                                    Cl    O  H    H    4-I                            EtO(CH.sub.2).sub.3 C(Me).sub.2 CH.sub.2                                                                    Cl    O  H    H    4-I                            EtO(CH.sub.2).sub.3 C(Me).sub.2 CH.sub.2                                                                    Cl    O  H    H    4-Et                           PrOCH.sub.2 CH.sub.2 C(Me).sub.2 CH.sub.2                                                                   Cl    O  H    H    4-Cl                           PrOCH.sub.2 CH.sub.2 C(Me).sub.2 CH.sub.2                                                                   Br    O  H    H    4-I                            __________________________________________________________________________

                  TABLE 2                                                          ______________________________________                                         In Compounds of the formula:                                                    ##STR14##                                                                     R               A      X  R.sup.1                                                                            R.sup.2                                                                            Q                                            ______________________________________                                         Cl.sub.2 CHC(Me).sub.2                                                                         Cl     O H    H   Q26-6-Cl                                     Cl.sub.2 CHC(Me).sub.2                                                                         Cl     O H    H   Q26-6-I                                      Cl.sub.2 CHC(Me).sub.2                                                                         I      O H    H   Q26-6-Cl                                     Cl.sub.2 CHC(Me).sub.2                                                                         Cl     O H    H   Q26-6-Br                                     Cl.sub.2 CHC(Me).sub.2                                                                         Cl     O H    H   Q26-6-OCH.sub.2 CF.sub.3                     Cl.sub.2 CHC(Me).sub.2                                                                         Cl     S  H   H   Q22                                          Cl.sub.2 CHC(Me).sub.2                                                                         Cl     S  H   H   Q22-5-Br                                     BrClCHC(Me).sub.2                                                                              Cl     O H    H   Q26-6-Cl                                     BrClCHC(Me).sub.2                                                                              Cl     O H    H   Q26-6-I                                      BrClCHC(Me).sub.2                                                                              Cl     S  H   H   Q22-4-Br                                     Br.sub.2 CHC(Me).sub.2                                                                         Cl     O H    H   Q26-6-Cl                                     Br.sub.2 CHC(Me).sub.2                                                                         Cl     O H    H   Q26-6-I                                      Br.sub.2 CHC(Me).sub.2                                                                         Cl     O H    H   Q17-5-Cl                                     Br.sub.2 CHC(Me).sub.2                                                                         Cl     O H    H   Q17-5-Me                                     Br.sub.2 CHC(Me).sub.2                                                                         Cl     O  H   H   Q26                                          Br.sub.2 CHC(Me).sub.2                                                                         Cl     S  H   H   Q22-5-Cl                                     Br.sub.2 CHC(Me).sub.2                                                                         Cl     S  H   H   Q22-5-OPr                                    Cl.sub.2 CHCH(CH.sub.2 Cl)                                                                     Cl     O H    H   Q26-6-Cl                                     Cl.sub.2 CHCH(CH.sub.2 Cl)                                                                     Cl     O H    H   Q26-6-I                                      BrCH.sub.2 CBr(Me)                                                                             Cl     O H    H   Q26-6-Cl                                     BrCH.sub.2 CBr(Me)                                                                             Cl     O H    H   Q26-6-I                                      MeCCl.sub.2 CH.sub.2                                                                           Cl     O H    H   Q26-6-Cl                                     MeCCl.sub.2 CH.sub.2                                                                           Cl     O H    H   Q26-6-I                                      MeCCl.sub.2 CH.sub.2                                                                           I      O H    H   Q26-6-Cl                                     MeCCl.sub.2 CH.sub.2                                                                           Cl     O H    H   Q26-6-Br                                     MeCCl.sub.2 CH.sub.2                                                                           Cl     O H    H   Q17-5-Cl                                     MeCCl.sub.2 CH.sub.2                                                                           Cl     O H    H   Q26-6-CF.sub.3                               MeCCl.sub.2 CH.sub.2                                                                           Cl     O H    H   Q26-6-CN                                     MeCCl.sub.2 CH.sub.2                                                                           Cl     S  H   H   Q22-2,4-Me.sub.2                             MeCCl.sub.2 CH.sub.2                                                                           Cl     S  H   H   Q22-2-OMe                                    MeCCl.sub.2 CH.sub.2                                                                           Cl     S  H   H   Q23                                          MeCBrClCH.sub.2 Cl     O H    H   Q26-6-Cl                                     MeCBrClCH.sub.2 Cl     O H    H   Q26-6-I                                      MeCBr.sub.2 CH.sub.2                                                                           Cl     O H    H   Q26-6-Cl                                     MeCBr.sub.2 CH.sub.2                                                                           Cl     O H    H   Q26-6-Br                                     MeCBr.sub.2 CH.sub.2                                                                           Cl     O H    H   Q26-6-F                                      MeCBr.sub.2 CH.sub.2                                                                           Cl     O H    H   Q17-5-Me                                     MeCBr.sub.2 CH.sub.2                                                                           Cl     O H    H   Q26-6-Me                                     MeCBr.sub.2 CH.sub.2                                                                           Cl     O H    H   Q26-6-OPr                                    MeCBr.sub.2 CH.sub.2                                                                           Cl     S  H   H   Q23-5-Bu-t                                   MeCBr.sub.2 CH.sub.2                                                                           Cl     S  H   H   Q23-4-Me                                     ClCH.sub.2 CHClCHCl                                                                            Cl     O H    H   Q26-6-Cl                                     ClCH.sub.2 CHClCHCl                                                                            Cl     O H    H   Q26-6-I                                      BrCH.sub.2 CHBrCHBr                                                                            Cl     O H    H   Q26-6-Cl                                     BrCH.sub.2 CHBrCHBr                                                                            Cl     O H    H   Q26-6-I                                      ClCH.sub.2 CCl.sub.2 CH.sub.2                                                                  Cl     O H    H   Q26-6-Cl                                     ClCH.sub.2 CCl.sub.2 CH.sub.2                                                                  Cl     O H    H   Q26-6-I                                      ClCH.sub.2 CCl.sub.2 CH.sub.2                                                                  Br     O H    H   Q26-6-Cl                                     ClCH.sub.2 CCl.sub.2 CH.sub.2                                                                  I      O H    H   Q26-6-I                                      ClCH.sub.2 CCl.sub.2 CH.sub.2                                                                  Cl     O H    H   Q26-6-Br                                     ClCH.sub.2 CCl.sub.2 CH.sub.2                                                                  Cl     O H    H   Q17-5-Cl                                     ClCH.sub.2 CCl.sub.2 CH.sub.2                                                                  Cl     O H    H   Q26-6-OEt                                    ClCH.sub.2 CCl.sub.2 CH.sub.2                                                                  Cl     O H    H   Q26-6-SMe                                    ClCH.sub.2 CCl.sub.2 CH.sub.2                                                                  Cl     S  H   H   Q23-5-Me                                     ClCH.sub.2 CCl.sub.2 CH.sub.2                                                                  Cl     S  H   H   Q23-4-Cl                                     ClCH.sub.2 CBrClCH.sub.2                                                                       Cl     O H    H   Q26-6-Cl                                     ClCH.sub.2 CBrClCH.sub.2                                                                       Cl     O H    H   Q26-6-I                                      BrCH.sub.2 CBrClCH.sub.2                                                                       Cl     O H    H   Q26-6-Cl                                     BrCH.sub.2 CBrClCH.sub.2                                                                       Cl     O H    H   Q26-6-I                                      BrCH.sub.2 CBr.sub.2 CH.sub.2                                                                  Cl     O H    H   Q26-6-Cl                                     BrCH.sub.2 CBr.sub.2 CH.sub.2                                                                  Cl     O H    H   Q26-6-I                                      BrCH.sub.2 CBr.sub.2 CH.sub.2                                                                  Cl     O H    H   Q26-6-Br                                     BrCH.sub.2 CBr.sub.2 CH.sub.2                                                                  Cl     O H    H   Q17-5-Cl                                     BrCH.sub.2 CBr.sub.2 CH.sub.2                                                                  Cl     S  H   H   Q23-4-Br                                     BrCH.sub.2 CBr.sub.2 CH.sub.2                                                                  Cl     S  H   H   Q23-5-Cl                                     ClCH.sub.2 CHClCH.sub.2                                                                        Cl     O H    H   Q26-6-Cl                                     ClCH.sub.2 CHClCH.sub.2                                                                        Cl     O H    H   Q26-6-I                                      ClCH.sub.2 CHClCH.sub.2                                                                        Cl     O H    H   Q26-6-F                                      ClCH.sub.2 CHClCH.sub.2                                                                        Cl     O H    H   Q17-5-Me                                     ClCH.sub.2 CHClCH.sub.2                                                                        Cl     O H    H   Q26-6-OMe                                    ClCH.sub.2 CHClCH.sub.2                                                                        Cl     O H    H   Q26-5-Br                                     ClCH.sub.2 CHClCH.sub.2                                                                        Cl     S  H   H   Q23-5-Br                                     ClCH.sub.2 CHClCH.sub.2                                                                        Cl     S  H   H   Q23-4,5-Me.sub.2                             ClCH.sub.2 CHBrCH.sub.2                                                                        Cl     O H    H   Q26-6-Cl                                     ClCH.sub.2 CHBrCH.sub.2                                                                        Cl     O H    H   Q26-6-I                                      BrCH.sub.2 CHClCH.sub.2                                                                        Cl     O H    H   Q26-6-Cl                                     BrCH.sub.2 CHClCH.sub.2                                                                        Cl     O H    H   Q26-6-I                                      BrCH.sub.2 CHBrCH.sub.2                                                                        Cl     O H    H   Q26-6-Cl                                     BrCH.sub.2 CHBrCH.sub.2                                                                        Cl     O H    H   Q26-6-I                                      BrCH.sub.2 CHBrCH.sub.2                                                                        I      O H    H   Q26-6-Cl                                     BrCH.sub.2 CHBrCH.sub.2                                                                        Cl     O H    H   Q26-6-Br                                     BrCH.sub.2 CHBrCH.sub.2                                                                        Cl     O H    H   Q17-5-Cl                                     BrCH.sub.2 CHBrCH.sub.2                                                                        Cl     O H    H   Q26-6-OPh                                    BrCH.sub.2 CHBrCH.sub.2                                                                        Cl     O H    H   Q26-2-Cl                                     BrCH.sub.2 CHBrCH.sub.2                                                                        Cl     S  H   H   Q23-2-OMe                                    BrCH.sub.2 CHBrCH.sub.2                                                                        Cl     S  H   H   Q24                                          ICH.sub.2 CHClCH.sub.2                                                                         Cl     O H    H   Q26-6-Cl                                     ICH.sub.2 CHBrCH.sub.2                                                                         Cl     O H    H   Q26-6-Cl                                     Me.sub.2 CClCHCl                                                                               Cl     O H    H   Q26-6-Cl                                     Me.sub.2 CClCHCl                                                                               Cl     O H    H   Q26-6-I                                      Me.sub.2 CClCHCl                                                                               Br     O H    H   Q26-6-I                                      Me.sub.2 CClCHCl                                                                               Cl     O H    H   Q17                                          Me.sub.2 CClCHCl                                                                               Cl     S  H   H   Q24-5-Cl                                     Me.sub.2 CClCHBr                                                                               Cl     O H    H   Q26-6-Cl                                     Me.sub.2 CClCHBr                                                                               Cl     O H    H   Q26-6-I                                      Me.sub.2 CClCHBr                                                                               Cl     S  H   H   Q24-5-Me                                     Me.sub.2 CBrCHCl                                                                               Cl     O H    H   Q26-6-Cl                                     Me.sub.2 CBrCHCl                                                                               Cl     O H    H   Q17-5-Cl                                     Me.sub.2 CBrCHCl                                                                               Cl     O H    H   Q17-5-Et                                     Me.sub.2 CBrCHBr                                                                               Cl     O H    H   Q26-6-Cl                                     Me.sub.2 CBrCHBr                                                                               Cl     O H    H   Q26-6-I                                      Me.sub.2 CBrCHBr                                                                               Cl     O H    H   Q26-6-F                                      Me.sub.2 CBrCHBr                                                                               Br     O H    H   Q17-5-Me                                     Me.sub.2 CBrCHBr                                                                               Cl     S  H   H   Q25                                          (ClCH.sub.2).sub.2 CClCH.sub.2                                                                 Cl     O H    H   Q26-6-Cl                                     (ClCH.sub.2).sub.2 CClCH.sub.2                                                                 Cl     O H    H   Q26-6-I                                      (ClCH.sub.2).sub.2 CClCH.sub.2                                                                 Br     O H    H   Q26-6-Cl                                     (ClCH.sub.2).sub.2 CClCH.sub.2                                                                 I      O H    H   Q26-6-I                                      (ClCH.sub.2).sub.2 CClCH.sub.2                                                                 Cl     O H    H   Q26-6-Br                                     (ClCH.sub.2).sub.2 CClCH.sub.2                                                                 Cl     O H    H   Q17-5-Cl                                     (ClCH.sub.2).sub.2 CClCH.sub.2                                                                 Cl     O H    H   Q17-6-Me                                     (ClCH.sub.2).sub.2 CClCH.sub.2                                                                 Cl     O H    H   Q18-2,6-Cl.sub.2                             (ClCH.sub.2).sub.2 CClCH.sub.2                                                                 Cl     S  H   H   Q25-2,4-Me.sub.2                             (ClCH.sub.2).sub.2 CClCH.sub.2                                                                 Cl     S  H   H   Q27                                          (ClCH.sub.2).sub.2 CBrCH.sub.2                                                                 Cl     O H    H   Q26-6-Cl                                     (ClCH.sub.2).sub.2 CBrCH.sub.2                                                                 Cl     O H    H   Q26-6-I                                      ClCH.sub.2 CBr(CH.sub.2 Br)CH.sub.2                                                            Cl     O H    H   Q26-6-Cl                                     ClCH.sub.2 CCl(Me)CH.sub.2                                                                     Cl     O H    H   Q26-6-Cl                                     ClCH.sub.2 CCl(Me)CH.sub.2                                                                     Cl     O H    H   Q26-6-I                                      ClCH.sub.2 CCl(Me)CH.sub.2                                                                     Br     O H    H   Q26-6-Cl                                     ClCH.sub.2 CCl(Me)CH.sub.2                                                                     Br     O H    H   Q26-6-I                                      ClCH.sub.2 CCl(Me)CH.sub.2                                                                     I      O H    H   Q26-6-Cl                                     ClCH.sub.2 CCl(Me)CH.sub.2                                                                     I      O H    H   Q26-6-I                                      ClCH.sub.2 CCl(Me)CH.sub.2                                                                     I      O H    H   Q26-6-Cl                                     ClCH.sub.2 CCl(Me)CH.sub.2                                                                     Cl     O H    H   Q26-6-F                                      ClCH.sub.2 CCl(Me)CH.sub.2                                                                     Cl     O H    H   Q17-5-Me                                     ClCH.sub.2 CCl(Me)CH.sub.2                                                                     Cl     O H    H   Q18-2-Cl                                     ClCH.sub.2 CCl(Me)CH.sub.2                                                                     I      O H    H   Q18-2-Cl-6-Me                                ClCH.sub.2 CCl(Me)CH.sub.2                                                                     Cl     S  H   H   Q27-6-Me                                     ClCH.sub.2 CCl(Me)CH.sub.2                                                                     Cl     S  H   H   Q27-6-Cl                                     ClCH.sub.2 CCl(Me)CH.sub.2                                                                     Cl     S  H   H   Q26-6-Cl                                     ClCH.sub.2 CBr(Me)CH.sub.2                                                                     Cl     O H    H   Q26-6-Cl                                     ClCH.sub.2 CBr(Me)CH.sub.2                                                                     Cl     O H    H   Q26-6-I                                      ClCH.sub.2 CBr(Me)CH.sub.2                                                                     Cl     S  H   H   Q28                                          ClCH.sub.2 CBr(Me)CH.sub.2                                                                     Cl     S  H   H   Q26-5-Cl                                     ClCH.sub.2 CHClCH(CH.sub.2 Cl)                                                                 Cl     O H    H   Q26-6-Cl                                     ClCH.sub.2 CHClCH(CH.sub.2 Cl)                                                                 Cl     O H    H   Q26-6-I                                      BrCH.sub.2 CHBrCH(CH.sub.2 Br)                                                                 Cl     O H    H   Q26-6-Cl                                     MeCCl.sub.2 CH(CH.sub.2 Cl)                                                                    Cl     O H    H   Q26-6-Cl                                     ClCH.sub.2 CHClC(Me).sub.2                                                                     Cl     O H    H   Q26-6-Cl                                     ClCH.sub.2 CHClCH(Me)                                                                          Cl     O H    H   Q26-6-Cl                                     MeCHClCH(CH.sub.2 Cl)                                                                          Cl     O H    H   Q26-6-Cl                                     ClCH.sub.2 CCl.sub.2 CHCl                                                                      Cl     O H    H   Q26-6-Cl                                     ClCH.sub.2 CCl.sub.2 CHCl                                                                      Cl     O H    H   Q26-6-I                                      ClCH.sub.2 CHClCCl(Me)                                                                         Cl     O H    H   Q26-6-Cl                                     Cl.sub.2 CHCHClCH.sub.2                                                                        Cl     O H    H   Q26-6-Cl                                     Cl.sub.2 CHCHClCH.sub.2                                                                        Cl     O H    H   Q26-6-I                                      BrClCHCHBrCH.sub.2                                                                             Cl     O H    H   Q26-6-I                                      Cl.sub.2 CHCCl.sub.2 CH.sub.2                                                                  Cl     O H    H   Q26-6-Cl                                     Cl.sub.2 CHCCl.sub.2 CH.sub.2                                                                  Cl     O H    H   Q26-6-I                                      Cl.sub.2 CHCCl.sub.2 CH.sub.2                                                                  Cl     O H    H   Q26-6-Br                                     Cl.sub.2 CHCCl.sub.2 CH.sub.2                                                                  Cl     O H    H   Q17-5-Cl                                     Cl.sub.2 CHCCl.sub.2 CH.sub.2                                                                  Cl     O H    H   Q32                                          Cl.sub.2 CHCCl.sub.2 CH.sub.2                                                                  Cl     S  H   H   Q28-4,6-Me.sub.2                             Cl.sub.2 CHCCl.sub.2 CH.sub.2                                                                  Cl     S  H   H   Q29                                          ClBrCHCClBrCH.sub.2                                                                            Cl     O H    H   Q26-6-Cl                                     ClBrCHCClBrCH.sub.2                                                                            Cl     O H    H   Q26-6-I                                      ClBrCHCClBrCH.sub.2                                                                            Br     O H    H   Q32-2-Cl                                     ClBrCHCClBrCH.sub.2                                                                            Cl     S  H   H   Q30                                          ClBrCHCClBrCH.sub.2                                                                            Cl     S  H   H   Q31                                          ClCH.sub.2 CH.sub.2 CHClCH.sub.2                                                               Cl     O H    H   Q26-6-Cl                                     ClCH.sub.2 CH.sub.2 CHClCH.sub.2                                                               Cl     O H    H   Q26-6-I                                      MeCHClCHClCH.sub.2                                                                             Cl     O H    H   Q26-6-Cl                                     MeCHClCHClCH.sub.2                                                                             Cl     O H    H   Q26-6-I                                      Me.sub.2 CClCHClCH.sub.2                                                                       Cl     O H    H   Q26-6-Cl                                     PrCCl(CH.sub.2 Cl)CH.sub.2                                                                     Cl     O H    H   Q26-6-Cl                                     MeCCl.sub.2 CHClCH.sub.2                                                                       Cl     O H    H   Q26-6-Cl                                     MeCCl.sub.2 CHClCH.sub.2                                                                       Cl     O H    H   Q26-6-I                                      ClCH.sub.2 CH(Me)                                                                              Cl     O H    H   Q26-6-Cl                                     ClCH.sub.2 CH(Me)                                                                              Cl     O H    H   Q26-6-I                                      ClCH.sub.2 C(Me).sub.2                                                                         Cl     O H    H   Q26-6-Br                                     ClCH.sub.2 C(Me).sub.2                                                                         Cl     O H    H   Q17-5-Cl                                     Cl(CH.sub.2).sub.3                                                                             Cl     O H    H   Q32-2-Me                                     Cl(CH.sub.2).sub.3                                                                             Cl     O H    H   Q45                                          Cl(CH.sub.2).sub.3                                                                             Cl     S  H   H   Q31                                          Cl(CH.sub.2).sub.3                                                                             Cl     S  H   H   Q33                                          Br(CH.sub.2).sub.3                                                                             Cl     O H    H   Q26-6-Cl                                     Br(CH.sub.2).sub.3                                                                             Cl     O H    H   Q26-6-I                                      Br(CH.sub.2).sub.3                                                                             Cl     S  H   H   Q30-2,6-Me.sub.2                             Br(CH.sub.2).sub.3                                                                             Cl     S  H   H   Q31-5-Cl                                     I(CH.sub.2).sub.3                                                                              Cl     O H    H   Q26-6-Cl                                     Me.sub.2 CClCH.sub.2                                                                           Cl     O H    H   Q26-6-Cl                                     Me.sub.2 CClCH.sub.2                                                                           Cl     O H    H   Q26-6-I                                      Me.sub.2 CClCH.sub.2                                                                           Br     O H    H   Q26-6-Cl                                     Me.sub.2 CClCH.sub.2                                                                           I      O H    H   Q26-6-I                                      Me.sub.2 CClCH.sub.2                                                                           Cl     O H    H   Q26-6-F                                      Me.sub.2 CClCH.sub.2                                                                           I      O H    H   Q17-5-Me                                     Me.sub.2 CClCH.sub.2                                                                           Cl     O H    H   Q45-5-Me                                     Me.sub.2 CClCH.sub.2                                                                           Cl     O H    H   Q50                                          Me.sub.2 CClCH.sub.2                                                                           Cl     S  H   H   Q33-5-Cl                                     Me.sub.2 CClCH.sub.2                                                                           Cl     S  H   H   Q33-6-Cl                                     Me.sub.2 CBrCH.sub.2                                                                           Cl     O H    H   Q26-6-Cl                                     Me.sub.2 CBrCH.sub.2                                                                           Cl     O H    H   Q26-6-I                                      Me.sub.2 CBrCH.sub.2                                                                           Cl     O H    H   Q26-6-Br                                     Me.sub.2 CBrCH.sub.2                                                                           I      O H    H   Q17-5-Cl                                     Me.sub.2 CBrCH.sub.2                                                                           Cl     O H    H   Q50-2-CF.sub.3                               Me.sub.2 CBrCH.sub.2                                                                           Cl     O H    H   Q50-2-Cl                                     Me.sub.2 CBrCH.sub.2                                                                           Cl     S  H   H   Q33-5-Me                                     Me.sub.2 CBrCH.sub.2                                                                           Cl     S  H   H   Q33-6-OCF.sub.3                              Cl(CH.sub.2).sub.4                                                                             Cl     O H    H   Q26-6-Cl                                     Cl(CH.sub.2).sub.4                                                                             Cl     O H    H   Q26-6-I                                      Br(CH.sub.2).sub.4                                                                             Cl     O H    H   Q26-6-Cl                                     Br(CH.sub.2).sub.4                                                                             Cl     O H    H   Q26-6-I                                      I(CH.sub.2).sub.4                                                                              Cl     O H    H   Q26-6-Cl                                     I(CH.sub.2).sub.4                                                                              Cl     O H    H   Q26-6-I                                      i-PrCCl(Me)CH.sub.2                                                                            Cl     O  H   H   Q26-6-Cl                                     i-PrCCl(Me)CH.sub.2                                                                            Cl     O H    H   Q26-6-I                                      i-PrCCl(Me)CH.sub.2                                                                            Cl     O H    H   Q26-6-F                                      i-PrCCl(Me)CH.sub.2                                                                            Cl     O H    H   Q17-5-Me                                     i-PrCCl(Me)CH.sub.2                                                                            Cl     O H    H   Q50-2-Me                                     i-PrCCl(Me)CH.sub.2                                                                            Cl     O H    H   Q52-1-Me-5-Cl                                i-PrCCl(Me)CH.sub.2                                                                            Cl     S  H   H   Q34                                          i-PrCCl(Me)CH.sub.2                                                                            Cl     S  H   H   Q34-2-Me                                     i-PrCBr(Me)CH.sub.2                                                                            Cl     O H    H   Q26-6-Cl                                     i-PrCBr(Me)CH.sub.2                                                                            Cl     O H    H   Q26-6-I                                      i-PrCBr(Me)CH.sub.2                                                                            Cl     S  H   H   Q34-2-CF.sub.3                               i-PrCBr(Me)CH.sub.2                                                                            Cl     S  H   H   Q35                                          EtCCl(Me)CH.sub.2                                                                              Cl     O H    H   Q26-6-Cl                                     EtCCl(Me)CH.sub.2                                                                              Cl     O H    H   Q26-6-I                                      EtCCl(Me)CH.sub.2                                                                              I      O H    H   Q26-6-Cl                                     EtCCl(Me)CH.sub.2                                                                              I      O H    H   Q26-6-I                                      EtCCl(Me)CH.sub.2                                                                              Cl     O H    H   Q26-6-F                                      EtCCl(Me)CH.sub.2                                                                              Cl     O H    H   Q17-5-Me                                     EtCCl(Me)CH.sub.2                                                                              Cl     O H    H   Q53-1-Me                                     EtCCl(Me)CH.sub.2                                                                              Cl     O H    H   Q54                                          EtCCl(Me)CH.sub.2                                                                              Cl     S  H   H   Q35-3-Me                                     EtCCl(Me)CH.sub.2                                                                              Cl     S  H   H   Q36                                          EtCBr(Me)CH.sub.2                                                                              Cl     O H    H   Q26-6-Cl                                     EtCBr(Me)CH.sub.2                                                                              Cl     O H    H   Q26-6-I                                      EtCBr(Me)CH.sub.2                                                                              Cl     S  H   H   Q36-2-Et                                     EtCBr(Me)CH.sub.2                                                                              Cl     S  H   H   Q37-1-Me                                     Et.sub.2 CClCH.sub.2                                                                           Cl     O H    H   Q26-6-Cl                                     Et.sub.2 CClCH.sub.2                                                                           Cl     O H    H   Q26-6-I                                      Et.sub.2 CClCH.sub.2                                                                           I      O H    H   Q26-6-Cl                                     Et.sub.2 CClCH.sub.2                                                                           Cl     O H    H   Q26-6-Br                                     Et.sub.2 CClCH.sub.2                                                                           Cl     O H    H   Q17-5-Cl                                     Et.sub.2 CClCH.sub.2                                                                           Cl     O H    H   Q26-6-OCH.sub.2 CF.sub.3                     Et.sub.2 CClCH.sub.2                                                                           Cl     O H    H   Q18                                          Et.sub.2 CClCH.sub.2                                                                           Cl     S  H   H   Q38-1-Me                                     Et.sub.2 CClCH.sub.2                                                                           Cl     S  H   H   Q39-1-Me                                     Et.sub.2 CBrCH.sub.2                                                                           Cl     O H    H   Q26-6-Cl                                     Et.sub.2 CBrCH.sub.2                                                                           Cl     O H    H   Q26-6-I                                      Et.sub.2 CBrCH.sub.2                                                                           Cl     S  H   H   Q40-1,3-Me.sub.2                             Et.sub.2 CBrCH.sub.2                                                                           Cl     S  H   H   Q41-1-Me                                     t-BuCHClCH.sub.2                                                                               Cl     O H    H   Q26-6-Cl                                     t-BuCCl(Me)CH.sub.2                                                                            Cl     O H    H   Q26-6-Cl                                     t-BuCCl(Me)CH.sub.2                                                                            Cl     O H    H   Q26-6-I                                      t-BuCCl(Me)CH.sub.2                                                                            Br     O H    H   Q26-6-Cl                                     t-BuCCl(Me)CH.sub.2                                                                            I      O H    H   Q26-6-Cl                                     t-BuCCl(Me)CH.sub.2                                                                            I      O H    H   Q26-6-I                                      t-BuCCl(Me)CH.sub.2                                                                            Cl     O H    H   Q26-6-Br                                     t-BuCCl(Me)CH.sub.2                                                                            Cl     O H    H   Q17-5-Cl                                     t-BuCCl(Me)CH.sub.2                                                                            Cl     O H    H   Q26                                          t-BuCCl(Me)CH.sub.2                                                                            Cl     S  H   H   Q42                                          t-BuCCl(Me)CH.sub.2                                                                            Cl     S  H   H   Q42-4-Me                                     t-BuCBr(Me)CH.sub.2                                                                            Cl     O H    H   Q26-6-Cl                                     t-BuCBr(Me)CH.sub.2                                                                            Cl     O H    H   Q26-6-I                                      t-BuCBr(Me)CH.sub.2                                                                            Cl     S  H   H   Q42-6-Me                                     t-BuCBr(Me)CH.sub.2                                                                            Cl     S  H   H   Q42-4-Cl                                     PrCCl(Me)CH.sub.2                                                                              Cl     O H    H   Q26-6-Cl                                     PrCCl(Me)CH.sub.2                                                                              Cl     O H    H   Q26-6-I                                      PrCCl(Me)CH.sub.2                                                                              I      O H    H   Q26-6-Cl                                     PrCCl(Me)CH.sub.2                                                                              I      O H    H   Q26-6-I                                      PrCCl(Me)CH.sub.2                                                                              Br     O H    H   Q26-6-F                                      PrCCl(Me)CH.sub.2                                                                              I      O H    H   Q17-5-Me                                     PrCCl(Me)CH.sub.2                                                                              Cl     O H    H   Q26-6-CF.sub.3                               PrCCl(Me)CH.sub.2                                                                              Cl     O H    H   Q26-6-CN                                     PrCCl(Me)CH.sub.2                                                                              Cl     S  H   H   Q42-8-Me                                     PrCCl(Me)CH.sub.2                                                                              Cl     S  H   H   Q42-8-Cl                                     PrCBr(Me)CH.sub.2                                                                              Cl     O H    H   Q26-6-Cl                                     PrCBr(Me)CH.sub.2                                                                              Cl     O H    H   Q26-6-I                                      PrCBr(Me)CH.sub.2                                                                              Cl     S  H   H   Q43                                          PrCBr(Me)CH.sub.2                                                                              Cl     S  H   H   Q43-2-Cl                                     i-PrCCl(Me)CH.sub.2                                                                            Cl     O H    H   Q26-6-Cl                                     i-PrCCl(Me)CH.sub.2                                                                            Cl     O H    H   Q26-6-I                                      i-PrCCl(Me)CH.sub.2                                                                            I      O H    H   Q26-6-Cl                                     i-PrCCl(Me)CH.sub.2                                                                            Cl     O H    H   Q26-6-Br                                     i-PrCCl(Me)CH.sub.2                                                                            F      O H    H   Q17-5-Cl                                     i-PrCCl(Me)CH.sub.2                                                                            Br     O H    H   Q26-6-Me                                     i-PrCCl(Me)CH.sub.2                                                                            I      O H    H   Q26-6-OPr                                    i-PrCCl(Me)CH.sub.2                                                                            Cl     S  H   H   Q44                                          i-PrCCl(Me)CH.sub.2                                                                            Cl     S  H   H   Q44-2-CF.sub.3                               i-PrCBr(Me)CH.sub.2                                                                            Cl     O H    H   Q26-6-Cl                                     i-PrCBr(Me)CH.sub.2                                                                            Cl     O H    H   Q26-6-I                                      i-PrCBr(Me)CH.sub.2                                                                            Cl     S  H   H   Q45-5-Cl                                     i-PrCBr(Me)CH.sub.2                                                                            Cl     S  H   H   Q45-5,6-Me.sub.2                             BuCCl(Me)CH.sub.2                                                                              Cl     O H    H   Q26-6-Cl                                     BuCCl(Me)CH.sub.2                                                                              Cl     O H    H   Q26-6-I                                      BuCCl(Me)CH.sub.2                                                                              I      O H    H   Q26-6-I                                      BuCCl(Me)CH.sub.2                                                                              Cl     O H    H   Q26-6-F                                      BuCCl(Me)CH.sub.2                                                                              Br     O H    H   Q17-5-Me                                     BuCCl(Me)CH.sub.2                                                                              Cl     O H    H   Q26-6-OEt                                    BuCCl(Me)CH.sub.2                                                                              Cl     S  H   H   Q45-6-Cl                                     BuCCl(Me)CH.sub.2                                                                              Cl     S  H   H   Q46                                          BuCBr(Me)CH.sub.2                                                                              Cl     O H    H   Q26-6-Cl                                     BuCBr(Me)CH.sub.2                                                                              Cl     S  H   H   Q46-3-Me                                     BuCBr(Me)CH.sub.2                                                                              Cl     S  H   H   Q46-6-Me                                     HexCHClCH.sub.2 Cl     O H    H   Q26-6-Cl                                     HexCHClCH.sub.2 Cl     O H    H   Q26-6-I                                      i-BuCCl(Me)CH.sub.2                                                                            Cl     O H    H   Q26-6-Cl                                     i-BuCCl(Me)CH.sub.2                                                                            Cl     O H    H   Q26-6-I                                      i-BuCCl(Me)CH.sub.2                                                                            Br     O H    H   Q26-6-Cl                                     i-BuCCl(Me)CH.sub.2                                                                            I      O H    H   Q26-6-I                                      i-BuCCl(Me)CH.sub.2                                                                            Cl     O H    H   Q26-6-Br                                     i-BuCCl(Me)CH.sub.2                                                                            I      O H    H   Q17-5-Cl                                     i-BuCCl(Me)CH.sub.2                                                                            Cl     O H    H   Q26-6-OMe                                    i-BuCCl(Me)CH.sub.2                                                                            Cl     O H    H   Q26-5-Br                                     i-BuCCl(Me)CH.sub.2                                                                            Cl     S  H   H   Q46-6-Cl                                     i-BuCCl(Me)CH.sub.2                                                                            Cl     S  H   H   Q47-7-Cl                                     i-BuCBr(Me)CH.sub.2                                                                            Cl     O H    H   Q26-6-Cl                                     i-BuCBr(Me)CH.sub.2                                                                            Cl     S   H  H   Q46-6-F                                      i-BuCBr(Me)CH.sub.2                                                                            Cl     S  H   H   Q47                                          s-BuCCl(Me)CH.sub.2                                                                            Cl     O H    H   Q26-6-Cl                                     s-BuCCl(Me)CH.sub.2                                                                            Cl     O H    H   Q26-6-I                                      s-BuCCl(Me)CH.sub.2                                                                            I      O H    H   Q26-6-Cl                                     s-BuCCl(Me)CH.sub.2                                                                            I      O H    H   Q26-6-I                                      s-BuCCl(Me)CH.sub.2                                                                            I      O H    H   Q26-6-Br                                     s-BuCCl(Me)CH.sub.2                                                                            I      O H    H   Q17-5-Cl                                     s-BuCCl(Me)CH.sub.2                                                                            I      O H    H   Q26-6-OPh                                    s-BuCCl(Me)CH.sub.2                                                                            Me     O H    H   Q26-2-Cl                                     s-BuCCl(Me)CH.sub.2                                                                            Cl     S  H   H   Q47-2,3-Me.sub.2                             s-BuCCl(Me)CH.sub.2                                                                            Cl     S  H   H   Q48                                          s-BuCBr(Me)CH.sub.2                                                                            Cl     O H    H   Q26-6-Cl                                     s-BuCBr(Me)CH.sub.2                                                                            Cl     O H    H   Q26-6-I                                      s-BuCBr(Me)CH.sub.2                                                                            Cl     S  H   H   Q48-5-Cl                                     s-BuCBr(Me)CH.sub.2                                                                            Cl     S  H   H   Q49-2,4-Me.sub.2                             PenCCl(Me)CH.sub.2                                                                             Cl     O H    H   Q26-6-Cl                                     PenCCl(Me)CH.sub.2                                                                             Cl     O H    H   Q26-6-I                                      ClCHCHCH.sub.2  Cl     O H    H   Q26-6-Cl                                     ClCHCHCH.sub.2  Cl     O H    H   Q26-6-I                                      ClCHC(Cl)CH.sub.2                                                                              Cl     O H    H   Q26-6-Cl                                     ClCHC(Cl)CH.sub.2                                                                              Cl     O H    H   Q26-6-I                                      Q3-2-Cl         Cl     O H    H   Q26-6-Cl                                     Q3-2-Cl         Cl     O H    H   Q26-6-I                                      Q3-2-Cl         I      O H    H   Q26-6-Cl                                     Q3-2-Cl         I      O H    H   Q26-6-I                                      Q3-2-Cl         Cl     O H    H   Q17-5-Cl                                     Q3-2-Cl         Cl     S  H   H   Q51-5-Me                                     Q3-2-Cl         Cl     S  H   H   Q52-5-Me                                     Q3-2-Br         Cl     O H    H   Q26-6-Cl                                     (Q4-1-Cl)CH.sub.2                                                                              Cl     O H    H   Q26-6-Cl                                     (Q4-1-Cl)CH.sub.2                                                                              Cl     O H    H   Q26-6-I                                      Q4-2-Cl         Cl     O H    H   Q26-6-Cl                                     Q4-2-Cl         Cl     O H    H   Q26-6-I                                      Q4-2-Cl         Br     O H    H   Q26-6-Cl                                     Q4-2-Cl         I      O H    H   Q26-6-I                                      Q4-2-Cl         Cl     O H    H   Q26-6-F                                      Q4-2-Cl         Cl     O H    H   Q17-5-Me                                     Q4-2-Cl         OMe    O H    H   Q17                                          Q4-2-Cl         SMe    O H    H   Q17-5-Et                                     Q4-2-Cl         Cl     S  H   H   Q52-1,5-Me.sub.2                             Q4-2-Cl         Cl     S  H   H   Q53                                          Q4-2-Br         Cl     O H    H   Q26-6-Cl                                     Q4-2-Br         Cl     O H    H   Q26-6-I                                      Q4-2-Br         Cl     S  H   H   Q53-1-Ph                                     Q4-2-Br         Cl     S  H   H   Q53-1,3,4-Me.sub.3                           Q5-2-Cl         Cl     O H    H   Q26-6-Cl                                     Q5-2-Cl         Cl     O H    H   Q26-6-I                                      Q5-2-Cl         Cl     S  H   H   Q54-1-Me-3-Bu-t                              Q5-2-Br         Cl     O H    H   Q26-6-Cl                                     Q10-2-Cl        Cl     O H    H   Q26-6-Cl                                     Q10-2-Cl        Cl     O H    H   Q26-6-I                                      Q10-2-Cl        Cl     S  H   H   Q26-6-Cl                                     Q10-2-Cl        Cl     S  H   H   Q26-6-I                                      Q10-2-Br        Cl     O H    H   Q26-6-Cl                                     Q10-2-Br        Cl     S  H   H   Q17-5-Cl                                     MeCCl(OMe)CH.sub.2                                                                             Cl     O H    H   Q26-6-Cl                                     MeCCl(OMe)CH.sub.2                                                                             Cl     O H    H   Q26-6-I                                      PrCCl(OMe)CH.sub.2                                                                             Cl     O H    H   Q26-6-Cl                                     MeCCl(COOMe)CH.sub.2                                                                           Cl     O H    H   Q26-6-Cl                                     MeCCl(COOMe)CH.sub.2                                                                           Cl     O H    H   Q26-6-I                                      MeCCl(SMe)CH.sub.2                                                                             Cl     O H    H   Q26-6-Cl                                     MeCCl(SMe)CH.sub.2                                                                             Cl     O H    H   Q26-6-I                                      PrCCl(SMe)CH.sub.2                                                                             Cl     O H    H   Q26-6-Cl                                     PrCCl(CH.sub.2 OMe)CH.sub.2                                                                    Cl     O H    H   Q26-6-Cl                                     PrCCl(CH.sub.2 SMe)CH.sub.2                                                                    Cl     O H    H   Q26-6-Cl                                     MeCCl(CH.sub.2 CH.sub.2 OMe)CH.sub.2                                                           Cl     O H    H   Q26-6-Cl                                     PrCCl(CH.sub.2 CN)CH.sub.2                                                                     Cl     O H    H   Q26-6-Cl                                     PrCCl(CH.sub.2 COOMe)CH.sub.2                                                                  Cl     O H    H   Q26-6-Cl                                     NCCH.sub.2 CCl(Me)CH.sub.2                                                                     Cl     O H    H   Q26-6-Cl                                     NCCH.sub.2 CCl(Me)CH.sub.2                                                                     Cl     O H    H   Q26-6-I                                      MeCOOCH.sub.2 CCl(Me)CH.sub.2                                                                  Cl     O H    H   Q26-6-Cl                                     MeCOOCH.sub.2 CCl(Me)CH.sub.2                                                                  Cl     O H    H   Q26-6-I                                      EtCOOCH.sub.2 CCl(Me)CH.sub.2                                                                  Cl     O H    H   Q26-6-Cl                                     MeOCH.sub.2 CCl(Me)CH.sub.2                                                                    Cl     O H    H   Q26-6-Cl                                     MeOCH.sub.2 CCl(Me)CH.sub.2                                                                    Cl     O H    H   Q26-6-I                                      EtOCH.sub.2 CCl(Me)CH.sub.2                                                                    Cl     O H    H   Q26-6-Cl                                     PrOCH.sub.2 CCl(Me)CH.sub.2                                                                    Cl     O H    H   Q26-6-Cl                                     MeSCH.sub.2 CCl(Me)CH.sub.2                                                                    Cl     O H    H   Q26-6-Cl                                     MeSCH.sub.2 CCl(Me)CH.sub.2                                                                    Cl     O H    H   Q26-6-I                                      EtSCH.sub.2 CCl(Me)CH.sub.2                                                                    Cl     O H    H   Q26-6-Cl                                     PrSCH.sub.2 CCl(Me)CH.sub.2                                                                    Cl     O H    H   Q26-6-Cl                                     MeCCl(CN)CH.sub. 2                                                                             Cl     O H    H   Q26-6-Cl                                     MeCCl(CN)CH.sub.2                                                                              Cl     O H    H   Q26-6-I                                      MeSO.sub.2 CCl(Me)CH.sub.2                                                                     Cl     O H    H   Q26-6-Cl                                     MeSO.sub.2 CCl(Me)CH.sub.2                                                                     Cl     O H    H   Q26-6-I                                      Me.sub.2 NCCl(Me)CH.sub.2                                                                      Cl     O H    H   Q26-6-Cl                                     Me.sub.2 NCCl(Me)CH.sub.2                                                                      Cl     O H    H   Q26-6-I                                      Me.sub.2 CClCH.sub.2                                                                           Cl     O H    H   Q26-6-Et                                     Me.sub.2 CClCH.sub.2                                                                           Cl     O H    H   Q26-6-Br                                     Me.sub.2 CClCH.sub.2                                                                           Cl     O H    H   Q26-6-CF.sub.3                               Me.sub.2 CClCH.sub.2                                                                           Br     O H    H   Q26-6-I                                      Me.sub.2 CClCH.sub.2                                                                           Cl     O H    H   Q26-6-OEt                                    Me.sub.2 CClCH.sub.2                                                                           Cl     O H    H   Q32-2-I                                      Me.sub.2 CClCH.sub.2                                                                           Cl     O H    H   Q32-2-Cl                                     Me.sub.2 CClCH.sub.2                                                                           Cl     O H    H   Q32-2-Et                                     Me.sub.2 CBrCH.sub.2                                                                           Cl     O H    H   Q26-6-Et                                     Me.sub.2 CBrCH.sub.2                                                                           Cl     O H    H   Q26-6-Br                                     Me.sub.2 CBrCH.sub.2                                                                           Cl     O H    H   Q32-2-Cl                                     Me.sub.2 CBrCH.sub.2                                                                           Cl     O H    H   Q32-2-Et                                     Me.sub.2 CBrCH.sub.2                                                                           Cl     O H    H   Q32-2-OEt                                    Me.sub.2 CBrCH.sub.2                                                                           Br     O H    H   Q26-6-I                                      Me.sub.2 CBrCH.sub.2                                                                           Br     O H    H   Q26-6-Cl                                     PrCCl(Me)CH.sub.2                                                                              Cl     O H    H   Q26-6-Et                                     PrCCl(Me)CH.sub.2                                                                              Cl     O H    H   Q32-2-Et                                     PrCCl(Me)CH.sub. 2                                                                             Cl     O H    H   Q32-2-Cl                                     PrCCl(Me)CH.sub.2                                                                              Br     O H    H   Q26-6-I                                      PrCCl(Me)CH.sub.2                                                                              Br     O H    H   Q26-6-Cl                                     PrCCl(Me)CH.sub.2                                                                              Cl     O H    H   Q17-5-CF.sub.3                               PrCBr(Me)CH.sub.2                                                                              Br     O H    H   Q26-6-Br                                     PrCBr(Me)CH.sub.2                                                                              Br     O H    H   Q26-6-I                                      Cl.sub.2 CCH    Cl     O H    H   Q26-6-Cl                                     Cl.sub.2 CCH    Cl     O H    H   Q26-6-I                                      MeCClCH         Cl     O H    H   Q26-6-I                                      MeCClCH         Cl     O H    H   Q26-6-Et                                     EtCClCH         Cl     O H    H   Q26-6-I                                      EtCClCH         Cl     O H    H   Q26-6-Cl                                     EtCClCH         Cl     O H    H   Q26-6-Br                                     PrCClCH         Cl     O H    H   Q26-6-I                                      PrCClCH         Cl     O H    H   Q26-6-Br                                     PrCClCH         Br     O H    H   Q26-6-Br                                     Me.sub.2 CCH    Cl     O H    H   Q26-6-I                                      Me.sub.2 CCH    Cl     O H    H   Q26-6-Br                                     Me.sub.2 CCH    Cl     O H    H   Q26-6-Et                                     Me.sub.2 CCH    Cl     O H    H   Q26-6-Cl                                     MeC(Et)CH       Cl     O H    H   Q26-6-I                                      MeC(Et)CH       Cl     O H    H   Q26-6-Cl                                     MeC(Pr)CH       Cl     O H    H   Q26-6-Cl                                     MeC(Pr)CH       Cl     O H    H   Q26-6-I                                      MeC(Pr)CH       Cl     O H    H   Q26-6-Br                                     MeC(Bu)CH       Cl     O H    H   Q26-6-I                                      CF.sub.3 CClCH  Cl     O  H   H   Q26-6-Cl                                     CF.sub.3 CClCH  Cl     O H    H   Q26-6-I                                      CF.sub.3 CBrCH  Cl     O H    H   Q26-6-I                                      CF.sub.3 CBrCH  Cl     O H    H   Q26-6-Br                                     CH.sub.2C(Me)CH.sub.2                                                                          Cl     O H    H   Q26-6-Cl                                     CH.sub.2C(Me)CH.sub.2                                                                          Cl     O H    H   Q26-6-I                                      CH.sub.2C(Me)CH.sub.2                                                                          Cl     O H    H   Q26-6-Br                                     CH.sub.2C(Me)CH.sub.2                                                                          Br     O H    H   Q26-6-I                                      CH.sub.2C(Et)CH.sub.2                                                                          Cl     O H    H   Q26-6-I                                      CH.sub.2C(Et)CH.sub.2                                                                          Cl     O H    H   Q26-6-Et                                     CH.sub.2C(Et)CH.sub.2                                                                          Cl     O H    H   Q26-6-Br                                     CH.sub.2C(Pr)CH.sub.2                                                                          Cl     O H    H   Q26-6-I                                      CH.sub.2C(Pr)CH.sub.2                                                                          Cl     O H    H   Q26-6-Br                                     CH.sub.2C(Pr)CH.sub.2                                                                          Br     O H    H   Q26-6-Br                                     CH.sub.2C(Bu)CH.sub.2                                                                          Cl     O H    H   Q26-6-I                                      CH.sub.2C(Bu)CH.sub.2                                                                          Cl     O H    H   Q26-6-Br                                     MeCHC(Me)CH.sub.2                                                                              Cl     O H    H   Q26-6-I                                      MeCHC(Me)CH.sub.2                                                                              Cl     O H    H   Q26-6-Cl                                     MeCHC(Me)CH.sub.2                                                                              Cl     O H    H   Q26-6-Br                                     EtCHC(Me)CH.sub.2                                                                              Cl     O H    H   Q26-6-I                                      EtCHC(Me)CH.sub.2                                                                              Cl     O H    H   Q26-6-Br                                     EtCHC(Me)CH.sub.2                                                                              Cl     O H    H   Q26-6-Cl                                     EtCHC(Me)CH.sub.2                                                                              Br     O H    H   Q26-6-I                                      PrCHC(Me)CH.sub.2                                                                              Cl     O H    H   Q26-6-I                                      PrCHC(Me)CH.sub.2                                                                              Cl     O H    H   Q26-6-Br                                     MeCHC(Et)CH.sub.2                                                                              Cl     O H    H   Q26-6-I                                      MeCHC(Et)CH.sub.2                                                                              Cl     O H    H   Q26-6-Cl                                     MeCHC(Et)CH.sub.2                                                                              Cl     O H    H   Q32-2-Et                                     CH.sub.2CHC(Me).sub.2 CH.sub.2                                                                 Cl     O H    H   Q26-6-Cl                                     CH.sub.2CHC(Me).sub.2 CH.sub.2                                                                 Cl     O H    H   Q26-6-Br                                     MeCHCHC(Me).sub.2 CH.sub.2                                                                     Cl     O H    H   Q26-6-I                                      MeCHCHC(Me).sub.2 CH.sub.2                                                                     Cl     O H    H   Q26-6-Cl                                     HCCC(Me).sub.2 CH.sub.2                                                                        Cl     O H    H   Q26-6-I                                      HCCC(Me).sub.2 CH.sub.2                                                                        Cl     O H    H   Q26-6-Br                                     MeCCC(Me).sub.2 CH.sub.2                                                                       Cl     O H    H   Q26-6-I                                      MeCCC(Me).sub.2 CH.sub.2                                                                       Cl     O H    H   Q26-6-Cl                                     CH.sub.2CHCH.sub.2 C(Me).sub.2 CH.sub.2                                                        Cl     O H    H   Q26-6-Br                                     CH.sub.2CHCH.sub.2 C(Me).sub.2 CH.sub.2                                                        Cl     O H    H   Q26-6-I                                      HCCCH.sub.2 C(Me).sub.2 CH.sub.2                                                               Cl     O H    H   Q26-6-I                                      HC CCH.sub.2 C(Me).sub.2 CH.sub.2                                                              Cl     O H    H   Q26-6-Cl                                     MeCCCH.sub.2 C(Me).sub.2 CH.sub.2                                                              Cl     O H    H   Q26-6-Br                                     MeCCCH.sub.2 C(Me).sub.2 CH.sub.2                                                              Cl     O H    H   Q26-6-I                                      Me.sub.2 C(OMe)CH.sub.2                                                                        Cl     O H    H   Q26-6-Cl                                     Me.sub.2 C(OMe)CH.sub.2                                                                        Cl     O H    H   Q26-6-Br                                     Me.sub.2 C(OMe)CH.sub.2                                                                        Cl     O H    H   Q26-6-I                                      Me.sub.2 C(OEt)CH.sub.2                                                                        Cl     O H    H   Q26-6-Cl                                     Me.sub.2 C(OEt)CH.sub.2                                                                        Cl     O H    H   Q26-6-I                                      Me.sub.2 C(OPr)CH.sub.2                                                                        Cl     O H    H   Q26-6-Br                                     Me.sub.2 C(OPr)CH.sub.2                                                                        Cl     O H    H   Q26-6-I                                      MeC(Et)(OMe)CH.sub.2                                                                           Cl     O H    H   Q26-6-Et                                     MeC(Et)(OMe)CH.sub.2                                                                           Cl     O H    H   Q26-6-I                                      MeC(Pr)(OMe)CH.sub.2                                                                           Cl     O H    H   Q26-6-I                                      MeC(Pr)(OMe)CH.sub.2                                                                           Cl     O H    H   Q26-6-Br                                     MeOCH.sub.2 C(Me).sub.2 CH.sub.2                                                               Cl     O H    H   Q26-6-Cl                                     MeOCH.sub.2 C(Me).sub.2 CH.sub.2                                                               Cl     O H    H   Q26-6-CF.sub.3                               MeOCH.sub.2 C(Me).sub.2 CH.sub.2                                                               Cl     O H    H   Q26-6-I                                      EtOCH.sub.2 C(Me).sub.2 CH.sub.2                                                               Cl     O H    H   Q26-6-I                                      EtOCH.sub.2 C(Me).sub.2 CH.sub.2                                                               Cl     O H    H   Q26-6-Br                                     EtOCH.sub.2 C(Me).sub.2 CH.sub.2                                                               Br     O H    H   Q26-6-Cl                                     PrOCH.sub.2 C(Me).sub.2 CH.sub.2                                                               Cl     O H    H   Q26-6-Cl                                     PrOCH.sub.2 C(Me).sub.2 CH.sub.2                                                               Cl     O H    H   Q26-6-I                                      MeOCH.sub.2 CH.sub.2 C(Me).sub.2 CH.sub.2                                                      Cl     O H    H   Q26-6-Br                                     MeOCH.sub.2 CH.sub.2 C(Me).sub.2 CH.sub.2                                                      Cl     O H    H   Q26-6-Cl                                     MeOCH.sub.2 CH.sub.2 C(Me).sub.2 CH.sub.2                                                      Br     O H    H   Q26-6-Cl                                     EtOCH.sub.2 CH.sub.2 C(Me).sub.2 CH.sub.2                                                      Cl     O H    H   Q26-6-I                                      EtOCH.sub.2 CH.sub.2 C(Me).sub.2 CH.sub.2                                                      Cl     O H    H   Q26-6-Br                                     EtOCH.sub.2 CH.sub.2 C(Me).sub.2 CH.sub.2                                                      Cl     O H    H   Q26-6-Cl                                     MeO(CH.sub.2).sub.3 C(Me).sub.2 CH.sub.2                                                       Cl     O H    H   Q26-6-Et                                     MeO(CH.sub.2).sub.3 C(Me).sub.2 CH.sub.2                                                       Cl     O H    H   Q26-6-Cl                                     EtO(CH.sub.2).sub.3 C(Me).sub.2 CH.sub.2                                                       Cl     O H    H   Q26-6-I                                      EtO(CH.sub.2).sub.3 C(Me).sub.2 CH.sub.2                                                       Cl     O H    H   Q26-6-Cl                                     ______________________________________                                    

                                      TABLE 3                                      __________________________________________________________________________     In compounds of the formula:                                                    ##STR15##                                                                     R              A    X  R.sup.1                                                                           J                                                    __________________________________________________________________________     Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 C.sub.6 H.sub.4 -3-Cl              Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 C.sub.6 H.sub.4 -4-CF.sub.3        Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 C.sub.6 H.sub.4 -4-Me              Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 C.sub.6 H.sub.4 -4-OMe             Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CHMeC.sub.6 H.sub.4 -4-Me                   Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 CH.sub.2 C.sub.6 H.sub.4                                     -4-Me                                                Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 OPh                                Me.sub.2 CClCH.sub.2                                                                          Br   O  H  CH.sub.2 CH.sub.2 OPh                                Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CHMeOPh                                     Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub. 2 OC.sub.6 H.sub.4 -4-Cl            Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 OC.sub.6 H.sub.4 -4-I              Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 O-Q17                              Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CHMeO-Q17                                   Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 O-Q26                              Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 O-Q28                              Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 O-Q27                              Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 O-Q24                              Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 O-Q30                              Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 O-Q48                              Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 O-Q52                              Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 O-Q23                              Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 O-Q18                              Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CHMeO-Q28                                   Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CHMeO-Q27                                   Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 O-Q17-5-Cl                         Me.sub.2 CClCH.sub.2                                                                          Cl   S  H  CH.sub.2 CH.sub.2 O-Q17-5-Cl                         Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 O-Q38                              Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 O-Q45                              Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 O-Q54                              Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 O-Q51                              Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 O-Q49                              Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 NHPh                               Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 N(Me)Ph                            Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 SPh                                Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 NH-Q17                             Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH(Me)CH.sub.2 OPh                                   Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  (CH.sub.2).sub.3 CO.sub.2 Me                         Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  (CH.sub.2).sub.3 CO.sub.2 Et                         Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CHMeCH.sub.2 CO.sub.2 Et                    Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CHCHCO.sub.2 Et                             Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CMeCHCO.sub.2 Et                            Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 OC(O)Et                            Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 OC(O)Pr                            Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 NHC(O)Pr                           Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 NHC(O)BuS                          Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 NHCO.sub.2 Et                      Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  (CH.sub.2).sub.3 CCCl                                Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  (CH.sub.2).sub.3 CCBr                                Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  (CH.sub.2).sub.3 CCI                                 Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  (CH.sub.2).sub.3 CCCH.sub.2 OMe                      Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CHNOEt                                      Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CHNOPr                                      Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CHNOBu                                      Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CHNOPri                                     Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CMeNOPr                                     Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 ONCHMe                             Me.sub.2 CClCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 ONCHEt                             Me.sub.2 CBrCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 OPh                                Me.sub.2 CBrCH.sub.2                                                                          Cl   O  H  CH.sub.2 CH.sub.2 O-Q17                              Me.sub.2 CBrCH.sub.2                                                                          Cl   O  H  CH.sub.2 CHNOPr                                      ClCH.sub.2 CCl(Me)CH.sub.2                                                                    Cl   O  H  CH.sub.2 CH.sub.2 OPh                                ClCH.sub.2 CCl(Me)CH.sub.2                                                                    Cl   O  H  CH.sub.2 CH.sub.2 O-Q17                              ClCH.sub.2 CCl(Me)CH.sub.2                                                                    Cl   O  H  CH.sub.2 CH.sub.2 O-Q28                              ClCH.sub.2 CCl(Me)CH.sub.2                                                                    Cl   O  H  CH.sub.2 CHMePh                                      ClCH.sub.2 CCl(Me)CH.sub.2                                                                    Cl   O  H  CH.sub.2 CH.sub.2 ONCHMe                             ClCH.sub.2 CCl(Me)CH.sub.2                                                                    Cl   O  H  CH.sub.2 CHNOPr                                      ClCH.sub.2 CCl(Me)CH.sub.2                                                                    Br   O  H  CH.sub.2 CHNOPr                                      ClCH.sub.2 CCl(Me)CH.sub.2                                                                    Me   O  H  CH.sub.2 CH.sub.2 O-Q17                              ClCH.sub.2 CCl(Me)CH.sub.2                                                                    Cl   S  H  CH.sub.2 CH.sub.2 OPh                                ClCH.sub.2 CBr(Me)CH.sub.2                                                                    Cl   O  H  CH.sub.2 CH.sub.2 OPh                                ClCH.sub.2 CBr(Me)CH.sub.2                                                                    Cl   O  H  CH.sub.2 CH.sub.2 O-Q17                              ClCH.sub.2 CBr(Me)CH.sub.2                                                                    Cl   O  H  CH.sub.2 CHNOPr                                      EtCCl(Me)CH.sub.2                                                                             Cl   O  H  CH.sub.2 CH.sub.2 OPh                                EtCCl(Me)CH.sub.2                                                                             Cl   O  H  CH.sub.2 CH.sub.2 O-Q17                              EtCCl(Me)CH.sub.2                                                                             Cl   O  H  CH.sub.2 CHMeOPh                                     EtCCl(Me)CH.sub.2                                                                             Cl   O  H  CH.sub.2 CH.sub.2 OC(O)Et                            EtCCl(Me)CH.sub.2                                                                             Cl   O  H  CH.sub.2 CH.sub.2 ONCHMe                             EtCCl(Me)CH.sub.2                                                                             Cl   O  H  CH.sub.2 CHNOPr                                      PrCCl(Me)CH.sub.2                                                                             Cl   O  H  CH.sub.2 CH.sub.2 OPh                                PrCCl(Me)CH.sub.2                                                                             Cl   O  H  CH.sub.2 CH.sub.2 O-Q17                              PrCCl(Me)CH.sub.2                                                                             Cl   O  H  CH.sub.2 CH.sub.2 O-Q28                              PrCCl(Me)CH.sub.2                                                                             Cl   O  H  CH.sub.2 CH.sub.2 OC(O)Et                            PrCCl(Me)CH.sub.2                                                                             Cl   O  H  CH.sub.2 CHNOPr                                      PrCCl(Me)CH.sub.2                                                                             Cl   O  H  CH.sub.2 CHNOEt                                      PrCCl(Me)CH.sub.2                                                                             Cl   O  H  CH.sub.2 CH(Me)CH.sub.2 CO.sub.2 Et                  PrCCl(Me)CH.sub.2                                                                             Cl   O  H  CH.sub.2 CH.sub.2 ONCHMe                             PrCCl(Me)CH.sub.2                                                                             Cl   O  H  (CH.sub.2).sub.3 CCCl                                PrCCl(Me)CH.sub.2                                                                             Cl   O  H  CH.sub.2 CH.sub.2 O-Q30                              PrCCl(Me)CH.sub.2                                                                             Cl   O  H  CH.sub.2 CH.sub.2 O-Q27                              PrCCl(Me)CH.sub.2                                                                             Cl   O  H  CH.sub.2 CH.sub.2 O-Q24                              PrCBr(Me)CH.sub.2                                                                             Cl   O  H  CH.sub.2 CH.sub. 2 OPh                               PrCBr(Me)CH.sub.2                                                                             Cl   O  H  CH.sub.2 CH.sub.2 O-Q17                              PrCBr(Me)CH.sub.2                                                                             Cl   O  H  CH.sub.2 CHNOPr                                      BuCCl(Me)CH.sub.2                                                                             Cl   O  H  CH.sub.2 CHNOPr                                      BuCCl(Me)CH.sub.2                                                                             Cl   O  H  CH.sub.2 CH.sub.2 OPh                                MeOCH.sub.2 CCl(Me)CH.sub.2                                                                   Cl   O  H  CH.sub.2 CH.sub.2 OPh                                MeOCH.sub.2 CCl(Me)CH.sub.2                                                                   Cl   O  H  CH.sub.2 CHNOPr                                      MeOCH.sub.2 CCl(Me)CH.sub.2                                                                   Cl   O  H  CH.sub.2 CH.sub.2 O-Q17                              EtOCH.sub.2 CCl(Me)CH.sub.2                                                                   Cl   O  H  CH.sub.2 CH.sub.2 OPh                                EtOCH.sub.2 CCl(Me)CH.sub.2                                                                   Cl   O  H  CH.sub.2 CHNOPr                                      EtOCH.sub.2 CCl(Me)CH.sub.2                                                                   Cl   O  H  CH.sub.2 CH.sub.2 OC(O)Et                            MeSCH.sub.2 CCl(Me)CH.sub.2                                                                   Cl   O  H  CH.sub.2 CH.sub.2 OPh                                MeSCH.sub.2 CCl(Me)CH.sub.2                                                                   Cl   O  H  CH.sub.2 CH.sub.2 CCCH.sub.2 OMe                     EtSCH.sub.2 CCl(Me)CH.sub.2                                                                   Cl   O  H  CH.sub.2 CH.sub.2 NHC(O)Pr                           EtSCH.sub.2 CCl(Me)CH.sub.2                                                                   Cl   O  H  CH.sub.2 CH.sub.2 OPh                                Q10-2-Cl       Cl   O  H  CH.sub.2 CH.sub.2 OPh                                Q10-2-Cl       Cl   O  H  CH.sub.2 CH.sub.2 O-Q17                              Q10-2-Cl       Cl   O  H  CH.sub.2 CHNOPr                                      Q3-2-Cl        Cl   O  H  CH.sub.2 CHNOPr                                      Q3-2-Cl        Cl   O  H  CH.sub.2 CH.sub.2 OPh                                Q3-2-Cl        Cl   O  H  CH.sub.2 CH.sub.2 ONCHMe                             Q4-2-Cl        Cl   O  H  CH.sub.2 CH.sub.2 OPh                                Q4-2-Cl        Cl   O  H  CH.sub.2 CHNOPr                                      Q7-2-Cl        Cl   O  H  CH.sub.2 CHMeOPh                                     Q7-2-Cl        Cl   O  H  CH.sub.2 CHNOPr                                      Q9-2-Cl        Cl   O  H  CH.sub.2 CH.sub.2 OPh                                Q9-2-Cl        Cl   O  H  CH.sub.2 CH.sub.2 O-Q17                              Q9-2-Cl        Br   O  H  CH.sub.2 CH.sub.2 OPh                                MeCCl(OMe)     Cl   O  H  CH.sub.2 CH.sub.2 OPh                                MeCCl(OMe)     Cl   O  H  CH.sub.2 CHNOPr                                      MeCCl(OMe)     Me   S  H  CH.sub.2 CHMeCH.sub.2 CO.sub.2 Et                    MeCCl(OEt)     Cl   O  H  CH.sub.2 CH.sub.2 OPh                                MeCCl(OEt)     Cl   O  H  CH.sub.2 CH.sub.2 OC(O)Pr-i                          Cl.sub.2 CCH   Cl   O  H  CH.sub.2 CH.sub.2 OPh                                Cl.sub.2 CCH   Cl   O  H  CH.sub.2 CH.sub.2 O-Q17                              Cl.sub.2 CCH   Br   O  H  CH.sub.2 CH.sub.2 OPh                                MeCClCH        Cl   O  H  CH.sub.2 CH.sub.2 OPh                                MeCClCH        Cl   O  H  CH.sub.2 CHNOPr                                      MeCClCH        Cl   S  H  CH.sub.2 CH.sub.2 ONCHEt                             EtCClCH        Cl   O  H  CH.sub.2 CH.sub.2 OPh                                EtCClCH        Cl   O  H  CH.sub.2 CH.sub.2 O-Q17                              PrCClCH        Cl   O  H  CH.sub.2 CH.sub.2 OPh                                PrCClCH        Cl   O  H  CH.sub.2 CHNOPr                                      PrCClCH        Br   O  H  CH.sub.2 CHNOPr                                      PrCClCH        Cl   O  H  CH.sub.2 CH.sub.2 O-Q17                              Me.sub.2 CCH   Cl   O  H  CH.sub.2 CH.sub.2 O-Q17                              Me.sub.2 CCH   Cl   O  H  CH.sub.2 CH.sub.2 O-Q17                              Me.sub.2 CCH   Cl   O  H  CH.sub.2 CHNOPr                                      Me.sub.2 CCH   Cl   O  H  CH.sub.2 CH.sub.2 NHCO.sub.2 Et                      Me.sub.2 CCH   Cl   O  H  CH.sub.2 CH.sub.2 ONCHMe                             MeC(Et)CH      Cl   O  H  CH.sub.2 CH.sub.2 OPh                                MeC(Et)CH      Cl   O  H  CH.sub.2 CH.sub.2 O-Q17                              MeC(Et)CH      Cl   O  H  CH.sub.2 CHNOPr                                      MeC(Pr)CH      Cl   O  H  CH.sub.2 CH.sub.2 OPh                                MeC(Pr)CH      Cl   O  H  CH.sub.2 CHNOPr                                      MeC(Pr)CH      Br   O  H  CH.sub.2 CH.sub.2 O-Q17                              CF.sub.3 CClCH Cl   O  H  CH.sub.2 CH.sub.2 OPh                                CF.sub.3 CClCH Cl   O  H  CH.sub.2 CH.sub.2 O-Q17                              CF.sub.3 CClCH Cl   O  H  CH.sub.2 CHNOPr                                      CH.sub.2C(Me)CH.sub.2                                                                         Cl   O  H  CH.sub.2 CH.sub.2 OPh                                CH.sub.2C(Me)CH.sub.2                                                                         Br   O  H  CH.sub.2 CH.sub.2 CHMeCCBr                           CH.sub.2C(Me)CH.sub.2                                                                         I    O  H  CH.sub.2 CH.sub.2 O-Q17                              CH.sub.2C(Et)CH.sub.2                                                                         Cl   O  H  CH.sub.2 CH.sub.2 OPh                                CH.sub.2C(Et)CH.sub.2                                                                         SO.sub.2 Me                                                                         O  H  CH.sub.2 CH.sub.2 NHC(O)Et                           CH.sub.2C(Pr)CH.sub.2                                                                         Cl   O  H  CH.sub.2 CH.sub.2 OPh                                CH.sub.2C(Pr)CH.sub.2                                                                         Cl   O  H  CH.sub.2 CHNOPr                                      MeCHC(Me)CH.sub.2                                                                             Cl   O  H  CH.sub.2 CH.sub.2 OPh                                MeCHC(Me)CH.sub.2                                                                             Cl   O  H  CH.sub.2 CHNOPr                                      MeCHC(Me)CH.sub.2                                                                             H    O  H  CH.sub.2 CH.sub.2 OPh                                EtCHC(Me)CH.sub.2                                                                             Cl   O  H  CH.sub.2 CH.sub.2 OPh                                EtCHC(Me)CH.sub.2                                                                             Cl   O  H  CH.sub.2 CH.sub.2 O-Q17                              EtCHC(Me)CH.sub.2                                                                             Cl   O  H  CH.sub.2 CHNOPr                                      PrCHC(Me)CH.sub.2                                                                             Cl   O  H  CH.sub.2 CH.sub.2 OPh                                PrCHC(Me)CH.sub.2                                                                             Br   O  H  CH.sub.2 CH.sub.2 N(Et)-Q17                          CH.sub.2CHC(Me).sub.2 CH.sub.2                                                                Cl   O  H  CH.sub.2 CH.sub.2 OPh                                CH.sub.2CHC(Me).sub.2 CH.sub.2                                                                Cl   O  H  CH.sub.2 CH.sub.2 O-Q17                              CH.sub.2CHC(Me).sub.2 CH.sub.2                                                                OMe  O  H  CH.sub.2 CHMeOPh                                     MeCHCHC(Me).sub.2 CH.sub.2                                                                    Cl   O  H  CH.sub.2 CHMeOPh                                     MeCHCHC(Me).sub.2 CH.sub.2                                                                    Cl   O  H  CH.sub.2 CH.sub.2 OPh                                HCCC(Me).sub.2 CH.sub.2                                                                       Cl   O  H  CH.sub.2 CH.sub.2 O-Q17                              HCCC(Me).sub.2 CH.sub.2                                                                       Cl   O  H  CH.sub.2 CH.sub.2 OPh                                HCCC(Me).sub.2 CH.sub.2                                                                       OEt  O  H  (CH.sub.2).sub.3 CCI                                 MeCCC(Me).sub.2 CH.sub.2                                                                      Cl   O  H  CH.sub.2 CH.sub.2 OPh                                MeCCC(Me).sub.2 CH.sub.2                                                                      Cl   O  H  CH.sub.2 CHMeOPh                                     CH.sub.2CHCH.sub.2 C(Me).sub.2 CH.sub.2                                                       Cl   O  H  CH.sub.2 CH.sub.2 O-Q17                              CH.sub.2CHCH.sub.2 C(Me).sub.2 CH.sub.2                                                       Cl   O  H  CH.sub.2 CHNOPr                                      HCCCH.sub.2 C(Me).sub.2 CH.sub.2                                                              Cl   O  H  CH.sub.2 CH.sub.2 OPh                                HCCCH.sub.2 C(Me).sub.2 CH.sub.2                                                              Cl   O  H  CH.sub.2 CH.sub.2 ONCHMe                             Me.sub.2 C(OMe)CH.sub.2                                                                       Cl   O  H  CH.sub.2 CH.sub.2 SPh                                Me.sub.2 C(OMe)CH.sub.2                                                                       Cl   O  H  CH.sub.2 CH.sub.2 OPh                                Me.sub.2 C(OMe)CH.sub.2                                                                       Cl   O  H  CH.sub.2 CH.sub.2 O-Q17                              Me.sub.2 C(OMe)CH.sub.2                                                                       Br   O  H  CH.sub.2 CHNOPr                                      Me.sub.2 C(OEt)CH.sub.2                                                                       Cl   O  H  CH.sub.2 CH.sub.2 ONCHMe                             Me.sub.2 C(OEt)CH.sub.2                                                                       Cl   O  H  CH.sub.2 CH.sub.2 OPh                                Me.sub.2 C(OEt)CH.sub.2                                                                       Cl   O  H  CH.sub.2 CHMeOPh                                     MeC(Et) (OMe)CH.sub.2                                                                         Cl   O  H  CH.sub.2 CH.sub.2 NHCO.sub.2 Bu                      MeC(Et) (OMe)CH.sub.2                                                                         Cl   O  H  CH.sub.2 CH.sub.2 NHC(O)Et                           MeC(Pr) (OMe)CH.sub.2                                                                         Cl   O  H  CH.sub.2 CH.sub.2 OPh                                MeC(Pr) (OMe)CH.sub.2                                                                         Cl   O  H  CH.sub.2 CH.sub.2 CHEtPh                             MeOCH.sub.2 C(Me).sub.2 CH.sub.2                                                              Cl   O  H  CH.sub.2 CH.sub.2 OPh                                MeOCH.sub. 2 C(Me).sub.2 CH.sub.2                                                             Cl   O  H  CH.sub.2 CHMeOPh                                     MeOCH.sub.2 C(Me).sub.2 CH.sub.2                                                              Cl   O  H  CH.sub.2 CH.sub.2 O-Q17                              MeOCH.sub.2 C(Me).sub.2 CH.sub.2                                                              Br   O  H  CH.sub.2 CH.sub.2 OPh                                EtOCH.sub.2 C(Me).sub.2 CH.sub.2                                                              Cl   O  H  CH.sub.2 CH.sub.2 OPh                                EtOCH.sub.2 C(Me).sub.2 CH.sub.2                                                              Cl   O  H  CH.sub.2 CHNOPr                                      EtOCH.sub.2 C(Me).sub.2 CH.sub.2                                                              Cl   O  H  CH.sub.2 CH.sub.2 O-Q17                              EtOCH.sub.2 C(Me).sub.2 CH.sub.2                                                              Cl   S  H  CH.sub.2 CH.sub.2 NHPh                               MeOCH.sub.2 CH.sub.2 C(Me).sub.2 CH.sub.2                                                     Cl   O  H  CH.sub.2 CH.sub.2 OPh                                MeOCH.sub.2 CH.sub.2 C(Me).sub.2 CH.sub.2                                                     Cl   O  H  CH.sub.2 CH.sub.2 O-Q17                              MeOCH.sub.2 CH.sub.2 C(Me).sub.2 CH.sub.2                                                     Br   O  H  (CH.sub.2).sub.3 CCCl                                MeOCH.sub.2 CH.sub.2 CCl(Me)CH.sub.2                                                          Cl   O  H  CH.sub.2 CH.sub.2 OPh                                MeOCH.sub.2 CH.sub.2 CCl(Me)CH.sub.2                                                          Cl   O  H  CH.sub.2 CH.sub.2 O-Q17                              MeOCH.sub.2 CH.sub.2 CCl(Me)CH.sub.2                                                          Cl   O  H  CH.sub.2 CHNOPr                                      EtOCH.sub.2 CH.sub.2 C(Me).sub.2 CH.sub.2                                                     Cl   O  H  CH.sub.2 CH.sub.2 OPh                                EtOCH.sub.2 CH.sub.2 C(Me).sub.2 CH.sub.2                                                     Cl   O  H  CH.sub.2 CH.sub.2 O-Q28                              MeO(CH.sub.2).sub.3 C(Me).sub.2 CH.sub.2                                                      Cl   O  H  CH.sub.2 CHNOPr                                      MeO(CH.sub.2).sub.3 C(Me).sub.2 CH.sub.2                                                      Cl   O  H  CH.sub.2 CH.sub.2 OPh                                __________________________________________________________________________

Q1 to Q56 in the Tables 1, 2 and 3 are groups represented by the folowing structural formula: ##STR16##

The preparations of the compounds of the present invention are described in detail by way of the following examples which are not to restrict the invention.

PREPARATION EXAMPLE 1

Synthesis of 5-(4-t-butylbenzylthio)-4-chloro-2-[(2,2-dichloro-1,1-dimethyl)-ethyl]-3(2H)-pyridazinone (Compound No. 2)

In 10 ml of methanol were dissolved 0.73 g of 4,5-dichloro-2-[(2,2-dichloro-1,1-dimethyl)-ethyl]-3(2H)-pyridazinone and 0.45 g of 4-t-butylbenzyl-mercaptan. The resulting solution was suspended with 0.27 g of sodium carbonate and then stirred for 3 hours at room temperature. The solution was poured into ice water and then filtered off. The crystals thus obtained were recrystallized from benzene-hexane to give 0.8 g of the intended compound.

melting point (m.p.): 162°-163° C.

PREPARATION EXAMPLE 2

Synthesis of 4-bromo-5-(4-chloro-benzyloxyl)-2-[(2,3-dichloro-2-methyl)-propyl]-3(2H)-pyridazinone (Compound No. 12)

In 10 ml of N,N-dimethylformamide were dissolved 1.90 g of 4,5-dibromo-2-[(2,3-dichloro-2-methyl)-propyl]-3(2H)-pyridazinone and 0.71 g of 4-chlorobenzyl alcohol. The solution was suspended in 0.33 g of powdery potassium hydroxide. The reaction mixture was stirred for one night at room temperature. The resulting solution was poured into ice water and extracted with benzene. The extract was washed with saturated saline and then with water and freed of solvent by distillation under reduced pressure. The oil thus obtained was separated and purified by means of column chromatography (on silica gel, eluting with chloroform) to give 1.10 g of the intended compound.

m.p.: 112°-114° C.

PREPARATION EXAMPLE 3

Synthesis of 2-(3'-bromopropyl)-4-chloro-5-(4'-chlorobenzyloxy)-3(2H)-pyridazinone (Compound No. 19)

To a mixed solvent of 150 ml of water and 150 ml of ethanol was added 22.3 g of 4,5-dichloro-2-(3'-hydroxypropyl)-3(2H)-pyridazinone (0.1 mol) and 19.6 g of potassium hydroxide (0.35 mol) and then heated under reflux for about 10 hours. After reaction, ethanol was removed under reduced pressure and added with water to filter off the insoluble matters. The filtrate was converted into acidity by diluted hydrochloric acid and the crystals produced were filtered off. The crystals thus obtained were washed with water and dried to give 14.5 g of 4-chloro-5-hydroxy-2-(3'-hydroxypropyl)-3(2H)-pyridazinone.

To 150 ml of N,N-dimethylformamide were added 10.2 g of 4-chloro-5-hydroxy-2-(3'-hydroxypropyl)-3(2H)-pyridazinone (0.05 mol), 8.4 g of 4-chlorobenzyl chloride (0.052 mol) and 10.4 g of anhydrous potassium carbonate (0.075 mol) and heated for about 3 hours at 100° C. to 120° C. After reaction, the mixture solution was poured into water and extracted with ethyl acetate. The resulting solution was washed with water and then with aqueous solution of 5% sodium hydroxide and further with saturated saline. The solution was dried over anhydrous sodium sulfate and the solvent was distilled off under reduced pressure. The solid product thus obtained was washed with n-hexane and dried to obtain 12.3 g of 4-chloro-5-(4'-chlorobenzyloxy)-2-(3'-hydroxypropyl)-3(2H)-pyridazinone.

To 170 ml of chloroform were added 9.9 g of 4-chloro-5-(4'-chlorobenzyloxy)-2-(3'-hydroxypropyl)-3(2H)-pyridazinone (0.03 mol) and slowly added 9.4 g of thionyl bromide (0.045 mol) under stirring for about 2 hours at -5° to 5° C. After reaction, the resulting solution was added little by little with water and the chloroform layer was separated. The layer was washed with water and then with aqueous solution of 5% sodium hydrogen carbonate, and further washed with saturated saline and dried over anhydrous sodium sulfate and freed of solvent by distillation under reduced pressure. The solid product thus obtained was recrystallized from a mixed solvent of n-hexane-benzene to give 5.2 g of 2-(3'-bromopropyl)-4-chloro-5-(4'-chlorobenzyloxy)-3(2H)-pyridazinone.

m.p.: 83°-87° C.

PREPARATION EXAMPLE 4

Synthesis of 4-chloro-2-[(2-chloro-2-methyl)-pentyl]-5-(4-iodobenzyloxy)-3(2H)-pyridazinone (Compound No. 33)

The procedures in Preparation Example 2 were repeated by using 1.42 g of 4,5-dichloro-2-[(2-chloro-2-methyl)-pentyl]-3(2H)-pyridazinone and 1.17 g of 4-iodobenzyl alcohol to give 1.72 g of the intended compound.

m.p.: 114°-115° C.

PREPARATION EXAMPLE 5

Synthesis of 4-chloro-2-[(2,3-dichloro-2-methyl-prpyl]-5-[(2-iodo-5-pyridyl)-methoxy]-3(2H)-pyridazinone (Compound No. 202)

The procedures in Preparation Example 2 were repeated by using 1.45 g of 4,5-dichloro-2-[(2,3-dichloro-2-methyl)-propyl]-3(2H)-pyridazinone and 1.18 g of 2-iodo-5-pyridinemethanol to give 1.33 g of the intended compound.

m.p.: 117°-120° C.

PREPARATION EXAMPLE 6

Synthesis of 4-chloro-2-(2-chloro-2-methylpropyl)-5-(2-phenoxy-ethoxy)-3(2H)-pyridazinone (Compound No. 326)

In 10 ml of N,N-dimethylformamide were dissolved 1.85 g of 2-(2-chloro-2-methylpropyl)-4,5-dichloro-3(2H)-pyridazinone and 1.00 g of 2-phenoxy ethanol, and thereto was added 0.48 g of powdery potassium hydroxide. The mixture solution was stirred for one night at room temperature. Then, the procedures in Preparation Example 2 were repeated to give 1.9 g of the intended compound.

m.p.: 82°-83° C.

PREPARATION EXAMPLE 7

Synthesis of 5-(4-t-buthyl-α-methylbenzyloxy)-4-chloro-2-vinyl-3(2H)-pyridazinone (Compound No. 129)

In 60 ml of N,N-dimethylformamide were dissolved 2.7 g of 2-(2-bromoethyl)-4,5-dichloro-3(2H)-pyridazinone and 1.8 g of 4-t-buthyl-α-methyl-benzyl alcohol, and thereto were added 1.4 g of powdery potassium hydroxide. The solution was stirred for one night at room temperature. After reaction, the mixture solution was poured into water and extracted with benzene. The benzene layer was washed with water and dried over anhydrous sodium sulfate and freed of solvent by distillation under reduced pressure. The residual viscous liquid was separated by means of column chromatography (on silica gel, eluting with benzene-ethyl acetate) to give 2.2 g of the intended compound. (viscous liquid)

¹ H-NMR (CDCl₃, δ, ppm)

1.37 (9H, s), 1.80 (3H, d, J=6 Hz), 4.95 (1H, d, J=9 Hz), 5.66 (1H, q, J=6 Hz), 5.67 (1H, d, J=15 Hz), 7.17-7.53 (4H, m), 7.68 (1H, d, d, J=9 Hz, 15 Hz), 7.78 (1H, s)

PREPARATION EXAMPLE 8

Synthesis of 4-chloro-2-(2-chloro-2-methylpentyl)-5-(4-ethylbenzyloxy)-3(2H)-pyridazinone (Compound No. 85)

In 20 ml of N,N-dimethylformamide were added 1.2 g of 2-(2-chloro-2-methylpentyl)-4,5-dichloro-3(2H)-pyridazinone and 0.64 g of 4-ethylbenzyl alcohol, and thereto was added 0.31 g of powdery potassium hydroxide under ice-cooling and stirred for one day at room temperature. Then, the procedures in Preparation Example 2 were repeated to give 600 mg of the intended compound.

m.p.: 81°-83° C.

PREPARATION EXAMPLE 9

Synthesis of 4-chloro-2-(2-chloro-2-methylpentyl)-5-(4-trifluoromethylbenzyloxy)-3(2H)-pyridazinone (Compound No. 56)

In 20 ml of N,N-dimethylformamide were dissolved 1.2 g of 2-(2-chloro-2-methylpentyl)-4,5-dichloro-3(2H)-pyridazinone and 0.78 g of 4-trifluoromethylbenzyl alcohol, and thereto were added 1.46 g of anhydrous potassium carbonate. The mixture solution was stirred for 8 hours at 50° C. Then, the procedures in Preparation Example 2 were repeated to give 1.0 g of the intended compound.

m.p.: 105°-106° C.

PREPARATION EXAMPLE 10

Synthesis of 4-chloro-2-(2-chloro-2-methylpropyl)-5-[(2-iodo-5-pyridyl)-methoxy]-3(2H)-pyridazinone and 4-chloro-5-[(2-iodo-5-pyridyl)-methoxy]-2-(2-methyl-1-propenyl)-3(2H)-pyridazinone (Compound Nos. 237 and 255)

In 10 ml of N,N-dimethylformamide were dissolved 1.4 g of 2-(2-chloro-2-methylpropyl)-4,5-dichloro-3(2H)-pyridazinone and 1.29 g of 2-iodo-5-pyridyl methanol, and thereto was added 0.33 g of powdery potassium hydroxide under ice-cooling. The mixture solution was stirred for one day at room temperature. Then, the procedures in Preparation Example 2 were repeated to give 0.74 g of 4-chloro-2-(2-chloro-2-methylpropyl)-5-[(2-iodo-5-pyridyl)methoxy]-3(2H)-pyridazinone (m.p.: 119°-123° C.) and 0.24 g of 4-chloro-5-[(2-iodo-5-pyridyl)-methoxy]-2-(2-methyl-1-propenyl)-3(2H)-pyridazinone (m.p.: 141°-142° C.).

PREPARATION EXAMPLE 11

Synthesis of 2-(2-chloro-2-methylpropyl)-5-(4-iodobenzyloxy)-4-methyl-3(2H)-pyridazinone (Compound No. 167)

In 5 ml of N,N-dimethylformamide were dissolved 0.33 g of 5-chloro-2-(2-chloro-2-methylpropyl)-4-methyl-3(2H)-pyridazinone and 0.33 g of 4-iodobenzyl alcohol, and thereto was added 0.1 g of powdery potassium hydroxide under ice-cooling. Then, the procedures in Preparation Example 2 were repeated to give 0.3 g of the intended compound.

m.p.: 121°-123° C.

PREPARATION EXAMPLE 12

Synthesis of 4,5-dichloro-2-(3-chloro-tetrahydro-2-pyranyl)-3(2H)-pyridazinone

In 20 ml of methylene chloride were dissolved 4 g of 2,4,5-trichloro-3(2H)-pyridazinone, and thereto dropwise added 2.5 g of 2,3-dihydro-pyran under ice-cooling. The solution was stirred for 30 minutes and the by-produced 4,5-dichloro-3(2H)-pyridazinone was filtered off. The filtrate was distilled off under reduced pressure. The oil thus obtained was separated by means of column chromatography (on silica gel, eluting with benzene) to give 1.5 g of trans-form as the first fraction (m.p.: 136°-137° C.) and 1.3 g of cis-form as the second fraction (m.p.: 109°-110° C.).

¹ H-NMR (CDCl₃, δ, TMS)

Trans-form 1.50-2.20 (m, 4H), 3.50-4.60 (m, 3H), 5.86 (d, 1H, 10 Hz), 7.77 (s, 1H)

Cis-form 1.90-2.50 (m, 4H), 3.50-4.60 (m, 3H), 6.05 (d, 1H, 3 Hz), 7.83 (s, 1H)

PREPARATION EXAMPLE 13

Synthesis of 4,5-dichloro-2-(2,3-dichloro-2-propenyl)-3(2H)-pyridazinone

To a mixture of 10.8 g of 4,5-dichloro-3(2H)-pyridazinone and 9.5 g of anhydrous potassium carbonate were added 65 ml of N,N-dimethylformamide and stirred for 10 minutes at room temperature. Then, 10.0 g of 1,2,3-trichloro-1-propene (mixture of E-from and Z-form) were added to the mixture solution and were stirred for 6 hours at 40° C. The solution was poured into a large quantity of water and extracted with benzene, and freed of solvent by distillation under reduced pressure to give 6.0 g of the intended compound (mixture of E-form and Z-form). The compound thus obtained was separated into isomer (m.p.: 93.7°-94.6° C., 112.8°-114.8° C.) by means of column chromatography (on silica gel, eluting with benzene).

¹ H-NMR (CDCl₃, δ, TMS)

Isomer 1 (m.p.: 93.7°-94.6° C.): 5.15 (s, 2H), 6.47 (s, 1H), 7.84 (s, 1H)

Isomer 2 (m.p.: 112.8°-114.8° C.). 5.00 (s, 2H), 6.70 (s, 1H), 7.84 (s, 1H)

PREPARATION EXAMPLE 14

Synthesis of 4,5-dichloro-2-(2-methyl-2-propenyl)-3(2H)-pyridazinone

To 50 ml of N,N-dimethylformamide were suspended 10 g of 4,5-dichloro-3(2H)-pyridazinone, 27 g of 3-chloro-2-methylpropene and 8.4 g of potassium carbonate. The mixtured solution was stirred for 5 hours at 40° C. Then, the procedures in Preparation Example 2 were repeated to give 4.9 g of the intended compound.

m.p.: 52°-54° C.

PREPARATION EXAMPLE 15

Synthesis of 2-(2-chloro-2-methyl-propyl)-4,5-dichloro-3(2H)-pyridazinone

In 100 ml of carbon tetrachloride were dissolved 5 g of 4,5-dichloro-2(2-methyl-2-propenyl)-3(2H)-pyridazinone and 0.1 g of trifluoromethyl ammonium chloride, and thereto were added 30 ml of concentrated hydrochloric acid. The mixture solution was stirred for 3 days at room temperature. The organic layer was separated and washed with water, and dried over anhydrous sodium sulfate and freed of solvent by distillation under reduced pressure to give 4.7 g of the intended compound.

m.p.: 61°-66° C.

Physical properties of compounds prepared according to any one of Preparation Examples 1 to 11 are shown in Tables 4, 5 and 6. In the Tables, Me represents methyl group, Et represents ethyl group, Pr represents propyl group, Bu represents butyl group, Pen represents pentyl group, Hex represents hexyl group, Ph represents unsubstituted phenyl group, t represents tertiary, s represents secondary, i represents iso and c represents cyclo.

The number of compounds listed in Tables 4, 5 and 6 will be referred to in the above Preparation Examples, and Formulation Examples and Test Examples later described.

                                      TABLE 4                                      __________________________________________________________________________     In Compounds of the formula:                                                    ##STR17##                                                                     No. R              A  X R.sup.1                                                                          R.sup.2                                                                           Y           m.p. (°C.)                     __________________________________________________________________________     1   Cl.sub.2 CHC(Me).sub.2                                                                        Cl O H H  4-Cl        108-109                               2   Cl.sub.2 CHC(Me).sub.2                                                                        Cl S H H  4-Bu-t      162-163                               3   ClCH.sub.2 CHClCH.sub.2                                                                       Cl O H H  4-Cl        123-125                               4   ClCH.sub.2 CHClCH.sub.2                                                                       Cl O H H  2,4-Cl.sub.2                                                                               96-98                                 5   ClCH.sub.2 CHClCH.sub.2                                                                       Cl S H H  4-Cl        120-124                               6   ClCH.sub.2 CHClCH.sub.2                                                                       Cl S H H  4-Bu-t      135-139                               7   Me.sub.2 CClCHCl                                                                              Cl O H H  4-Cl        124-125                               8   Me.sub.2 CClCHCl                                                                              Cl S H H  4-Bu-t      183-184                               9   ClCH.sub.2 CCl(Me)CH.sub.2                                                                    Cl O H H  4-Cl        115-118                               10  ClCH.sub.2 CCl(Me)CH.sub.2                                                                    Cl O H H  4-I         124-127                               11  ClCH.sub.2 CCl(Me)CH.sub.2                                                                    Cl O H H  2,4-Cl.sub.2                                                                               111-117                               12  ClCH.sub.2 CCl(Me)CH.sub.2                                                                    Br O H H  4-Cl        112-114                               13  ClCH.sub.2 CCl(Me)CH.sub.2                                                                    Br O H H  2,4-Cl.sub.2                                                                               107-113                               14  ClCH.sub.2 CCl(Me)CH.sub.2                                                                    Cl S H H  4-Bu-t      106-109                               15  ClCH.sub.2 CBr(Me)CH.sub.2                                                                    Cl O H H  4-Cl        68-70                                 16  ClCH.sub.2 CBr(Me)CH.sub.2                                                                    Cl O H H  2,4-Cl.sub.2                                                                               130-133                               17  MeCHClCHClCH.sub.2                                                                            Cl O H H  4-Cl        108-110                               18  MeCHClCHClCH.sub.2                                                                            Cl O H H  2,4-Cl.sub.2                                                                               105-107                               19  Br(CH.sub.2).sub.3                                                                            Cl O H H  4-Cl        83-87                                 20  Br(CH.sub.2).sub.3                                                                            Cl O H H  4-I         100-102                               21  Br(CH.sub.2).sub.3                                                                            Cl S H H  4-Bu-t      130-132                               22  Br(CH.sub.2).sub.4                                                                            Cl O H H  4-Cl        112-114                               23  Br(CH.sub.2).sub.4                                                                            Cl O H H  4-I         101-104                               24  EtCCl(Me)CH.sub.2                                                                             Cl O H H  4-Cl        118-120                               25  EtCCl(Me)CH.sub.2                                                                             Cl O H H  4-I         122-124                               26  EtCCl(Me)CH.sub.2                                                                             Cl O H H  2,4-Cl.sub.2                                                                               109-110                               27  Et.sub.2 CClCH.sub.2                                                                          Cl O H H  4-Cl        100-101                               28  Et.sub.2 CClCH.sub.2                                                                          Cl O H H  4-I         98-100                                29  Et.sub.2 CClCH.sub.2                                                                          Cl S H H  4-Cl        75-78                                 30  Et.sub.2 CClCH.sub.2                                                                          Cl S H H  4-Bu-t      115-117                               31  t-BuCCl(Me)CH.sub.2                                                                           Cl O H H  4-I         168-170                               32  PrCCl(Me)CH.sub.2                                                                             Cl O H H  4-Cl        94-99                                 33  PrCCl(Me)CH.sub.2                                                                             Cl O H H  4-I         114-115                               34  PrCCl(Me)CH.sub.2                                                                             Cl O H H  2,4-Cl.sub.2                                                                               114-116                               35  PrCCl(Me)CH.sub.2                                                                             Cl S H H  4-Bu-t      110-111                               36  i-PrCCl(Me)CH.sub.2                                                                           Cl O H H  4-Cl        123-125                               37  i-PrCCl(Me)CH.sub.2                                                                           Cl O H H  4-I         124-126                               38  BuCCl(Me)CH.sub.2                                                                             Cl O H H  4-Cl        90-92                                 39  BuCCl(Me)CH.sub.2                                                                             Cl O H H  4-I         78-79                                 40  Q3-2-Cl        Cl O H H  4-Cl        134-136                               41  Q3-2-Cl        Cl O H H  2,4-Cl.sub.2                                                                               162-166                               42  Q3-2-Cl        Cl S H H  4-Bu-t      143-144                               43  (Q4-1-Cl)CH.sub.2                                                                             Cl O H H  4-Cl        113-115                               44  (Q4-1-Cl)CH.sub.2                                                                             Cl O H H  4-I         155-156                               45  Q4-2-Cl (cis-form)                                                                            Cl O H H  4-Cl        160-161                               46  Q4-2-Cl (cis-form)                                                                            Cl O H H  2,4-Cl.sub.2                                                                               199-200                               47  Q4-2-Cl (cis-form)                                                                            Cl S H H  4-Cl        142-144                               48  Q4-2-Cl (cis-form)                                                                            Cl S H H  4-Bu-t      158-160                               49  Q5-2-Cl        Cl O H H  4-Cl        120-121                               50  Q5-2-Cl        Cl O H H  2,4-Cl.sub.2                                                                               140-141                               51  Q5-2-Cl        Cl S H H  4-Bu-t      146-148                               52  Q9-3-Cl (trans-form)                                                                          Cl O H H  4-Cl        168-170                               53  Q9-3-Cl (trans-form)                                                                          Cl O H H  4-Cl        140-143                               54  PrCCl(Me)CH.sub.2                                                                             Cl O H H  2-F, 4-Cl   84-86                                 55  PrCCl(Me)CH.sub.2                                                                             Cl O H H  4-F         100-101                               56  PrCCl(Me)CH.sub.2                                                                             Cl O H H  4-CF.sub.3  105-106                               57  PrCCl(Me)CH.sub.2                                                                             Cl O H H  4-CO(C.sub.6 H.sub.4 Cl-4)                                                                 144-145                               58  PrCCl(Me)CH.sub.2                                                                             Cl O H H  4-SMe       96-97                                 59  PrCCl(Me)CH.sub.2                                                                             Cl O H H  4-OCH.sub.2(C.sub.6 H.sub.4 Cl-4)                                                          120-123                               60  ClCHC(Cl)CH.sub.2                                                                             Cl O H H  4-Cl        131-133                               61  ClCHC(Cl)CH.sub.2                                                                             Cl O H H  4-I         132-133                               62  PrCCl(Me)CH.sub.2                                                                             Cl O H H  4-Br        112-113                               63  PrCCl(Me)CH.sub.2                                                                             Cl O H H  4-Me        107-108                               64  PrCCl(Me)CH.sub.2                                                                             Cl O H H  4-Ph        136-137                               65  PrCCl(Me)CH.sub.2                                                                             Cl O H H  4-O(C.sub.6 H.sub.3 Cl-2, CF.sub.3 -4)                                                     105-107                               66  PenCHClCH.sub.2                                                                               Cl O H H  4-I         109-111                               67  HexCHClCH.sub.2                                                                               Cl O H H  4-Cl        102-105                               68  HexCHClCH.sub.2                                                                               Cl O H H  4-I         107-109                               69  ClCH.sub.2 CH(OEt)                                                                            Cl O H H  4-I         121-122                               70  i-BuCCl(Me)CH.sub.2                                                                           Cl O H H  4-Cl        102-103                               71  i-BuCCl(Me)CH.sub.2                                                                           Cl O H H  4-I         111-113                               72  CH.sub.2C(Cl)CH.sub.2                                                                         Cl O H H  4-Cl        86-88                                 73  CH.sub.2C(Cl)CH.sub.2                                                                         Cl O H H  4-I         133-134                               74  ClCHCHCH.sub.2 Cl O H H  4-I         107-112                               75  MeOCH.sub.2 CCl(Me)CH.sub.2                                                                   Cl O H H  4-Cl         99-101                               76  MeOCH.sub.2 CCl(Me)CH.sub.2                                                                   Cl O H H  4-I          97-99                                77  Q9-3-Cl (trans-form)                                                                          Cl O H H  4-I         159-162                               78  Q9-3-Cl (cis-form)                                                                            Cl O H H  4-I         169-172                               79  PrCCl(Me)CH.sub.2                                                                             Cl O H H  3,4-Cl.sub.2                                                                               102-104                               80  ClCH.sub.2 CH.sub.2 CCl(Me)CH.sub.2                                                           Cl O H H  4-Cl        100-101                               81  ClCH.sub.2 CH.sub.2 CCl(Me)CH.sub.2                                                           Cl O H H  4-I           99-104                              82  PrCCl(Me)CH.sub.2                                                                             Cl O H H  3-CF.sub.3  93-94                                 83  PrCCl(Me)CH.sub.2                                                                             Cl O H H  2-CF.sub.3  108-110                               84  PrCCl(Me)CH.sub.2                                                                             Cl O H H  4-OMe       82-83                                 85  PrCCl(Me)CH.sub.2                                                                             Cl O H H  4-Et        81-83                                 86  PrCCl(Me)CH.sub.2                                                                             Cl O H H                                                                                  ##STR18##  105-106                               87  PrCCl(Et)CH.sub.2                                                                             Cl O H H  4-I         92-93                                 88  EtCHClCCl(Me)CH.sub.2                                                                         Cl O H H  4-I         129-131                               89  PenCCl(Me)CH.sub.2                                                                            Cl O H H  4-I         100-102                               90  PenCCl(Me)CH.sub.2                                                                            Cl O H H  4-Cl        88-90                                 91  PenCCl(Me)CH.sub.2                                                                            Cl O H H  3-CF.sub.3  43-45                                 92  ClCH.sub.2 CH(OMe)CH.sub.2                                                                    Cl O H H  4-I         108-109                               93  PrCCl(Me)CH.sub.2                                                                             Cl O H H  4-S(O)Me    89-92                                 94  PrCCl(Me)CH.sub.2                                                                             Cl O H H  4-SO.sub.2 Me                                                                              142-144                               95  PrCCl(Me)CH.sub.2                                                                             Cl O H H  4-OPh        99-100                               96  ClCH.sub.2 CCl(Me)CH.sub.2                                                                    Cl O H H  4-OPh       116-121                               97  ClCH.sub.2 CCl(Me)CH.sub.2                                                                    Cl O H H  4-CF.sub.3  107-109                               98  CH.sub.2C(CH.sub.2 Cl)CH.sub.2                                                                Cl O H H  4-I         96-98                                 99  CH.sub.2C(CH.sub.2 Cl)CH.sub.2                                                                Cl S H H  4-Bu-t      125-127                               100 PrCCl(Me)CH.sub.2                                                                             Cl O H H  4-Pr        68-69                                 101 PrCCl(Me)CH.sub.2                                                                             Cl O H H  4-Pr-i      101-102                               102 PrCCl(Me)CH.sub.2                                                                             Cl O H H  4-Bu        68-70                                 103 PrCCl(Me)CH.sub.2                                                                             Cl O H H  4-Bu-t      116-117                               104 Me.sub.2 CClCH.sub.2                                                                          Cl O H H  4-I         129-131                               105 (ClCH.sub.2).sub.2 CClCH.sub.2                                                                Cl O H H  4-I         111-112                               106 PrCCl(Me)CH.sub.2                                                                             Cl O H H  4-OEt       73-74                                 107 ClCH.sub.2 CH.sub.2 CCl(Me)CH.sub.2                                                           Cl O H H  4-CF.sub.3  94-95                                 108 ClCH.sub.2 CH.sub.2 CCl(Me)CH.sub.2                                                           Cl O H H  4-Et        86-87                                 109 EtOCH.sub.2 CCl(Me)CH.sub.2                                                                   Cl O H H  4-I         105-106                               110 EtOCH.sub.2 CCl(Me)CH.sub.2                                                                   Cl O H H  4-CF.sub.3  114-115                               111 EtOCH.sub.2 CCl(Me)CH.sub.2                                                                   Cl O H H  4-Et        69-70                                 112 MeOCH.sub.2 CH.sub.2 CCl(Me)CH.sub.2                                                          Cl O H H  4-I         63-64                                 113 MeOCH.sub.2 CH.sub.2 CCl(Me)CH.sub.2                                                          Cl O H H  4-CF.sub.3  95-96                                 114 MeOCH.sub.2 CH.sub.2 CCl(Me)CH.sub.2                                                          Cl O H H  4-Et         99-100                               115 Me.sub. 2 CClCH.sub.2                                                                         Cl O H H  4-CF.sub.3  119-121                               116 Me.sub.2 CClCH.sub.2                                                                          Cl O H H  4-Et        122-125                               117 ClCH.sub.2 C(Me)(OMe)CH.sub.2                                                                 Cl O H H  4-I         95-97                                 118 Me.sub.2 CBrCH.sub.2                                                                          Cl O H H  4-I         127-128                               119 Me.sub.2 CBrCH.sub.2                                                                          Cl O H H  4-Et        128-129                               120 Me.sub.2 CBrCH.sub.2                                                                          Cl O H H  4-CF.sub.3  127-129                               121 PrCCl(Me)CH.sub.2                                                                             Cl O H H  4-CN        135-138                               122 ClCH.sub.2 CCl(Et)CH.sub.2                                                                    Cl O H H  4-I         102-104                               123 ClCH.sub.2 CCl(Et)CH.sub.2                                                                    Cl O H H  4-CF.sub.3  121-123                               124 ClCH.sub.2 CCl(Et)CH.sub.2                                                                    Cl O H H  4-Et        76-78                                 125 Cl(CH.sub.2).sub.3 CCl(Me)CH.sub.2                                                            Cl O H H  4-I         82-83                                 126 Cl(CH.sub.2).sub.3 CCl(Me)CH.sub.2                                                            Cl O H H  4-CF.sub.3  82-83                                 127 Q7-3-Cl        Cl O H H  4-I         178-179                               128 CH.sub.2CH     Cl O H H  4-Me        129-130                               129 CH.sub.2CH     Cl O H Me 4-Bu-t      oil                                   130 CH.sub.2CH     Cl O H H  3-F         108-119                               131 CH.sub.2CH     Cl O H H  4-Cl        151-153                               132 CH.sub.2CH     Cl O H H  4-CF.sub.3  175-177                               133 CH.sub.2CH     Cl O H H  4-Ph        189-191                               134 CH.sub.2CH     Cl O H H  4-OPr       108-110                               135 CH.sub.2CH     Cl O H H  4-OCH.sub.2(C.sub.6 H.sub.4 F-4)                                                           125-129                               136 CH.sub.2CHCH.sub.2                                                                            Cl S H H  4-Bu-t      131-134                               137 CH.sub.2CHCH.sub.2                                                                            Cl O H H  4-Cl        74-77                                 138 CH.sub.2CHCH.sub.2                                                                            Cl O H H  4-Ph        133-136                               139 CH.sub.2CHCH.sub.2                                                                            Cl O H H  4-CO(C.sub.6 H.sub.4 Cl-4)                                                                 133-136                               140 MeCHCHCH.sub.2 Cl O H H  4-Me        101-102                               141 MeCHCHCH.sub.2 Cl O H H  4-Pr-i      118-119                               142 MeCHCHCH.sub.2 Cl O H H  4-Bu-t      112-114                               143 MeCHCHCH.sub.2 Cl O H H  4-F         132-133                               144 MeCHCHCH.sub.2 Cl O H H  4-Cl        118-119                               145 MeCHCHCH.sub.2 Cl O H H  3,4-Cl.sub.2                                                                               143-144                               146 MeCHCHCH.sub.2 Cl O H H  4-CO(C.sub.6 H.sub.4 Cl-4)                                                                 127-136                               147 HCCCH.sub.2    Cl S H H  4-Bu-t      100-102                               148 HCCCH.sub.2    Cl S H H  4-Cl        135-140                               149 HCCCH.sub.2    Cl S H H  4-Ph        125-132                               150 CH.sub.2CH     Cl S H H  4-Bu-t      115-116                               151 CH.sub.2C(Me)CH.sub.2                                                                         Cl S H H  4-Bu-t      114-117                               152 CH.sub.2C(Me)CH.sub.2                                                                         Cl O H H  4-Cl        113-115                               153 CH.sub.2C(Me)CH.sub.2                                                                         Cl O H H  4-I         111-113                               154 MeOCH(Me)CH.sub.2                                                                             Cl O H H  4-Cl        104-108                               155 Me.sub.2 CCH   Cl O H H  4-I         146-149                               156 Pr(Me)CH       Me O H H  4-I         106-108                               157 MeOC(Me).sub.2 CH.sub.2                                                                       Cl O H H  4-I         108-109                               158 MeOC(Me).sub.2 CH.sub.2                                                                       Cl O H H  4-CF.sub.3  91-92                                 159 PrCCl(Me)CH.sub.2                                                                             Cl O H H  4-NO.sub.2  121-122                               160 PrCCl(Me)CH.sub.2                                                                             Cl O H H  4-OCF.sub.3 84-85                                 161 PrCCl(Me)CH.sub.2                                                                             Cl O H H  4-CO.sub.2 Me                                                                              98-99                                 162 PrCCl(Me)CH.sub.2                                                                             Cl O H H  4-OPr-i     112-113                               163 ClCH.sub.2 C(Me).sub.2 CH.sub.2                                                               Cl O H H  4-I         103-109                               164 Me.sub.2 CClCH.sub.2                                                                          Cl O H H  4-OCF.sub.3 79-81                                 165 Me.sub.2 CClCH.sub.2                                                                          Cl O H H  4-CO.sub.2 Me                                                                              157-158                               166 Me.sub.2 CClCH.sub.2                                                                          Cl O H H  4-OPr-i     105-106                               167 Me.sub.2 CClCH.sub.2                                                                          Me O H H  4-I         121-123                               168 EtCCl(Me)CH.sub.2                                                                             Cl O H H  4-OCF.sub.3 74-75                                 169 ClCH.sub.2 CCl(Me)CH.sub.2                                                                    Cl O H H  4-OCF.sub.3 70-72                                 170 ClCH.sub.2 CCl(Me)CH.sub.2                                                                    Cl O H H  4-CO.sub.2 Me                                                                              172-174                               171 ClCH.sub.2 CCl(Me)CH.sub.2                                                                    Cl O H H  4-OEt       103-104                               172 ClCH.sub.2 CCl(Me)CH.sub.2                                                                    Cl O H H  4-OPr-i     94-95                                 173 Cl(CH.sub.2).sub.3 CCl(Me)CH.sub.2                                                            Cl O H H  4-Et        n.sub.D.sup.20 1.5750                 174 ClCHCHCH.sub.2 Cl S H H  4-Bu-t      120-124                                   (trans-form)                                                               175 ClCHCHCH.sub.2 Cl S H H  4-Cl        143-145                                   (trans-form)                                                               176 PrCCl(Me)CH.sub.2                                                                             Cl O H Me 4-Cl        55-62                                 177 Pr(Me)CCH      Cl O H H  4-I         155-156                                   (trans-form)                                                               178 Pr(Me)CCH      Cl O H H  4-I         128-129                                   (cis-form)                                                                 179 ClCH.sub.2 C(Me)CH                                                                            Cl O H H  4-I         128-129                               180 EtCHC(Me)CH.sub.2                                                                             Cl O H H  4-I         107-108                               __________________________________________________________________________

                                      TABLE 5                                      __________________________________________________________________________     In Compounds of the formula:                                                    ##STR19##                                                                     No. R              A   X  R.sup.1                                                                           R.sup.2                                                                           Q       m.p. (°C.)                      __________________________________________________________________________     201 ClCH.sub.2 CCl(Me)CH.sub.2                                                                    Cl  O  H  H  Q26-6-Cl                                                                               117-119                                202 ClCH.sub.2 CCl(Me)CH.sub.2                                                                    Cl  O  H  H  Q26-6-I 117-120                                203 ClCH.sub.2 CCl(Me)CH.sub.2                                                                    Br  O  H  H  Q26-6-Cl                                                                               106-108                                204 ClCH.sub.2 CCl(Me)CH.sub.2                                                                    Br  O  H  H  Q26-6-I 127-128                                205 Br(CH.sub.2).sub.3                                                                            Cl  O  H  H  Q26-6-Cl                                                                               138-139                                206 EtCCl(Me)CH.sub.2                                                                             Cl  O  H  H  Q26-6-Cl                                                                               124-126                                207 EtCCl(Me)CH.sub.2                                                                             Cl  O  H  H  Q26-6-I 120-123                                208 Et.sub.2 CClCH.sub.2                                                                          Cl  O  H  H  Q26-6-Cl                                                                               96-98                                  209 Et.sub.2 CClCH.sub.2                                                                          Cl  O  H  H  Q26-6-I 111-113                                210 t-BuCCl(Me)CH.sub.2                                                                           Cl  O  H  H  Q26-6-Cl                                                                               177-178                                211 PrCCl(Me)CH.sub.2                                                                             Cl  O  H  H  Q26-6-Cl                                                                               101-105                                212 PrCCl(Me)CH.sub.2                                                                             Cl  O  H  H  Q26-6-I 96-97                                  213 i-PrCCl(Me)CH.sub.2                                                                           Cl  O  H  H  Q26-6-Cl                                                                               140-141                                214 BuCCl(Me)CH.sub.2                                                                             Cl  O  H  H  Q26-6-Cl                                                                               90-92                                  215 BuCCl(Me)CH.sub.2                                                                             Cl  O  H  H  Q26-6-I 93-97                                  216 (Q41Cl)CH.sub.2                                                                               Cl  O  H  H  Q26-6-Cl                                                                               128-130                                217 Q42Cl (cis     Cl  O  H  H  Q26-6-Cl                                                                               187-188                                form)                                                                          218 Q93Cl (trans   Cl  O  H  H  Q26-6-Cl                                                                               147-149                                form)                                                                          219 Q93Cl (cis     Cl  O  H  H  Q26-6-Cl                                                                               189-192                                form)                                                                          220 ClCHC(Cl)CH.sub.2                                                                             Cl  O  H  H  Q26-6-Cl                                                                                 167-169(*)                           221 ClCHC(Cl)CH.sub.2                                                                             Cl  O  H  H  Q26-6-Cl                                                                                 103-105(**)                          222 PenCHClCH.sub.2                                                                               Cl  O  H  H  Q26-6-Cl                                                                               78-81                                  223 HexCHClCH.sub.2                                                                               Cl  O  H  H  Q26-6-Cl                                                                               90-92                                  224 ClCH.sub.2 CH(OEt)                                                                            Cl  O  H  H  Q26-6-Cl                                                                               116-117                                225 Br(CH.sub.2).sub.4                                                                            Cl  O  H  H  Q26-6-Cl                                                                               115-116                                226 i-BuCCl(Me)CH.sub.2                                                                           Cl  O  H  H  Q26-6-Cl                                                                               90-92                                  227 CH.sub.2C(Cl)CH.sub.2                                                                         Cl  O  H  H  Q26-6-Cl                                                                               111-113                                228 MeOCH.sub.2 CCl(Me)CH.sub.2                                                                   Cl  O  H  H  Q26-6-Cl                                                                               97-99                                  229 Q9-3-Cl (trans Cl  O  H  H  Q26-6-I 157-158                                form)                                                                          230 ClCH.sub.2 CH.sub.2 CCl(Me)CH.sub.2                                                           Cl  O  H  H  Q26-6-Cl                                                                               110-113                                231 PrCCl(Et)CH.sub.2                                                                             Cl  O  H  H  Q26-6-Cl                                                                               89-91                                  232 EtCHClCCl(Me)CH.sub.2                                                                         Cl  O  H  H  Q26-6-Cl                                                                               130-131                                233 PenCCl(Me)CH.sub.2                                                                            Cl  O  H  H  Q26-6-Cl                                                                               71-72                                  234 ClCH.sub.2 CCl.sub.2 CH.sub.2                                                                 Cl  O  H  H  Q26-6-Cl                                                                               141-143                                235 CH.sub.2C(CH.sub.2 Cl)CH.sub.2                                                                Cl  O  H  H  Q26-6-Cl                                                                               128-130                                236 Me.sub.2 CClCH.sub.2                                                                          Cl  O  H  H  Q26-6-Cl                                                                               128-130                                237 Me.sub.2 CClCH.sub.2                                                                          Cl  O  H  H  Q26-6-I 119-123                                238 (ClCH.sub.2).sub.2 CClCH.sub.2                                                                Cl  O  H  H  Q26-6-Cl                                                                               107-111                                239 ClCH.sub.2 CH.sub.2 CCl(Me)CH.sub.2                                                           Cl  O  H  H  Q26-6-I 78-80                                  240 EtOCH.sub.2 CCl(Me)CH.sub.2                                                                   Cl  O  H  H  Q26-6-Cl                                                                               96-98                                  241 MeOCH.sub.2 CH.sub.2 CCl(Me)CH.sub.2                                                          Cl  O  H  H  Q26-6-Cl                                                                               87-90                                  242 PrCCl(Me)CH.sub.2                                                                             Cl  O  H  H  Q55     81-83                                  243 Me.sub.2 CBrCH.sub.2                                                                          Cl  O  H  H  Q26-6-Cl                                                                               128-130                                244 Me.sub.2 CClCH.sub.2                                                                          Cl  O  H  H  Q26-6-Br                                                                               142-143                                245 EtCCl(Me)CH.sub.2                                                                             Cl  O  H  H  Q26-6-Br                                                                               126-128                                246 PrCCl(Me)CH.sub.2                                                                             Cl  O  H  H  Q26-6-Br                                                                               113-115                                247 ClCH.sub.2 CCl(Me)CH.sub.2                                                                    Cl  O  H  H  Q26-6-Br                                                                               129-130                                248 ClCH.sub.2 CCl(Et)CH.sub.2                                                                    Cl  O  H  H  Q26-6-Cl                                                                               129-130                                249 Cl(CH.sub.2).sub.3 CCl(Me)CH.sub.2                                                            Cl  O  H  H  Q26-6-Cl                                                                               85-87                                  250 Q7-3-Cl        Cl  O  H  H  Q26-6-Cl                                                                               174-175                                251 Q7-3-Cl        Cl  O  H  H  Q26-6-I 176-177                                252 MeCHCHCH.sub.2 Cl  O  H  H  Q56     128-130                                253 MeCHCHCH.sub.2 Cl  O  H  H  Q55     151-153                                254 CH.sub.2C(Me)CH.sub.2                                                                         Cl  O  H  H  Q26-6-Cl                                                                                98-104                                255 (Me).sub.2 CCH Cl  O  H  H  Q26-6-I 141-142                                256 MeOC(Me).sub.2 CH.sub.2                                                                       Cl  O  H  H  Q26-6-I 120-121                                257 PrCCl(Me)CH.sub.2                                                                             Cl  O  H  H  Q26-6-OEt                                                                              88-91                                  258 PrCCl(Me)CH.sub.2                                                                             Cl  O  H  H  Q23-5-Me                                                                               101-103                                259 PrCCl(Me)CH.sub.2                                                                             Cl  O  H  H  Q23-5-Br                                                                               110-112                                260 PrCCl(Me)CH.sub.2                                                                             Cl  O  H  H  Q23-4-Br                                                                               95-96                                  261 PrCCl(Me)CH.sub.2                                                                             Cl  O  H  H  Q23-5-I 106-108                                262 PrCCl(Me)CH.sub.2                                                                             Cl  O  H  H  Q26-6-OPr-i                                                                            114-115                                263 ClCH.sub.2 C(Me).sub.2 CH.sub.2                                                               Cl  O  H  H  Q26-6-I 131- 132                               264 Me.sub.2 CClCH.sub.2                                                                          Cl  O  H  H  Q26-6-OEt                                                                              108-110                                265 Me.sub.2 CClCH.sub.2                                                                          Me  O  H  H  Q26-6-I 109-111                                266 ClCH.sub.2 CCl(Me)CH.sub.2                                                                    Cl  O  H  H  Q26-6-OEt                                                                              89-90                                  267 ClCH.sub.2 CCl(Me)CH.sub.2                                                                    Cl  O  H  H  Q23-5-Me                                                                               99-101                                 268 ClCH.sub.2 CCl(Me)CH.sub.2                                                                    Cl  O  H  H  Q23-5-Br                                                                               89-91                                  269 ClCH.sub.2 CCl(Me)CH.sub.2                                                                    Cl  O  H  H  Q23-4-Br                                                                               120-122                                270 ClCH.sub.2 CCl(Me)CH.sub.2                                                                    Cl  O  H  H  Q23-5-I 115-116                                271 Cl(CH.sub.2).sub.3 CCl(Me)CH.sub.2                                                            Cl  O  H  H  Q26-6-I 95-98                                  272 PrCCl(Me)CH.sub.2                                                                             Cl  O  H  H  Q26-6-Et                                                                               92-94                                  273 Pr(Me)CCH (trans                                                                              Cl  O  H  H  Q26-6-I 172-173                                form)                                                                          274 ClCH.sub.2 C(Me)CH                                                                            Cl  O  H  H  Q26-6-I 136-137                                __________________________________________________________________________      (*)  TLC (Silica gel: C.sub.6 H.sub.6 (10)CH.sub.3 COOEt(1)) Rf value =        0.15                                                                           (**)  TLC (Silica gel: C.sub.6 H.sub.6 (10)CH.sub.3 COOEt(1)) Rf value =       0.22                                                                     

                                      TABLE 6                                      __________________________________________________________________________     In Compounds of the formula:                                                    ##STR20##                                                                     No. R          A   X  R.sup.1                                                                           J                          m.p.                       __________________________________________________________________________                                                         (°C.)               301 ClCH.sub.2 CCl(Me)CH.sub.2                                                                Cl  O  H  CH.sub.2 CH.sub.2 OC.sub.6 H.sub.4 -4-Cl                                                                  106-107                    302 ClCH.sub.2 CCl(Me)CH.sub.2                                                                Cl  O  H  CH.sub.2 CH(Me)O-Q17       69-70                      303 ClCH.sub.2 CCl(Me)CH.sub.2                                                                Cl  O  H  CH.sub.2 CH.sub.2 OPh      106-107                    304 ClCH.sub.2 CCl(Me)CH.sub.2                                                                Cl  O  H  CH.sub.2 CH.sub.2 ONCHMe   n.sub.d.sup.20                                                                 1.3241                     305 PrCCl(Me)CH.sub.2                                                                         Cl  O  H  CH.sub.2 CH.sub.2 C.sub.6 H.sub.4 -4-Cl                                                                   95-97                      306 PrCCl(Me)CH.sub.2                                                                         Cl  O  H  CH.sub.2 CH.sub.2 C.sub.6 H.sub.4 -3-Cl                                                                   61-62                      307 PrCCl(Me)CH.sub.2                                                                         Cl  O  H  CH.sub.2 CH.sub.2 C.sub.6 H.sub.4 -3-Me                                                                   49-51                      308 PrCCl(Me)CH.sub.2                                                                         Cl  O  H  CH.sub.2 CH.sub.2 C.sub.6 H.sub.4 -2-Me                                                                   75-76                      309 PrCCl(Me)CH.sub.2                                                                         Cl  O  H  CH.sub.2 CH.sub.2 C.sub.6 H.sub.4 -4-F                                                                    58-60                      310 PrCCl(Me)CH.sub.2                                                                         Cl  O  H  CH.sub.2 CH.sub.2 C.sub.6 H.sub.4 -4-CF.sub.3                                                             98-99                      311 PrCCl(Me)CH.sub.2                                                                         Cl  O  H  CH.sub.2 CH.sub.2 C.sub.6 H.sub.4 -3-CF.sub.3                                                             58-60                      312 PrCCl(Me)CH.sub.2                                                                         Cl  O  H  CH.sub.2 C(Me).sub.2 O(C.sub.6 H.sub.3 -2,5-Me.su                              b.2)                       60-62                      313 PrCCl(Me)CH.sub.2                                                                         Cl  O  H  CH.sub.2 CMeCH(C.sub.6 H.sub.4 -4-Et)                                                                     82-83                      314 PrCCl(Me)CH.sub.2                                                                         Cl  O  H  (CH.sub.2).sub.3 CC-Br     53-56                      315 PrCCl(Me)CH.sub.2                                                                         Cl  O  H  CH.sub.2 CH.sub.2 C.sub.6 H.sub.4 -4-Me                                                                   n.sub.d.sup.20                                                                 1.5641                     316 PrCCl(Me)CH.sub.2                                                                         Cl  O  H  CH.sub.2 CH.sub.2 C.sub.6 H.sub.3 -2,4-Cl.sub.2                                                           71-73                      317 PrCCl(Me)CH.sub.2                                                                         Cl  O  H  CH.sub.2 CHMeO(C.sub.6 H.sub.3 -2,5-Me.sub.2)                                                             n.sub.d.sup.20                                                                 1.5557                     318 PrCCl(Me)CH.sub.2                                                                         Cl  O  H  CH.sub.2 CH.sub.2 OPh      n.sub.d.sup.20                                                                 1.5578                     319 PrCCl(Me)CH.sub.2                                                                         Cl  O  H  CH.sub.2 CH.sub.2 OC.sub.6 H.sub.4 -4-Me                                                                  67-69                      320 PrCCl(Me)CH.sub.2                                                                         Cl  O  H  CH.sub.2 CH.sub.2 NHCO.sub.2 Et                                                                           67-68                      321 PrCCl(Me)CH.sub.2                                                                         Cl  O  H  (CH.sub.2).sub.3 CCH       59-61                      322 PrCCl(Me)CH.sub.2                                                                         Cl  O  H  CH.sub.2 CH.sub.2 ONCHMe   n.sub.d.sup.20                                                                 1.5314                     323 Me.sub.2 CClCH.sub.2                                                                      Cl  O  H  CH.sub.2 CH.sub.2 C.sub.6 H.sub.4 -4-CF.sub.3                                                             126-127                    324 Me.sub.2 CClCH.sub.2                                                                      Cl  O  H  (CH.sub.2).sub.3 CCBr      n.sub.d.sup.20                                                                 1.5670                     325 Me.sub.2 CClCH.sub.2                                                                      Cl  O  H  (CH.sub.2).sub.3 CCH       42-44                      326 Me.sub.2 CClCH.sub.2                                                                      Cl  O  H  CH.sub.2 CH.sub.2 OPh      82-83                      327 Me.sub.2 CClCH.sub.2                                                                      Cl  O  H  (CH.sub.2).sub.3 -Q17-5-Br 109-110                    328 PrCCl(Me)CH.sub.2                                                                         Cl  O  H  (CH.sub.2).sub.3 Ph        54-57                      329 PrCCl(Me)CH.sub.2                                                                         Cl  O  H  (CH.sub.2).sub.3 CO.sub.2 H                                                                               93-95                      330 PrCCl(Me)CH.sub.2                                                                         Cl  O  H  CH.sub.2 C(Me)NOPr         n.sub.d.sup.20                                                                 1.3458                     331 PrCCl(Me)CH.sub.2                                                                         Cl  O  H  CH.sub.2 CH.sub.2 CCCH.sub.2 OMe                                                                          45-47                      332 PrCCl(Me)CH.sub.2                                                                         Cl  O  H  (CH.sub.2).sub.3 CO.sub.2 Et                                                                              n.sub.d.sup.20                                                                 1.5231                     333 ClCH.sub.2 CCl(Me)CH.sub.2                                                                Cl  O  H  CH.sub.2 C(Me)NOPr         60-61                      334 Me.sub.2 CClCH.sub.2                                                                      Cl  O  H  CH.sub.2 CH.sub.2 CCCH.sub.2 OMe                                                                          n.sub.d.sup.20                                                                 1.5453                     335 PrCCl(Me)CH.sub.2                                                                         Cl  O  H  CH.sub.2 C(Me)CHCO.sub.2 Et                                                                               88-90                      __________________________________________________________________________

The definition of Q in the Tables 4, 5 and 6 are the same as that of Q in the Tables 1, 2 and 3.

When the compounds according to the present invention are used for insecticidal, acaricidal and nematicidal compositions and compositions for expelling ticks parasitic on animals, they are generally mixed with suitable carriers, for instance, solid carriers such as clay, talc, bentonite or diatomaceous earth, or liquid carriers such as water, alcohols (e.g., methanol and ethanol), aromatic hydrocarbons (e.g., benzene, toluene and xylene), chlorinated hydrocarbons, ethers, ketones, esters (e.g., ethyl acetate) or acid amides (e.g., dimethylformamide). If desired, to these mixtures may be added emulsifier, dispersing agent, suspension agent, penetrating agent, spreader, stabilizer and the like to put them into practical use in the form of emulsifiable concentrate, oil solution, wettable powder, dust, granule, flowable or the like.

Moreover, the mixtures may be incorporated with other insecticides, various herbicides, fungicides, plant-growth regulating agents, synergists during formulation or application thereof, as necessary.

The amount of the compounds of the invention to be used as an active ingredient is suitably in the range of 0.005 to 50 kg per hectare although it varies depending upon the place and the seasons where the compounds are applied, manner of application, diseases and insect pests to be applied, cultivated crops to be protected and the like.

The following is formulatin proportion and kinds of various preparations of the present invention.

    ______________________________________                                                                            Other                                              Active           Surface-   component                                          ingredient                                                                             Carrier  active agent                                                                              (adjuvant)                                  ______________________________________                                         Emulsifiable                                                                            1-25      52-95    3-20      0-20                                     concentrates                                                                   Oil solutions                                                                           1-30      70-99                                                       Flowables                                                                               1-70      10-90    1-20      0-10                                     Wettable 1-70      15-93    3-10     0-5                                       powders                                                                        Dusts    0.01-30   67-99.5           0-3                                       Granules 0.01-30   67-99.5           0-8                                       ______________________________________                                    

The numeral values in the above table represent "percent by weight".

In use, emulsifiable concentrates, oil solutions, flowables and wettable powder are diluted with a predetermined amount of water and applied. Dusts and granules are directly applied without being diluted with water. The granules contain baits.

Each component of the above formulations is exemplified as follows.

Emulsifiable concentrates

Active ingredient: Present compound

Carrier: xylene, dimethylformamide, methylnaphthalene, cyclohexanone, dichlorobenzene, isophorone

Surface-active agent: Solpol 2680, Solpol 3005X, Solpol 3353

Other ingredients: piperonylbutoxide, benzotriazole

Oil solution

Active ingredient: Present compound

Carrier: xylene, methylcellosolve, kerosense

Flowables

Active ingredient: Present compound

Carrier: water

Surface-active agent: Lunox 1000C, Solpol 3353, Soprophor FL, Nippol, Agrisol S-710, sodium lignin sulfate

Other ingredients: Xanthan gum, formalin, ethylene glycol, propylene glycol

Wettable powders

Active ingredient: Present compound

Carrier: potassium carbonate, kaolinite, Zeeklite D, Zeeklite PFP, diatomaceous earth, talc

Surface-active ingredients: Solpol 5039, Lunox 1000C, calcium lignin sulfonate, sodium dodecyl benzenesulfonate, Solpol 5050, Solpol 005D, Solpol 5029-0

Other ingredient: Carplex #80

Dusts

Active ingredient: Present compound

Carrier: potassium carbonate, kaolinite, Zeeklite D, talc

Other ingredient: diisopropyl phosphate, Carplex #80

Granules (1)

Active ingredient: Present compound

carrier: potassium carbonate, kaolinite, bentonite, talc

Other ingredients: calcium lignin sulfonate, polyvinyl alcohol

Granules (2)

Active ingredient: Present compound

Carrier: wheat flour, wheat bran, corn grits, Zeeklite D

Other ingredients: paraffin, bean oil

In the following, there are shown formulation examples of insecticidal, acaricidal and nematicidal compositions and compositions for ticks parasitic on animals, said compositions containing the compounds of the present invention as an active ingredient. These examples are only illustrative and not to restrict the present invention. In the following formulation examples, "part" means "part by weight".

Formulation Example 1: Emulsifiable concentrate

Present compound: 1 part

Xylene: 75 parts

N,N-dimethylformamide: 20 parts

Solpol 2680 (trade name: a mixture of a non-ionic surface-active agent and an anionic surface-active agent manufactured by Toho Chemical, Co., Ltd., Jap: 4 parts

Formulation Example 2: Emulsifiable concentrate

Present compound: 5 parts

Xylene: 70 parts

N,N-dimethylformamide: 20 parts

Solpol 2680: 5 parts

Formulation Example 3: Emulsifiable concentrate

Present compound: 10 parts

Xylene: 70 parts

N,N-dimethylformamide: 5 parts

Solpol 2680: 10 parts

Piperonyl butoxide: 5 parts

Formulation Example 4: Emulsifiable concentrate

Present compound: 20 parts

Xylene: 50 parts

N,N-dimethylformamide: 7 parts

Solpol 2680: 3 parts

Piperonyl butoxide: 20 parts

Formulation Example 5: Emulsifiable concentrate

Present compound: 25 parts

Xylene: 50 parts

N,N-dimethylformamide: 2 parts

Solpol 2680: 20 parts

Piperonyl butoxide: 3 parts

In the above respective emulsifiable concentrates, each component of the respective emulsifiable concentrates are mixed intimately to form respective emulsifiable concentrates. Upon use, the emulsifiable concentrates are diluted with water up to one fiftieth to one twenty thousandth in concentration and applied at a rate of 0.005 to 50 kg of the active ingredient per hectare.

Formulation Example 6: Wettable powders

Present compound: 1 part

Zeeklite PFP (trade name, a mixture of kaolinite and sericite manufactured by Zeeklite Mining Industries,

Co., Ltd.: 93 parts

Solpol 5039 (trade name, anionic surface-active agent manufactured by Toho Chemical, Co., Ltd., Japan): 4 parts

Carplex #80 (trade name, white carbon manufactured by Shionogi Seiyaku K.K., Japan): 2 parts

Formulation Example 7: Wettable powders

Present compound: 10 parts

Zeeklite PFP: 80 parts

Solpol 5039: 6 parts

Carplex #80: 4 parts

Formulation Example 8: Wettable powders

Present compound: 25 parts

Zeeklite PFP: 66 parts

Solpol 5039: 4 parts

Carplex #80: 2 parts

Calcium lignin sulfonate: 3 parts

Formulation Example 9: Wettable powder

Present compound: 50 parts

Zeeklite PFP: 47 parts

Solpol 5039: 2 parts

Carplex #80: 1 part

Formulation Example 10: Wettable powder

Present compound: 70 parts

Zeeklite PFP: 15 parts

Solpol 5039: 6 parts

Carplex #80: 4 parts

Calcium lignin sulfonate: 5 parts

In the above respective wettable powders, each component of the respective wettable powders are intimately mixed and ground to form respective wettable powder. Upon use, the wettable powders are diluted with water up to one fiftieth to one twenty thousandth in concentration and applied at a rate of 0.005 to 50 kg of the active ingredient per hectare.

Formulation Example 11: Oil solutions

Present compound: 1 part

Methylcellosolve: 99 parts

Formulation Example 12: Oil solutions

Present compound: 20 parts

Methylcellosolve: 80 parts

Formulation Example 13: Oil solutions

Present compound: 30 parts

Methylcellosolve: 70 parts

In the above respective oil solutions, each component of the respective oil solutions are homogeneously mixed together to form the respective oil solutions. Upon use, the oil solutions are applied at a rate of 0.005 to 50 kg of the active ingredient per hectare.

Formulation Example 14: Dusts

Present compound: 0.01 part

Carplex #80 (trade name, white carbon manufactured by Shionogi Seiyaku K.K., Japan): 0.1 part

Clay: 99.5 parts

diisopropyl phosphate: 0.39 part

Formulation Example 15: Dusts

Present compound: 0.1 part

Carplex #80: 0.1 part

Clay: 99.5 parts

diisopropyl phosphate: 0.3 part

Formulation Example 16: Dusts

Present compound: 1 part

Clay: 99 parts

Formulation Example 17: Dusts

Present compound: 10 parts

Carplex #80: 0.2 part

Clay: 89 parts

diisopropyl phosphate: 0.8 part

Formulation Example 18: Dusts

Present compound: 30 parts

Carplex #80: 1 part

Clay: 67 parts

diisopropyl phosphate: 2 parts

In the above respective dusts, components of the respective dusts are homogeneously mixed together to form the respective dusts. Upon use, the dusts are applied at a rate of 0.005 to 50 kg of the active ingredient per hectare.

Formulation Example 19: Granules (1)

Present compound: 0.01 part

Bentonite: 59.5 parts

Talc: 40 parts

Calcium lignin sulfonate: 0.49 part

Formulation Example 20: Granules (1)

Present compound: 0.5 part

Bentonite: 59.5 parts

Talc: 40 parts

Formulation Example 21: Granules (1)

Present compound: 1 part

Bentonite: 40 parts

Talc: 51 parts

Calcium lignin sulfonate: 8 parts

Formulation Example 22: Granules (1)

Present compound: 5 parts

Bentonite: 54 parts

Talc: 40 parts

calcium lignin sulfonate: 1 part

Formulation Example 23: Granules (1)

Present compound: 30 parts

Bentonite: 37 parts

Talc: 30 parts

calcium lignin sulfonate: 3 parts

In the above respective granules (1), each components of the respective granules (1) are mixed intimately together and ground, incorporated with a small amount of water and mixed together with stirring. The resulting mixture is granulated by means of extrusion-granulator and dried to form granules. Upon use, the granule is applied to at a rate of 0.005 to 50 kg of the active ingredient per hectare.

Formulation Example 24: Granules (2)

Present compound: 0.01 part

Wheat flour: 49.5 parts

Wheat bran: 50 parts

Bean oil: 0.49 part

Formulation Example 25: Granules (2)

Present compound: 0.5 part

Wheat flour: 49.5 parts

Wheat bran: 50 parts

Formulation Example 26: Granules (2)

Present compound: 1 part

Wheat flour: 40 parts

Wheat bran: 51 parts

Bean oil: 4 parts

Paraffin: 4 parts

Formulation Example 27: Granules (2)

Present compound: 5 parts

Wheat flour: 44 parts

Wheat bran: 50 parts

Bean oil: 1 part

Formulation Example 28: Granules (2)

Present compound: 30 parts

Wheat flour: 27 parts

Wheat bran: 40 parts

Bean oil: 3 parts

In the above respective granules (2), each components of the respective granules (2) are mixed intimately together to form respective bait. Upon use, the granule is applied at a rate of 0.005 to 50 kg of the active ingredient per hectare.

Formulation Example 29: Flowables

Present compound: 1 part

Solpol 3353 (trade name, non-ionic surface-active agent manufactured by Toho Chemicals, Co., Ltd., Japan): 0.9 part

Lunox 1000C (trade name, as anionic surface-active agent manufactured by Toho Chemicals, Co., Ltd., Japan): 0.1 part

1% aqueous solution of Xanthan gum (natural high-molecular compound): 8 parts

Water: 90 parts

Formulation Example 30: Flowables

Present compound: 15 parts

Solpol 3353: 15 parts

Lunox 1000C: 5 parts

Water: 65 parts

Formulation Example 31: Flowables

Present compound: 35 parts

Solpol 3353: 14 parts

Lunox 1000C: 1 part

1% aqueous solution of Xanthan gum 10 parts

Water: 45 parts

Formulation Example 32: Flowables

Present compound: 50 parts

Solpol 3353: 9 parts

Lunox 1000C: 1 part

1% aqueous solution of Xanthan gum: 10 parts

Water: 30 parts

Formulation Example 33: Flowables

Present compound: 70 parts

Solpol 3353: 9 parts

Lunox 1000C: 1 part

1% aqueous solution of Xanthan gum: 10 parts

Water: 10 parts

In the above respective flowables, each component except the active ingredient (present compound) are uniformly mixed together to form a solution. The resulting mixture is added by the present compound thoroughly stirred and wet-ground by means of sand mill to form respective flowables. Upon use, the flowables are diluted up to one fiftieth to one twenty thousandth with water and applied at a rate of 0.005 to 50 kg of the active ingredient per hectare.

In the following, the effects of the present compounds as an insecticide are explained in detail by way of the test examples.

Test Example 1: Insecticidal test on Green rice leafhopper (Nephotettix cincticeps)

A 5% emulsifiable concentrate (or a 25% wettable powder) of a compound of the present invention was diluted with water containing a spreader to give a 500 ppm solution of the compound.

The stems and leaves of rice-plant in a 1/20000 are pot were sufficiently applied with the resulting solution and then airdried. Thereafter, 20 second instar nymphae of green rice leafhopper (Nephotettix cincticeps) which resist organic phosphorous insecticides and carbamate insecticides were released in the pot.

The rice-plant thus treated was covered with a cylindrical wire gauze and kept in a thermostatic chamber.

Thirty (30) days after, the number of the green rice leafhoppers parasitic on the rice-plant was counted and the mortality thereof was determined according to the following equation: ##EQU1##

The test was conducted twice for each compound. In the results, the following compounds exhibited high effects of 100% of mortality.

Compound Nos. 9, 10, 12, 15, 17, 19, 24, 25, 27, 28, 32, 33, 38, 39, 45, 49, 50, 52, 53, 75, 76, 77, 78, 80, 81, 85, 87, 92, 97, 104, 105, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 120, 122, 124, 125, 126, 127, 155, 156, 201, 202, 203, 204, 206, 207, 208, 209, 211, 212, 218, 219, 226, 228, 229, 230, 231, 234, 236, 237, 238, 239, 240, 244, 245, 247, 250, 251, 314, 321, 324, 325

Test Example 2: Insecticidal test on Brown rice planthopper (Nilaparvata lugens)

The procedures in Test Example 1 were repeated by using second instar nymphae of brown rice planthopper (Nilaparvata lugens) instead of the second instar nymphae of green rice leafhoppers which resist organic phosphorous insecticides and carbamate insecticides. In the results, the following compounds exhibited high effects of 100% of mortality.

Compound Nos. 11, 25, 34, 48, 93, 201, 202, 203, 204, 205, 207, 208, 209, 211, 212, 214, 215, 219, 228, 229, 230, 231, 234, 236, 237, 238, 239, 240, 243, 244, 245, 246, 247, 249, 250, 251, 254, 255, 256, 257, 259, 263, 264, 265, 271, 302

Test Example 3: Insecticidal test on Red flour beetle (Tribolium castaneum)

In a transparent small test tube was placed 5% emulsifiable concentrate of a compound of the present invention (or a 25% wettable powder or a 20% oil solution thereof), and thereto was added acetone to give a 500 ppm acetone solution of the compound. Ten (10) cc of the acetone solution was added to 10 g of wheat flour placed in a laboratory dish of 9 cm in diameter. After stirring, acetone was distilled away from the mixture. Then, 10 adults each of male and female red flour beetle (Tribolium castaneum) were released in the dish. The dish containing the adults was kept in a thermostatic chamber.

Ninety (90) days after, evaluation was conducted by counting the number of the adults which came out.

The test was conducted twice of each compound.

As a result, no emerged adult was observed at all in the dish treated with any one of the following compounds.

Compound Nos. 9, 10, 12, 15, 19, 24, 25, 32, 33, 39, 70, 71, 75, 76, 77, 78, 79, 80, 81, 84, 85, 86, 87, 92, 93, 94, 95, 97, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 155, 156, 159, 160, 161, 163, 164, 168, 169, 173, 201, 202, 203, 204, 206, 207, 208, 209, 211, 212, 226, 227, 228, 229, 230, 231, 232, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 255, 257, 263, 264, 266, 271

Test Example 4: Insecticidal test on House mosquito (Culex pipiens pallens)

A 5% emulsifiable concentrate (or a 25% wettable powder or 20% oil solution) of a compound of the present invention was diluted with deionized water to give a 10 ppm solution of the compound.

Two hundred (200) ml of the solution was poured in a tall laboratory dish of 9 cm in diameter and 6 cm in height. Ten larvae of house mosquito (Culex pipiens pallens) were released in the dish. The dish containing the larvae was kept in a thermostatic chamber of 25° C.

Seven (7) days after, the number of the larvae killed was counted.

The test was conducted twice of each compound.

As the result, no emerged adult was observed at all in the dish treated with any one the following compounds.

Compound Nos. 1, 2, 3, 4, 5, 6, 9, 10, 12, 14, 15, 17, 18, 19, 24, 25, 27, 28, 30, 32, 33, 34, 35, 38, 39, 45, 49, 52, 53, 70, 71, 72, 73, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 90, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 122, 123, 124, 125, 126, 127, 155, 156, 158, 160, 163, 164, 168, 169, 173, 201, 202, 203, 204, 205, 206, 207, 208, 209, 211, 212, 215, 217, 218, 219, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 236, 237, 238, 239, 240, 241, 242, 244, 245, 246, 250, 251, 255, 257, 264, 266, 301

Test Example 5: Insecticidal test on Almond moth (Cadra cautella)

In a transparent small test tube was placed 5% emulsifiable concentrate of a compound of the present invention (or a 25% wettable powder or a 20% oil solution thereof), and thereto was added acetone to give a 500 ppm acetone solution of the compound. Ten (10) cc of the acetone solution was added to 10 g of rice bran placed in a laboratory dish of 9 cm in diameter. After stirring, acetone was distilled away from the mixture. Then, 10 larvae of almond moth (Cadra cautella) were released in the dish. The dish containing the larvae was kept in a thermostatic chamber.

Thirty (30) days after, evaluation was conducted by counting the number of the adults which came out.

The test was conducted twice of each compound.

As a result, no emerged adult was observed at all in the dish treated with any one of the following compounds.

Compound Nos. 9, 10, 11, 12, 15, 19, 24, 25, 27, 28, 32, 33, 34, 38, 39, 52, 53, 70, 71, 73, 74, 75, 76, 77, 78, 79, 80, 81, 84, 85, 86, 87, 89, 90, 92, 93, 94, 95, 97, 98, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 124, 125, 126, 127, 155, 156, 160, 162, 163, 164, 166, 167, 168, 169, 171, 172, 173, 201, 202, 203, 204, 206, 207, 208, 209, 211, 212, 214, 215, 217, 218, 219, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 249, 250, 251, 256, 257, 258, 259, 260, 261, 262, 263, 264, 265, 266, 268, 270, 271, 302, 314, 318, 319

Test Example 6: Insecticidal test on Green peach aphid (Myzus persicae)

A 5% emulsifiable concentrate (or a 25% wettable powder) of a compound of the present invention was diluted with water containing a spreader to give a 500 ppm solution of the compound.

Discs of leaves of cabbage (Brassica oleracea) were put in each laboratory dish of 3 cm in diameter in which a moistured paper was placed. In each laboratory dish was released 5 third instar nymphae of green peach aphid (Myzus persicae) and sprayed from a sprinkler.

The laboratory dishes were kept in a thermostatic chamber.

Seven (7) days after, the number of surviving green peach aphids was counted and the mortality thereof was determined according to the equation as described in Test Example 1. The test was conducted four times of each compound.

As a result, the following compounds exhibited high effects of 100% of mortality.

Compound Nos. 9, 10, 12, 15, 25, 27, 28, 32, 33, 34, 36, 37, 38, 39, 54, 55, 56, 58, 59, 61, 62, 64, 75, 76, 84, 85, 87, 93, 95, 96, 97, 100, 101, 102, 103, 104, 105, 107, 108, 110, 111, 115, 116, 118, 119, 120, 123, 124, 125, 126, 156, 159, 160, 161, 163, 164, 165, 167, 168, 169, 170, 173, 201, 202, 203, 204, 207, 208, 209, 211, 212, 215, 228, 231, 234, 244, 245, 246, 247, 250, 251, 255, 257, 259, 260, 261, 262, 264, 265, 266, 268, 270, 271, 301, 302, 303, 305, 306, 307, 310, 314, 318, 319, 320, 321

Test Example 7: Insecticidal test on Diamond back moth (Plutella xylostella)

A 5% emulsifiable concentrate (or a 25% wettable powder) of a compound of the present invention was diluted with water containing a spreader to give a 500 ppm solution of the compound.

Leaves of cabbage (Brassica oleracea) were dipped in the solution, air-dried and then put in a laboratory dish of 7 cm in diameter. Ten (10) third larvae of diamond back moth (Plutella xylostella) were released in each laboratory dish and kept in a thermostatic chamber.

Twenty (20) days after, the number of emerged adults was counted and the mortality thereof was determined according to the equation as described in Test Example 1. The test was conducted twice of each compound.

As a result, the follwoing compounds exhibited high effects of 100% of mortality.

Compound Nos. 9, 10, 11, 12, 15, 17, 19, 24, 25, 27, 28, 32, 33, 34, 38, 39, 80, 81, 85, 104, 105, 118, 119, 124, 125, 127, 155, 156, 201, 202, 203, 204, 206, 207, 211, 212, 214, 215, 230, 231, 234, 236, 237, 243, 244, 245, 246, 247, 249, 250, 251, 255, 256, 257, 263, 264, 265, 271

Test Example 8: Insecticidal test on Maize weevil (Sitophilus oryzae)

A 5% emulsifiable concentrate (or a 25% wettable powder) of a compound of the present invention was diluted with water containing a spreader to give a 500 ppm solution of the compound.

Ten (10) g of unmilled rice in a laboratory dish were dipped with the obtained solution and air-dried, and then maize weevil adults each 10 of male and female were released therein. The laboratory dishes were kept in a thermostatic chamber.

Ninety (90) days after, evaluation was conducted by counting the number of the adults which came out.

The test was conducted twice of each compound.

As a result, no emerged adult was observed at all in the dishes treated with any one of the following compounds.

Compound Nos. 24, 33, 62, 85, 100, 104, 106, 109, 115, 116, 118, 119, 120, 155, 160, 164, 165, 168, 203, 205, 206, 207, 211, 212, 228, 231, 237, 239, 240, 243, 244, 245, 246, 247, 249, 257, 264, 266

Test Example 9: Insecticidal test on German cockroach (Blattella germanica)

In a transparent small test tube was weighed and placed 5% emulsifiable concentrate of a compound of the present invention (or a 25% wettable powder or a 20% oil solution thereof), and thereto was added acetone to give a 500 ppm acetone solution of the compound. Ten (10) cc of the acetone solution was added to 10 g of powder feed for small animals placed in a laboratory dish of 9 cm in diameter. After stirring, acetone was distilled away from the mixture. This laboratory dish was placed in a large laboratory dish of 20 cm in diameter to prepare a bait. In this large laboratory dish were released 10 five instar nymphae of German cockroaches (Blattella germanica). The large laboratory dish was kept in a thermostatic chamber. In the large laboratory dish, a laboratory dish containing moistured sanitary cottom was placed so as to give a water to the nymphae.

Sixty (60) days after, evaluation was conducted by counting the number of the adults which came out.

The test was conducted twice of each compound.

As a result, no adult was observed at all in the dish treated with any one of the following compounds.

Compound Nos. 201, 202, 203, 204, 206, 207, 211, 212, 230, 236, 237, 239, 243, 244, 245, 246, 247, 250, 251, 257, 265, 266 

What is claimed is:
 1. A 3(2H)-pyridazinone compound of the formula ##STR21## wherein, R represents an alkyl group having 3 to 6 carbon atoms substituted by 1 to 3 halogen atoms;A represents halogen atom; J represents --CH₂ --Q or ##STR22## in which R² represents hydrogen atom or methyl group and Q represent ##STR23## in which Y is selected from the group consisting of hydrogen atom, halogen atom, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, a haloalkyl group having 1 to 4 carbon atoms and a haloalkoxy group having 1 to 4 carbon atoms.
 2. A 3(2H)-pyridazinone compound as claimed in claim 1, wherein the compound has the following formula: ##STR24##
 3. A 3(2H)-pyridazinone compound as claimed in claim 1, wherein the compound has the following formula: ##STR25##
 4. A 3(2H)-pyridazinone compound as claimed in claim 1, wherein the compound has the following formula: ##STR26##
 5. A 3(2H)-pyridazinone compound as claimed in claim 1, wherein the compound has the following formula: ##STR27##
 6. A 3(2H)-pyridazinone compound as claimed in claim 1, wherein the compound has the following formula: ##STR28##
 7. A 3(2H)-pyridazinone compound wherein the compound has the following formula: ##STR29##
 8. A 3(2H)-pyridazinone compound as claimed in claim 1, wherein the compound has the following formula: ##STR30##
 9. A 3(2H)-pyridazinone compound as claimed in claim 1, wherein the compound has the following formula: ##STR31##
 10. A 3(2H)-pyridazinone compound as claimed in claim 1, wherein the compound has the following formula: ##STR32##
 11. A 3(2H)-pyridazinone compound as claimed in claim 1, wherein the compound has the following formula: ##STR33##
 12. Insecticidal, acaricidal, nematicidal compositions and compositions for expelling ticks parasitic on animals, containing as an active ingredient a 3(2H)-pyridazinone compound of the formula: ##STR34## wherein, R represents an alkyl group having 3 to 6 carbon atoms substituted by 1 to 3 halogen atoms;A represents halogen atom; J represents --CH₂ --Q or ##STR35## in which R² represents hydrogen atom or methyl group and Q represent ##STR36## in which Y is selected from the group cosisting of hydrogen atom, halogen atom, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, a haloalkyl group having 1 to 4 carbon atoms and a haloalkoxy group having 1 to 4 carbon atoms, and a carrier. 